Engineering Commons^™

A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb

Masters Theses

One of the biggest challenges the clinical research industry currently faces is the accurate forecasting of patient enrollment (namely if and when a clinical trial will achieve full enrollment), as the stochastic behavior of enrollment can significantly contribute to delays in the development of new drugs, increases in duration and costs of clinical trials, and the over- or under- estimation of clinical supply. This study proposes a Machine Learning model using a Fully Convolutional Network (FCN) that is trained on a dataset of 100,000 patient enrollment data points including patient age, patient gender, patient disease, investigational product, study phase, blinded …

Detecting Pathobiomes Using Machine Learning, Valerie Jackson, Valerie Jackson

Industrial Engineering Undergraduate Honors Theses

Machine learning is a field with high growth potential due to the overall continuous progressions, developments, advancements, and improvements caused by the way it is used to help interpret and use large amounts of data [1]. One type of data that can be collected and analyzed by these machine learning models is data that is associated with DNA and information that the DNA gives. The research will be focusing specifically on using machine learning technology to detect pathobiomes indicative of salmonella pork. The pathobiome associated with salmonella is very similar to others, and this causes a problem for classification/detection with …

The Impact Of Case Management Intervention For Insured Asthma Patients In Louisiana, An Empirical Study, Mohamed Mohamed Ohaiba

LSU Doctoral Dissertations

Asthma is a chronic condition whose symptoms are managed/prevented using medication and interventions. The overarching objective of this study was to evaluate the impact of patients' demographics on case management enrollment and healthcare utilization, as well as to develop machine learning models to predict high-cost patients.

To accomplish these goals, the Man-Whiteness test, the chi-squares test, logistic regression and odds ratios, and machine learning models were implemented. The average cost of the non-enrolled CM group was significantly higher than the enrolled group (p-value .0001). In addition, the non-enrolled groups had considerably more visits to the emergency department than the other …

A Machine Learning Approach For Early Diagnosis Of Transthyretin Amyloid Cardiomyopathy Among Heart Failure Patients, Tanjim Ahmed

Graduate Theses, Dissertations, and Problem Reports

Transthyretin Amyloid Cardiomyopathy (ATTR-CM) is a rare, progressive, and fatal disease. Prevalence of ATTR-CM ranges from 4 to 17 per 100000 cases where the mean survival time is less than 4 years. It has a history of being underdiagnosed and misdiagnosed. The diagnosis delay has a weighted mean of 6.1 years for wild-type ATTR-CM. Low awareness, the necessity of invasive procedures, and lack of treatment are the key reasons for delayed diagnosis. But, with the introduction of non-invasive tests like nuclear scintigraphy with ^99mTC-PYP and the disease modifying drug Tafamidis, the diagnosis delay signifies a missed opportunity to increase …

Integrated Machine Learning And Optimization Approaches, Dogacan Yilmaz

Dissertations

This dissertation focuses on the integration of machine learning and optimization. Specifically, novel machine learning-based frameworks are proposed to help solve a broad range of well-known operations research problems to reduce the solution times. The first study presents a bidirectional Long Short-Term Memory framework to learn optimal solutions to sequential decision-making problems. Computational results show that the framework significantly reduces the solution time of benchmark capacitated lot-sizing problems without much loss in feasibility and optimality. Also, models trained using shorter planning horizons can successfully predict the optimal solution of the instances with longer planning horizons. For the hardest data set, …

Using Reinforcement Learning To Improve Network Reliability Through Optimal Resource Allocation, Henley Wells

Graduate Theses and Dissertations

Networks provide a variety of critical services to society (e.g. power grid, telecommunication, water, transportation) but are prone to disruption. With this motivation, we study a sequential decision problem in which an initial network is improved over time (e.g., by adding or increasing the reliability of edges) and rewards are gained over time as a function of the network’s all-terminal reliability. The actions during each time period are limited due to availability of resources such as time, money, or labor. To solve this problem, we utilized a Deep Reinforcement Learning (DRL) approach implemented within OpenAI-Gym using Stable Baselines. A Proximal …

