Life Sciences Commons^™

Plasma And Extracellular Vesicle–Enriched Protein Profiles In Chronic Rhinosinusitis, Aryana Amin, Rutviben P. Shah Bds, Dhvani Parikh Mph, Niki Mirhosseini Bs, Baharan Fekry Phd, Donyea L. Moore, Mahboobeh Mahdavinia Md, Phd

Summer Research Program Abstracts

No abstract provided.

Personalizable Metabolic Models To Enable Immune Characterization And Drug Discovery, Joshua Loecker

Department of Biochemistry: Dissertations, Theses, and Student Research

Cellular metabolism is reshaped by disease and physiological state, and genome-scale metabolic networks (GSMNs) offer a systematic way to interrogate this biology and identify therapeutic targets. Building a GSMN from expression data, however, requires a sequence of stages including read processing, normalization and gene-activity classification, multi-omic integration, model reconstruction, simulation, and biological interpretation. These are typically handled by disconnected tools spanning multiple programming languages, file formats, and databases. The resulting reliance on heterogeneous interfaces and manual steps threatens reproducibility. This work develops an ecosystem of computational tools that carry an analysis from raw sequencing reads to mechanistic biological interpretation. First, …

Implementation Study Of Aortagpt, An Ai Decision Support Tool For Heritable Thoracic Aortic Disease, Noah Mathai

Summer Research Program Abstracts

No abstract provided.

Microrna Regulation Of Human Trophoblast Stem Cell Proliferation, Eva E. Adams, Madison Vu, Jacqueline G. Parchem

Summer Research Program Abstracts

No abstract provided.

Exploring Primary Care Providers’ Compassionate Care And Their Evidence-Based Practice With Death, Grief, And Loss: Patient Experience And Perspective, Kathryn Krzykala

Dissertations

Research on primary care providers’ (PCPs) education regarding Death, Grief, and Loss (DGL) remains limited. Specifically, data is lacking regarding patients' perceptions and opinions on what they need and expect from their PCPs regarding grief and loss. This exploratory mixed-method study comprised 146 participants who had experienced death and non-death loss. It examined participants' perceptions of 1) PCP compassion, 2) PCP utilization of evidence-based grief and loss practices, 3) their own level of comfort discussing DGL with their PCPs during medical visits, and 4) their personal grief and loss experiences. The findings revealed that PCPs' grief-informed evidence-based treatment, as reflected …

Analysis Of Priority Vaccine-Preventable Diseases Using The Paho-Adapted Hanlon Method In Bogor City In 2024, Sonia Annisa Br Ketaren, Tri Yunis Miko Wahyono, Bai Kusnadi

Jurnal Epidemiologi Kesehatan Indonesia

Vaccine-preventable diseases (VPDs) remain a major public health challenge despite substantial progress in immunization programs. In Indonesia, routine immunization coverage has shown a post-pandemic recovery trend; however, disparities in access to health services and surveillance quality persist across regions. This study aimed to determine priority VPD problems in Bogor City and identify factors contributing to the highest-ranked disease. A mixed-methods study was conducted in Bogor City from October 2024 to January 2025. Quantitative prioritization was performed using the Pan American Health Organization (PAHO)-adapted Hanlon method across eight VPDs. Qualitative data were collected through in-depth interviews with key informants and analyzed …

Association Of Household Economic Status And Birth Order With Stunting Among Children Aged 24-35 Months: Malawi Mics 2019–20, Sibongire B. Ngoma, Asri C. Adisasmita, Renti Mahkota, Septyana Choirunisa, Melisa Nyamukondiwa

Jurnal Epidemiologi Kesehatan Indonesia

Stunting remains a major public health concern in Malawi, with a national prevalence of 35.5% among children under five. However, evidence on the independent and combined effects of household economic status and birth order on stunting among Malawian children aged 24-35 months remains limited. This study aimed to examine the independent and combined association of household economic status and birth order with stunting among children aged 24-35 months in Malawi. A secondary data analysis of a cross-sectional 2019-20 Malawi Multiple Indicator Cluster Survey (MICS) was conducted, and the final sample comprised 2,764 children aged 24-35 months with complete data. Stunting …

Crispr/Cas9-Based Genome Editing: Understanding Differences In Dna Repair Pathways, Profiles, And Outcomes, Samuel Effah, Shirley Barrera, Nahia Urturi Ortiz, Will Dampier, Michael Nonnemacher, Brian Wigdahl

