Life Sciences Commons^™

Prevalence Of Low Energy Availability (Lea) Risk In Division Iii Female Distance Athletes, Ciara Murphy

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE The objective of this study was to explore the prevalence of LEA among division III female distance athletes.

The Effectiveness Of An Educational Program On Young Swimmers Water Consumption And Dry Land Exercises, Maria Thibodeaux, Shelby Bay, Maddie Hoyt, Elizabeth Starns, Elizabeth Nix

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE/CONTEXT Although shown to improve performance, many young swimmers are reluctant to participate in dry land exercises.¹ They are also more likely to become dehydrated than their non-swimming counterparts, suggesting they are not adequately hydrating during activity and throughout their day.² Therefore, this study aimed to evaluate the impact of a four-week educational program on dry land exercises and water consumption.

From Focal Chondral Defect To Matrix-Induced Autologous Chondrocyte Implantation In An Active Adult: A Case Study, Zoey Scott

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE Present a clinical case detailing the undetermined consequential factors associated with FCD progression  in athletic populations, and the subsequent challenges.

Post-Surgical Dislocations: A Latarjet Procedure, Brianagh Dean, Kimberly S. Peer

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

BACKGROUND The glenohumeral joint is the most frequently dislocated joint in the body, with an incidence rate of 40.4 per 100,000 in men and 15.5 per 100,000 women. Recurrence rates following a first-time anterior shoulder dislocation range from 33-40%, particularly among adolescent collision-sport athletes. Arthroscopic Bankart repair is performed to address anterior instability, however recurrent instability may occur in the presence of glenoid bone loss. The Latarjet surgery is indicated in cases of recurrent anterior instability with significant bony deficiency, functioning through a triple-blocking mechanism increasing glenoid surface area via coracoid transfer, creating a dynamic sling effect from the conjoined …

Oral Contraceptives Rate Of Reduction On Anterior Cruciate Ligament Injuries In Females: A Critically Appraised Topic, Paige Trent, Sara Stiltner

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

CLINICAL SCENARIO Anterior cruciate ligament (ACL) injuries occur more frequently in females than males, with estimates suggesting a 2-10 greater likelihood of females to sustain this trauma.3 FIFA issued a recent call to action encouraging further investigation into why females are still predisposed to this trauma.2 ACL incident rate is highest amongst females between 14–18-years-old with approximately 227.6 exposures per 100,000 persons per year.1 Multifactorial influences are suggested as predisposing risk factors including anatomical or hormonal components.1 Growing interest in hormonal contributions has led researchers to examine how fluctuations in estrogen, progesterone, and testosterone impact ligamentous integrity.8

Estrogen receptors are …

Case Report: Chronic Peroneal Subluxation, Natalie Weissman, Morgan Cooper Bagley, Colin Reidy

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE The case study presented explores the sign, symptoms, and unique treatment of a patient with a chronic peroneal subluxation of the right ankle. The clinical evaluation showed full range of motion with visible peroneal tendon movement over the right lateral malleolus. Surgery was not done or recommended; a four-phase rehabilitation with a return to play protocol was used. This case showed how rehabilitation through a non-surgical approach is still achievable.

The Effect Of Taper On Scapular Positioning In Division Iii Collegiate Swimmers, Maddie Hoyt, Elizabeth Starns, Andrew Busch

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE Scapular asymmetry and lateral translation are prevalent in competitive swimmers due to the repetitive overhead nature of the sport.^1,2 Additionally, ambiguity exists in the reliability of non-invasive scapular assessments. First, this study aimed to compare differences in scapular positioning during the competitive swimming season to the tapered season. The tapered season is marked by a significant decrease in intensity.^3,4,5 Second, this study aimed to determine the reliability of three commonly used scapular assessments.

