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Articles 151 - 180 of 282
Full-Text Articles in Operations Research, Systems Engineering and Industrial Engineering
Extracting Patterns In Medical Claims Data For Predicting Opioid Overdose, Ryan Sanders
Extracting Patterns In Medical Claims Data For Predicting Opioid Overdose, Ryan Sanders
Graduate Theses and Dissertations
The goal of this project is to develop an efficient methodology for extracting features from time-dependent variables in transaction data. Transaction data is collected at varying time intervals making feature extraction more difficult. Unsupervised representational learning techniques are investigated, and the results compared with those from other feature engineering techniques. A successful methodology provides features that improve the accuracy of any machine learning technique. This methodology is then applied to insurance claims data in order to find features to predict whether a patient is at risk of overdosing on opioids. This data covers prescription, inpatient, and outpatient transactions. Features created …
Systems Approach To Evaluating Mih-Cp (Mobile Integrated Healthcare – Community Paramedicine): A Case Study Of East Baton Rouge Parish (Ebrp) Emergency Medical Services (Ems) Community Paramedicine Program Initiative, Oluwakemi Aiyedun
LSU Doctoral Dissertations
This study applied a holistic method of healthcare program assessment, known as systems approach, to evaluate the efficacy of the East Baton Rouge Parish (EBRP) EMS Community-integrated Health Program (CIHP). The author developed assessment metrics following the Quadruple Aim Framework: IHI (Institute for Healthcare Improvement) Triple Aim + Provider Experience.
Results showed that the CP program in this study delivers high ratings on patient experience and provided a 51% return on investment (ROI) through reduced emergency service utilization, ED visits and inpatient hospital admissions. However, findings did not demonstrate meaningful improvement in patients’ health-related quality of life (HRQoL) and self-efficacy …
Data-Driven Surgical Duration Prediction Model For Surgery Scheduling: A Case-Study For A Practice-Feasible Model In A Public Hospital, Kar Way Tan, Francis Ngoc Hoang Long Nguyen, Boon Yew Ang, Jerald Gan, Sean Shao Wei Lam
Data-Driven Surgical Duration Prediction Model For Surgery Scheduling: A Case-Study For A Practice-Feasible Model In A Public Hospital, Kar Way Tan, Francis Ngoc Hoang Long Nguyen, Boon Yew Ang, Jerald Gan, Sean Shao Wei Lam
Research Collection School Of Computing and Information Systems
Hospitals have been trying to improve the utilization of operating rooms as it affects patient satisfaction, surgery throughput, revenues and costs. Surgical prediction model which uses post-surgery data often requires high-dimensional data and contains key predictors such as surgical team factors which may not be available during the surgical listing process. Our study considers a two-step data-mining model which provides a practical, feasible and parsimonious surgical duration prediction. Our model first leverages on domain knowledge to provide estimate of the first surgeon rank (a key predicting attribute) which is unavailable during the listing process, then uses this predicted attribute and …
Simulating Alternative Tuberculosis Diagnosis Methods In Underdeveloped Countries, Luke Turner
Simulating Alternative Tuberculosis Diagnosis Methods In Underdeveloped Countries, Luke Turner
Industrial Engineering Undergraduate Honors Theses
Tuberculosis is the deadliest infectious disease in the world; it is especially rampant in underdeveloped countries because they do not have the infrastructure, technology, or funding to properly combat the infection. However, the development of portable point-of-care diagnosis machines can reverse this epidemic as they far surpass conventional laboratory identification. The question now is where to place these machines, which is a difficult decision with a lack of data. Therefore, a flexible simulation model is created to test the implementation of these machines with different countries and configurations. The simulation tests the baseline model and three proposed implementations of the …
Data Visualization Of Treatment Outcomes For Tuberculosis Patients, Joy Jenkins
Data Visualization Of Treatment Outcomes For Tuberculosis Patients, Joy Jenkins
Industrial Engineering Undergraduate Honors Theses
Tuberculosis is an infectious disease, and different treatments have been discovered over the years. However, patients may develop various drug resistance levels that affect the likelihood of becoming cured or dying. In this study, we sought to employ data visualization to explore the relationship between treatment trajectory, as indicated by smear and culture results in the follow-up tests and patient outcomes. A large sample of patients have been broken down by demographics including age, gender, and drug resistance status. Sankey diagrams were used to visualize the pathway progression of the patients over time split between two time periods- months 0-6 …
Managing Healthcare Data Assets As A Complex Adaptive System, Katie Clifton
Managing Healthcare Data Assets As A Complex Adaptive System, Katie Clifton
Systems Science Friday Noon Seminar Series
A major project is underway to develop a shared platform for data and analytics in a highly federated healthcare delivery organization. In the status quo data environment, analysts have integrated information from various domains — medical records, claims, membership — to produce a multitude of reports and analysis. Duplicative, mis-aligned, and siloed datasets were created as an unintended consequence.