Kimmel Cancer Center Faculty Papers

Over a decade of advances in Clustered Regularly Interspersed Short Palindromic Repeats (CRISPR) and CRISPR-associated protein 9 (Cas9)-based technologies have culminated in the first-ever FDA-approved CRISPR/Cas-based therapy. Aside from this approved therapy for sickle cell anemia, several CRISPR/Cas-based therapies are currently under development or testing for a range of chronic diseases, including viral diseases like human immunodeficiency virus type 1 (HIV-1) infection, genetic diseases like familial hypercholesterolemia, and cancer. The success of these therapies hinges on the effective delivery of CRISPR/Cas9 components to target regions, efficient Cas endonuclease editing, repair profiles generated, and their resulting outcomes. Here, we discuss the …

Endophytic Actinobacteria: Deciphering Therapeutic And Industrial Potential, And Prospects Of Genome Mining In Novel Products Discovery, Yusra Waheed, Rabia Shahdin, Imran Sajid

Journal of Bioresource Management

Endophytic actinobacteria are a diverse group of Gram-positive bacteria with high G+C content, which inhabit plants’ internal tissues, and represent a significant yet underexplored reservoir of bioactive secondary metabolites. In host plants, a remarkable repertoire of metabolites, including broad-spectrum antibiotics, anticancer, antiviral, antifungal, antioxidant, and immunomodulatory compounds, is synthesized by these microbial allies, carrying significant medicinal and agricultural potential. These endophytes, in contrast to their soil relatives, have developed unique biosynthetic gene clusters (BGCs) strongly influenced by plant-associated factors, leading to the production of structurally novel metabolites. In recent years, the advances in genome mining, metagenomics, and metabolomics have accelerated …

Modeling Framework To Demonstrate Elimination Of A Vector Population: Tsetse Elimination In Chad, John Hargrove, Mahamat Hissene Mahamat, Moukhtar Aldjibert, Wilfrid Yoni, Djoukzoumka Signaboubo, Justin Darnas, Ernest Salou, Inaki Tirados, Albert Mugenyi, Priscille Barreaux, Philippe Solano, Antoine Marc Gaby Barreaux

All Peer-Reviewed Publications

Every year, over 700,000 people, particularly children under five, die from vector-borne diseases worldwide. Effectively controlling endemics and preventing new outbreaks requires an integrated approach that can lead to the elimination of both vectors and diseases. In the last two decades, integrating medical interventions and vector control has significantly reduced the incidence of Gambian Human African Trypanosomiasis (g-HAT), with the World Health Organization validating eight countries as having eliminated the disease as a public health problem. However, elimination of the tsetse vector has not been confirmed, leaving the possibility of re-emergence. We developed a six-step modeling framework to assess vector …

Liver Function Test (Lfts) Revealed Ameliorative Effect Of Probiotics And Antibiotics As Therapeutic Agents Against Experimentally Induced Enterotoxemia In Goat, Muhammad Mohsen, Jam Kashif Zaman, Amjad Hussain Mirani, Nazeer Hussain Kalhoro, Benazir Sahito

Journal of Bioresource Management

Present study was conducted to evaluate the various liver enzymes in experimentally induced enterotoxemic goat inorder to ensure the therapeutic potential of probiotics and antibiotics. Experiment was conducted at Department of Veterinary Medicine, Sindh Agriculture University Tandojam in which 35 non-descriptive goats were housed and experimenatally induced with enterotoxemia by inoculation of Clostridium perfringens culture surgically by performing laparotomy into intestine. After apperence of positive clinical signs of infection, goats were randomly divided into 5 treatment groups i.e. Group 1 (negative control), Group 2 (positive control), Group 3 (yogurt, 5 % solution, 50 mL/time), Group 4 (Yeast, 5 % solution, …

Prevalence And Risk Factors Association Of Babesiosis In Cattle And Buffaloes In District Naushahro Feroze, Sindh, Pakistan, Kazim Raza, Amjad Hussain, Sajid Moin, Huzaifa Arain, Muhammad Mohsen, Maria Abubakar, Erum Bughio, Barkat Ali

Journal of Bioresource Management

Background: Bovine babesiosis is a protozoan disease that is transmitted by ticks and has significant veterinary and economic impacts on tropical livestock systems. Prior to this study, no epidemiological data was available of Sindh, Pakistan.

