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Full-Text Articles in Biological Engineering
A Novel Biochamberfor Modeling Of Atherosclerotic Arteries: In-Vitro Capabilities And Applications, Iman Salafian, Angelos Karagiannis, Benjamin S. Terry, Yiannis S. Chatzizisis
A Novel Biochamberfor Modeling Of Atherosclerotic Arteries: In-Vitro Capabilities And Applications, Iman Salafian, Angelos Karagiannis, Benjamin S. Terry, Yiannis S. Chatzizisis
Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research
Atherosclerosis is a chronic disease that involves the lipid accumulation and inflammation of the arterial wall [1,2]. Despite great efforts,its pathophysiology has not been fully elucidated. Existent drugs can reduce its progression but there are no available drugs to prevent its complications [3,4]. Atherosclerosis remains the leading global cause of death[5].
The purpose of this work is to design and build a customized biochamber which can be used for the following studies:
•Study the pathophysiology of atherosclerosis in vitro & ex vivo
•Investigate the mechanisms of atherosclerotic plaque disruption
•Examine the direct effect of different anti-atherosclerotic drugs on lesions
•Use …