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Department of Mechanical and Materials Engineering: Faculty Publications
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Full-Text Articles in Biological Engineering
Characterization Of Closed Head Impact Injury In Rat, Yi Hua, Praveen Akula, Matthew Kelso, Linxia Gu
Characterization Of Closed Head Impact Injury In Rat, Yi Hua, Praveen Akula, Matthew Kelso, Linxia Gu
Department of Mechanical and Materials Engineering: Faculty Publications
The closed head impact (CHI) rat models are commonly used for studying the traumatic brain injury. The impact parameters vary considerably among different laboratories, making the comparison of research findings difficult. In this work, numerical CHI experiments were conducted to investigate the sensitivities of intracranial responses to various impact parameters (e.g., impact depth, velocity, and position; impactor diameter, material, and shape). A three-dimensional finite element rat head model with anatomical details was subjected to impact loadings. Results revealed that impact depth and impactor shape were the two leading factors affecting intracranial responses.The influence of impactor diameter was region-specific and an …