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Full-Text Articles in Engineering

Effects Of Magnetically Induced Micro-Mixing On Nanofiltration Performance, Guanghui Song Dec 2015

Effects Of Magnetically Induced Micro-Mixing On Nanofiltration Performance, Guanghui Song

Graduate Theses and Dissertations

Nanofiltration (NF) is a relatively new membrane separation process mainly used for removing low molecular weight species from aqueous and non-aqueous solutions. NF membranes suffer from concentration polarization leading to membrane fouling thus compromised membrane performance. Magnetically responsive nanofiltration (NF) membranes functionalized with superparamagnetic nanoparticles (SPNs) attached to the chain ends of grafted polymer nanolayers have been shown to be effective in breaking concentration polarization at the membrane-liquid interface under an appropriate external oscillating magnetic field. Under an oscillating magnetic field, the movement of the polymer chains acts as micro-mixer leading to the suppression of concentration polarization and improved filtration …


Pressure Field Estimation Using Particle Image Velocimetry, Jean O. Calzada Dec 2015

Pressure Field Estimation Using Particle Image Velocimetry, Jean O. Calzada

Theses and Dissertations

In recent years, scientist and engineers have shown the advantages created by using the Particle Image Velocimetry (PIV) method as flow diagnostic tool to characterize instantaneous velocity fields. One of the important benefits is found on its non-intrusive nature, this leads to accurate velocity fields. From the velocity field obtained by PIV important quantities can be derived, such as pressure and vorticity. The present study, uses PIV data of an incompressible turbulent pulsed jet to determine the pressure field associated with the flow field. The pressure is calculated by using the averaged velocity field along with three different fundamental equation: …


A Handcrafted Multi-Branch Nerve Scaffold For In Vivo Peripheral Nerve Regeneration, Ridwan Fayaz Hossain Dec 2015

A Handcrafted Multi-Branch Nerve Scaffold For In Vivo Peripheral Nerve Regeneration, Ridwan Fayaz Hossain

Theses and Dissertations

Arm and leg peripheral nerve injuries contribute largely to functional disability. These injuries seldom affect a single-line nerve; rather the injury goes beyond and disrupts the nerve tissue across multiple nerve paths. Here we investigate handcrafted PDMS based multi-branch nerve guidance conduit, which addresses this crucial branching from the sciatic nerve to aid with the regeneration to their appropriate distal targets. The design concept of the developed multiple branch nerve scaffolds is not specific for the sciatic nerve but can be modified for general use of all peripheral nerves and additional applications. Microchannels are also fabricated into a device in …


Model Development And Validation For Wind Generation Transmission Systems, Mahmood Shihadeh Saadeh Dec 2015

Model Development And Validation For Wind Generation Transmission Systems, Mahmood Shihadeh Saadeh

Graduate Theses and Dissertations

In this research a new benchmark system is proposed for wind energy transmission systems. New model development, validation, and calibration methods for power transmission systems are proposed and implemented as well. First, a model reduction criteria is chosen based on electrical interconnection and geographical information. Model development is then done using reduction techniques on an operation model provided by a transmission operator based on the chosen criteria. Then model validation is performed using actual PMU synchrophasor measurements provided by a utility company. The model development and validation process ensures the accuracy of the developed model and makes for a realistic …


Modulation Of Valve Interstitial Cell Function Through Cell Shape And Phenotype, Atefeh Razavi Dec 2015

Modulation Of Valve Interstitial Cell Function Through Cell Shape And Phenotype, Atefeh Razavi

Graduate Theses and Dissertations

The aortic valve is a highly dynamic structure responding to actively to the chemical, mechanical and physical cues of the valve microenvironment. Valve interstitial cells are dispersed throughout the valve tissue and play an important role in maintaining the integrity and optimum function of the valve. They are a heterogeneous population composed of various phenotype. These phenotypes have specific functions characteristic of valve physiological and pathological conditions. The effect of mechanical loading and chemical modulators on the behavior of the valve interstitial cells have largely been studied. However the role of valve interstitial cell shape as an intrinsic physical cue …


Compounds Released From Biomass Deconstruction: Understanding Their Effect On Cellulose Enzyme Hydrolysis And Their Biological Activity, Angele Djioleu Dec 2015

Compounds Released From Biomass Deconstruction: Understanding Their Effect On Cellulose Enzyme Hydrolysis And Their Biological Activity, Angele Djioleu