Supervised Representation Learning For Improving Prediction Performance In Medical Decision Support Applications, Phawis Thammasorn

Graduate Theses and Dissertations

Machine learning approaches for prediction play an integral role in modern-day decision supports system. An integral part of the process is extracting interest variables or features to describe the input data. Then, the variables are utilized for training machine-learning algorithms to map from the variables to the target output. After the training, the model is validated with either validation or testing data before making predictions with a new dataset. Despite the straightforward workflow, the process relies heavily on good feature representation of data. Engineering suitable representation eases the subsequent actions and copes with many practical issues that potentially prevent the …

Predicting Zero Bin In The Semiconductor Manufacturing Industry: Machine Learning Algorithms, Yazmin Montoya

Open Access Theses & Dissertations

The semiconductor industry has faced supply chain manufacturing shortages that ultimately led to a worldwide chip shortage during the COVID-19 pandemic. These chip manufacturers use sophisticated and advanced manufacturing machinery in their fabs to manufacture chips. As experienced during the pandemic, manufacturing unavailability is often due to the lack of critical manufacturing-related spare parts. This thesis evaluates the effectiveness of machine learning algorithms to identify significant factors contributing to manufacturing part outages (i.e., zero-bin) to keep manufacturing equipment running at total capacity within the organization. We propose clustering methods to segment the data and use logistic regression, logistic lasso regression, …

Advanced Analytics In Smart Manufacturing: Anomaly Detection Using Machine Learning Algorithms And Parallel Machine Scheduling Using A Genetic Algorithm, Meiling He

Theses and Dissertations

Industry 4.0 offers great opportunities to utilize advanced data processing tools by generating Big Data from a more connected and efficient data collection system. Making good use of data processing technologies, such as machine learning and optimization algorithms, will significantly contribute to better quality control, automation, and job scheduling in Smart Manufacturing. This research aims to develop a new machine learning algorithm for solving highly imbalanced data processing problems, implement both supervised and unsupervised machine learning auto-selection frameworks for detecting anomalies in smart manufacturing, and develop a genetic algorithm for optimizing job schedules on unrelated parallel machines. This research also …

Statistical Modeling, Learning And Computing For Stochastic Dynamics Of Complex Systems, Mohammadmahdi Hajiha

Graduate Theses and Dissertations

With the recent advances in sensor technology, it is much easier to collect and store streams of system operational and environmental (SOE) data. These data can be used as input to model the underlying behavior of complex engineered systems and phenomenons if appropriate algorithms with well-defined assumptions are developed. This dissertation is comprised of the research work to show the applicability of SOE data when fed into proposed tailored algorithms. The first purposes of these algorithms are to estimate and analyze the reliability of a system as elaborated in Chapter 2. This chapter provides the derivation of closed-form expressions that …

Subnational Map Of Poverty Generated From Remote-Sensing Data In Africa: Using Machine Learning Models And Advanced Regression Methods For Poverty Estimation, Lionel N. Hanke

Master's Theses

According to the 2020 poverty estimates from the World Bank, it is estimated that 9.1% - 9.4% of the global population lived on less than $1.90 per day. It is estimated that the Covid-19 pandemic further aggravated the issue by pushing more than 1% of the global population below the international poverty line of $1.90 per day (WorldBank, 2020). To provide help and formulate effective measures, poverty needs to be located as exact as possible. For this purpose, it was investigated whether regression methods with aggregated remote-sensing data could be used to estimate poverty in Africa. Therefore, five distinct regression …

Bibliometric Review Of Predictive Maintenance Using Vibration Analysis, Aashna Midha Ms., Ishita Maheshwari Ms., Kaushik Ojha Mr., Kritika Gupta Ms., Shripad V. Deshpande Mr.