Anterior Cruciate Ligament Autograft Reconstruction Outcomes In Adolescents And Young Adults: A Critically Appraised Topic, Klevione D. Brown, River A. Hamilton, Elizabeth A. Starns

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

CLINICAL SCENARIO Anterior cruciate ligament (ACL) tears are one of the most common serious knee injuries seen in high school and college-aged athletes.¹ Many athletes opt for surgical reconstruction because ACL injuries often result in knee instability and impair their ability to return to play in their sport.² There are three primary types of autografts used in reconstruction: bone-patellar tendon-bone (BTB), hamstring tendon (HT), and quadriceps tendon (QT) autografts.³ It is important to determine if a graft type has better return-to-play outcomes for adolescent and young adult athletes.

Sport-Related Concussion Incidents Across Sports, Surfaces, And Injury Mechanisms: A Retrospective Analysis Of A Digital Concussion Database, Justin Belle, Jay Alberts, Jason Cruickshank, Richard Figler, Kelsey Owen, Sami Rifat

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE/CONTEXT Sport-related concussion (SRC) represents a significant injury burden in youth athletics. Advances in digital injury surveillance platforms allow for large-scale clinical databases that may provide insight into injury mechanisms, sport distribution, and management patterns. The purpose of this study was to describe the distribution of concussion-related incidents across sports, playing surfaces, and mechanisms of injury using data from a prospectively maintained clinical concussion database.

Dysautonomia In Adolescent Athletes With Persistent Post‑Concussion Complaints, Jason A. Cruickshank

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE/BACKGROUND Dysautonomia is dysfunction in autonomic nervous system manifesting following concussion, contributing to Persistent Post‑Concussion Complaints (PPCC).^1,5 Patients with dysautonomia may present with dizziness, tachycardia, postural intolerance, headaches, cognitive fog, and activity/exercise intolerance.^1,5 Recognition of autonomic involvement is essential to recovery and preventing prolonged symptoms^.1,5

The Effectiveness Of A Mental Health Literacy Webpage For Parents, Coaches, And Athletic Trainers, Mackenzie Warner, Kimberly Peer, Hannah Harnar, David Dees

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

INTRODUCTION Mental health illnesses continue to emerge as a major public health concern, particularly among adolescents and young adults. Secondary school student-athletes face unique pressures related to academics, athletic performance, time management, injuries, and social expectations, all of which may contribute to anxiety, depression, stress, or other mental health conditions. However, there is limited research that explores secondary school student-athletes and how mental health affects their everyday lives. This could be due to the lack of mental health literacy in the individuals who surround secondary school student-athletes, including parents, coaches, and athletic trainers. Increasing their understanding of mental health literacy …

Understanding Athletic Trainer's Knowledge And Perceptions Of Mental Health Best Practices: A Mixed-Methods Study, Chelsea Pasukinis, Yvette Ingram, Malissa Martin, Robert B. Krueger

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE Mental health disorders are increasing in our society. Research on athletic trainers' (AT) knowledge and perception of mental health disorders, and whether policies are developed and used, is limited. The purpose of this study is to investigate AT’s knowledge of mental health illness, current policies and procedures, and the perceptions ATs have of mental health.

A Case Report Of Blunt Renal Trauma In A High School Football Athlete, Mariah Reeder

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE/BACKGROUND Blunt abdominal trauma in football athletes is uncommon but carries significant risk for internal organ injury and hemorrhage. Although sport-related renal injuries are rare, a significant portion of them are high-grade (IV-V) and may require advanced medical intervention if not recognized promptly.¹ Symptoms may initially appear benign, such as “having the wind knocked out,” increasing the risk of delayed diagnosis. Athletic trainers often serve as first responders and play a critical role in early recognition, on-field management, and prompt referral for advanced medical care. This case highlights athletic trainer led clinical decision making and interdisciplinary coordination following blunt …

Assessment Of A Middle School Return To Learn Concussion Protocol, Aaron Yaksich, Laura L. Harris

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE To evaluate the effectiveness of a newly implemented return to learn (RTL) concussion protocol in an adolescent athletic population.

