Biological Engineering Commons^™

Fuzzy Modeling Of Skin Permeability Coefficients, Angela K. Pannier, Rhonda M. Brand, David D. Jones

Department of Biological Systems Engineering: Papers and Publications

Purpose. The purpose of this work was to determine whether a new modeling methodology using fuzzy logic can predict skin permeability coefficients that are given compound descriptors that have been proven to affect percutaneous penetration.
Methods. Three fuzzy inference models were developed using subtractive clustering to define natural structures within the data and assign subsequent rules. The numeric parameters describing the rules were refined through the use of an Adaptive Neural Fuzzy Inference System implemented in MatLab. Each model was evaluated using the entire data set. Then predicted outputs were compared to the published experimental data.
Results. All databases produced …