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Full-Text Articles in Explosives Engineering
Low-Intensity Blast Induces Acute Glutamatergic Hyperexcitability In Mouse Hippocampus Leading To Long-Term Learning Deficits And Altered Expression Of Proteins Involved In Synaptic Plasticity And Serine Protease Inhibitors, Shanyan Chen, Heather R. Siedhoff, Hua Zhang, Pei Liu, Ashley Balderrama, Runting Li, Catherine E. Johnson, For Full List Of Authors, See Publisher's Website.
Low-Intensity Blast Induces Acute Glutamatergic Hyperexcitability In Mouse Hippocampus Leading To Long-Term Learning Deficits And Altered Expression Of Proteins Involved In Synaptic Plasticity And Serine Protease Inhibitors, Shanyan Chen, Heather R. Siedhoff, Hua Zhang, Pei Liu, Ashley Balderrama, Runting Li, Catherine E. Johnson, For Full List Of Authors, See Publisher's Website.
Mining Engineering Faculty Research & Creative Works
Neurocognitive consequences of blast-induced traumatic brain injury (bTBI) pose significant concerns for military service members and veterans with the majority of "invisible injury." However, the underlying mechanism of such mild bTBI by low-intensity blast (LIB) exposure for long-term cognitive and mental deficits remains elusive. Our previous studies have shown that mice exposed to LIB result in nanoscale ultrastructural abnormalities in the absence of gross or apparent cellular damage in the brain. Here we tested the hypothesis that glutamatergic hyperexcitability may contribute to long-term learning deficits. Using brain slice electrophysiological recordings, we found an increase in averaged frequencies with a burst …