Life Sciences Commons^™

The Electrophysiological And Neuropsychological Organization Of Long Term Memory, Richard J. Addante

Psychology Faculty Publications

The electrophysiological correlates of recognition memory retrieval were examined in order to identify the neural conditions that precede accurate memory retrieval, characterize the processes that contribute to high and low confidence memory responses, and determine which memory processes are impaired after brain injury. Human electroencephalogram (EEG) was recorded during recognition confidence and source memory judgments in three experiments. In Experiment 1, mid-frontal pre-stimulus theta oscillations were found to precede the stimulus presentation of items that were successfully recollected, but they were not found to be predictive of item familiarity. Moreover, during stimulus presentation, recollection was associated with an increase in …

Change Detection Memory In Rhesus Monkeys And Humans, Lauren C. Elmore

Dissertations & Theses (Open Access)

Visual short-term memory (VSTM) is the storage of visual information over a brief time period (usually a few seconds or less). Over the past decade, the most popular task for studying VSTM in humans has been the change detection task. In this task, subjects must remember several visual items per trial in order to identify a change following a brief delay interval. Results from change detection tasks have shown that VSTM is limited; humans are only able to accurately hold a few visual items in mind over a brief delay. However, there has been much debate in regard to the …

The Dissociation Of Location And Object Working Memory Using Fmri And Meg, Antony Passaro

Dissertations & Theses (Open Access)

Visual working memory (VWM) involves maintaining and processing visual information, often for the purpose of making immediate decisions. Neuroimaging experiments of VWM provide evidence in support of a neural system mainly involving a fronto-parietal neuronal network, but the role of specific brain areas is less clear. A proposal that has recently generated considerable debate suggests that a dissociation of object and location VWM occurs within the prefrontal cortex, in dorsal and ventral regions, respectively. However, re-examination of the relevant literature presents a more robust distribution suggestive of a general caudal-rostral dissociation from occipital and parietal structures, caudally, to prefrontal regions, …

Empathy-Based Conservation: An Interdisciplinary Approach To Conservation Policy And Decision-Making, Kaitlyn Delashmutt

Department of Environmental Studies: Undergraduate Student Theses

In the late 20^th century, neuroscientists in Italy discovered a neuron in the brain capable of mentally mimicking the emotions derived from the actions of others (Rizzolatti and Craighero, 2004). It is the process that makes your elbow ache when someone else knocks their elbow on the counter or the uncontrollable smile that creeps up when someone smiles at you. No questions asked, people intuitively sense what others are feeling. The old school of thought was that humans deduced through logic and reason the actions of others and interpreted the emotions through a rational process (Carew et al, 2008). …

The Impact Of Category Separation On Unsupervised Categorization, Shawn W. Ell, Gregoryh F. Ashby

Psychology Faculty Scholarship

Most previous research on unsupervised categorization has used unconstrained tasks in which no instructions are provided about the underlying category structure or the stimuli are not clustered into categories. Few studies have investigated constrained tasks in which the goal is to learn pre-defined stimulus clusters in the absence of feedback. These studies have generally reported good performance when the stimulus clusters could be separated by a one-dimensional rule. The present study investigated the limits of this ability. Results suggest that even when two stimulus clusters are as widely separated as in previous studies, performance is poor if within-category variance on …

Effects Of Methamphetamine On Sexual Behavior, Karla S. Frohmader

Electronic Thesis and Dissertation Repository

Methamphetamine (Meth) is a highly addictive psychostimulant associated with enhanced sexual desire, arousal, and sexual pleasure. Moreover, Meth abuse is frequently linked with the practice of sexual risk behavior and increased prevalence of Human Immunodeficiency Virus (HIV). Currently, the neurobiological basis for this drug-sex nexus is unknown. Moreover, there is a lack of studies investigating the effects of Meth on sexual behavior and more importantly, compulsive sex-seeking behavior, under controlled experimental settings in animal models. First, using immuhistochemistry for mating- and Meth-induced neural activation it was demonstrated that Meth administration in male rats activates neurons in brain regions of the …

Broad, Deep And Indirect: The Potential Influence Of Neuroscience In Law, Amanda C. Pustilnik

Amanda C Pustilnik

No abstract provided.

