Engineering Commons^™

In Vitro Microfluidics System For Mechanobiologic Investigations, Michael A. Daanen

Honors Theses

Mechanobiology is an emerging field that aims to study the relationships between mechanical forces and cellular behavior. Such mechanobiological relationships are especially critical in the cardiovascular system, where endothelial cells lining the vasculature align in response to fluid shear stresses from blood flow (Sinha, 2016). Implanted flow devices, diabetes, chronic hypertension, and various other diseases and pathophysiologies alter vessel geometries and flow dynamics. Such alterations impact fluid shear stress and endothelial cell behavior, leading to microcirculatory dysfunction, vessel leakage, and organ failure (Poredos, 2021; Papadaki, 1999; Leitschuh, 1987). To simulate dysfunctional endothelial cell behavior in vitro and evaluate novel therapeutic …

Non-Invasive Glucose Monitoring Using Ppg, Ai, And Iot-Driven Mobile Integration For Real-Time Diabetes Management, Mostafa Abdelaziz, Amr Refaie

Mechanical Engineering

Diabetes mellitus patients must regularly monitor their blood glucose levels to manage glycaemia, typically requiring capillary tests at least three times daily and laboratory tests one to two times per month. These conventional methods involve finger pricking, causing significant discomfort and stress. This study introduces an innovative non-invasive glucose monitoring approach by integrating photoplethysmography (PPG) technology with an artificial intelligence (AI) algorithm, complemented by a mobile application using Flutter, IoT systems, and Firebase cloud for real-time data access. Among the AI models tested, polynomial regression demonstrated superior accuracy in glucose prediction, achieving a Mean Squared Error (MSE) of 14.76 and …

Ai-Driven Robotic System For Predictive Maintenance: Urban Road Defect Detection In Smart Cities, Mostafa Abdelaziz, Mahmoud Khedr

Mechanical Engineering

This paper presents the development and evaluation of an integrated AI & robotic solution for predictive maintenance in smart cities, focusing on urban road defect detection. The proposed system integrates a mobile robot equipped with a high-resolution camera and a GPS module to capture video footage and geolocation data of road surfaces. The collected data is processed using cloud-based AI models, with YOLOv9 and Roboflow 3.0 Object Detection (Fast) identified as the most effective for analyzing footage to detect cracks and potholes. Experimental results validate the system's ability to accurately identify defects and generate timely reports for maintenance teams. While …

Framework To Guide The Review And Update Of Wvdoh Schedule Review Practices And Specifications, Myles Joshua Avery

Graduate Theses, Dissertations, and Problem Reports (ETD)

Roadway and bridge construction projects are often complex, necessitating high quality schedules to ensure the work is completed on time and within budget. The West Virginia Division of Highways (WVDOH) utilizes scheduling procedures and policies outlined within the Prosecution and Progress section of its Standard Specifications for Roads and Bridges to ensure timely and cost-effective project deliveries. Recently, concern has risen that the existing language within this section is outdated and fails to cater to modern scheduling techniques, technologies, and industry practices. In turn, WVDOH personnel question whether schedules that follow the existing specifications align with the complexities, types, values, …

Evaluation Of Rare Earth Element Hydraulic Preconcentrate Material Strength Characteristics And Operation Manual Development For Triaxial Machine Testing, Nicholas C. Stalnaker

Graduate Theses, Dissertations, and Problem Reports (ETD)

As part of ongoing efforts to establish a domestic Rare Earth Elements (REE) supply chain, Hydraulic Preconcentrate (HPC) generated at the Horseshoe Bend (HsB) treatment plant was produced and evaluated as a potential feedstock source. Following adjustment of the site’s clarifiers to the required pH set points, HPC was collected and pumped into 24 geobags. These geobags were passively dewatered to raise the total solids content. The evaluation included three geobag types: woven geotextile, composite (woven and non-woven), and geobags enhanced with Capillary Channel Fiber (CCF) (Bird, 2024). Hydraulic Preconcentrate (HPC) material is collected through efforts to contain and properly …

Analysis And Field Demonstration Of A Mobile Dewatering Cell For Acid Mine Drainage And Rare Earth Element Hydraulic Preconcentrate, Hunter David Vance

