Applied Mechanics Commons^™

Influence Of Extracellular Matrix Stiffness And Topography On Neuronal Cell Behavior And Neurite Outgrowth, Mohan Yasodharababu

Graduate Theses and Dissertations

The focus of regeneration therapy for traumatic brain injuries and Alzheimer's disease is on the promotion and growth of neuronal cells. In vitro research attempts to improve this by modifying the stiffness and topography of the extracellular matrix (ECM). However, the limitations of in vitro experiments make it difficult to control the individual factors influencing neuronal cell growth. A computational model can be used to decouple individual factors and study them individually to gain a better understanding of the mechanics between the neuronal cell and ECM, which will aid in the design of in vitro experimental studies.

This study develops …

Fluid-Structure Interaction Of Nrel 5-Mw Wind Turbine, Mohamed Sayed Elkady Abd-Elhay

Theses and Dissertations

Wind energy is considered one of the major sources of renewable energy. Nowadays, wind turbine blades could exceed 100 m to maximize the generated power and minimize produced energy cost. Due to the enormous size of the wind turbines, the blades are subjected to failure by aerodynamics loads or instability issues. Also, the gravitational and centrifugal loads affect the wind turbine design because of the huge mass of the blades. Accordingly, wind turbine simulation became efficient in blade design to reduce the cost of its manufacturing. The fluid-structure interaction (FSI) is considered an effective way to study the turbine's behavior …

Computational Design Of Nonlinear Stress-Strain Of Isotropic Materials, Askhad M.Polatov, Akhmat M. Ikramov, Daniyarbek Razmukhamedov

Chemical Technology, Control and Management

The article deals with the problems of numerical modeling of nonlinear physical processes of the stress-strain state of structural elements. An elastoplastic medium of a homogeneous solid material is investigated. The results of computational experiments on the study of the process of physically nonlinear deformation of isotropic elements of three-dimensional structures with a system of one- and double-periodic spherical cavities under uniaxial compression are presented. The influence and mutual influence of stress concentrators in the form of spherical cavities, vertically located two cavities and a horizontally located system of two cavities on the deformation of the structure are investigated. Numerical …

A Single-Stage Passive Vibration Isolation System For Scanning Tunneling Microscopy, Toan T. Le

Master's Theses

Scanning Tunneling Microscopy (STM) uses quantum tunneling effect to study the surfaces of materials on an atomic scale. Since the probe of the microscope is on the order of nanometers away from the surface, the device is prone to noises due to vibrations from the surroundings. To minimize the random noises and floor vibrations, passive vibration isolation is a commonly used technique due to its low cost and simpler design compared to active vibration isolation, especially when the entire vibration isolation system (VIS) stays inside an Ultra High Vacuum (UHV) environment. This research aims to analyze and build a single-stage …