Challenging The Standard: A Case Report Of Postpartum Rehabilitation Prior To Return To High-Intensity Functional Training, Aly Matejka

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE Postpartum athletes frequently attempt to return to high-intensity training without graded rehabilitation of the deep core and pelvic floor complex, contributing to urinary incontinence, impaired load transfer, unresolved diastasis recti, and decreased performance capacity. Despite increasing participation of postpartum individuals in high-load functional training, there is limited applied literature outlining structured, criterion-based return-to-exercise progressions that address breathing mechanics, pelvic floor function, and force development prior to reintroduction of impact and resistance training. This case report describes the implementation of a 15-week postpartum rehabilitation and return-to-training protocol designed to restore neuromuscular control, muscular endurance and strength, and impact tolerance prior …

A Post-Professional Athletic Training Education Module For Detecting Skin Conditions In Diverse Skin Tones, Lauren Oskam, Laura L. Harris

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE To develop and evaluate a learning module designed to improve athletic trainers’ proficiency in identifying skin conditions commonly acquired in the sport of wrestling across diverse skin tones.

Developing Antibodies Against Galectin-3 And Galectin-9 To Target Endometriosis, Ashleigh Burger, Noah Farnsworth, Jared J. Reisnouer, Cheyenne Vue

2026 Symposium

Endometriosis is a disease characterized by pelvic pain and the formation of endometrial-like tissue on the outside of the uterine lining. This condition affects nearly 10% of women across the globe and confirming whether someone has endometriosis requires visualization in surgery. While the specific causes of this disease remain unclear, the over-expression of the Galectins 3 and 9 in ectopic endometrial tissues suggests a role in the development and maintenance of the condition. Monoclonal antibodies (mAbs) are highly specific proteins with potential as diagnostic or treatment tools. The goal of this study is to generate antibodies against Gal3 and Gal9. …

Replication And Extension Of Kras-Associated Gene Expression Signatures In Lung Adenocarcinoma: A Cox Proportional Hazards Analysis Of Mutation Status, Gene Expression, Multi-Gene Mutation Count, And Ras De Novo Signature, Camryn Berry

Theses & Dissertations

This study evaluates the robustness and reproducibility of a previously published analysis of lung adenocarcinoma gene expression data (Schabath et al.), which examined KRAS-associated biology in relation to co-occurring STK11 and TP53 mutations. The original study used Kaplan-Meier (KM) survival analysis and gene expression signatures to assess associations between driver mutations, tumor suppressor mutations, and patient outcomes. The aim of this work is to replicate these analyses and evaluate consistency across independent datasets (Wilkerson and Selamat), with extension using Cox proportional hazards (PH) models. Two hypotheses are evaluated: (1) that the number of mutated genes increases the hazard of death, …

The Meaning Of Physical Activity In The Context Of Health Sciences: A Concept Analysis, Martín G. Farinola

International Journal of Physical Activity and Health

Physical activity has been defined in numerous ways. Thus, this study aimed to conduct a concept analysis of the existing physical activity definitions in the health sciences literature to evaluate its conceptual precision and assess the need for a revised or novel concept better suited for this domain. The concept analysis was accomplished using tools derived from philosophical semantics. The analysis identified six definitions that explicitly state what physical activity is with sufficient clarity to allow for conceptual examination. The findings indicated that these definitions frequently merge the concept of physical activity with its contextual attributes. To address these semantic …

Assessing The Risk Of Low Energy Availability In Ncaa Division Iii Female Soccer Players, Emma C. Sturts

Masters Theses/Capstone Projects

Low Energy Availability (LEA) can occur when an athlete’s energy intake is insufficient to meet the physiological demands of training as well as normal physiological functions. Female soccer players may be at an increased risk of developing LEA due to the high exercise energy expenditure paired with decreased energy intake. The purpose of this study is to assess the prevalence of LEA among Division III female soccer players. Division III female soccer players (n = 11) completed the Low Energy Availability in Females Questionnaire (LEAF-Q). 45.5% (n = 5) of the participants were classified as “At Risk” for LEA. Of …

Spectral Characterization Of Colorectal Cancer Using Excitation-Scanning Hyperspectral Imaging, Natalie Hadad