One objective of the project is to produce outcomes (reports, analysis) that are more standardized and efficient than the status quo without sacrificing adaptability. Standards and practices are being intentionally developed as a mechanism for this emerging system to achieve more …
Healthcare Robotics: Key Factors That Impact Robot Adoption In Healthcare, Sujatha Alla, Pilar Pazos
Healthcare Robotics: Key Factors That Impact Robot Adoption In Healthcare, Sujatha Alla, Pilar Pazos
Engineering Management & Systems Engineering Faculty Publications
In the current dynamic business environment, healthcare organizations are focused on improving patient satisfaction, performance, and efficiency. The healthcare industry is considered a complex system that is highly reliant of new technologies to support clinical as well as business processes. Robotics is one of such technologies that is considered to have the potential to increase efficiency in a wide range of clinical services. Although the use of robotics in healthcare is at the early stages of adoption, some studies have shown the capacity of this technology to improve precision, accessibility through less invasive procedures, and reduction of human error during …
Étude Exploratoire Sur Les Pratiques Des Fabricants De Machines Au Québec En Lien Avec L’Intégration De La Sécurité Des Machines Dès Leur Conception, Yuvin Chinniah, François Gauthier, George Abdul-Nour, Sabrina Jocelyn, Barthélemy Aucourt, Guy Bordeleau
Étude Exploratoire Sur Les Pratiques Des Fabricants De Machines Au Québec En Lien Avec L’Intégration De La Sécurité Des Machines Dès Leur Conception, Yuvin Chinniah, François Gauthier, George Abdul-Nour, Sabrina Jocelyn, Barthélemy Aucourt, Guy Bordeleau
Rapports de recherche scientifique
Le présent rapport est destiné principalement à tout organisme québécois œuvrant en matière de prévention des lésions professionnelles (ex. : la Commission des normes, de l’équité, de la santé et de la sécurité du travail (CNESST), les associations sectorielles paritaires (ASP)), pour un ou plusieurs secteurs industriels donnés. Il porte sur une étude exploratoire concernant l’intégration de la sécurité dès la conception des machines et qui a été réalisée auprès de fabricants. Ce rapport intéressera également les concepteurs et fabricants désireux de se renseigner sur la manière dont la sécurité est prise en compte dans la mise en œuvre de …
A Game-Theoretic Approach To Share The Costs Of Cooperating Healthcare Networks, Jay M. Lightfoot
A Game-Theoretic Approach To Share The Costs Of Cooperating Healthcare Networks, Jay M. Lightfoot
Journal of International Technology and Information Management
The growing demand for healthcare services combined with the disarray in the health insurance market in the United States has created a situation where rival health networks are aggressively competing by building duplicate health facilities and providing redundant services in localized geographic regions. Unfortunately, this strategy can reduce the quality of patient care and decrease profits (Kaissi & Charland, 2013). A solution to this problem is for health networks to cooperate and share healthcare equipment, facilities, and personnel. Toward that end, this paper presents a game-theoretic method that can share these costs in a fair, efficient, and repeatable manner.
Performance Study Of An Unconventional Breathresponse Papr Against A N95 Ffr And Conventional Paprs, Huihui Yang
Performance Study Of An Unconventional Breathresponse Papr Against A N95 Ffr And Conventional Paprs, Huihui Yang
Graduate Theses, Dissertations, and Problem Reports (ETD)
Healthcare workers (HCWs) are the first responders when infectious pathogens occur. Powered air-purifying respirators (PAPRs) are one of the most widely used personal protective equipment for healthcare workers. Currently, few studies have been performed with HCWs in the actual healthcare work environments to assess discomforts, acceptance and protective efficiency towards wearing and use of PAPRs. The main purpose of this dissertation was to introduce and assess a brand new unconventional PAPR (Koken breath-response PAPR). The protection performance and user preferance of this unconventional PAPR were studided and compared to that of a N95 FFR and traditional PAPRs.