Graduate Theses, Dissertations, and Problem Reports (ETD)

A field scale mobile dewatering cell was constructed and demonstrated to investigate the filtration efficiency and dewatering characteristics of the cell. The cell was tested using hydraulic preconcentrate (HPC) from an active AMD treatment plant located in the Morgantown, WV area. HPC is a sludge-like material that comes from a two-stage treatment process of acid mine drainage, and it contains various rare earth elements. The cell was filled with HPC over time and the influent HPC and effluent water exiting the cell were tested each time the cell was filled. Taking these samples and other measurements, the filtration efficiency and …

On High-Speed Breakup Of Water Droplets Behind High Mach Number Shocks, Sydney M. Briggs

Graduate Thesis and Dissertation post-2024

Water droplet breakup in high-speed flow is a relatively popular experimental study to analyze breakup mechanisms. There is a plethora of experiments performed at low Mach number and low Weber number, but studies with higher speed flows and higher Weber numbers are less common. In this study, water droplet breakup is assessed using high-speed shock waves (Mach 2.3-above Mach 5) in a shock tube. Multiple methods are used to introduce droplets, and multiple different water purity levels are considered. An assessment was made into whether cavitation played a role in the breakup process physically, as this has been a budding …

Macro-Ergonomic And Organizational Behavior Mapping For Organic Waste Management Using Hofstede Culture In Semarang, Indonesia : Pca & Sem Analysis Using Smart Pls, Ratih Setyaningrum, Sahana Pramukti, Ravindran Balasubramani

ASEAN Journal on Science and Technology for Development

Waste management has a very close and complex relationship with community behavior and culture . This relationship is two-way: community culture influences how waste is managed, and conversely, waste management practices can shape or change culture. This study to assess the organizational behavior related to organic waste management. Employing a quantitative methodology, data were gathered using the Hofstede Values Survey Module 13 (VSM 13) - closed questionnaire, with 109 Semarang city Community participants responding via a Google Form. The collected data were analyzed utilizing Hofstede's prescribed formula. The next stage is PCA (Principal Component Analysis) and SEM (Structural Equation Modeling) …

Evaluation Of Heavy Metal Bioaccumulation And Growth In Hemp From Chicken Manure, Vermicompost, And Wastewater Sludge With Biochar And Health Risk Assessment, Chutiphan Sangsoda

Chulalongkorn University Theses and Dissertations (Chula ETD)

Hemp (Cannabis sativa L.) has become an economically valuable crop with a wide range of benefits. To promote more sustainable agricultural systems, the use of recycled substrates has increasingly replaced traditional fertilizers. However, substrates such as dry chicken manure, vermicompost, and wastewater sludge (WWS) combined with biochar often contain heavy metal contaminants, which may pose health risks through exposure to hemp. This study investigated three cultivars Rosella, Superwoman S1, and Red Robin over a 120-day period. The objectives were: (1) to compare the effects of dry chicken manure, vermicompost, and wastewater sludge (with and without biochar) on soil nutrient quality …

Interaction Between Extreme Temperature Events And Air Pollution On Mortality In Thailand : A Nationwide Time Series Study, Phichet Khunthong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Climate change has increased the frequency and intensity of extreme temperature events (ETEs; heat and cold waves), concomitantly affecting PM2.5 fluctuation. However, limited research has investigated the interaction of ETEs and PM2.5 on mortality, particularly in tropical regions where the interaction could influence differently from cold countries. A two-stage time-series using distributed lag non-linear models was employed to estimate region-specific relative risks and 95% confidence intervals (RRs and 95% CIs) of ETEs and PM2.5 on daily cardiovascular and respiratory mortality. The relative excess risk due to interaction (RERI) was examined to quantify additive effects. Cold waves had the greatest effect …

