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Full-Text Articles in Biological Engineering
Computational Modeling Of Oxidative Stress: An Analysis Of Nad (P)H Effects On Nitric Oxide And Superoxide During Hypertension, Aaron Strobel
Computational Modeling Of Oxidative Stress: An Analysis Of Nad (P)H Effects On Nitric Oxide And Superoxide During Hypertension, Aaron Strobel
Biological and Agricultural Engineering Undergraduate Honors Theses
Nitric oxide (NO) is inactivated in the human body when exposed to superoxide (O2 -). This reaction forms peroxynitrite (ONOO-). Superoxide is produced in the cardiac system by several different ways, including NAD(P)H oxidase. Superoxide dismutase (SOD) breaks down superoxide into oxygen and hydrogen peroxide. This prevents superoxide from reacting with nitric oxide and allows normal function to take place. Superoxide and peroxynitrite are main contributors to vascular disease in the human body, in particular hypertension. Experiments have shown that there was an increase of superoxide production in spontaneously hypertensive rats (SHR) vs. age-matched Wistar Kyoto rats (WKY) that were …