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Articles 1 - 4 of 4
Full-Text Articles in Life Sciences
Distinct Phenotypes In Zebrafish Models Of Human Startle Disease, Lisa R. Ganser, Qing Yan, Victoria M. James, Robert Kozol, Maya Topf, Robert J. Harvey, Julia E. Dallman
Distinct Phenotypes In Zebrafish Models Of Human Startle Disease, Lisa R. Ganser, Qing Yan, Victoria M. James, Robert Kozol, Maya Topf, Robert J. Harvey, Julia E. Dallman
Faculty and Research Publications
Startle disease is an inherited neurological disorder that causes affected individuals to suffer noise- or touch-induced non-epileptic seizures, excessive muscle stiffness and neonatal apnea episodes. Mutations known to cause startle disease have been identified in glycine receptor subunit (GLRA1 and GLRB) and glycine transporter (SLC6A5) genes, which serve essential functions at glycinergic synapses. Despite the significant successes in identifying startle disease mutations, many idiopathic cases remain unresolved. Exome sequencing in these individuals will identify new candidate genes. To validate these candidate disease genes, zebrafish is an ideal choice due to rapid knockdown strategies, accessible embryonic stages, and stereotyped behaviors. The …
Chimpanzee Vocal Signaling Points To A Multimodal Origin Of Human Language, Jared P. Taglialatela, Jamie L. Russell, Jennifer A. Schaeffer, William D. Hopkins
Chimpanzee Vocal Signaling Points To A Multimodal Origin Of Human Language, Jared P. Taglialatela, Jamie L. Russell, Jennifer A. Schaeffer, William D. Hopkins
Faculty and Research Publications
The evolutionary origin of human language and its neurobiological foundations has long been the object of intense scientific debate. Although a number of theories have been proposed, one particularly contentious model suggests that human language evolved from a manual gestural communication system in a common ape-human ancestor. Consistent with a gestural origins theory are data indicating that chimpanzees intentionally and referentially communicate via manual gestures, and the production of manual gestures, in conjunction with vocalizations, activates the chimpanzee Broca’s area homologue – a region in the human brain that is critical for the planning and execution of language. However, it …
Cortical Representation Of Lateralized Grasping In Chimpanzees (Pan Troglodytes): A Combined Mri And Pet Study, William D. Hopkins, Jared P. Taglialatela, Jamie L. Russell, Talia M. Nir, Jennifer Schaeffer
Cortical Representation Of Lateralized Grasping In Chimpanzees (Pan Troglodytes): A Combined Mri And Pet Study, William D. Hopkins, Jared P. Taglialatela, Jamie L. Russell, Talia M. Nir, Jennifer Schaeffer
Faculty and Research Publications
Functional imaging studies in humans have localized the motor-hand region to a neuroanatomical landmark call the KNOB within the precentral gyrus. It has also been reported that the KNOB is larger in the hemisphere contralateral to an individual's preferred hand, and therefore may represent the neural substrate for handedness. The KNOB has also been neuronatomically described in chimpanzees and other great apes and is similarly associated with handedness. However, whether the chimpanzee KNOB represents the hand region is unclear from the extant literature. Here, we used PET to quantify neural metabolic activity in chimpanzees when engaged in unilateral reach-and-grasping responses …
Behavioral Evidence For Chemosensory And Thermosensory Pathway Convergence In The Caenorhabditis Elegans Nervous System, Bowman O. Davis Jr., Lewis Vanbrackle, Darren Pittard
Behavioral Evidence For Chemosensory And Thermosensory Pathway Convergence In The Caenorhabditis Elegans Nervous System, Bowman O. Davis Jr., Lewis Vanbrackle, Darren Pittard
Faculty and Research Publications
The nematode, Caenorhabditis elegans, is an established model system to explore the ways simple nervous systems detect and direct organismal responses to environmental changes. C. elegans possesses specialized receptor cells for the detection of a variety of environmental stimuli. Separate cell types respond to volatile chemical and thermal stimuli and the neural pathways for these show anatomical evidence of convergence. This work reports findings from behavioral assays during simultaneous exposure of nematodes to both thermal differences and attractant volatile chemicals. Combined exposure to benzaldehyde and cold neutralized the behavioral responses to both stimuli in 24°C acclimated worms. Diacetyl and mild …