Exploration And Synthesis Of Tin Intermetallic Single Crystals, Jared L. Shortt

Graduate Theses/Dissertations

This thesis presents the synthesis and characterization of two tin-based intermetallic compounds: Mn₄.₁₂Sn and Ni₆Sn₈Ge₀.₄₇. Single crystals were grown using a high-temperature self-flux method, allowing for the formation of phase-pure samples suitable for structural and physical property analysis. The crystalline phases were identified and refined using powder and single-crystal X-ray diffraction (XRD), while scanning electron microscopy combined with energy-dispersive X-ray spectroscopy (SEM/EDS) was employed to verify stoichiometry and homogeneity. Magnetization measurements performed using a superconducting quantum interference device (SQUID) magnetometer revealed distinct magnetic behavior in the manganese-rich compound, while the nickel-based compound was explored for potential magnetic features arising from …

Evaluation Of Practical Methods To Determine If A Karst Creek Is Gaining Or Losing: Case Study Of Leith Creek, Elizabeth Jones

Graduate Theses/Dissertations

Karst landscapes are abundant in Missouri, with features such as caves, springs, and sinkholes that form through the dissolution of limestone. Leith Creek is a small stream in Polk County, Missouri fed by two springs and the shallow unconfined Springfield Plateau aquifer, a highly karstified aquifer which is made up of limestone and minor interbedded shale-mudstone units. To determine if Leith Creek is gaining or losing, stream flow, water chemistry and temperature sensors were monitored. Stream flow results required multiple visits to take measurements while temperature sensors required two visits, one to install the dataloggers and another to remove the …

A Novel Low-Complex Optimized Resource Allocation Algorithm Using Gwo Optimization Technique In Energy Scavenging For Wban, M. Samir Abou El-Seoud, Amira Olazan, Albashir A. Youssef

Computer Science

In wireless body area networks (WBANs) powered by energy scavenging, effectively managing renewable energy is critical to ensuring delay-sensitive services. This paper proposes a novel low-complex optimized resource allocation algorithm using the Grey Wolf Optimization (GWO) technique to allocate resources, specifically energy and communication channels, and maximize user utility while guaranteeing the worst-case delay. To achieve this, firstly, a formulation of a user utility optimization problem that accounts for the stochastic nature of energy scavenging and consumption without requiring prior knowledge of these processes is performed. Utilizing GWO optimization techniques, optimization problems broke down into four sub-problems: battery management, collection …

Fatigue Life Of Pre-Cut Seam Asphalt Mixture Composite Beams: A Combined Study Of Fatigue Damage Evolution And Reflective Cracking Extension, Hongfu Liu, Hong Lu, Xun Zhu, Zhengwei Yi, Xin Yu, Dongzhao Jin, Xinghai Peng, Songtao Lv

Michigan Tech Publications

This study investigated the impact of reflective cracking on the fatigue performance of asphalt pavements after milling and resurfacing under various conditions. Fatigue life was assessed through four-point flexural fatigue tests, while the crack extension pattern of composite beams was analyzed by digital image correlation (DIC) at both macroscopic and microscopic scales. Evaluation parameters such as stress ratios, immersion time, porosity, and types of viscous oils were assessed. A fatigue life prediction model of composite beams was established, accounting for the combined influence of these factors. To enhance the accuracy of determining composite beam failure, the critical fatigue damage was …

พฤติกรรมการเปลี่ยนช่องจราจรบริเวณจุดรับส่งผู้โดยสาร, ศุภวิชญ์ มัธยมนันทน์

Chulalongkorn University Theses and Dissertations (Chula ETD)

