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The Effect Of Haloxon And Thiabendazole On The Free-Living Stages Of Haemonchus Contortus, Gary Mccallister
The Effect Of Haloxon And Thiabendazole On The Free-Living Stages Of Haemonchus Contortus, Gary Mccallister
Theses and Dissertations
This study was undertaken to determine the effect of thiabendazole and haloxon on the free-living stages of Haemonchus contortus and to determine the suitability of the free-living stages for their use in primary drug evaluation for chemotherapy or for chemical control of free-living stages. Cleaned unembryonated ova, embryonated ova, first-, second-, third-, and exsheathed third-stage larvae were exposed to suspensions of 5.0%, 1.0%, 0.5%, 0.25%, 0.12%, 0.05%, and water soluble concentrations of each drug for exposure times of 0.25, 0.50, 1.0, 2.0, 4.0, 8.0, and 16.0 hours at pH 7.0 and 25° C. Survival was assessed by observing any subsequent …
A Proposed Mechanism Of Action For In Vitro Excystation Of Two Species Of Coccidia, William Ronald Jolley
A Proposed Mechanism Of Action For In Vitro Excystation Of Two Species Of Coccidia, William Ronald Jolley
Theses and Dissertations
Excystation of coccidian oocysts is accomplished in vitro by altering wall permeability with CO2 and a reducing agent, then activating the enclosed sporozoites with a solution of trypsin and bile. Elucidation of the mechanism of action of the CO2-reducing agent treatment was the basic intent of this study. Oocysts of Eimeria stiedae (rabbit) and E. tenella (chicken) were tested for the presence of an excystation-associated enzyme by incubating sporulated oocysts in fluids extracted from variously treated oocysts, and by carbon-14 labelling; the effect of CO2 -reducing agent treatment on oocyst walls was investigated by titration with acid or base for …