Operations Research, Systems Engineering and Industrial Engineering Commons^™

Barriers To Integrating Magnetic Resonance Imaging Systems In Emergency Medical Service Ambulances For Stroke Care, Arvind Kolangarakath

All Theses

Stroke is a life-threatening condition that can cause permanent damage by stopping blood flow in the brain. Quick and precise intervention is imperative, as every second lost increases tissue deterioration and impacts patient outcomes. Several technological advancements such as Magnetic Resonance Imaging (MRI), have revolutionized stroke care by enabling more accurate and quicker diagnoses in hospitals. Portable head MRI scanners with lower magnetic fields are a recent innovation capable of providing neuroimaging at the point of care within hospital settings. Integrating such a device into ambulances could potentially enhance stroke care during transit, facilitating prompt diagnosis and prognosis. However, few …

Modeling And Solution Methodologies For Mixed-Model Sequencing In Automobile Industry, Ibrahim Ozan Yilmazlar

All Dissertations

The global competitive environment leads companies to consider how to produce high-quality products at a lower cost. Mixed-model assembly lines are often designed such that average station work satisfies the time allocated to each station, but some models with work-intensive options require more than the allocated time. Sequencing varying models in a mixed-model assembly line, mixed-model sequencing (MMS), is a short-term decision problem that has the objective of preventing line stoppage resulting from a station work overload. Accordingly, a good allocation of models is necessary to avoid work overload. The car sequencing problem (CSP) is a specific version of the …

Examining Individuals' Use Of The Internet For Healthcare Activities Over Time: Statistical Analysis Of Nhis Data, Zachary Junkins

All Theses

Telehealth is an increasingly important component of healthcare services. Telehealth services may present an opportunity to increase the equity, accessibility, and effectiveness of healthcare. As such, it is critical that telehealth design focus on reducing the barriers to access and usability that may impair some telehealth users. I utilized data from the National Health Interview Survey (NHIS) and multiple logit regression models focused on different aspects of telehealth in order to determine demographic characteristics, behaviors, or opinions which may predict groups that are likely to face a barrier to using telehealth services. This analysis provides an exploratory look at the …

Variability In Anesthesia And Its Implications For Improving Patient Safety, Joshua Michael Biro

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Improving patient safety in anesthesia has proven to be an arduous and challenging task. Despite the many strategies and interventions to improve patient safety that have been employed, patient harm in anesthesia remains a problem. The struggle to reduce patient harm in anesthesia is both attributable to and representative of the complexity of the anesthesia system. In navigating this complex system, anesthesia providers have different approaches to how they accomplish their work, which results in variability in anesthesia practice. This variability provides an immense challenge to designing and implementing efforts to improve patient safety, as rigid interventions are often met …

Essays On Integer Programming Approaches To Analyze Equilibrium Solutions In Games, Lucky Cho

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In this dissertation, we present three applications of integer programming to analyze non-cooperative games. In a non-cooperative game, players of the game act selfishly and choose the best response given every other player's decision. The game reaches a Nash equilibrium when no player can benefit by changing its decisions. Our goal is to create an integer program that can identify these Nash equilibriums by modeling the best response of the game's players in the constraints. We prove a one-to-one correspondence between the game's Nash equilibrium and the feasible solution of a corresponding integer program. The one-to-one correspondence allows us to …

Network Effects Of Emergency Department Clinician Strain And Patient Congestion, Aisha Nelson

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We develop a discrete-event simulation model to study how staffing strain affects patient outcomes across a network of Emergency Departments (EDs). The aim is to observe how clinician staffing and transfers throughout the system affect the system’s behavior. We will study the network of the seven EDs in the Prisma Health-Upstate system. Patient acuity and resource need are stratified using the five-level Emergency Severity Index (ESI). Patient flow data within and between EDs are collected from EPIC, staffing data from ShiftAdmin, and environmental COVID-19 prevalence data from the Department of Health and Environmental Control. Time periods include the Omicron wave …

