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The Synthesis And Evaluation Of Peptide-Based Probes For The Imaging Of Rhamm Expressing Carcinoma And Glp-1r On Pancreatic Beta Cells, Ashley Esarik
The Synthesis And Evaluation Of Peptide-Based Probes For The Imaging Of Rhamm Expressing Carcinoma And Glp-1r On Pancreatic Beta Cells, Ashley Esarik
Electronic Thesis and Dissertation Repository
Peptide-based probes are developed into imaging agents to target two different receptors: receptor for HA mediated motility (RHAMM) and glucagon-like peptide 1 receptor (GLP-1R).
In the first project, peptides are derived from tubulin and mimic HA (hyaluronan), the natural ligand of RHAMM. In order to develop the lead candidate peptides into imaging agents, a DOTA chelator which can coordinate a radiometal was coupled onto the lead peptides. Gallium labelling studies were performed and the labelled probes were used in in vivo mouse studies. Various analogues of two of the candidate peptides were also synthesized using bioisosteric, unnatural as well as …