Graduate Theses and Dissertations

The effect of compounds produced during biomass pretreatment on cellulolytic enzyme was investigated. Liquid prehydrolyzates were prepared by pretreating switchgrass using 24 combinations of temperature, time, and sulfuric acid concentration based on a full factorial design. Temperature was varied from 140°C to 180°C; time ranged from 10 to 40 min; and the sulfuric acid concentrations were 0.5% or 1% (v/v). Identified products in the prehydrolyzates included xylose, glucose, hydroxymethylfurfural (HMF), furfural, acetic acid, formic acid, and phenolic compounds at concentration ranging from 0 to 21.4 g/L. Pretreatment conditions significantly affected the concentrations of compounds detected in prehydrolyzates. When assayed in …


Modified Polysulfone Nanofiltration Membrane Synthesis For Hydraulic Fracturing Water Recycle, Blake Alexander Johnson Dec 2015

Modified Polysulfone Nanofiltration Membrane Synthesis For Hydraulic Fracturing Water Recycle, Blake Alexander Johnson

Graduate Theses and Dissertations

The use of hydraulic fracturing has resulted in significant increases in the yield of oil and natural gas, as water pumped into wells at high pressure cracks the formations and releases the hydrocarbons that are locked in the rocks. This process has created large volumes of brackish water that is very difficult to process and is often disposed of into injection wells. Suspended solids and some dissolved solids are more readily removed, but the multivalent ions found in certain salts can precipitate in a well and complicate the reuse of flowback in future hydraulic fracturing operations.

Nanofiltration, a membrane separation …


Eicosapentaenoic Acid (Epa) From Porphyridium Cruentum: Increasing Growth And Productivity Of The Microalgae For Pharmaceutical Products, Maryam Asgharpour Dec 2015

Eicosapentaenoic Acid (Epa) From Porphyridium Cruentum: Increasing Growth And Productivity Of The Microalgae For Pharmaceutical Products, Maryam Asgharpour

Graduate Theses and Dissertations

One of the major nutritional requirements in our diet is an adequate intake of omega-3 specially eicosapentaenoic acid (EPA). In the present study, the effects of two temperatures (16°C & 20˚C) and light intensities (140 & 180µE/M2.S) and four nitrate levels (0.075, 0.3, 0.5 and 0.7g/L) on the cell growth and lipid productivity of Porphyridium cruentum, one of the most promising oil-rich species of microalgae, were investigated. A growth comparison was carried out using pure CO2 and 5% CO2/air. Additionally, the ratio of the fatty acids with omega-3 and omega-6 groups at various growth conditions were compared, since an appropriate …


Design And Development Of A Wearable Wireless Health Monitoring System: A Smart Watch Approach, Keerthi Paranikumar Dec 2015

Design And Development Of A Wearable Wireless Health Monitoring System: A Smart Watch Approach, Keerthi Paranikumar

Graduate Theses and Dissertations

According to Statistics, every year, about 610,000 people die because of heart disease in United States of America. (i.e. 1 in every 4 deaths.*) Heart disease is common for both men and women. Annually, about 370,000 people die because of coronary heart disease, which is the most common type of heart disease [1]. About 735,000 Americans have heart attack every year. In this, 210,000 people gets heart attack who already has heart problems and 525,000 people get heart attack for the first time [2]. Not many people know that they have heart problems. Around 47% of the people in United …


Wireless Monitoring Of Driver's Pulse Rate And Temperature Using Hand Gloves Approach, Rohith Reddy Narala Dec 2015

Wireless Monitoring Of Driver's Pulse Rate And Temperature Using Hand Gloves Approach, Rohith Reddy Narala

Graduate Theses and Dissertations

There is growing concern about dangers correlated with driving, for people with known cardiovascular diseases. However, the association between having a chronic cardiovascular disease and being involved in a motor vehicle crash remains controversial. This study aims to monitor people with known medical emergencies or other medical conditions while driving [1]. It also helps the co-passengers to be cautious while the person is driving with an abnormal health condition. Designed it to be convenient and also can be easily adaptable by the end user.

