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Articles 1 - 11 of 11
Full-Text Articles in Life Sciences
Sex-Associated Mitochondrial Genes: Tools For Understanding Unionid Reproduction And Development, Amy Louise Maynard
Sex-Associated Mitochondrial Genes: Tools For Understanding Unionid Reproduction And Development, Amy Louise Maynard
MSU Graduate Theses
Gonochoristic species of the bivalve order Unionida possess two types of mitochondria. The female-inherited mitochondria (F-mt) is found in the somatic cells of both sexes, while male-inherited mitochondria (M-mt) is found in the male gonad. These mitochondria possess different open reading frames (M-ORF or F-ORF respectively). Previous studies suggested that two types of sperm might exist, each carrying one or the other mitochondrial haplotype, and it was hypothesized that the presence of either F-mt or M-mt in sperm may be involved in determination of offspring sex. I investigated this hypothesis in Bleedingtooth (Venustaconcha pleasii). Sperm samples were obtained from field-collected …
Investigation Of Nocifensive And Cellular Effects Of Dihydroergotamine In A Model Of Chronic Migraine, Jennifer Elise Denson
Investigation Of Nocifensive And Cellular Effects Of Dihydroergotamine In A Model Of Chronic Migraine, Jennifer Elise Denson
MSU Graduate Theses
The goal of my study was to investigate the nocifensive behavioral and cellular effects of dihydroergotamine (DHE) and sumatriptan in a model of sustained trigeminal activation. Trigeminal nerves provide sensory innervation to the head and face and their activation has been implicated in migraine pathology. The most commonly prescribed medications for migraine treatment are the triptan class of drugs. However, triptans are not an effective therapy for all migraine patients and some develop triptan resistance. Ergot-derivatives, including DHE, could be a potential alternative for this subpopulation of patients. To cause activation of the trigeminal system, adult male Sprague Dawley rats …
Examination Of The Cytotoxicity Of Carboxyl Functionalized Single-Walled Carbon Nanotubes On Escherichia Coli, Brittany Linn Twibell
Examination Of The Cytotoxicity Of Carboxyl Functionalized Single-Walled Carbon Nanotubes On Escherichia Coli, Brittany Linn Twibell
MSU Graduate Theses
The growing use of carbon nanotubes (CNTs) in industrial and consumer products raises important questions about their environmental fate and impact on prokaryotes. In the environment, CNTs are exposed to a variety of conditions (e.g. UV light) that could lead to decomposition and changes in their chemical properties. Therefore, the potential cytotoxic effect of both pristine and artificially aged carboxyl functionalized single-walled CNTs at neutral and acidic conditions on Escherichia coli K12 was analyzed using a minimal inhibitory concentration (MIC) assay, which also allowed monitoring of non-lethal growth effects. However, there were no observable MIC or significant changes in growth …
Evaluation Of Anti-Migraine Drugs In An In Vivo Rat Model Of Chronic Migraine, Shannon Nicole Stiles
Evaluation Of Anti-Migraine Drugs In An In Vivo Rat Model Of Chronic Migraine, Shannon Nicole Stiles
MSU Graduate Theses
Approximately 2% of the US population is affected by chronic migraine (CM). CM is a recurring, neurological disorder characterized by painful headache, along with autonomic, gastrointestinal, and other somatic symptoms. Prolonged sensitization of the trigeminal system, which is implicated in CM, is comprised of peripheral primary trigeminal ganglion neurons that provide sensory innervation of the head and face and second order neurons in the spinal trigeminal nucleus (STN). The goal of my study was to evaluate anti-migraine drugs for their ability to inhibit ongoing peripheral and central sensitization of trigeminal nociceptors. An in vivo animal model was used to determine …
Maximum Entropy Modeling Of Indiana Bat (Myotis Sodalis) Maternity Roost Habitat, Joseph Robert Lemen
Maximum Entropy Modeling Of Indiana Bat (Myotis Sodalis) Maternity Roost Habitat, Joseph Robert Lemen
MSU Graduate Theses
Since 1967, the Indiana bat (Myotis sodalis) has been on the U.S. Endangered Species list due to disruption of hibernating bats in caves, summer habitat degradation, and more recently, the onset of White-nose Syndrome. The purpose of this study is to evaluate landscape variables associated with Indiana bat maternity roost trees in an attempt to better understand what factors play a role in their distribution in north central Missouri. I tracked reproductive female Indiana bats to 20 different primary and secondary roost trees; these are roosts that had multiple bats visit them on multiple occasions. GPS location data for these …
Functional Connection Between Yeast Dynamin And Retromer At The Endosome, Christopher Robert Trousdale
Functional Connection Between Yeast Dynamin And Retromer At The Endosome, Christopher Robert Trousdale
MSU Graduate Theses
