Electrical and Computer Engineering Commons^™

Simulation Studies Of Pulsed Voltage Effects On Cells, Jiahui Song

Electrical & Computer Engineering Theses & Dissertations

This dissertation research focuses on the new field of pulsed electric field interactions with biological cells. In particular, "Intracellular Electromanipulation" which has important biomedical applications, is probed. Among the various aspects studied, nanosecond, high-intensity pulse induced electroporation is one phenomena. It is simulated based on a coupled scheme involving the current continuity and Smoluchowski equations. A dynamic pore model can be achieved by including a dependence on the pore population density and a variable membrane tension. These changes make the pore formation energy E(r) self-adjusting and dynamic in response to pore formation. Additionally, molecular dynamics (MD) simulations are also discussed …

Multi-Scale Edge Detection Algorithms And Their Information-Theoretic Analysis In The Context Of Visual Communication, Bo Jiang

Electrical & Computer Engineering Theses & Dissertations

The unrealistic assumption that noise can be modeled as independent, additive and uniform can lead to problems when edge detection methods are applied to low signal-to-noise ratio (SNR) images. The main reason for this is because the filter scale and the threshold for the gradient are difficult to determine at a regional or local scale when the noise estimate is on a global scale. Therefore, in this dissertation, we attempt to solve these problems by using more than one filter to detect the edges and discarding the global thresholding method in the edge discrimination. The proposed multi-scale edge detection algorithms …

Experimental Investigation Of A Non-Thermal Atmospheric Pressure Plasma Jet, Asma Begum

Electrical & Computer Engineering Theses & Dissertations

The main objective of this dissertation is to understand the formation of the plasma jet from the plasma pencil, and the propagation of the plasma jet in the ambient atmosphere where the effect of the external electric field is almost zero. Before investigating the formation and propagation phenomenon of the plasma jet, common physical properties of plasma jets are determined by using the imaging technique and optical emission spectroscopy. The first goal of this dissertation is to establish the laminar helium gas flow channel through a plasma pencil.

The formation position, formation time, and the criterion of the plasma jet …

Wavelet-Based Enhancement Technique For Visibility Improvement Of Digital Images, Numan ÜNaldı

Electrical & Computer Engineering Theses & Dissertations

Image enhancement techniques for visibility improvement of color digital images based on wavelet transform domain are investigated in this dissertation research.

In this research, a novel, fast and robust wavelet-based dynamic range compression and local contrast enhancement (WDRC) algorithm to improve the visibility of digital images captured under non-uniform lighting conditions has been developed. A wavelet transform is mainly used for dimensionality reduction such that a dynamic range compression with local contrast enhancement algorithm is applied only to the approximation coefficients which are obtained by low-pass filtering and down-sampling the original intensity image. The normalized approximation coefficients are transformed using …

Simultaneous Higher Harmonic Detection And Extraction Of Information From Oxygen Spectra, Karan Dineshchandra Mohan

Electrical & Computer Engineering Theses & Dissertations

Wavelength Modulation Spectroscopy (WMS) is a highly sensitive technique that utilizes synchronous detection at the N-th harmonics of a modulating frequency, by modulating the laser beam used to probe a gaseous species. The advantage of this technique lies in the greater effective signal-to-noise ratio one obtains as a direct consequence of the larger amount of structure present in the higher harmonics, and thus a greater amount of information that can be obtained from that structure. We present the development of a novel technique where data at multiple harmonics is obtained simultaneously, rather than sequentially. This removes the susceptibility of the …

Analysis And Optimization Of Dynamic Spectrum Sharing For Cognitive Radio Networks, Manish Wadhwa

Electrical & Computer Engineering Theses & Dissertations

The goal of this dissertation is to present the analysis and optimization of dynamic spectrum sharing for cognitive radio networks (CRNs). Spectrum scarcity is a well known problem at present. In order to deal with this problem, dynamic spectrum sharing (DSS) was proposed. DSS is a technique where cognitive radio networks dynamically and opportunistically share the channels with primary users. The major contribution of this dissertation is in analyzing the problem of dynamic spectrum sharing under different scenarios and developing optimal solutions for these scenarios. In the first scenario, a contention based dynamic spectrum sharing model is considered and its …

Human Osteoblast Proliferation In Culture Following A Nanosecond Pulsed Electric Field (Nspef), Leonard Joseph Carinci Jr.