Mapping Information Flows That Support Adaptive Capacity In The Sterile Processing Department (Spd), Jacob Hionis

All Theses

The Sterile Processing Department (SPD) is the part of the hospital that is responsible for decontaminating, assembling, and sterilizing surgical trays for use in the Operating Rooms (ORs). Errors in the SPD can lead to delayed surgeries or patient harm. The SPD is a complex system, with multiple interconnected subdepartments and roles. Complex systems require coordination between stakeholders. This study aims to discover how an organization can adapt to scale, and how information flows support these adaptations. In this study, observations, semi-structured interviews, and on-the-job interviews were conducted with members across the SPD and OR to elicit pressures, adaptations, and …

Studying Pedestrian’S Unmarked Midblock Crossing Behavior On A Multilane Road When Interacting With Autonomous Vehicles Using Virtual Reality, Fengjiao Zou

All Dissertations

This dissertation focuses on the challenge of pedestrian interaction with autonomous vehicles (AVs) at unmarked midblock locations where the right-of-way is unspecified. A virtual reality (VR) simulation was developed to replicate an urban unmarked midblock environment where pedestrians cross a four-lane arterial roadway and interact with AVs. One research goal is to investigate the impact of roadway centerline features (undivided, two-way left-turn lane, and median) and AV operational schemes portrayed through on-vehicle signals (no signal, yellow negotiating indication, and yellow/blue negotiating/no-yield indications) on pedestrian crossing behavior. Results demonstrate that both roadway centerline design features and AV operations and signaling show …

Essays On Perioperative Services Problems In Healthcare, Amogh S. Bhosekar

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One of the critical challenges in healthcare operations management is to efficiently utilize the expensive resources needed while maintaining the quality of care provided. Simulation and optimization methods can be effectively used to provide better healthcare services. This can be achieved by developing models to minimize patient waiting times, minimize healthcare supply chain and logistics costs, and maximize access. In this proposal, we study some of the important problems in healthcare operations management. More specifically, we focus on perioperative services and study scheduling of operating rooms (ORs) and management of necessary resources such as staff, equipment, and surgical instruments. We …

On Variants Of Sliding And Frank-Wolfe Type Methods And Their Applications In Video Co-Localization, Seyed Hamid Nazari

All Dissertations

In this dissertation, our main focus is to design and analyze first-order methods for computing approximate solutions to convex, smooth optimization problems over certain feasible sets. Specifically, our goal in this dissertation is to explore some variants of sliding and Frank-Wolfe (FW) type algorithms, analyze their convergence complexity, and examine their performance in numerical experiments. We achieve three accomplishments in our research results throughout this dissertation. First, we incorporate a linesearch technique to a well-known projection-free sliding algorithm, namely the conditional gradient sliding (CGS) method. Our proposed algorithm, called the conditional gradient sliding with linesearch (CGSls), does not require the …

Multiple Heat Exchanger Cooling System For Automotive Applications – Design, Mathematical Modeling, And Experimental Observations, Zaker Syed

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The design of the automotive cooling systems has slowly evolved from engine-driven mechanical to computer-controlled electro-mechanical components. With the addition of computer-controlled variable speed actuators, cooling system architectures have been updated to maximize performance and efficiency. By switching from one large radiator to multiple smaller radiators with individual flow control valves, the heat rejection requirements may be precisely adjusted. The combination of computer regulated thermal management system should reduce power consumption while satisfying temperature control objectives. This research focuses on developing and analyzing a multi-radiator system architecture for implementation in ground transportation applications. The premise is to use a single …

Design And Operations Of A New Facility In A Next Generation Logistic System Based On Horizontal Collaboration, Dilhani Marasinghe