Firstly, a laboratory …
Point-Of-Care Assessment At A Free, Out-Of-Hours Orthopedic Clinic, Whitney M. Graves, Zachary K. Winkelmann, Kenneth E. Games
Point-Of-Care Assessment At A Free, Out-Of-Hours Orthopedic Clinic, Whitney M. Graves, Zachary K. Winkelmann, Kenneth E. Games
Clinical Practice in Athletic Training
Access to healthcare is a challenge for many Americans living in rural communities. Hospital systems have created programs and developed models to improve access to care. However, documentation of the role of these clinics serving different populations and various types of communities is quite scarce. The purpose of this article is to describe the patient satisfaction and procedures assessed at the point-of-care during a 14-week, out-of-hours free orthopedic clinic in the Southeastern United States. One hundred and twenty-nine patients attended the orthopedic clinic and completed a patient satisfaction survey following their patient encounter. At the end of the 14-week, 89% …
Analysis Of User Preference With N95 And Powered Air-Purifying Respirators In A Healthcare Work Environment, Brittany Renee Carver
Analysis Of User Preference With N95 And Powered Air-Purifying Respirators In A Healthcare Work Environment, Brittany Renee Carver
Graduate Theses, Dissertations, and Problem Reports (ETD)
For those working in the healthcare field, personal protective equipment is vital. Healthcare workers are often first responders when it comes to dealing with patients who are infected or when a disease outbreak occurs. The Occupational Safety and Health Administration (OSHA) requires all healthcare operations to provide employee protection against blood borne pathogens. With the increase of life-threatening disease outbreaks, such as SARS in 2003 and Ebola in 2014, it is of the upmost importance to make sure respirators are best suited for users and acceptable for long term use. It has been shown through previous studies that due to …
Smart Disease Prevention App: Informing The Public In Their Own Geographic Location, Apoorva Sulakhe, Shafali Rana, Zoe Disori, William Nogay, Kyle Plummer, Meredith Shannon, Morgan Young, Alyssa Zielinski, Vincent G. Duffy
Smart Disease Prevention App: Informing The Public In Their Own Geographic Location, Apoorva Sulakhe, Shafali Rana, Zoe Disori, William Nogay, Kyle Plummer, Meredith Shannon, Morgan Young, Alyssa Zielinski, Vincent G. Duffy
Purdue Journal of Service-Learning and International Engagement
Apoorva Sulakhe and Shefali Rana are graduate students in the School of Industrial Engineering at Purdue. They have both been teaching assistants under their coauthor, Dr. Vincent Duffy, while supervising multiple projects. Coauthors Zoe Disori, William Nogay, Kyle Plummer, Meredith Shannon, Morgan Young, and Alyssa Zielinski are listed in alphabetical order. They were all seniors in School of Industrial Engineering at the time of this project in 2017. The purpose of their study, described in this article, was to develop an application to provide users with accurate information about diseases spreading in their geographic locations.
Identifying Key Factors Associated With High Risk Asthma Patients To Reduce The Cost Of Health Resources Utilization, Amani Ahmad
Identifying Key Factors Associated With High Risk Asthma Patients To Reduce The Cost Of Health Resources Utilization, Amani Ahmad
LSU Master's Theses
Asthma is associated with frequent use of primary health services and places a burden on the United States economy. Identifying key factors associated with increased cost of asthma is an essential step to improve practices of asthma management.
The aim of this study was to identify factors associated with over utilization of primary health services and increased cost via claims data and to explore the effectiveness of case management program in reducing overall asthma related cost.