Biological Sciences Theses & Dissertations

Osteoblasts are mononucleate bone forming cells responsible for the deposition of new bone. Application of mechanical stress on bone reveals its ability to produce and release electric potentials across the cell membrane called piezoelectricity. The electric potentials produced in response to mechanical stress may have a direct correlation on osseous cells and the signaling pathways that regulate proliferation. Nanosecond pulsed electric fields (nsPEFs) are high intensity, ultrashort pulses which have the ability to maintain the integrity of the cell membrane by avoiding traditional electroporation. We delivered 8 nsPEFs (0.5 Hz) of a 25 kV/cm or 35 kV/cm electric field strength …

Nuclear Electromagnetic Currents In Chiral Effective Field Theory, Saori Pastore

Physics Theses & Dissertations

A nucleon-nucleon potential and consistent nuclear electromagnetic currents are derived in chiral effective field theory retaining pions and nucleons as explicit degrees of freedom. The calculation of the potential is carried out up to next-to-next-to leading order (N²LO), while the currents include up to N³LO corrections. The potential at N² LO and currents at N³LO consist of two-pion-exchange and contact contributions. The currents are then utilized to study a number of low-energy electromagnetic observables induced by magnetic dipole transitions, such as the deuteron and trinucleon magnetic moments and the np, nd and n …

Analysis Of Jump Linear Systems Driven By Lumped Processes, Jorge R. Chavez Fuentes

Electrical & Computer Engineering Theses & Dissertations

Safety critical control systems such as flight control systems use fault-tolerant technology to minimize the effect of faults and increase the dependability of the system. In fault-tolerant systems, the system availability process indicates the current operational mode of an interconnection of digital logic devices. It is a process that results from the transformation of the stochastic processes characterizing the availability of the devices forming the system. To assess safety critical control systems, the following measures of performance will be considered: the steady-state mean output power, the mean output energy, the mean time to failure and the mean time to repair. …

Prostate Cancer Region Prediction Using Maldi Mass Spectra, Ayyappa Vadlamudi, Shao-Hui Chuang, Xiaoyan Sun, Lisa Cazares, Julius Nyalwidhe, Dean Troyer, O. John Semmes, Jiang Li, Frederic D. Mckenzie

Electrical & Computer Engineering Faculty Publications

For the early detection of prostate cancer, the analysis of the Prostate-specific antigen (PSA) in serum is currently the most popular approach. However, previous studies show that 15% of men have prostate cancer even their PSA concentrations are low. MALDI Mass Spectrometry (MS) proves to be a better technology to discover molecular tools for early cancer detection. The molecular tools or peptides are termed as biomarkers. Using MALDI MS data from prostate tissue samples, prostate cancer biomarkers can be identified by searching for molecular or molecular combination that can differentiate cancer tissue regions from normal ones. Cancer tissue regions are …

Excitation-Induced Germanium Quantum Dot Formation On Si (100)-(2×1), Ali Oguz Er, Hani E. Elsayed-Ali

Physics Faculty Publications

The effect of nanosecond pulsed laser excitation on the self-assembly of Ge quantum dots grown by pulsed laser deposition on Si (100)-(2×1) was studied. In situ reflection high-energy electron diffraction and ex situ atomic force microscopy were used to probe the quantum dot structure and morphology. At room temperature, applying the excitation laser decreased the surface roughness of the grown Ge film. With surface electronic excitation, crystalline Ge quantum dots were formed at 250 °C, a temperature too low for their formation without excitation. At a substrate temperature of 390 °C, electronic excitation during growth was found to improve the …

Structure Prediction For The Helical Skeletons Detected From The Low Resolution Protein Density Map, Kamal Al Nasr, Weitao Sun, Jing He

Computer Science Faculty Publications

Background: The current advances in electron cryo-microscopy technique have made it possible to obtain protein density maps at about 6-10 Å resolution. Although it is hard to derive the protein chain directly from such a low resolution map, the location of the secondary structures such as helices and strands can be computationally detected. It has been demonstrated that such low-resolution map can be used during the protein structure prediction process to enhance the structure prediction.

