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- Protein interactions (2)
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Articles 1 - 6 of 6
Full-Text Articles in Life Sciences
Telomere Roles In Fungal Genome Evolution And Adaptation, Mostafa Rahnama, Baohua Wang, Jane Dostart, Olga Novikova, Daniel Yackzan, Andrew T. Yackzan, Haley Bruss, Maray Baker, Haven Jacob, Xiaofei Zhang, April Lamb, Alex Stewart, Melanie Heist, Joey Hoover, Patrick Calie, Li Chen, Jinze Liu, Mark L. Farman
Telomere Roles In Fungal Genome Evolution And Adaptation, Mostafa Rahnama, Baohua Wang, Jane Dostart, Olga Novikova, Daniel Yackzan, Andrew T. Yackzan, Haley Bruss, Maray Baker, Haven Jacob, Xiaofei Zhang, April Lamb, Alex Stewart, Melanie Heist, Joey Hoover, Patrick Calie, Li Chen, Jinze Liu, Mark L. Farman
Plant Pathology Faculty Publications
Telomeres form the ends of linear chromosomes and usually comprise protein complexes that bind to simple repeated sequence motifs that are added to the 3′ ends of DNA by the telomerase reverse transcriptase (TERT). One of the primary functions attributed to telomeres is to solve the “end-replication problem” which, if left unaddressed, would cause gradual, inexorable attrition of sequences from the chromosome ends and, eventually, loss of viability. Telomere-binding proteins also protect the chromosome from 5′ to 3′ exonuclease action, and disguise the chromosome ends from the double-strand break repair machinery whose illegitimate action potentially generates catastrophic chromosome aberrations. Telomeres …
Human Apobec3 Variations And Viral Infection, Shiva Sadeghpour, Saeideh Khodaee, Mostafa Rahnama, Hamzeh Rahimi, Diako Ebrahimi
Human Apobec3 Variations And Viral Infection, Shiva Sadeghpour, Saeideh Khodaee, Mostafa Rahnama, Hamzeh Rahimi, Diako Ebrahimi
Plant Pathology Faculty Publications
Human APOBEC3 (apolipoprotein B mRNA-editing catalytic polypeptide-like 3) enzymes are capable of inhibiting a wide range of endogenous and exogenous viruses using deaminase and deaminase-independent mechanisms. These enzymes are essential components of our innate immune system, as evidenced by (a) their strong positive selection and expansion in primates, (b) the evolution of viral counter-defense mechanisms, such as proteasomal degradation mediated by HIV Vif, and (c) hypermutation and inactivation of a large number of integrated HIV-1 proviruses. Numerous APOBEC3 single nucleotide polymorphisms, haplotypes, and splice variants have been identified in humans. Several of these variants have been reported to be associated …
Genetic Relationships In The Toxin-Producing Fungal Endophyte, Alternaria Oxytropis Using Polyketide Synthase And Non-Ribosomal Peptide Synthase Genes, Rebecca Creamer, Deana Baucom Hille, Marwa Neyaz, Tesneem Nusayr, Christopher L. Schardl, Daniel Cook
Genetic Relationships In The Toxin-Producing Fungal Endophyte, Alternaria Oxytropis Using Polyketide Synthase And Non-Ribosomal Peptide Synthase Genes, Rebecca Creamer, Deana Baucom Hille, Marwa Neyaz, Tesneem Nusayr, Christopher L. Schardl, Daniel Cook
Plant Pathology Faculty Publications
The legume Oxytropis sericea hosts a fungal endophyte, Alternaria oxytropis, which produces secondary metabolites (SM), including the toxin swainsonine. Polyketide synthase (PKS) and non-ribosomal peptide synthase (NRPS) enzymes are associated with biosynthesis of fungal SM. To better understand the origins of the SM, an unannotated genome of A. oxytropis was assessed for protein sequences similar to known PKS and NRPS enzymes of fungi. Contigs exhibiting identity with known genes were analyzed at nucleotide and protein levels using available databases. Software were used to identify PKS and NRPS domains and predict identity and function. Confirmation of sequence for selected gene …
A Novel Viral Strategy For Host Factor Recruitment: The Co-Opted Proteasomal Rpn11 Protein Interaction Hub In Cooperation With Subverted Actin Filaments Are Targeted To Deliver Cytosolic Host Factors For Viral Replication, Melissa Molho, Wenwu Lin, Peter D. Nagy
A Novel Viral Strategy For Host Factor Recruitment: The Co-Opted Proteasomal Rpn11 Protein Interaction Hub In Cooperation With Subverted Actin Filaments Are Targeted To Deliver Cytosolic Host Factors For Viral Replication, Melissa Molho, Wenwu Lin, Peter D. Nagy
Plant Pathology Faculty Publications
Positive-strand (+)RNA viruses take advantage of the host cells by subverting a long list of host protein factors and transport vesicles and cellular organelles to build membranous viral replication organelles (VROs) that support robust RNA replication. How RNA viruses accomplish major recruitment tasks of a large number of cellular proteins are intensively studied. In case of tomato bushy stunt virus (TBSV), a single viral replication protein, named p33, carries out most of the recruitment duties. Yet, it is currently unknown how the viral p33 replication protein, which is membrane associated, is capable of the rapid and efficient recruitment of numerous …
Dynamic Interplay Between The Co-Opted Fis1 Mitochondrial Fission Protein And Membrane Contact Site Proteins In Supporting Tombusvirus Replication, Wenwu Lin, Zhike Feng, K. Reddisiva Prasanth, Yuyan Liu, Peter D. Nagy
Dynamic Interplay Between The Co-Opted Fis1 Mitochondrial Fission Protein And Membrane Contact Site Proteins In Supporting Tombusvirus Replication, Wenwu Lin, Zhike Feng, K. Reddisiva Prasanth, Yuyan Liu, Peter D. Nagy
Plant Pathology Faculty Publications
Plus-stranded RNA viruses have limited coding capacity and have to co-opt numerous pro-viral host factors to support their replication. Many of the co-opted host factors support the biogenesis of the viral replication compartments and the formation of viral replicase complexes on subverted subcellular membrane surfaces. Tomato bushy stunt virus (TBSV) exploits peroxisomal membranes, whereas the closely-related carnation Italian ringspot virus (CIRV) hijacks the outer membranes of mitochondria. How these organellar membranes can be recruited into pro-viral roles is not completely understood. Here, we show that the highly conserved Fis1 mitochondrial fission protein is co-opted by both TBSV and CIRV via …
Introduction To Special Issue Of Plant Virus Emergence, Michael M. Goodin, Jeanmarie Verchot
Introduction To Special Issue Of Plant Virus Emergence, Michael M. Goodin, Jeanmarie Verchot
Plant Pathology Faculty Publications
No abstract provided.