Claims data analysis for Medicaid insured asthma patients in Louisiana was conducted. Asthma patients were identified using their ICD-9 and ICD-10 codes, forward variable …
In Vitro Cytocompatibility Of Antibacterial Levels Of Polymer Nitric Oxide Release, Rana Gbyli, Christina Zito, Kagya Amoako
In Vitro Cytocompatibility Of Antibacterial Levels Of Polymer Nitric Oxide Release, Rana Gbyli, Christina Zito, Kagya Amoako
Mechanical and Industrial Engineering Faculty Publications
Although the antibacterial property of nitric oxide (NO) has been well documented in gram positive and gram negative bacteria cultures, its cytotoxic effects are not completely clear. To limit potential in vivo cytotoxicity, our group recently investigated the effects of a range of NO fluxes on S. epidermidis and S. aureus to determine a minimum effective NO level. In this study, we report the antibacterial function of this minimum NO level also on gram negative Pseudomonas aeruginosa as well as its cytocompatibility effects on lung and kidney cells. Standardized bacterial cultures were treated with NO releasing PDMS substrates followed by …
Bounded Rank Optimization For Effective And Efficient Emergency Response, Pallavi Madhusudan Manohar, Pradeep Varakantham, Hoong Chuin Lau
Bounded Rank Optimization For Effective And Efficient Emergency Response, Pallavi Madhusudan Manohar, Pradeep Varakantham, Hoong Chuin Lau
Research Collection School Of Computing and Information Systems
Effective placement of emergency response vehicles (such as ambulances, fire trucks, police cars) to deal with medical, fire or criminal activities can reduce the incident response time by few seconds, which in turn can potentially save a human life. Owing to its adoption in Emergency Medical Services (EMSs) worldwide, existing research on improving emergency response has focused on optimizing the objective of bounded time (i.e. number of incidents served in a fixed time). Due to the dependence of this objective on temporal uncertainty, optimizing the bounded time objective is challenging. In this paper, we propose a new objective referred to …
Reserved Optimisation: Handling Incident Priorities In Emergency Response Systems, Muralidhar Konda, Supriyo Ghosh, Pradeep Varakantham
Reserved Optimisation: Handling Incident Priorities In Emergency Response Systems, Muralidhar Konda, Supriyo Ghosh, Pradeep Varakantham
Research Collection School Of Computing and Information Systems
Emergency (medical, fire or criminal) Management Systems(EMSs) are crucial for ensuring public safety and security. Typically in many cities, less than 20% of the cases received by EMSs belong to the extremely serious category and require immediate help. Rest of the incidents typically are less serious and thereby allow more flexibility in response time. Therefore, for efficient management of EMS requests, several EMSs now categorise an incoming emergency request into apriority level based on well studied “triaging” methods. Leading research on optimising emergency response has either focussed on data-driven models for settings with homogenous incidents or on generic heuristics (that …
Design Of A Distributed Real-Time E-Health Cyber Ecosystem With Collective Actions: Diagnosis, Dynamic Queueing, And Decision Making, Yanlin Zhou
Department of Electrical and Computer Engineering: Dissertations, Theses, and Student Research
In this thesis, we develop a framework for E-health Cyber Ecosystems, and look into different involved actors. The three interested parties in the ecosystem including patients, doctors, and healthcare providers are discussed in 3 different phases. In Phase 1, machine-learning based modeling and simulation analysis is performed to remotely predict a patient's risk level of having heart diseases in real time. In Phase 2, an online dynamic queueing model is devised to pair doctors with patients having high risk levels (diagnosed in Phase 1) to confirm the risk, and provide help. In Phase 3, a decision making paradigm is proposed …
Dispensing Medical Countermeasures In Public Health Emergencies Via Home Health Agencies And Points Of Distribution, Anna Hudgeons
Dispensing Medical Countermeasures In Public Health Emergencies Via Home Health Agencies And Points Of Distribution, Anna Hudgeons
Industrial Engineering Undergraduate Honors Theses
A major concern regarding emergency preparedness on the state government level involves the handling and dispensing of the Strategic National Stockpile (SNS) of medicinal supplies. Each state is required to update and maintain a plan of action for dispensing SNS materials that would effectively provide care to the state’s population in times of distress. This research evaluates a state’s ability to dispense an adequate amount of medicine to her population in a timely manner, specifically after it has been received by the state government. Although simulation modeling has previously been utilized to replicate the dispensing process at pre-designated points of …
Transportation And Distribution Of Strategic National Stockpile Supplies In A Public Health Emergency, Olivia A. Goss
Transportation And Distribution Of Strategic National Stockpile Supplies In A Public Health Emergency, Olivia A. Goss
Industrial Engineering Undergraduate Honors Theses
In the event of a public health emergency in the United States, it is important that public
authorities are equipped to distribute medical supplies to every person in need as quickly as
possible. Federal guidelines state that all persons in an area affected by a public health
emergency should receive their medical countermeasures within 48 hours of the emergency’s
declaration. While the CDC has determined a general dispensing plan for each state and county
to follow, it is ultimately up to the state and county to formalize and implement detailed plans.