Intracellular trafficking from the late endosome to Golgi in cells is termed retrograde transport, essential for recycling of important macromolecules including cell membrane receptors. Retrograde transport is regulated by a family of proteins known as the "Retromer” composed of 5 VPS proteins (Vps5, Vps17, Vps26, Vps29, and Vps35). Retromer acts as the coat proteins for vesicles emerging from late endosomes. Loss of Retromer function has been previously implicated in both Parkinson's and Alzheimer's disease. Vps1, a yeast dynamin-like protein, plays a role in intracellular trafficking. Vps1 has been shown to localize at the endocytic sites to promote pinching off of …
Dynamin Association With Clathrin And Its Physiological Roles At The Golgi And Targeting Mechanism To The Golgi, Shiva Kumar Goud Gadila
Dynamin Association With Clathrin And Its Physiological Roles At The Golgi And Targeting Mechanism To The Golgi, Shiva Kumar Goud Gadila
MSU Graduate Theses
Vps1 (Vacuole protein sorting 1), a dynamin-like protein in yeast, is implicated in diverse membrane trafficking pathways and localized to many organelles, including the Golgi. It has been proposed that Vps1 is functionally linked to clathrin heavy chain 1 (Chc1), but the question of how, where, and when they function together remains unknown. Lines of evidence suggest that Chc1 and Vps1 are located at the late Golgi. Therefore, I hypothesized that Vps1 binds to Chc1 and functions together at the Golgi for efficient Golgi-to-endosome membrane trafficking. Using the yeast-two hybrid assay, I present evidence that Vps1 binds to the C-terminal …
Nesting Success And Parental Behavior Of The Prothonotary Warbler (Protonotaria Citrea) In Southwestern Missouri, Kathryn Marie Siverly
Nesting Success And Parental Behavior Of The Prothonotary Warbler (Protonotaria Citrea) In Southwestern Missouri, Kathryn Marie Siverly
MSU Graduate Theses
The breeding biology and singing rates of Prothonotary Warblers (Protonotaria citrea) were studied in southwestern Missouri in 2014 and 2015, using wooden nesting boxes. Data were collected on clutch and brood sizes, the numbers of young fledged, parental care and male singing rates. Five pairs were studied over the course of the two summers. Of 28 eggs laid, 14 young fledged. In 2015, significant flooding resulted in the loss of all young and eggs for that year. First clutches were larger than second clutches. Observations suggest females may contribute more to the care of offspring, in terms of foraging and …
Effects Of Low Concentrations Of Carbon Nanotubes On Growth And Gas Exchange In Arabidopsis Thaliana, Rajeeva Voleti
Effects Of Low Concentrations Of Carbon Nanotubes On Growth And Gas Exchange In Arabidopsis Thaliana, Rajeeva Voleti
MSU Graduate Theses
The effect of pure single-walled carbon nanotubes (SWCNTs) on plant growth and gas exchange was investigated in Arabidopsis thaliana. To date there has been no research on the effects of SWCNTs on whole plant physiology. A. thaliana seeds were directly grown in growth medium containing SWCNTs concentrations of 24.93micrograms/ml and 53.55 micrograms/ml. control plants were grown in media containing distilled water. I determined growth by measuring dry mass of plants. I determined gas exchange by measuring photosynthetic rates, stomatal conductance, transpiration rates, and water use efficiency. I also examined the following physiological mechanisms that would limit plant growth: ATP and …
Reintroduction Biology Of Head-Started Ornate Box Turtles, Eric R. Sievers
Reintroduction Biology Of Head-Started Ornate Box Turtles, Eric R. Sievers
MSU Graduate Theses
The ornate box turtle (Terrapene ornata) is a prairie-dwelling species that has experienced population declines, especially near the northern edge of its range. In order to provide supporting research for a reintroduction program at the Upper Mississippi River National Wildlife and Fish Refuge in northwestern Illinois, I compared the relative success of different approaches to reintroduction. Specifically, I tested the null hypothesis that reintroduced turtles exhibited equal reintroduction success when, 1) released at a site that is known to support a viable ornate box turtle population, 2) ‘soft-released' in a fenced enclosure at a site where very few ornate box …
Calcitonin Gene-Related Peptide Promotes Peripheral And Central Trigeminal Sensitization, Lauren Elise Cornelison
Calcitonin Gene-Related Peptide Promotes Peripheral And Central Trigeminal Sensitization, Lauren Elise Cornelison
MSU Graduate Theses
Temporomandibular joint disorder is characterized by peripheral and central sensitization of trigeminal nociceptive neurons. Although CGRP is implicated in the development of central sensitization by stimulating glial activation via its receptor, the mechanism by which CGRP promotes and maintains sensitization of trigeminal nociceptive neurons is not well understood. The goal of my study was to investigate the role of calcitonin gene-related peptide (CGRP) on the initiation and maintenance of a nocifensive withdrawal response to mechanical stimulation following activation of primary trigeminal sensory neurons. For my studies, I used adult male Sprague Dawley rats that were injected with CGRP alone or …