ในสภาพการจราจรจริง การไหลของกระแสจราจรมักถูกรบกวนจากยานพาหนะที่จอดเพื่อรับ–ส่งผู้โดยสาร ส่งผลให้ยานพาหนะที่ขับขี่ตามมามีสองทางเลือก ได้แก่ การรอให้ยานพาหนะด้านหน้าเคลื่อนตัวต่อไป หรือการเปลี่ยนช่องจราจรไปยังช่องที่สามารถเคลื่อนที่ได้ ซึ่งทั้งสองทางเลือกล้วนทำให้ประสิทธิภาพการไหลของจราจรลดลงเมื่อเทียบกับกรณีที่ไม่มีการรบกวนดังกล่าว ในปัจจุบัน การใช้แบบจำลองจราจรช่วยให้สามารถทำความเข้าใจและคาดการณ์สภาพการจราจรได้โดยไม่ต้องทดลองในพื้นที่จริง แต่แบบจำลองทั่วไปยังขาดความเฉพาะเจาะจงเมื่อต้องเผชิญสถานการณ์เฉพาะทาง โดยมักใช้พฤติกรรมพื้นฐานเพียงชุดเดียวในการแทนพฤติกรรมผู้ขับขี่ทุกกรณี งานวิจัยนี้มีวัตถุประสงค์เพื่อศึกษาพฤติกรรมการเปลี่ยนช่องจราจรของผู้ขับขี่เมื่อแล่นตามหลังรถที่จอดรับ–ส่งผู้โดยสาร จากนั้นนำพฤติกรรมที่ได้จากภาคสนามไปใช้ในการพัฒนาแบบจำลองสภาพจราจรใน PTV VISSIM และทำการเปรียบเทียบกับพฤติกรรมจริง ข้อมูลภาคสนามถูกเก็บรวบรวมด้วยการบันทึกวิดีโอและประมวลผลด้วย Video Analytics ก่อนนำไปสร้างแบบจำลอง ผลการศึกษาพบว่า แบบจำลองสามารถจำลองพฤติกรรมการเริ่มต้นเข้าสู่การเปลี่ยนช่องจราจรได้ใกล้เคียงกับข้อมูลจริง โดยช่องว่างเชิงเวลา (Lag Gap) ของยานพาหนะที่ขับขี่ตามมามีค่าเฉลี่ย 0.425 วินาทีในภาคสนาม และ 0.375 วินาทีในแบบจำลอง อย่างไรก็ตาม แบบจำลองยังไม่สามารถสะท้อนพฤติกรรมการเปลี่ยนช่องจราจรได้ครบถ้วนทุกด้าน ซึ่งเป็นประเด็นที่ควรได้รับการพัฒนาเพิ่มเติมในงานวิจัยอนาคต

Integrated Valuation Of The Ecological, Social And Economic Benefits Provided By A Multifunctional Nature-Based Solution, Laura Costadone, Shan Zhang

ODU Articles

Nature-based Solutions (NbS) offer multifunctional approaches to address climate change and environmental challenges, providing a sustainable alternative to traditional gray infrastructure. Despite their promise, widespread adoption remains limited, in part due to an incomplete understanding of their full costs and benefits relative to conventional infrastructure. Traditional benefit–cost analyses often overlook non-monetized benefits and the interconnected ecosystem services provided by NbS. This study introduces a methodological approach to quantify both the physical and monetary value of ecosystem services and co-benefits delivered by an NbS project. We applied an integrated valuation framework to a case study in Virginia Beach, VA, USA, where …

Mitigating Frost Heave And Thaw Weakening In Roads Using Wicking Geotextile, Javad Galinmoghadam

Doctoral Dissertations

"Excess water is known to be the primary cause of soil and foundation problems. In cold regions, water-related problems are exacerbated by seasonal freezing and thawing cycles. Frost heave and thaw weakening is the leading cause of premature pavement failure and consume considerable budgets of the Department of Transportations in cold regions. The first step to designing mitigation measures is the ability to predict frost heave under different conditions. This study aims to introduce a new method for quantifying frost heave using a prediction model based on the state surface approach. This proposed model addressed many inconsistencies and limitations of …

Applying Human System Integration Principles To The Investigation, Design And Validation Of Interventions For Self-Escape In Underground Mines, Eugene Adubofour Gyawu

Doctoral Dissertations

This dissertation investigates the use of human systems integration (HSI) to develop technologies for miners’ self-escape during a mine emergency, addressing barriers that compromise miner safety during emergencies.

Recognizing the inherently hazardous nature of underground mining, this study has three core objectives: (1) assessing miners' perceptions of proposed self-escape interventions, (2) designing interventions based on these insights, and (3) validating their effectiveness using experimental testing. This work evaluates self-escape interventions for both coal and metal/non-metal miners using scenario-based surveys, information design reviews, label designs and experimental testing methods varying across three distinct studies.