The proposed project focuses on a wearable sensor glove that equipped with a pulse rate sensor, …


High-Frequency Transformer Design For Solid-State Transformers In Electric Power Distribution Systems, Roderick Javier Garcia Montoya Dec 2015

High-Frequency Transformer Design For Solid-State Transformers In Electric Power Distribution Systems, Roderick Javier Garcia Montoya

Graduate Theses and Dissertations

The objective of this thesis is to present a high- or medium-frequency transformer design methodology for Solid-State Transformer (SST) applications. SSTs have been proposed as a replacement of the traditional 50/60 Hz transformer in applications demanding high-power density. Moreover, due to the high penetration of distributed generation, DC grids, energy storage systems, and sensitive loads, SSTs have been considered as an enabling technology for envisioned future energy systems. These applications demand additional functionalities that may not be achieved with traditional transformers. For example, active power flow control, harmonic suppression, voltage regulation, voltage sag compensation, and reduced size and volume.

In …


Field Amplified Sample Stacking On Amyloid Beta (1-42) Oligomers Using Capillary Electrophoresis, Sadia Ali Paracha Dec 2015

Field Amplified Sample Stacking On Amyloid Beta (1-42) Oligomers Using Capillary Electrophoresis, Sadia Ali Paracha

Graduate Theses and Dissertations

According to recent literature, it is believed that the oligomeric form of amyloid beta (Aβ) is the leading cause of Alzheimer’s disease (1; 8; 10; 12-18). Additionally, recent studies have eluded to the impact of Alzheimer’s disease (AD) both economically and Socially in today’s society where an increase of about 71% of AD related deaths were recorded between 2000 and 2013 (7). Since the oligomeric forms of Aβ vary in size, shape and some believe conformation, it is vital to utilize a separation technique, such as capilllary electrophoresis (CE) to further understand Aβ aggregation. By understanding Aβ aggregation, treatment of …


Production Of Ethanol From Cereal Food Fines Using Dilute-Acid Hydrolysis, Andrew Edward Arnett Dec 2015

Production Of Ethanol From Cereal Food Fines Using Dilute-Acid Hydrolysis, Andrew Edward Arnett

Graduate Theses and Dissertations

Cereal food fines are a leftover by-product from breakfast cereal processing that is typically sold as animal feed or used as a pet food ingredient; however this product could be of greater value as a feedstock for the production of fuel ethanol via fermentation. In order for this material to be fermented it has to be broken down in to simple sugars using hydrolysis. One method of hydrolysis is called dilute-acid hydrolysis, whereby low concentrations of acid are added to the feedstock to facilitate the breaking of chemical bonds. This study investigates the effect of different concentrations of acid to …


Wind Tunnel Flow Characterization Utilizing Turbulence Spheres, David Omar Cano Aug 2015

Wind Tunnel Flow Characterization Utilizing Turbulence Spheres, David Omar Cano

Theses and Dissertations - UTB/UTPA

When it comes to designing products that will be highly subjected to the aerodynamics of the atmospheric freestream, it’s vital to take into consideration parameters such as geometry and surface smoothness. The optimization of the performance of certain products may be done so with the usage of wind tunnel testing. In order to utilize this tool to its full potential, the flow quality must be pre-determined before running tests. In determining the flow quality there are two main parameters needed to obtain this value. These parameters are referred to as the Turbulence Factor (TF) and Turbulence Intensity (TI). To calculate …


Two Dimensional Inverse Dynamics Model Of Human Knee Dynamics During The Moderate Squat Exercise, Ricardo Gomez Jr. Aug 2015

Two Dimensional Inverse Dynamics Model Of Human Knee Dynamics During The Moderate Squat Exercise, Ricardo Gomez Jr.

Theses and Dissertations - UTB/UTPA

The purpose of this research is to investigate the internal forces on the human knee joint during moderate squat exercise. An inverse dynamics, two dimensional, anatomic dynamic knee model is developed. The model describes the motion in the sagittal plane of human leg, and includes tibia, femur, ligamentous knee structures, tendons and muscles. The software package Matlab is used to solve the inverse dynamics model. Numerical simulations are conducted for walking (the stance phase of the gait cycle) in order to validate the model, and for moderate squatting in order to predict ligament, contact and muscle forces during this exercise.