Pain As Fact And Heuristic: How Pain Neuroimaging Illuminates Moral Dimensions Of Law, Amanda Pustilnik

Amanda C Pustilnik

Legal statuses, prohibitions, and protections often turn on the presence and degree of physical pain. In legal domains ranging from tort to torture, pain and its degree do important definitional work by delimiting boundaries of lawfulness and of entitlements. The omnipresence of pain in law suggests that the law embodies an intuition about the ontological primacy of pain. Yet, for all the work done by pain as a term in legal texts and practice, it has had a confounding lack of external verifiability. As with other subjective states, we have been able to impute pain’s presence but have not been …

Serotonin, Motivation, And Playfulness In The Juvenile Rat, Stephen M. Siviy, Loren M. Deron, Chelsea R. Kasten

Psychology Faculty Publications

The effects of the selective 5HT1A agonist 8-OH-DPAT were assessed on the play behavior of juvenile rats. When both rats of the test pair were comparably motivated to play, the only significant effect of 8-OH-DPAT was for play to be reduced at higher doses. When there was a baseline asymmetry in playful solicitation due to a differential motivation to play and only one rat of the pair was treated, low doses of 8-OH-DPAT resulted in a collapse of asymmetry in playful solicitations. It did not matter whether the rat that was treated initially accounted for more nape contacts or fewer …

A Model Of Intracellular Θ Phase Precession Dependent On Intrinsic Subthreshold Membrane Currents., L Stan Leung

Physiology and Pharmacology Publications

A hippocampal place cell fires at an increasingly earlier phase in relation to the extracellular theta rhythm as a rodent moves through the place field. The present report presents a compartment model of a CA1 pyramidal cell that explains the increase in amplitude and the phase precession of intracellular theta oscillations, with the assumption that the cell receives an asymmetric ramp depolarization (<10 >mV) in the place field and rhythmic inhibitory and/or excitatory synaptic driving. Intracellular subthreshold membrane potential oscillations (MPOs) increase in amplitude and frequency, and show phase precession within the place field. Theta phase precession and MPO power …

Prestimulus Theta Activity Predicts Correct Source Memory Retrieval, Richard J. Addante, Andrew J. Watrous, Andrew P. Yonelinas, Arne D. Ekstrom, Charan Ranganath

Psychology Faculty Publications

Recent evidence indicates that the processing of a stimulus can be influenced by preceding patterns of brain activity. Here we examine whether prestimulus oscillatory brain activity can influence the ability to retrieve episodic memories. Neural activity in the theta-frequency band (4-8 Hz) was enhanced before presentation of test items which elicited accurate recollection of contextual details of the prior study episode ("source retrieval"), relative to trials for which item recognition was successful but source retrieval failed. Poststimulus theta activity was also related to source retrieval, and the magnitude of poststimulus theta was predicted by the magnitude of the prestimulus theta …

Neuropsychological And Neurophysiological Effects Of Low-Intensity Strengthening Exercise On Cognition, Vadim V. Yerokhin

Honors Theses

With the growing aging population, it’s becoming increasingly important to find ways to either deter or prevent dementia. To date, most research has concentrated on the effects of aerobic exercise on cognition. Unfortunately, a large portion of older adults are often contraindicated to perform aerobic exercise due to different risk factors, which increase with age. Alas, alternate ways of exercise are necessary. Low-intensity strengthening exercise is a type of exercise aimed at improving balance and strengthening muscles without requiring one to overstrain. The current 11-week long exercise study test neuropsychological effects of exercise with a neuropsychological battery and neurophysiological effects …

Embraining Culture: Leaky Minds And Spongy Brains, Julian Kiverstein, Mirko Farina

Mirko Farina

We offer an argument for the extended mind based on considerations from brain development. We argue that our brains develop to function in partnership with cognitive resources located in our external environments. Through our cultural upbringing we are trained to use artefacts in problem solving that become factored into the cognitive routines our brains support. Our brains literally grow to work in close partnership with resources we regularly and reliably interact with. We take this argument to be in line with complementarity or “second-wave” defences of the extended mind that stress the functional differences between biological elements and external, environmental …

Cocaine Dependence: The Role Of Serotonin Genes In, Lorena Maili

Dissertations & Theses (Open Access)

Animal studies have shown that behavioral responses to cocaine-related cues are altered by serotonergic medications. The effects of pharmacological agents on serotonin receptors 2a (5-HT2A) and 2c (5-HT2C), have yielded results suggesting that selective 5-HT2A antagonists and 5-HT2C agonists promote the disruption of cocaine-associated memories. One measure of cocaine related cues in humans is attentional bias, in which cocaine dependent individuals show greater response latency for cocaine related words than neutral words. Data from our laboratory shows that cocaine dependent subjects have altered attentional bias compared to controls. The purpose of this thesis was to investigate the role of the …

The Neural Substrates Of Multisensory Speech Perception, Audrey R. Nath

Dissertations & Theses (Open Access)

Comprehending speech is one of the most important human behaviors, but we are only beginning to understand how the brain accomplishes this difficult task. One key to speech perception seems to be that the brain integrates the independent sources of information available in the auditory and visual modalities in a process known as multisensory integration. This allows speech perception to be accurate, even in environments in which one modality or the other is ambiguous in the context of noise. Previous electrophysiological and functional magnetic resonance imaging (fMRI) experiments have implicated the posterior superior temporal sulcus (STS) in auditory-visual integration of …

Dissociable And Dynamic Components Of Cognitive Control: A Developmental Electrophysiological Investigation, Matthew Waxer