Results reveal that miners identified improvements to …

Mid-Field Shock And Impulse Estimation Methods For Blast Loading On Tall Targets, Ethan Allan Steward

Doctoral Dissertations

Blast resistant structural design continues to be a major research area for governments around the world due to explosive threats from both state and non-state actors. Many of the typical targets of explosive attacks, such as government buildings, commercial high rise office buildings, and apartment complexes are mid to high-occupancy buildings that present a tall profile relative to the charge size and are often clad in curtain walls. In blast resistant structural design, the origin of a shock wave is typically assumed to be in the far-field, creating a wave that is nearly planar and parallel to at least one …

Supporting Human-Ai Interaction From User Expectations To Mental Models, Harishankar Vasudevanallur Subramanian

Doctoral Dissertations

Explainable AI (XAI) aims to unravel the "black box" nature of AI systems and provide insights into the inner workings that lead to a prediction. However, the best XAI communication varies depending on the individual, task, and broader context. It is challenging to anticipate the best XAI for a particular use case. One strategy is for users to build an appropriate mental model of AI with both prediction and system level XAI. To date, little research has focused on quantitatively measuring users interacting with system-level XAI. This dissertation has three primary contributions. The first contribution is a scoping review paper …

Extraction And Separation Of Metal Cations From Synthetic Acidic Solutions Using Emulsion Liquid Membrane, Nouhaila Filali

Masters Theses

The work is organized into two main papers supported by experimental and comparative studies using Emulsion Liquid Membrane (ELM) systems. The first paper explores the individual extraction of heavy metals (Cd, Cr, As, Ni) from synthetic phosphoric acid using Alamine 336 and D2EHPA as carriers. Alamine 336 achieved the highest extraction efficiency (>90%) and stability, offering a promising route to reduce toxic impurities in fertilizer-grade acid. The second paper examines the selective separation of Ni2+ and Co2+ from various acidic solutions using the ELM configuration. Systematic variation of carriers, stripping agent and feed acidity, clarified transport mechanisms and stability, …

Application Of Edge-Enhanced Phase Analysis To Active Microwave Thermographic Measurements, Douglas Blaine Fleetwood

Masters Theses

Nondestructive testing and evaluation (NDT&E) encompasses a range of inspection techniques that assess materials, components, and structures while maintaining their integrity and performance. Among these techniques, thermography is particularly attractive due to its non-contact imaging approach with easy-to-interpret results. Active Microwave Thermography (AMT) has emerged as a promising NDT&E inspection technique that utilizes electromagnetic energy to heat materials through dielectric and magnetic absorption, with subsequent infrared imaging used to detect subsurface defects. While AMT offers significant advantages including material-specific heating optimization and lower power requirements compared to conventional thermographic methods, the technique faces a persistent challenge related to the thermal …

Biological Computing From Microscopic To Macroscopic Evolution, Xiaofeng Ding

Masters Theses

A unified theory from microscopic to macroscopic DNA-based biological systems is explained in terms of the rule components used when the system size is increased. Even though the eight female rules in each ruleset are provided with an equal probability of the computation-state outcomes, the initial ensemble of the computation states will exponentially settle into one dominant rule that supports the nutrition needed for growth. The remaining seven rules form into two minority groups to provide the biological characteristics of the system's growth from a micro to macroscopic evolution. The object of this study is to prove that such a …

Mitigation Of Antibiotic Resistance Using Ultraviolet Light-Emitting Diodes For Water Treatment, Nicole Heyniger, Patrick J. Mcnamara, Anthony D. Kappell, Brandon Schultz, Troy Skwor, Brooke K. Mayer

Civil and Environmental Engineering Faculty Research and Publications

The presence of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in the environment is a growing issue, which has been exacerbated by the overuse and misuse of antibiotics in health care and agricultural systems. One means of mitigating antibiotic resistance is through drinking water and wastewater treatment, specifically during disinfection processes. Ultraviolet light-emitting diodes (UV-LEDs) are an emerging disinfection technology featuring adjustable peak wavelength emissions. We assessed the use of UV-LED for treating waterborne ARB (Escherichia coli and Aeromonas hydrophila) and ARGs (intracellular and extracellular) compared to conventional low-pressure UV (LP-UV). Overall, less efficient reduction (bacterial inactivation and/or gene …