A body of academic literature focuses on optimizing the …
Assessment Of Ergonomics In Indian Dental Practice: A Workplace Analysis, Divya Gadde
Assessment Of Ergonomics In Indian Dental Practice: A Workplace Analysis, Divya Gadde
Masters Theses & Specialist Projects
Dental practice requires unique working conditions such as prolonged working hours, strained body postures and laborious, high finesse dental techniques. However, it can be more efficiently performed by the application of ergonomics, rather than physically forcing the worker's body to fit the job. Posture is highly influenced by factors such as inadequate working level, incorrect patient positioning, and poor visual comfort. In order to eliminate musculoskeletal disorders it is necessary to control these and other factors, and design the human work environment to be more ergonomic. The aim of this study was to assess ergonomics within Indian dental practice and …
Evaluation Of The Effectiveness Of A Gaze-Based Training Intervention On Latent Hazard Anticipation Skills For Young Drivers: A Driving Simulator Study, Yusuke Yamani, Pinar Biçaksiz, Dakota B. Palmer, Nathan Hatfield, Siby Samuel
Evaluation Of The Effectiveness Of A Gaze-Based Training Intervention On Latent Hazard Anticipation Skills For Young Drivers: A Driving Simulator Study, Yusuke Yamani, Pinar Biçaksiz, Dakota B. Palmer, Nathan Hatfield, Siby Samuel
Psychology Faculty Publications
A PC-based training program (Road Awareness and Perception Training or RAPT; Pradhan et al., 2009), proven effective for improving young novice drivers' hazard anticipation skills, did not fully maximize the hazard anticipation performance of young drivers despite the use of similar anticipation scenarios in both, the training and the evaluation drives. The current driving simulator experiment examined the additive effects of expert eye movement videos following RAPT training on young drivers' hazard anticipation performance compared to video-only and RAPT-only conditions. The study employed a between-subject design in which 36 young participants (aged 18-21) were equally and randomly assigned to one …
Dispatch Guided Allocation Optimization For Effective Emergency Response, Supriyo Ghosh, Pradeep Varakantham
Dispatch Guided Allocation Optimization For Effective Emergency Response, Supriyo Ghosh, Pradeep Varakantham
Research Collection School Of Computing and Information Systems
Effective emergency (medical, fire or criminal) response iscrucial for improving safety and security in urban environments. Recent research in improving effectiveness of emergency management systems (EMSs) has utilized data-drivenoptimization models for efficient allocation of emergency response vehicles (ERVs) to base locations. However, thesedata-driven optimization models either ignore the dispatchstrategy of ERVs (typically the nearest available ERV is dispatched to serve an incident) or employ myopic approaches(e.g., greedy approach based on marginal gain). This resultsin allocations that are not synchronised with the real evolution dynamics on the ground or can be improved significantly.To bridge this gap, we make the following contributions: …
Proactive Coordination In Healthcare Service Systems Through Near Real-Time Analytics, Seung Yup Lee
Proactive Coordination In Healthcare Service Systems Through Near Real-Time Analytics, Seung Yup Lee
Wayne State University Dissertations
The United States (U.S.) healthcare system is the most expensive in the world. To improve the quality and safety of care, health information technology (HIT) is broadly adopted in hospitals. While EHR systems form a critical data backbone for the facility, we need improved 'work-flow' coordination tools and platforms that can enhance real-time situational awareness and facilitate effective management of resources for enhanced and efficient care. Especially, these IT systems are mostly applied for reactive management of care services and are lacking when they come to improving the real-time "operational intelligence" of service networks that promote efficiency and quality of …
Data-Driven Modeling For Decision Support Systems And Treatment Management In Personalized Healthcare, Milad Zafar Nezhad
Data-Driven Modeling For Decision Support Systems And Treatment Management In Personalized Healthcare, Milad Zafar Nezhad
Wayne State University Dissertations
Massive amount of electronic medical records (EMRs) accumulating from patients and populations motivates clinicians and data scientists to collaborate for the advanced analytics to create knowledge that is essential to address the extensive personalized insights needed for patients, clinicians, providers, scientists, and health policy makers. Learning from large and complicated data is using extensively in marketing and commercial enterprises to generate personalized recommendations. Recently the medical research community focuses to take the benefits of big data analytic approaches and moves to personalized (precision) medicine. So, it is a significant period in healthcare and medicine for transferring to a new paradigm. …
Venous Thromboembolism (Vte) Harm Measurement And Risk Assessment In Real-Time Using Electronic Health Records(Ehr), Seyed Mani Marashi
Venous Thromboembolism (Vte) Harm Measurement And Risk Assessment In Real-Time Using Electronic Health Records(Ehr), Seyed Mani Marashi
Wayne State University Dissertations
Venous Thromboembolism (VTE) is a deadly disease and is considered as one of the top reasons for avoidable hospital deaths in the United States and around the world. Patients who survive this disease often must face life-long complications such as Post-thrombotic syndrome (PTS), Chronic thromboembolic pulmonary hypertension (CTPH), etc. Therefore, it is important to monitor and reduce the number of VTE instances in hospitals. This study shows how Electronic Health Records (EHRs) can be utilized to achieve this goal.
