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Articles 61 - 61 of 61
Full-Text Articles in Life Sciences
Combinatorial Control Of Yeast Fet4 Gene Expression By Iron, Zinc, And Oxygen, Brian M. Waters, David J. Eide
Combinatorial Control Of Yeast Fet4 Gene Expression By Iron, Zinc, And Oxygen, Brian M. Waters, David J. Eide
Department of Agronomy and Horticulture: Faculty Publications
Acquisition of metals such as iron, copper, and zinc by the yeast Saccharomyces cerevisiae is tightly regulated. High affinity uptake systems are induced under metal-limiting conditions to maintain an adequate supply of these essential nutrients. Low affinity uptake systems function when their substrates are in greater supply. The FET4 gene encodes a low affinity iron and copper uptake transporter. FET4 expression is regulated by several environmental factors. In this report, we describe the molecular mechanisms underlying this regulation. First, we found that FET4 expression is induced in iron-limited cells by the Aft1 iron-responsive transcriptional activator. Second, FET …