Library Philosophy and Practice (e-journal)

Every day the world is depending more and more on machines in almost every aspect of life. With the increasing use of machines, there also needs to be an evolution in the maintenance of these machines. Predictive maintenance is a process used to monitor the equipment and machinery during its operation to detect any damages and/or deteriorations and enable the required maintenance plan in advance, resulting in reduced operational costs and full utilization of tools and parts. The fundamental goal of this bibliometric review paper is a comprehension of the extent and sources of the literature available for predictive maintenance …

Medical Surge Capability: Performance Modeling Of Hospital Emergency Departments, Egbe-Etu Emmanuel Etu

Wayne State University Dissertations

Hospitals are faced with significant challenges during and after natural or human-caused disasters. Surge planning is a critical component of every healthcare facility’s emergency plan and response system. The process of managing and allocating scarce resources by tackling the vulnerability inherent to patients means that defining improvement priorities is one of the main challenges healthcare systems face when responding to a medical surge event (e.g., COVID-19). The consequences of these challenges include increased patient mortality, ambulance diversion, long wait times, and unavailability of beds. Previous efforts in hospital operations management have successfully applied operations research techniques in analyzing and optimizing …

Prediction Of Tensile Behaviors Of L-Ded 316 Stainless Steel Parts Using Machine Learning, Israt Zarin Era

Graduate Theses, Dissertations, and Problem Reports

Directed energy deposition (DED) is a rising field in the arena of metal additive manufacturing and has extensive applications in aerospace, medical and rapid prototyping. The process parameters, such as laser power, scanning speed and specimen height, play a great deal in controlling and affecting the properties of DED fabricated parts. Nevertheless, both experimental and simulation methods have shown constraints and limited ability to generate accurate and efficient computational predictions on the correlations between the process parameters and the final part quality. In this work, a data driven machine learning model XGBoost has been built and applied to predict the …

Identification Of Moving Bottlenecks In Production Systems, Funmilayo Mofoluwasola Adeyinka

Graduate Theses, Dissertations, and Problem Reports

Manufacturing sector have been plagued by bottlenecks from time immemorial, leading to loss of productivity and profitability, various research effort has been expended towards identifying and mitigating the effects of bottlenecks on production lines. However, traditional approaches often fail in identifying moving bottlenecks. The current data boom and giant strides made in the machine learning field proffers an alternative means of using the large volume of data generated by machines in identifying bottlenecks. In this study, a hierarchical agglomerative clustering algorithm is used in identifying potential groups of bottlenecks within a serial production line.

A serial production line with five …

Comparison Of Classification Algorithms And Undersampling Methods On Employee Churn Prediction: A Case Study Of A Tech Company, Heather Cooper

Master's Theses

Churn prediction is a common data mining problem that many companies face across industries. More commonly, customer churn has been studied extensively within the telecommunications industry where there is low customer retention due to high market competition. Similar to customer churn, employee churn is very costly to a company and by not deploying proper risk mitigation strategies, profits cannot be maximized, and valuable employees may leave the company. The cost to replace an employee is exponentially higher than finding a replacement, so it is in any company’s best interest to prioritize employee retention.

This research combines machine learning techniques with …

Combining Machine Learning And Empirical Engineering Methods Towards Improving Oil Production Forecasting, Andrew J. Allen

Master's Theses

Current methods of production forecasting such as decline curve analysis (DCA) or numerical simulation require years of historical production data, and their accuracy is limited by the choice of model parameters. Unconventional resources have proven challenging to apply traditional methods of production forecasting because they lack long production histories and have extremely variable model parameters. This research proposes a data-driven alternative to reservoir simulation and production forecasting techniques. We create a proxy-well model for predicting cumulative oil production by selecting statistically significant well completion parameters and reservoir information as independent predictor variables in regression-based models. Then, principal component analysis (PCA) …

Characterizing Statin Use Among Prediabetic Patients With Predictive Analytics, Alexandra Gentile

Industrial Engineering Undergraduate Honors Theses

Diabetes is one of the leading causes of death in the United States and can cause severe impairments to those diagnosed. Prediabetes is a state when a patient has higher fasting plasma glucose levels than a non-diabetic person but is not quite high enough to be considered diabetes. Both diabetic and prediabetic patients are at higher risk for cardiovascular diseases (CVD), which is the leading cause of death in the United States. The primary form for prevention and treatment of CVD is through statin therapy. Statins are a class of medications used to treat and prevent CVD by limiting cholesterol …