All Dissertations

The growing amount of freight combined with systemic inefficiencies are stressing current logistic systems. Including horizontal collaboration in the future could provide significant help but this strategy will require several new types of facilities. The most flexible type of horizontal collaboration, however, required freight routing decisions to be made dynamically, in real time, and based on last minute information. This research explores one new facility type operating in this environment that handles a high throughput of pallets or pallet-like containers. A key design feature is how much storage these facilities should have to better coordinate outbound loads. The approach taken …

Park Equity Modeling: A Case Study Of Asheville, North Carolina, Anisa Young

All Theses

Parks and greenspaces are publicly available entities that serve the vital purpose of promoting multiple aspects of human welfare. Unfortunately, the existence of park disparities is commonplace within the park setting. Specifically, marginalized individuals encounter limited park access, insufficient amenity provision, and poor maintenance. To remedy these disparities, we propose a process in which we select candidate park facilities and utilize facility location models to determine the optimal primary parks from both existing and candidate sites.

We note that platforms currently exist to identify the geographical areas where residents lack sufficient access to parks. However, these platforms do not yet …

Generating Sex Trafficking Networks From Text Documents, Maria Diaz

All Theses

Qualitative coding is a long and strenuous process that requires a well-skilled investigator. Natural language processing techniques have made leaps and bounds as far as usability and application domain, although it does not work for every task. In this work, we have created a natural language processing framework to help qualitative coders automatically obtain the nodes and node arcs from federal case files, dockets, and indictments within a sex trafficking network. The produced nodes and arcs allows us to perform network modeling by providing us with the information needed to create network structures that can then be used for interdiction …

Optimal Global Supply Chain And Warehouse Planning Under Uncertainty, Avnish Kishor Malde

All Dissertations

A manufacturing company's inbound supply chain consists of various processes such as procurement, consolidation, and warehousing. Each of these processes is the focus of a different chapter in this dissertation.

The manufacturer depends on its suppliers to provide the raw materials and parts required to manufacture a finished product. These suppliers can be located locally or overseas with respect to the manufacturer's geographic location. The ordering and transportation lead times are shorter if the supplier is located locally. Just In Time (JIT) or Just In Sequence (JIS) inventory management methods could be practiced by the manufacturer to procure the raw …

Adaptive Design And Flexible Approval Of Clinical Trials, Saeid Delshad Sisi

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Dose-finding clinical trials are among the most critical cornerstones of the healthcare system. In this broad research area, there are many decision making problems that are extremely challenging to address. However, a small improvement may result in significant benefits to the society. Dose-finding clinical trials are extremely expensive and require multiple time-consuming and complicated R&D phases. Despite all the costs and the long time these trials need to conclude (on average over ten years for each new drug/technology), only less than 15\% of these trials successfully end up in a new approved drug entering the market. This problem is even …

Improving Patient Safety, Patient Flow And Physician Well-Being In Emergency Departments, Vishnunarayan Girishan Prabhu

All Dissertations

Over 151 million people visit US Emergency Departments (EDs) annually. The diverse nature and overwhelming volume of patient visits make the ED one of the most complicated settings in healthcare to study. ED overcrowding is a recognized worldwide public health problem, and its negative impacts include patient safety concerns, increased patient length of stay, medical errors, patients left without being seen, ambulance diversions, and increased health system expenditure. Additionally, ED crowding has been identified as a leading contributor to patient morbidity and mortality. Furthermore, this chaotic working environment affects the well-being of all ED staff through increased frustration, workload, stress, …

Investigations Of External Resources And The Impact Of Imaging On Patient Flow In The Emergency Department, Marisa Shehan

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The problems associated with Emergency Department (ED) crowding are numerous, varied, and complex. Though overcrowded Emergency Departments are frequently attributed to overcrowded hospitals, crowding is also impacted by bottlenecks in patient flow. While discrete-event simulation (DES) is commonly used to model ED flow, external resources are typically excluded from these models due to their complexity and the limited amount of known information for these processes. Instead, external resources such as consults, labs, and imaging are modeled using estimation and/or educated guesswork. In this study, the impact of imaging on patient flow was assessed through data analysis of specific imaging factors, …