Honors Theses

Colorectal cancer is one of the most common and deadly cancers worldwide, with a lifetime risk of approximately one in twenty-three for men and one in twenty-five for women. Although early detection significantly improves survival, current diagnostic approaches such as tissue biopsy are invasive, reliant on subjective interpretation, have extended turnaround times, and risk missing flat or depressed lesions that are more difficult to detect than raised polyps. These limitations highlight the need for objective, minimally invasive technologies capable of detecting early tissue changes. This study investigates excitation-scanning hyperspectral imaging (Ex-HSI) as a label-free optical approach for identifying colorectal cancer–associated …

Novel Biomarker Discovery In Multiple Sclerosis, Manisha Gangasani

Honors Theses

Multiple Sclerosis (MS) is a chronic neuroinflammatory disorder affecting the brain, spinal cord, and optic nerve. Patients experience cognitive, motor, autonomic, and emotional symptoms that often overlap with other neurological conditions, making early diagnosis challenging. Current diagnostic criteria require evidence of lesions with dissemination in time and space. Racial disparities in MS outcomes are well documented, with Black individuals often exhibiting greater disease severity, higher relapse rates, and increased disability compared to White individuals. These differences likely reflect a combination of genetic, biological, environmental, and healthcare access factors, underscoring the need to improve early diagnosis and reduce inequities in care. …

Developing A Protocol For Non-Cellular Transplantation Of Donor Mitochondria Into Recipient Cells, Andrew Parton

Honors Theses

Tumor innervation has emerged as a critical feature of cancer progression, with increased nerve density correlating with enhanced aggressiveness, metastatic dissemination, and poor clinical outcome. However, the functional contribution of neurons to tumor biology remains incompletely defined. We recently identified the intercellular transfer of mitochondria from neurons to cancer cells as a mechanism that promotes tumor progression. We therefore hypothesized that disruption of this transfer could attenuate tumor aggressivity. To directly investigate this process, we developed an approach to isolate mitochondria from donor cells and transplant them into recipient cancer cells independently of canonical cell-cell interactions. Transferred mitochondria were tracked …

Mechanisms Of Synergy Between Nanosecond Pulsed Electric Field (Nspef) And Cold Atmospheric Pressure Plasma Discharge (Cap) In Pancreatic Cancer: The Role Of Ros-Mediated Oxidative Stress And Apoptosis, Zobia Minhas

Biomedical Sciences Theses & Dissertations

Pancreatic ductal adenocarcinoma is a highly lethal malignancy characterized by poor prognosis and resistance to conventional therapies. Novel treatment strategies are needed to overcome this resistance. Non-thermal physical modalities, including nanosecond pulsed electric field (nsPEF) and cold atmospheric pressure plasma discharge (CAP), have emerged as potential anticancer approaches; however, the mechanisms underlying their combined effects remain unclear.

This study evaluated whether nsPEF enhances CAP-induced cytotoxicity and investigated the associated molecular mechanisms using the murine Pan02 pancreatic cancer cell line. Cell viability was assessed by WST-1 metabolic activity assays and electric cell–substrate impedance sensing (ECIS). Intracellular reactive oxygen species (ROS) were …

Preclinical Animal Modeling To Investigate Redox-Mediated Molecular Dysfunction In Traumatic Brain Injury, Brandon Z. Mcdonald

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Impacts associated with traumatic brain injury (TBI) induce a multitude of neurological morbidities mediated by a spread of biochemical dysfunction. Redox stress is a significant contributor to TBI pathophysiology and several redox stress markers have substantial evidence to support their role in diagnosing preclinical and clinical TBI. However, there is a critical need to verify their translational utility through correlations with behavioral, imaging, and molecular modalities. In chapter two, we examined the therapeutic efficacy of an antioxidant treatment (NPC3) using a controlled cortical impact (CCI) mouse model of TBI. NPC3 alleviated glial expression and reactivity while influencing the expression of …