Electronic Thesis and Dissertation Repository

One standard task used to investigate the development of cognitive control is the Dimensional Change Card Sort (DCCS). Performance and patterns of brain activity associated with the DCCS show continued age-related advances into early adolescence. According to many theoretical accounts, the DCCS places demands on a single underlying executive control process. Three experiments examined the possibility that the DCCS places demands on multiple control processes that follow distinct developmental trajectories. In Experiment 1, rule switching and conflict processing made orthogonal contributions to DCCS performance. Rule switching was associated with a cue-locked late frontal negativity (LFN) event-related potential (ERP) and conflict …

On The Origin Of Stories: Evolution, Cognition, And Fiction, Hope Hollocher, Agustín Fuentes, Charles H. Pence, Grant Ramsey, Daniel John Sportiello, Michelle M. Wirth

Faculty Publications

No abstract provided.

Cognitive Systems And The Extended Mind, Mirko Farina

Mirko Farina

No abstract provided.

Orbitofrontal Cortex Provides Cross-Modal Valuation Of Self-Generated Stimuli, William A. Cunningham, Ingrid J. Haas, Ashley S. Waggoner

Department of Political Science: Faculty Publications

Prior research has shown that the orbitofrontal cortex (OFC) plays an important role in the representation of the evaluation of stimuli, regardless of stimulus modality. Based on these findings, researchers have proposed that the OFC serves a common currency function, allowing for the direct comparison of different types of perceptual stimuli (e.g. food, drink, money). The present study was designed to extend this research and investigate whether these same regions of OFC that have been identified in previous research are involved in evaluating imagined stimuli. Specifically, we asked participants to draw on prior attitudinal knowledge to generate internal representations of …

Contextual Information And Memory For Unfamiliar Tunes In Older And Younger Adults, Samantha A. Deffler, Andrea R. Halpern

Faculty Journal Articles

We examined age differences in the effectiveness of multiple repetitions and providing associative facts on tune memory. For both tune and fact recognition, three presentations were beneficial. Age was irrelevant in fact recognition, but older adults were less successful than younger in tune recognition. The associative fact did not affect young adults' performance. Among older people, the neutral association harmed performance; the emotional fact mitigated performance back to baseline. Young adults seemed to rely solely on procedural memory, or repetition, to learn tunes. Older adults benefitted by using emotional associative information to counteract memory burdens imposed by neutral associative information.

The Persistence Of Musical Memories: A Descriptive Study Of Earworms, Andrea R. Halpern, James C. Bartlett

Faculty Journal Articles

We describe some characteristics of persistent musical and verbal retrieval episodes, commonly known as "earworms." In Study 1, participants first filled out a survey summarizing their earworm experiences retrospectively. This was followed by a diary study to document each experience as it happened. Study 2 was an extension of the diary study with a larger sample and a focus on triggering events. Consistent with popular belief, these persistent musical memories were common across people and occurred frequently for most respondents, and were often linked to recent exposure to preferred music. Contrary to popular belief, the large majority of such experiences …

Differentiable Cortical Networks For Inferences Concerning People’S Intentions Versus Physical Causality, Robert Mason, Marcel Just

Marcel Adam Just

No abstract provided.

Task-Invariant Brain Responses To The Social Value Of Faces., Alex Todorov, Chris Said, Nicholas Oosterhof, Andrew Engell

Andrew Engell

Autism Spectrum Traits In The Typical Population Predict Structure And Function In The Posterior Superior Temporal Sulcus., Elisabeth Von Dem Hagen, Lauri Nummenmaa, R Yu, Andrew Engell, Michael Ewbank, Andy Calder

Andrew Engell

Autonomy Of Lower-Level Perception From Global Processing In Autism: Evidence From Brain Activation And Functional Connectivity, Yanni Liu, Vladimir L. Cherkassky, Nancy J. Minshew, Marcel Adam Just

Marcel Adam Just

No abstract provided.

Inter-Regional Brain Communication And Its Disturbance In Autism, Sarah E. Schipul, Timothy A. Keller, Marcel Adam Just

Marcel Adam Just

No abstract provided.

Quantitative Modeling Of The Neural Representation Of Objects: How Semantic Feature Norms Can Account For Fmri Activation, Kai-Min Kevin Chang, Tom Mitchell, Marcel Adam Just

Marcel Adam Just

No abstract provided.

Individual Differences In The Neural Basis Of Causal Inferencing, Chantel S. Prat, Robert A. Mason, Marcel Adam Just

Marcel Adam Just

No abstract provided.

Commonality Of Neural Representations Of Words And Pictures, Svetlana V. Shinkareva, Vincente L. Malave, Robert A. Mason, Tom M. Mitchell, Marcel Adam Just

Marcel Adam Just

No abstract provided.

The Neural Basis Of Deictic Shifting In Linguistic Perspective-Taking In High-Functioning Autism, Akiko Mizuno, Yanni Liu, Diane L. Williams, Timothy A. Keller, Nancy J. Minshew, Marcel Adam Just

Marcel Adam Just

No abstract provided.