Separating The Impacts Of A Corrosion Inhibitor From Copper Corrosion Products On Antibiotic Resistance In Drinking Water, Veronika Folvarska, Maya Adelgren, Emily Lou Lamartina, Ryan J. Newton, Yin Wang, Patrick J. Mcnamara

Civil and Environmental Engineering Faculty Research and Publications

Antibiotic resistance is a growing threat to public health, and environmental factors, including metals in drinking water distribution systems, are increasingly recognized as contributors to the spread of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs). Zinc orthophosphate, a common corrosion inhibitor, and copper corrosion products (CuO and Cu₂O) are frequently present in drinking water systems. While each has been shown to increase ARB and ARGs individually, their combined effects remain unknown. The objective of this study was to evaluate the combined impact of copper corrosion products and the corrosion inhibitor zinc orthophosphate on antibiotic resistance. Two …

The Genetic Role Of The Dopamine Receptor D4 Gene, Zayden Hill

Student Research Design & Innovation Symposium

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that affects over 22 million Americans today. Typically, ADHD is first presented during childhood, the exact cause of ADHD is unknown. Genetic mutations, such as those in the DRD4 gene on chromosome 11, have been linked to ADHD. This gene encodes for dopamine receptor D4, which inhibits adenylyl cyclase, an enzyme involved in cell signaling. A missense mutation in DRD4 could hinder the receptor function, contributing to inattentiveness, hyperactivity and impulsivity--core symptoms of ADHD. Epigenetics also plays a role in ADHD development and symptomology. Maternal omega-3 supplementation has been linked to …

Field-Based Device To Test Possible Concussions, Lauren Powers, Samantha Davy, Jianna Truppi

Student Research Design & Innovation Symposium

Traumatic Brain Injuries (TBI) are injuries to the brain caused by an outside force from car accidents, falls, and strikes to the head. TBI’s make up 30% of injury related deaths in the US. The market for screening TBI’s was deemed profitable, thus research and development (R&D) was done to create a field-based device. This device targets the demographic of patients with less access to important TBI care, like DIII and high school athletes. It also targets the demographic of people injured in motor vehicle accidents. This inexpensive field-based device is designed to tell a first responder or athletic trainer, …

The Genetic Role Of Pcsk 1, Lisbeth Aquino

Student Research Design & Innovation Symposium

Proprotein convertase subtilisin/Kexin type 1 (PCSK 1) is a rare inherited metabolic disorder associated with severe digestive issues, delayed puberty, and obesity. The cause of this genetic mutation occurs when a person inherits two copies of an autosomal recessive gene. Recessive traits are more common in families who marry close relatives. When the PCSK 1 gene is negatively impacted, it can impair the enzyme function, worsening the disease. As the gene is being mutated, it can create other mutations such as N309K, RCV001374497-rs143209024, and c.1095 + 1G > A. The N309K gene affects the active site of an enzyme that causes …

Bear Claw – An Assistive Grip Device, Brandon Daniels, Nathaniel Neville

Student Research Design & Innovation Symposium

Globally, there are over one million spinal cord injuries (SCI) every year. Out of all trauma patients admitted to US hospitals in that time frame, 3.7% suffer from an SCI with the highest at-risk demographic being males aged 20 to 29. Low-cervical spinal injuries (C5 to C8) make up a large portion of these injuries, which can vastly affect motor control throughout the whole arm in addition to the total functionality of body control below the chest. These patients are wheelchair users and many live with limited control of their arms.

The Bear Claw addresses the daily challenges of gross …

Veritas Brand Guidelines Book, Matteo Lopergolo

Student Research Design & Innovation Symposium

This project followed the development of a comprehensive visual identity standard for the fictitious brand, Veritas International Airlines. The project demonstrated the designer’s thorough understanding of visual identity systems and the application of design principles to create a cohesive and effective brand representation. The designer transformed a basic logo into a fully realized visual identity system, culminating in the creation of a brand standards guide booklet which effectively communicated the brand's identity. A brand standards book ensures consistent use of a brand’s visual and messaging elements, detailing guidelines for logos, colors, typography, and tone. The designer elevated and refined the …