A Machine Learning Approach For Allocating Route Cost To Customers For Transportation And Logistics Services., Alison Davis

Electronic Theses and Dissertations

Advancements in big data enabled management practices inspire logistics companies to study deeper into their transportation operations with a data driven approach. One such question asks: How can a logistics firm identify high-cost customers in their service network? In the presence of rich data on routes involving many customers, this thesis develops a framework to allocate a route cost among customers that the route serves, where each route is associated with multiple route features related to the transportation cost. Cost is allocated using the proportional allocation approach in combination with the random forest method in machine learning. First, this framework …

Dynamic Prediction Of Treatment Outcomes For Recurrent Tuberculosis Patients, Nicole Hayes

Industrial Engineering Undergraduate Honors Theses

Tuberculosis (TB) is a disease that affects people around the world, especially people in underdeveloped countries. TB is one of the top ten causes of death globally so improvement in understanding diagnosis and treatment of TB affected patients could lead to major improvements in world health. This thesis research evaluated relapse patients specifically, deeming a relapse patient as one who has either been cured or completed their last treatment and then is diagnosed with TB again.

This research uses dynamic predictive modeling, based upon the random forest algorithm, to predict treatment outcomes for recurrent TB patients using demographic and follow-up …

Developing Leading And Lagging Indicators To Enhance Equipment Reliability In A Lean System, Dhanush Agara Mallesh

Masters Theses

With increasing complexity in equipment, the failure rates are becoming a critical metric due to the unplanned maintenance in a production environment. Unplanned maintenance in manufacturing process is created issues with downtimes and decreasing the reliability of equipment. Failures in equipment have resulted in the loss of revenue to organizations encouraging maintenance practitioners to analyze ways to change unplanned to planned maintenance. Efficient failure prediction models are being developed to learn about the failures in advance. With this information, failures predicted can reduce the downtimes in the system and improve the throughput.

The goal of this thesis is to predict …

Predictive Power And Validity Of Connectome Predictive Modeling: A Replication And Extension, Michael Wang, Joaquin Goni, Enrico Amico

The Summer Undergraduate Research Fellowship (SURF) Symposium

Neuroimaging, particularly functional magnetic resonance imaging (fMRI), is a rapidly growing research area and has applications ranging from disease classification to understanding neural development. With new advancements in imaging technology, researchers must employ new techniques to accommodate the influx of high resolution data sets. Here, we replicate a new technique: connectome-based predictive modeling (CPM), which constructs a linear predictive model of brain connectivity and behavior. CPM’s advantages over classic machine learning techniques include its relative ease of implementation and transparency compared to “black box” opaqueness and complexity. Is this method efficient, powerful, and reliable in the prediction of behavioral measures …

Explorations Into Machine Learning Techniques For Precipitation Nowcasting, Aditya Nagarajan

Masters Theses

Recent advances in cloud-based big-data technologies now makes data driven solutions feasible for increasing numbers of scientific computing applications. One such data driven solution approach is machine learning where patterns in large data sets are brought to the surface by finding complex mathematical relationships within the data. Nowcasting or short-term prediction of rainfall in a given region is an important problem in meteorology. In this thesis we explore the nowcasting problem through a data driven approach by formulating it as a machine learning problem.

State-of-the-art nowcasting systems today are based on numerical models which describe the physical processes leading to …

Rule-Based Risk Monitoring Systems For Complex Datasets, Mona Haghighi

USF Tampa Graduate Theses and Dissertations

In this dissertation we present rule-based machine learning methods for solving problems with high-dimensional or complex datasets. We are applying decision tree methods on blood-based biomarkers and neuropsychological tests to predict Alzheimer’s disease in its early stages. We are also using tree-based methods to identify disparity in dementia related biomarkers among three female ethnic groups. In another part of this research, we tried to use rule-based methods to identify homogeneous subgroups of subjects who share the same risk patterns out of a heterogeneous population. Finally, we applied a network-based method to reduce the dimensionality of a clinical dataset, while capturing …