Purpose: To estimate the Babesia spp. prevalence and estimate the risk factors with respect to cattle and buffaloes in five tehsils of District Naushahro Feroze, Sindh, Pakistan.

Methods: A cross-sectional study was conducted using 200 blood samples (100 Thari cattle; 100 Kundhi buffaloes; both sexes) in five tehsils (Kandiaro, Moro, Mehrabpur, Bhiria and Naushahro Feroze). Thin blood smears under Giemsa stain were viewed under oil-immersion …

Urban-Rural Differences In The Association Between Physical Activity And Overweight/Obesity Among Indonesian Adolescents: A Cross-Sectional Study, Wahyu Wulandari, Mufti As Siddiq M. Irzal, Lady Farah Fatmawati

Jurnal Epidemiologi Kesehatan Indonesia

Adolescent overweight/obesity is an increasing public health concern and contributes to the risk of non-communicable diseases later in life. Physical activity plays an important role in weight regulation. However, its association with overweight/obesity may vary according to residential setting. This study aimed to examine the association between physical activity and overweight/obesity among adolescents living in rural and urban areas of Indonesia. A cross-sectional study was conducted using data from the 2023 Indonesian Health Survey. The study included 115,372 adolescents aged 10–18 years. Physical activity was classified based on total Metabolic Equivalent of Task (MET)-minutes per week (≥600 MET-minutes/week), while nutritional …

Exploring Psychological Traits And Feedback Strategies In Physical Therapy Providers Learning Acceptance And Commitment Therapy, Dustin Cox

Journal of Applied Disciplines

Providing treatment interventions to clients with chronic pain is a complex task for any professional. Research suggests that clients with chronic pain experience declines in physical, emotional, and psychological quality of life. Client’s that have chronic pain have complex effects from dealing with this condition in their lives. Clients with chronic pain (i.e., pain lasting > three months) process pain through the emotional and reward circuitry in the brain which is different than client with acute pain. The literature base provides evidence that clients with chronic pain who receive psychologically based interventions along with physical rehabilitation have better outcomes than individuals …

Teachers’ Awareness Of Family Engagement In Multilingual Education, Sedighe Zamani Roodsari

Journal of Multicultural Affairs

This study investigated public school teachers’ awareness of family engagement as a linguistic and cultural resource for multilingual students. Multilinguals are typically described as individuals who can communicate in more than one language, with English not being their native language, and their linguistic choices are influenced by societal norms and systems (Šifrar Kalan et al., 2024; Wei, 2008). Preparing pre-service teachers to enhance opportunities for multilingual students remains a critical need in teacher education programs, as they strive to move beyond monolingual ideologies in their teaching practices (Cárdenas Curiel et al., 2024; Kim & Choi, 2020; Williams & Ewing, 2019). …

Dimensional Welfare Beyond Pain: Extending The Precautionary Principle In Birch’S “The Edge Of Sentience”, Willa M. Lane, Nicola S. Clayton

Animal Sentience

Birch's (2024) The Edge of Sentience identifies sentience candidates primarily through the pain-focused LSE Criteria. Yet, as Birch himself notes in Proposal 17, sentience is not pain. We argue that statutory welfare protections must therefore reach beyond pain, and that the right tool for doing so is Birch et al.’s (2020) dimensionality framework, which characterises conscious experience across five domains. Used together, the LSE Criteria establish that welfare is at stake, while the dimensionality framework maps what is at stake beyond pain to provide a taxon-specific profile of where captivity impoverishes experience. We apply this approach to invertebrate welfare and …

Instructions To Authors, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Journal Acknowledgements And Editorial Board, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Keynote Address And Meeting Program, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Business Meeting Report (Secretary's And Treasurer's Report), Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Artificial Food Colors Are Not Needed To Attract Ruby-Throated Hummingbirds (Archilochus Colubris) To Feeders, A. Siddiqui, R. Kannan

Journal of the Arkansas Academy of Science

No abstract provided.