Interdiction Models To Disrupt The Operations Of Sex Trafficking And Other Forced Illicit Labor Networks, Michael T. Clark

All Theses

Sex traffickers often force their victims to work in both commercial sex markets and perform other illicit activities (e.g., drug dealing, theft, and fraud). Current literature has failed to address interdiction models that aim to disrupt all components of a sex traffickers’ operation, including these other illicit activities. In this thesis, we present a interdiction problem, and its single-level linear optimization reformulation, to reduce the profit of a human trafficking network concurrently operating in the commercial sex market and other illicit activity markets. Our novel formulation aims to investigate the practical implications of interdiction decisions made to disrupt a human …

Selected Interdiction Games With Uncertain, Risk-Averse, And Simultaneous Play Considerations, Di H. Nguyen

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This dissertation examines two network interdiction problems: a shortest-path interdiction problem under uncertainty and a network interdiction problem in a simultaneous game. Both problems happen in two stages over a directed network, and involve a leader and a follower who have opposing interests.

In the first problem, the leader acts first to lengthen a subset of arcs, and a follower acts second to select a shortest path across the network. The cost for a follower’s arc consists of a base cost if the arc is not interdicted, plus an additional cost that is incurred if the arc is interdicted. The …

Design And Analysis Of Efficient Freight Transportation Networks In A Collaborative Logistics Environment, Vishal Badyal

All Dissertations

The increase in total freight volumes, reducing volume per freight unit, and delivery deadlines have increased the burden on freight transportation systems of today. With the evolution of freight demand trends, there also needs to be an evolution in the freight distribution processes. Today's freight transportation processes have a lot of inefficiencies that could be streamlined, thus preventing concerns like increased operational costs, road congestion, and environmental degradation. Collaborative logistics is one of the approaches where supply chain partners collaborate horizontally or/and vertically to create a centralized network that is more efficient and serves towards a common goal or objective. …

Fathom In Color: Expansion Of Reproduceable Color In Interference Pattern-Based Printed Motion And Depth Effects, Dovie Jeffcoat

All Theses

Value-added printed embellishments are increasingly sought after as brands compete for consumer attention. Fathom Optics’ method for printing motion and depth effects provides a cost-efficient, reduced waste embellishment option. One of Fathom’s current limitations is producing effects with vibrant color. The current standard practice for producing color Fathom Effects tends to darken and desaturate the final embellishment’s color. This study endeavors to determine how an ink color's components (hue, value and chroma) may determine a Fathom Effect’s contrast or intensity. To achieve this, fifteen color inks were selected to flexographically print the effect patterns. Samples were taken from each color …

A Study Of Scheduling Problems With Sequence Dependent Restrictions And Preferences, Nitin Srinath

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In some applications like fabric dying, semiconductor wafer processing, and flexible manufacturing, the machines being used to process jobs must be set up and serviced frequently. These setup processes and associated setup times between jobs often depend on the jobs and the sequence in which jobs are placed onto machines. That is, the scheduling of jobs on machines must account for the sequence-dependent setup times as well. These setup times can be a major factor in operational costs. In fabric dyeing processes, the sequence in which jobs are processed is also important for quality, i.e., there is a strong preference …

Double Tolerance Design In Stochastic Production Environments, Di Liu

All Dissertations

In a production process, it is impossible to produce parts with exact specifications. Thus, specific ranges, i.e., tolerances, are commonly employed to define intervals for the quality characteristics of conforming products (Wu & Tang (1998)). Usually, a product is deemed conforming when the measurement of the quality characteristic falls within the tolerance. If the measurement falls outside the tolerance, the product is nonconforming and it can be reworked or scrapped. One of the important engineering problems commonly faced by practitioners is to determine optimal engineering tolerances to be used in production. As a result, tolerance design techniques are widely used …

