Life Sciences Commons^™

The Acute Effects Of Multiple Resisted Sled-Pull Loads On Subsequent Sprint-Running Performances, Carl Stephen Crouse

Dissertations and Theses @ UNI

Sled-pulling is a commonly implemented form of training for various sports. However, few studies have used sled-pulling as a means of acutely enhancing sprintrunning performances. The purpose of this study was to investigate how various sledpulling resistance loads (95% and 110% of body mass) effect subsequent, unloaded, sprint-running performances, possibly with aid from the effect known as Post-Activation Potentiation (PAP). PAP is a physiological phenomenon which increases the rate of force development of skeletal muscle which may result in the enhancement of power (speed-strength) dominant activities such as sprint-running and jumping.

Participants were a mix of males (n = 11; …

D-Galactose Decreases Mitoneet Levels In Liver Cancer Cells: Impact On Cellular Bioenergetics, Sudip Paudel

Masters Theses

Galactose is a simple sugar that at supraphysiological concentrations accelerates aging and age-related complications, which lead to impaired mitochondrial functions. MitoNEET is a small mitochondrial membrane protein with a molecular mass of 12.2 kDa that functions in diabetes, iron metabolism, regulation of oxidative phosphorylation (OXPHOS) and reactive oxygen species (ROS) homeostasis. MitoNEET knockdown increases cellular respiration rates and ROS levels similar to galactose treatment. Pioglitazone, an antidiabetic drug, binds to mitoNEET and ameliorates galactose toxicity. Cellular mitoNEET levels, exposure of cells to galactose medium, and pioglitazone treatment directly influence cellular respiration. To elucidate the role of mitoNEET in galactose induced …