Sperm Morphology In The Eastern Narrow-Mouthed Frog, Gastrophryne Carolinensis (Anura: Microhylidae), S. E. Trauth

Journal of the Arkansas Academy of Science

Studies by Scheltinga et al. (2002) and Scheltinga and Jamieson (2003) provide the most comprehensive analysis and only review of sperm morphology in Narrow-Mouthed Frogs (family Microhylidae). Of the 490+ species known to occur in this anuran family (Vitt and Caldwell 2014), only 3 are distributed in the United States (Powell et al. 2016), and 2 of these occur in Arkansas (Trauth et al. 2004). Surprisingly, sperm studies on only 12 microhylid species have been conducted (Scheltinga and Jamieson 2003), and no sperm studies are available on any North American species.

Multiple Nuclear Configurations And Microtubular Arrangements In Spermatozoa Of The Western Siren, Siren Nettingi (Caudata: Sirenidae), S. E. Trauth

Journal of the Arkansas Academy of Science

I examined the ultrastructure of spermatozoa of the Western Siren, Siren nettingi, using transmission electron microscopy. My primary objective in this study was to elucidate, for the first time, the unique morphological complexity of biflagellated sperm in this species. This study also represents my fifth addition in a series of investigations that highlight the novel nature of all aspects of spermatogenesis in this salamander I show the basic sperm transverse and sagittal design which includes a nucleus, 2 axial fibers supporting 2 undulating membranes which have 2 axonemes residing at their terminal ends, several circular mitochondria, and several electron-dense masses. …

Binucleation And Seasonal Cycle Of Sertoli Cells In The Western Lesser Siren, Siren Nettingi (Caudata: Sirenidae), S. E. Trauth

Journal of the Arkansas Academy of Science

I examined binucleation and the seasonal cycle of Sertoli cells in the Western Siren (Siren nettingi) using light microscopy and transmission electron microscopy. My primary objective in this study was to report, for the first time, the presence of double nuclei in Sertoli cells in a salamander. This study also represents the sixth contribution in a series of investigations that highlight the novel nature of all aspects of spermatogenesis in this unique salamander. My findings add to a growing list of extraordinary morphological and reproductive features that distinguish this salamander from all other vertebrates.

Distal Urogenital Anatomy And Epithelial Morphology In The Male Eastern Narrow-Mouthed Frog, Gastrophryne Carolinensis (Anura: Microhylidae), S. E. Trauth

Journal of the Arkansas Academy of Science

I investigated the microanatomy of the distal urogenital system in male Eastern Narrow-Mouthed Frogs (Gastrophryne carolinensis) from a small sample (n = 5) collected in central Arkansas in April, May, and July (2021) and May 2022. Specifically, my primary goals were to elucidate the histology of the following: (1) the paired Wolffian (urogenital) ducts caudally from the kidneys to their merging with the urodeum of the cloaca, (2) the structure of seminal vesicles, and (3) the epithelial morphologies among the distal urogenital tract, the posterior alimentary canal, and the cloaca. My histological analysis confirmed the presence of …

Academy Presidents And Institutional Members, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Table Of Contents, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Journal Of The Arkansas Academy Of Science Volume 79, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Closing The Gaps: Reforming Maryland Controls On Veterinary Antimicrobial Distribution, Samantha Capaldo, Kerry Mcclaughry

Journal of Food Law & Policy

Antimicrobials have been used in livestock and other food animals in the United States (“U.S.”) since the late 1940s. An antimicrobial is “[a]ny natural, synthetic, or semisynthetic substance that can eradicate or prevent the growth of microbes,” including “[a]ntibacterial, antifungal, antiparasitic, and antiviral medications.” Antimicrobial use in food animals is subject to a complex statutory and regulatory framework at both the state and federal levels. Antimicrobial use in food animals has been widely criticized for contributing to antimicrobial-resistant bacterial infections in humans. In response to this criticism, the U.S. Food and Drug Administration (“FDA”) and several states, including Maryland, have …

Advocating For A Care-Based Ethic: Stories Of Pregnancy And Birth From Caregivers Of Children With Down Syndrome, Lydia Ocasio-Stoutenburg, Nayma Sultana Mim

Developmental Disabilities Network Journal

Down syndrome (DS) impacts about 1 in every 640 childbirths in the United States. While quality of life has improved for people with DS, systemic inequities and deficit-based perceptions have persisted throughout history, with material impacts on people with DS and their caregivers. Researchers have documented how caregivers of children with DS have had negative experiences with healthcare providers and genetic counselors, whose biased views about DS translate into subtle and overt pressures. Few studies explicitly focus on the experiences of Caregivers of Color, multilingual families, as well as families with varying economic experiences who have children with DS. This …