Development Of Metallic And Ceramic Nanotubes Via Magnetron Sputtering, Hillario Cortez Aug 2015

Development Of Metallic And Ceramic Nanotubes Via Magnetron Sputtering, Hillario Cortez

Theses and Dissertations - UTB/UTPA

Nanotechnology has been extensively studied throughout the years and has allowed for the development of new structures and technologies. Nanofibers in particular have intrinsically unique properties such as large surface area to volume ratio. Nanofiber structures have a wide range of applications that include: catalysts, sensors, biomedical scaffolds, filtration devices, high performance textiles, energy storage systems, sensitized solar cells, photonics, nanocomposites, membranes, drug delivery systems, and electronics. The objective of this work is to fabricate nanotubular structures by employing the template approach. The template approach consists in the fabrication of circular shaped templates, nanofibers, and then coating the template fibers …


Two-Dimensional Dynamics Model Of The Lower Limb To Include Viscoelastic Knee Ligaments, Eduardo Granados Aug 2015

Two-Dimensional Dynamics Model Of The Lower Limb To Include Viscoelastic Knee Ligaments, Eduardo Granados

Theses and Dissertations - UTB/UTPA

A dynamic, 2D, anatomical knee joint model has been developed to simulate knee reactions to external input forces. A deformable contact area approach is used to find contact forces and moments, and a method of applying nonlinear viscoelastic ligament strain rate response was also developed and implemented on the model to account for the effects of viscoelasticity on the ligament fibers. The ligaments were then tested for various deficiencies to identify their effects on the natural frequency of the knee. Internal knee forces from ligaments, muscles, and contacting surfaces are modeled and then numerically found for different exercises. Static and …


Development, Optimization, And Implementation Of A Vibration Based Defect Detection Algorithm For Railroad Bearings, Amy Gonzalez Aug 2015

Development, Optimization, And Implementation Of A Vibration Based Defect Detection Algorithm For Railroad Bearings, Amy Gonzalez

Theses and Dissertations - UTB/UTPA

Of the three main rail accident types in the United States, derailments are the most common. Studies have shown that derailments occurring above 25 mph are caused by equipment failures such as bearing failures. As a preventative measure, condition-monitoring systems are required to detect defective bearings in the field. Based on data compiled from multiple experiments of healthy and defective bearings at UTPA, an algorithm has been devised to identify bearing abnormalities. Vibration analysis techniques are utilized to potentially determine whether a bearing is defective and the defect type and size using the acquired vibration signatures. Implementation of a defect …


Onboard Load Sensor Prototype For Use In Freight Railcar Service, Thomas Michael Diedrich Aug 2015

Onboard Load Sensor Prototype For Use In Freight Railcar Service, Thomas Michael Diedrich

Theses and Dissertations - UTB/UTPA

Determining the exact load carried by an individual railcar is crucial in the railroad industry. With an accurate load measurement, the filling process can be optimized to provide maximum cargo load without exceeding the loading thresholds set by the Association of American Railroads (AAR). In addition to optimizing the cargo load, an accurate load measurement will make it possible to identify any load imbalance in the railcar which has detrimental effects on bearing. Previous work conducted with a strain-gauge-based load sensor suspended between a thermoplastic steering pad and a bearing adapter provided accurate load data in the laboratory setting. This …


Nonlinear Dynamics Of Electrostatically Actuated M/Nems Plates To Include Casimir And Van Der Waals Effects, Reynaldo Oyervides Aug 2015

Nonlinear Dynamics Of Electrostatically Actuated M/Nems Plates To Include Casimir And Van Der Waals Effects, Reynaldo Oyervides

Theses and Dissertations - UTB/UTPA

The amplitude-frequency response and voltage-amplitude response of electrostatically actuated micro and nano-electromechanical systems (M/NEMS) clamped circular plates are investigated. The system is actuated by soft AC voltage at frequency near half natural frequency of the plate, and another case near natural frequency of the plate, they resulting in primary and parametric resonances of the system, respectively. The system is first analytically modeled using the Method of Multiple Scales (MMS). MMS results are then compared to Reduced Order Model (ROM) method frequency response numerical simulations. Besides MMS and ROM, time response simulations are conducted. The agreement of the frequency responses of …


Natural Polymer Based Composite Scaffolds For Tissue Engineering Applications, Marcos R. Villarreal Aug 2015

Natural Polymer Based Composite Scaffolds For Tissue Engineering Applications, Marcos R. Villarreal