First, a new near real-time VTE harm measurement model was developed. Not only the developed model can deliver near real-time results, …
The Impact Of Machine Learning Algorithms On Benchmarking Process In Healthcare Service Delivery, Egbe-Etu Emmanuel Etu
The Impact Of Machine Learning Algorithms On Benchmarking Process In Healthcare Service Delivery, Egbe-Etu Emmanuel Etu
Wayne State University Theses
Currently, organizations have adopted and implemented a variety of innovative quality management philosophies, approaches, and techniques to stay competitive in an ever-changing global economy. Benchmarking is one of such techniques deployed by organizations to stay competitive. The motivation for this research stems from a real-world problem being faced by hospitals in the healthcare industry who have amassed a ton of data and want to embark on benchmarking project to assess the performance of the emergency departments due to challenges faced with poor management of operations which has led to high patient boarding rates, high patient wait-times, poor quality service, low …
Effects Of Motion Segment Simulation And Joint Positioning On Spinal Loads In Trunk Musculoskeletal Models, F. Ghezelbash, A. H. Eskandari, A. Shirazi-Adl, N. Arjmand, Z. El Ouaaid, A. Plamondon
Effects Of Motion Segment Simulation And Joint Positioning On Spinal Loads In Trunk Musculoskeletal Models, F. Ghezelbash, A. H. Eskandari, A. Shirazi-Adl, N. Arjmand, Z. El Ouaaid, A. Plamondon
Études primaires
Musculoskeletal models represent spinal motion segments by spherical joints/beams with linear/nonlinear properties placed at various locations. We investigated the fidelity of these simplified models (i.e., spherical joints with/without rotational springs and beams considering nonlinear/linear properties) in predicting kinematics of the ligamentous spine in comparison with a detailed finite element (FE) model while considering various anterior-posterior joint placements. Using the simplified models with different joint offsets in a subject-specific musculoskeletal model, we computed local spinal forces during forward flexion and compared results with intradiscal pressure measurements. In comparison to the detailed FE model, linearized beam and spherical joint models failed to …
The Rhetoric Of Science Education And Technology, Iwasan D. Kejawa
The Rhetoric Of Science Education And Technology, Iwasan D. Kejawa
School of Computing: Faculty Publications
Nearly thousands of science experiments are performed both on humans and animals every year in the United States (Gregory, 1999). Does Science enormously play a role in the well-beings of individual in the society? Research has found that science education is through motivation and satisfying the needs of humans. The scientific world is part of an elongated human development. This can be substantiated with the use and evolution of TECHNOLOGY and SCIENCE (Minton, 2004). Education of the entities that comprise the need to achieve the goal of TECHNOLOGY and SCIENCE which are important issues of today. Research has shown that …
Achieving Totally Local Anticoagulation On Blood Contacting Devices, Rana Gbyli, Anna Mercaldi, Harihara Sundaram, Kagya Amoako
Achieving Totally Local Anticoagulation On Blood Contacting Devices, Rana Gbyli, Anna Mercaldi, Harihara Sundaram, Kagya Amoako
Mechanical and Industrial Engineering Faculty Publications
The recent years have witnessed an increased activity in biocompatibility research aimed at limiting biomaterial-induced blood coagulation. From 2008 to 2016, a total of $36,946,764.00 USD was awarded in grants to 213 research proposals and as large as 50.4% ($18,627,854.00) of that award monies were distributed to 101 proposals over the fiscal years of FY14 to FY16 alone. However, the complexity in blood responses to biomaterials, variability in blood function between individuals and animal species, and differences in medical device application and test setting all continue to pose difficulties in making a breakthrough in this field. This review focuses on …