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Full-Text Articles in Life Sciences
Isolating Highly Specific Antibodies Against Cancer Target Hprt, Austin J. Hansen, Christopher J. Haynie, Kiara V. Whitley, Michelle Townsend, Abby Johnson, Hunter Lindsay, Laura Baird, Kim L. O'Neill
Isolating Highly Specific Antibodies Against Cancer Target Hprt, Austin J. Hansen, Christopher J. Haynie, Kiara V. Whitley, Michelle Townsend, Abby Johnson, Hunter Lindsay, Laura Baird, Kim L. O'Neill
Library/Life Sciences Undergraduate Poster Competition 2023
Effective immunotherapeutic targeting of cancer cells requires identification of specific antigenic differences between cancerous and healthy cells. Hypoxanthine-guanine phosphoribosyltransferase (HPRT) is a cytoplasmic enzyme involved in the salvage pathway for DNA synthesis. Certain cancers (e.g., prostate and breast) upregulate and express HPRT on the cell membrane, making HPRT a potential cancer biomarker for cancer immunotherapies. Antibodies specific for unique cancer proteins are critical to develop targeted cancer immunotherapies. Using a yeast display library and cell sorting, we selected for high-affinity human single-chain (scFv) antibodies against HPRT that can be utilized in chimeric antigen receptor (CAR) T cell therapies and antibody-dependent …
Is There A Link Between Male Gonopodium Size And Mating Strategies Amongst Fish In The Family Poeciliidae?, Ryen Hunsaker, Jerald B. Johnson
Is There A Link Between Male Gonopodium Size And Mating Strategies Amongst Fish In The Family Poeciliidae?, Ryen Hunsaker, Jerald B. Johnson
Library/Life Sciences Undergraduate Poster Competition 2023
Have different male mating strategies led to evolutionary changes in male gonopodium size?
Natural selection should act strongly on any traits that affect successful reproduction. Fish species in the family Poeciliidae (livebearers) have a unique form of reproduction.
Do Regional Dna Barcode Databases Lead To More Efficient Specimen Identification?, Michael Kerr, Steven D. Leavitt
Do Regional Dna Barcode Databases Lead To More Efficient Specimen Identification?, Michael Kerr, Steven D. Leavitt
Library/Life Sciences Undergraduate Poster Competition 2023
DNA barcoding is a method for identifying specimens from specific regions of DNA. 1 Metabarcoding focuses on large, multi specimen scales. 2 These approaches rely on DNA databases for sequence identification, 2 but these databases often lack data from many species, 3 especially from poorly studied groups such as fungi 4 and lichens, which can lead to failure in specimen identification.