Examining The Impact Of Design Features Of Electronic Health Records Patient Portals On The Usability And Information Communication For Shared Decision Making, Rong Yin

All Dissertations

The use of the Electronic Health Records (EHR) patient portal has been shown to be effective in generating positive outcomes in patients’ healthcare, improving patient engagement and patient-provider communication. Government legislation also required proof of its meaningful use among patients by healthcare providers. Typical patient portals also include features such as health information and patient education materials. However, little research has examined the specific use of patient portals related to individuals with specific diseases such as inflammatory bowel diseases (IBDs). IBDs are life-long, not curable, chronic diseases that can impact the whole population. Individuals with IBDs may have higher needs …

An Algorithm For Biobjective Mixed Integer Quadratic Programs, Pubudu Jayasekara Merenchige

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Multiobjective quadratic programs (MOQPs) are appealing since convex quadratic programs have elegant mathematical properties and model important applications. Adding mixed-integer variables extends their applicability while the resulting programs become global optimization problems. Thus, in this work, we develop a branch and bound (BB) algorithm for solving biobjective mixed-integer quadratic programs (BOMIQPs). An algorithm of this type does not exist in the literature.

The algorithm relies on five fundamental components of the BB scheme: calculating an initial set of efficient solutions with associated Pareto points, solving node problems, fathoming, branching, and set dominance. Considering the properties of the Pareto set of …

Development And Application Of A Digital Twin For Chiller Plant Performance Assessment, Mihir Kale

All Theses

As the complexity of industrial equipment continues to increase, the management of the individual machines and integrated operations becomes difficult without computer tools. The availability of streaming data from manufacturing floors, plant operations, and deployed fleets can be overwhelming to analyze, although it provides opportunities to improve performance. The use of dedicated monitoring systems in the plant and field to troubleshoot machinery can be integrated within a product lifecycle management (PLM) architecture to offer greater features. PLM offers virtual processes and software tools for the design, analysis, monitoring, and support of engineering systems and products. Within this paradigm, a digital …

Covid Response: Iterative Model Development In The Deployment Of Hand Sanitation Stations At A Large Public University, Tyler Obrien

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This study illustrates the significance of iterative model development using the deployment of hand sanitizer stations in buildings at Clemson University as a case study. The COVID-19 problem affected Clemson University, a major institution, in several ways requiring adaptations to existing policies and procedures to take place. Following guidelines provided by the Centers for Disease and Control (CDC), the university implemented several new strategies including placing hand sanitizer stations in several buildings on campus in order to try and mitigate the transmission of the virus. This study focuses on learning how the initial decision-making took place to then design a …

Multistage Stochastic Programming: Algorithms, Modelling And Applications, Murwan Siddig

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This dissertation comprises four di˙erent topics related to multistage stochastic program-ming (MSP) algorithms, modeling, and applications.

First, we extend the adaptive partition-based approach for solving two-stage stochastic programs with a fixed recourse matrix and a fixed cost vector to the MSP setting, where the stochastic process is assumed to be stage-wise independent. The proposed algorithms integrate the adaptive partition-based strategy with a popular approach for solving multistage stochastic programs, the stochastic dual dynamic programming (SDDP) algorithm, according to two main strategies. These two strategies are distinct from each other in the manner by which they refine the partitions during the …

Control Of Infectious Diseases In A Metapopulation, Ceyda Best

All Dissertations

With the motivation of the complex infectious disease control problem, we provide two different approaches to model the resource allocation problem to control an epidemic in a metapopulation. All of our models utilize a detailed stochastic simulation model that is validated with the data from the 2014 Ebola epidemic. This simulation model provides a tool for comparing the performance of different policies.

The first model defines a dynamic allocation problem, which is modeled by a Markov Decision Process, and aims to find feasible and effective quarantine policies to control an epidemic with limited resources. We assume that the populations share …