Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Biological Engineering
Effect Of L-Ascorbic Acid And All-Trans Retinoic Acid On Smooth Muscle Cells Cultured On Pcl Scaffolds, Brandon Chaffay
Effect Of L-Ascorbic Acid And All-Trans Retinoic Acid On Smooth Muscle Cells Cultured On Pcl Scaffolds, Brandon Chaffay
Electronic Thesis and Dissertation Repository
The aim of vascular tissue engineering (VTE) is to fabricate tissues that are both mechanically and biologically competent similar to the native vessel they are intended to replace. To this end, the incorporation of sufficient extracellular matrix elastin and collagen is important. The objective of this thesis work was to evaluate the effect of two biochemical factors, l-ascorbic acid (AA) and all-trans retinoic acid (atRA), on elastin synthesis when coronary artery smooth muscle cells were cultured on 3D polycaprolactone (PCL) scaffolds. First, porous PCL scaffolds were fabricated using a solvent casting and particulate leaching approach. The effect of different …