Results: We have developed an approach to predict the 3-dimensional structure for the helical skeletons that can be detected from the low resolution protein density …

Bioelectric Applications For Treatment Of Melanoma, Stephen J. Beebe, Karl H. Schoenbach, Richard Heller

Bioelectrics Publications

Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT) or by applying rapid rise-time nanosecond pulsed electric fields (nsPEFs). EGT has been used to locally deliver cytokines such as IL-12 to activate an immune response, resulting in bystander effects. NsPEFs locally induce apoptosis-like effects and affect vascular networks, both promoting tumor demise and restoration of normal vascular homeostasis. EGT with IL-12 is in melanoma clinical trials and nsPEFs are used in models with B16F10 melanoma in vitro and in …

Experimental Studies On The Plasma Bullet Propagation And Its Inhibition, Erdinc Karakas, Mounir Laroussi

Electrical & Computer Engineering Faculty Publications

Plasma bullets generated by atmospheric pressure low temperature plasma jets have recently been an active research topic due to their unique properties and their enhanced plasma chemistry. In this paper, experimental insights into the plasma bullet lifetime and its velocity are reported. Data obtained from intensified charge-coupled device camera and time-resolved optical emission spectroscopy (OES) elucidated the existence of a weakly ionized channel between the plasma bullet and its source (such as the plasma pencil). Factors responsible for the inhibition of the propagation of the bullet, such as low helium mole fraction, the magnitude of the applied voltage, and the …

Rf And Structural Characterization Of Srf Thin Films, A.M. Valente-Feliciano, H.L. Phillips, C.E. Reece, J. Spradlin, X. Zhao, D. Gu, H. Baumgart, D. Beringer, R.A. Lukaszew, B. Xiao, K. Seo

Electrical & Computer Engineering Faculty Publications

In the past years, energetic vacuum deposition methods have been developed in different laboratories to improve Nb/Cu technology for superconducting cavities. JLab is pursuing energetic condensation deposition via Electron Cyclotron Resonance. As part of this study, the influence of the deposition energy on the material and RF properties of the Nb thin film is investigated. The film surface and structure analyses are conducted with various techniques like X-ray diffraction, Transmission Electron Microscopy, Auger Electron Spectroscopy and RHEED. The microwave properties of the films are characterized on 50 mm disk samples with a 7.5 GHz surface impedance characterization system. This paper …

Finite Element Analysis Of Ring-Shaped Emission Profile In Plasma Bullet, Yukinori Sakiyama, David B. Graves, Julien Jarrige, Mounir Laroussi

Electrical & Computer Engineering Faculty Publications

Using a one-way coupled model of neutral gas flow and plasma dynamics we report a mechanism to explain the ring-shaped emission pattern that has been observed experimentally in plasma bullets at atmospheric pressure. We solve a fluid model with the local field approximation in one-dimensional cylindrical coordinates, corresponding to a cross-section of a plasma bullet. Pulselike uniform electric field is assumed to be applied perpendicular to the simulation domain. Time and spatially resolved spectroscopic measurements support the simulation results.

Prediction Of Brain Tumor Progression Using A Machine Learning Technique, Yuzhong Shen, Debrup Banerjee, Jiang Li, Adam Chandler, Yufei Shen, Frederic D. Mckenzie, Jihong Wang, Nico Karssemeijer (Ed.), Ronald M. Summers (Ed.)

Electrical & Computer Engineering Faculty Publications

A machine learning technique is presented for assessing brain tumor progression by exploring six patients' complete MRI records scanned during their visits in the past two years. There are ten MRI series, including diffusion tensor image (DTI), for each visit. After registering all series to the corresponding DTI scan at the first visit, annotated normal and tumor regions were overlaid. Intensity value of each pixel inside the annotated regions were then extracted across all of the ten MRI series to compose a 10 dimensional vector. Each feature vector falls into one of three categories:normal, tumor, and normal but progressed to …

Design Of Organic Tandem Solar Cells Using Pcpdtbt: Pc61 Bm And P3ht: Pc71bm, Gon Namkoong, Patrick Boland, Keejoo Lee, James Dean

Electrical & Computer Engineering Faculty Publications

We conducted optical and electrical simulations with the goal of determining the optimal design for conjugated polymer-fullerene tandem solar cells using poly[2,6-(4,4-bis-(2-ethylhexyl)- 4H-cyclopenta[2,1- b;3,4- b′] dithiophene)-alt-4,7-(2,1,3-benzothiadiazole)] (PCPDTBT): [6,6]-phenyl C₆₁ butyric acid methyl ester (PC₆₁ BM) as a bottom cell and poly(3-hexylthiophene) (P3HT): [6,6]-phenyl C₇₁ butyric acid methyl ester (PC₇₁BM) as a top cell. The effects of photon density, absorption, balanced and unbalanced charge carrier transport, and bimolecular recombination in the two subcells were incorporated into the simulations. We found that the maximum energy conversion efficiency (η) is 9% when charge carrier mobilities in …