Validation Of A Real-Time Pcr Laboratory Developed Test For The Detection Of Pneumocystis Jirovecii In Bronchoalveolar Lavage Samples, Caitlyn Moon

Honors Scholar Theses

Pneumocystis jirovecii is an opportunistic, host-obligate fungal pathogen responsible for causing P. jirovecii pneumonia (PJP) in humans. PJP is treated with trimethoprim-sulfamethoxazole (TMP-SMX), a strong broad-spectrum antibiotic that carries risk of renal and hepatotoxicity. Therefore, rapid diagnosis or exclusion of PJP is crucial to ensure PJP-positive patients receive effective treatment and PJP-negative patients avoid unnecessary antibiotics. Unlike most microorganisms, P. jirovecii cannot be cultured, presenting complications for the typical methods of diagnosing fungal pathogens. Historically, the gold standard for diagnosis was direct microscopic examination with stains such as methenamine silver and calcofluor white, but this diagnostic technique requires highly skilled …

The Development Of A Crispr-Based Calibrated Functional Assay For Classifying Pathogenicity Of Msh2 And Msh6 Variants In Lynch Syndrome, Olivia N. Amodeo

Honors Scholar Theses

Lynch syndrome is a hereditary disease caused by the inheritance of a mismatch repair gene variant. Individuals with this condition are predisposed to cancer development, most commonly colorectal cancer. Current guidelines for variant classification are based on numerous evidence categories, including functional evidence. However, many novel clinical variants are not well characterized, and evidence is difficult to obtain if functional assays are not calibrated.

To address this, our lab created a calibrated functional assay that calculates an odds of pathogenicity score for MSH2 and MSH6 gene variants that can be used as evidence for classifying variants of uncertain significance. This …

Pattern Dynamics And Stochasticity Of Brain Rhythms And Spike Trains In A Tauopathy Mouse Model Of Alzheimer’S Disease, Clarissa M. Hoffman

Dissertations and Theses (Open Access)

Systems neuroscience posits that every aspect of perceived physical reality, every aspect of animal and human behavior, and every cognitive phenomenon emerges from patterns of neuronal activity. While most researchers embrace this idea, there are major difficulties in describing and analyzing these complex neuronal dynamics—spike flows produced by cells ensembles, synchronized extracellular field oscillations, and other patterns—which limits our understanding of how the activity of individual neurons and the whole-animal cognition and behavior might be connected. In particular, we lack the approaches and even the semantics for connecting the individual cell outputs and the integrated results of their activity. Current …

Platelet Gαz Regulates Ovarian Tumor Growth And Mediates The Effects Of Chronic Stress, María G. Torres Carrizalez

Dissertations and Theses (Open Access)

Ovarian cancer is the most aggressive gynecologic cancer, with 12,450 estimated deaths in 2026. Elevated platelet counts are commonly observed in patients with ovarian cancer and are associated with enhanced tumor growth and poor prognosis. Patients with ovarian cancer are frequently exposed to elevated levels of stress, which has been correlated with accelerated disease progression and increased mortality. Interestingly, the platelet Gαz protein is activated by epinephrine through the α2A-adrenergic receptor, suggesting a potential mechanistic link between stress signaling and platelet-driven tumor progression. To investigate this, I evaluated the role of platelet Gαz in ovarian cancer using control (Gz^{fl/fl …}

Determining Zap-70 Signaling Pathways Mediated By Ccr7 In Tcr T Cell Activation, Vivian Torres

Open Access Theses & Dissertations

Activation of T lymphocytes is the main event that occurs in the adaptive immune response after engagement of the T cell receptor (TCR) with the peptide of the major histocompatibility complex (pMHC) molecules that are demonstrated by antigen presenting cells [1]. A key step in this process is the recruitment and activation of the zeta chain associated protein of 70 kDa (ZAP-70). ZAP-70 couples TCR engagement to downstream intracellular signaling pathways through phosphorylation of tyrosine residues within intracellular tyrosine activation motifs (ITAMs) [2]. Although there have been extensive studies on the signaling response through TCR activation, the regulatory influence of …