Theses and Dissertations - UTB/UTPA

The fabrication, characterization, and bio-assessment of two types of perspective tissue engineering (TE) scaffolds are presented. Principally derived of biopolymers, both types of scaffolds generally followed porous scaffold methodologies for synthesis. Differentiating the two scaffold varieties was chiefly driven by crosslinking attainment, where crosslinking is argued to add structural stability and aid in regulating biodegradability rates in TE scaffolds. Microwave irradiation via conventional microwave was one method used to prospectively crosslink cornstarch to chitosan and sodium alginate. Triethyl orthoformate, was used to prospectively crosslink collagen and chitosan. After the scaffolds were “crosslinked” they were subjected to freeze drying techniques in …


Investigation Of Slective Laser Melting Of Mecanically Alloyed Metastable Al5fe2 Powder, Hugo Montiel Aug 2015

Investigation Of Slective Laser Melting Of Mecanically Alloyed Metastable Al5fe2 Powder, Hugo Montiel

Theses and Dissertations - UTB/UTPA

Selective Laser Melting (SLM), an Additive Manufacturing (AM) technology, enables the production of complex structured metal products. Aluminum alloys are used in SLM as high-strength lightweight materials for weight reduction in structural components. Previous investigations report high laser powers (300 W) and slow scanning speeds (500 mm/s) to process aluminum alloys under SLM. This research investigates the SLM processing of Al-Fe alloy by utilizing metastable Al5Fe2 powder system produced by mechanical alloying. Metastable systems are thermodynamically activated with internal energy that can generate an energy shortcut when processing under SLM. The optimum laser power, scan speeds and scan distances were …


Traction-Separation Relationships For Hydrogen-Induced Grain Boundary Embrittlement In Nickel Via Molecular Dynamics Simulations, Wesley Allen Barrows Jul 2015

Traction-Separation Relationships For Hydrogen-Induced Grain Boundary Embrittlement In Nickel Via Molecular Dynamics Simulations, Wesley Allen Barrows

Graduate Theses and Dissertations

The deleterious effects of atomic and molecular hydrogen on the mechanical properties of metals have long been observed. Although several theories exist describing the mechanisms by which hydrogen negatively influences the failure of materials, a consensus has yet to be reached regarding the exact mechanism or combination of mechanisms. Two mechanisms have gained support in explaining hydrogen’s degradative role in non-hydride forming metals: hydrogen-enhanced localized plasticity and hydrogen-enhanced decohesion. Yet, the interplay between these mechanisms and microstructure in metallic materials has not been explained. Accordingly, for this thesis, the three main objectives are: (i) to develop a numerical methodology to …


Swelling-Etching Characterization Of Copper (I) Oxide - Pdms For The Development Of Micro/Nano - Particles Composite Mems Corrosion Sensor, Abdoul Kader Maiga Jul 2015

Swelling-Etching Characterization Of Copper (I) Oxide - Pdms For The Development Of Micro/Nano - Particles Composite Mems Corrosion Sensor, Abdoul Kader Maiga

Graduate Theses and Dissertations

The primary objective for this thesis is to contribute to the understanding of the oxide removal process for a corrosion sensing device. The goal for designing such a device is for monitoring corrosion on metallic structures. The sensing material (6.35mm x 1mm discs) of the device is composed of copper (I) oxide particles mixed in some polydimethylsiloxane (PDMS). The PDMS, “housing,” is meant for controlling the oxidation rate through the sensing material. A solvent was used to facilitate the etchant diffusion through the PDMS matrix. Toluene and acetic acid were the ideal solvent and etchant, respectively, for carrying out the …


Modeling Radiation Heat Transfer For Building’S Cooling And Heating Loads: Considering The Role Of Clear, Cloudy, And Dusty Conditions In Hot And Dry Climates, Salem Ahmed Algarni Jul 2015

Modeling Radiation Heat Transfer For Building’S Cooling And Heating Loads: Considering The Role Of Clear, Cloudy, And Dusty Conditions In Hot And Dry Climates, Salem Ahmed Algarni

Graduate Theses and Dissertations

The influence of transient factors such as sky long wave radiation exchange and atmospheric aerosols (i.e., smog, and dust – made up of sand, clay, and silt) are not carefully considered in current building design and simulation models. Therefore, the research objective was to better understand and account for such variables, resulting in improved radiative predictive capabilities, especially important for hot and dry climates under different sky conditions including clean, cloudy, and dusty. Overall, results of this dissertation provided a better prediction method for sky long wave radiation exchange with a building’s roof and the impact of dust accumulation on …


A Non-Invasive Fluorescence-Based Oxygen Sensor And Platform For Studying Cell Responses To Metabolic Agents In Real-Time, Koutilya Reddy Buchapudi Jul 2015

A Non-Invasive Fluorescence-Based Oxygen Sensor And Platform For Studying Cell Responses To Metabolic Agents In Real-Time, Koutilya Reddy Buchapudi

Doctoral Dissertations

A fluorescence-based sensor in a transverse flow/stop measurement platform has been developed to determine real-time changes in oxygen consumption rates for cell metabolic studies. The oxygen sensitive fluorophore platinum octaethylporphyrin was embedded in a cellulose acetate matrix and affixed to a fiber optic bundle, which provided for transmission of the excitation and emission wavelengths of the film. The fiber optic bundle was sealed in a sensor head that can be used in standard 24-well plates common to research labs. The utility of the sensor and sensing platform were determined by measuring the changes in oxygen consumption rates of Candida albicans …


Fabrication Of Sub-10 Nm Metallic Structures Via Nanomasking Technique For Plasmonic Enhancement Applications, Stephen Joseph Bauman Jul 2015

Fabrication Of Sub-10 Nm Metallic Structures Via Nanomasking Technique For Plasmonic Enhancement Applications, Stephen Joseph Bauman

Graduate Theses and Dissertations

One area of nanoscience that has become popular in recent years is the study of optics at the nanoscale. Due to enhanced fabrication techniques, new geometries and improved dimensional resolutions have been allowing the creation of nanostructures for use in this area. Nanoscale geometries cause unique optical effects such as enhancement of the signal’s electric field strength at the surface of a substrate. Specifically, structures separated by nanogaps (10 nm and smaller) have been shown to exhibit strong field enhancement within the gaps. This has opened up the potential for surface enhanced spectroscopies, enhanced absorption for photovoltaics, and improved sensing …


A Cradle To Farm Gate Life Cycle Analysis Of Land Use In U.S. Pork Production, William Benjamin Putman Jul 2015

A Cradle To Farm Gate Life Cycle Analysis Of Land Use In U.S. Pork Production, William Benjamin Putman

Graduate Theses and Dissertations

The goal of this study was to conduct a detailed Life Cycle Assessment (LCA) of the U.S. live swine production supply chain to quantify land use requirements and to assess the impact associated with various ration compositions. The functional unit was defined as one kilogram (2.2 pounds) of live swine at the farm gate, ready for transport to the abattoir. This assessment focused on the three highest producing USDA regions, which encompassed the Midwest (Regions 5 and 7) and the Southeast (Region 4), representing 86% of U.S. market hog production.

First, a literature review was conducted to summarize the most …


Numerical Simulation Of Terahertz Wave Interaction With Breast Cancer Tumor Tissue Sections, Abayomi Omotola Omolewu Jul 2015

Numerical Simulation Of Terahertz Wave Interaction With Breast Cancer Tumor Tissue Sections, Abayomi Omotola Omolewu

Graduate Theses and Dissertations

This thesis presents numerical simulation of terahertz (THz) wave interaction with breast cancer tumor tissue sections. The obtained results are expressed in THz images of heterogeneous material that mimics the excised breast cancer tissue sections. The finite-element software package ANSYS High Frequency Structural Simulator (HFSS) was used in this work. HFSS is a full wave frequency domain three-dimensional (3D) electromagnetic simulation package. In this work, four breast cancer tissue models based on pathology images were simulated and images of the models were obtained at 1 THz. An incident Gaussian beam was raster scanned over tissue model configurations and the reflected …


Surface Modification Of Noble Metal Nanostructures Toward Biomedical Applications, Samir V. Jenkins Jul 2015

Surface Modification Of Noble Metal Nanostructures Toward Biomedical Applications, Samir V. Jenkins

Graduate Theses and Dissertations

Noble metal nanostructures have seen a steady increase in biomedical application over the last several decades; new diagnostic and therapeutic modalities are under intense investigation. Many of these applications are possible because of post-synthetic modifications to the particle surface. These modifications take a variety of forms and can significantly affect the pharmacokinetics of these particles. In this work, various surface modifications were investigated. Particle agglomeration, which occurs when particle surfaces remain in contact, can significantly affect the toxicity and efficacy of a nanomedicine. Darkfield microscopy and single-particle ICP-MS were developed as complementary methods to detect agglomeration in blood, with the …