Engineering Commons^™

Immuno-Anti-Infective Drug Design Using Bioai, Cathy Chen, Vivian Zhang

Bioengineering Senior Theses

According to the World Health Organization, antibiotic resistance is one of the biggest threats to global health, food security, and development today. A growing number of infections, like Methicillin-resistant Staphylococcus aureus, are becoming harder to treat as the antibiotics used to treat them become less effective. As a result, the primary concern for infections in the hospital setting is due to the S. aureus’s growing resistance to antibiotics. Therefore, in response to this global health threat, our project focuses on furthering the research in developing a drug that S. aureus will not develop resistance to. In this paper, we assess …

Shear Detection Of Microencapsulated Cells For Monoclonal Antibody Production Scaleup, Kendall Defelippi, Dwight Johnson

Bioengineering Senior Theses

Scale the reported hydrodynamic shear values in industrial bioreactors for monoclonal antibody production to the shear stress measured in our custom microneedle prototype by extruding microencapsulated CHO cells. A correlation between the number of extrusion loops to reduction in cell viability enables a scalable screening method for bioprocessing efficiency.

Training Thinner And Deeper Neural Networks: Jumpstart Regularization, Carles Riera, Camilo Rey, Thiago Serra, Eloi Puertas, Oriol Pujol

Faculty Conference Papers and Presentations

Neural networks are more expressive when they have multiple layers. In turn, conventional training methods are only successful if the depth does not lead to numerical issues such as exploding or vanishing gradients, which occur less frequently when the layers are sufficiently wide. However, increasing width to attain greater depth entails the use of heavier computational resources and leads to overparameterized models. These subsequent issues have been partially addressed by model compression methods such as quantization and pruning, some of which relying on normalization-based regularization of the loss function to make the effect of most parameters negligible. In this work, …

Prescriptive And Performance-Based Analysis Of Colorado Liberal Arts College, Victor Wight

Fire Protection Engineering: Culminating Experience Project Reports

This project consists of a prescriptive and performance-based analysis of an existing two-story college building. The building is located in downtown Colorado Springs, Colorado. Colorado Liberal Arts College is used for general education courses with the focus on creative fields such as dance, graphic design, and art. The building consists of classrooms, offices, an art gallery, dance studio, and a bookstore.

A prescriptive based design was completed using the code requirements laid out in the International Building Code (IBC) 2015 Edition and applicable National Fire Protection Association (NFPA) Codes. The prescriptive based analysis consisted of analyzing life safety and egress, …

Two-Storey Office Building, Colin Mallett

Fire Protection Engineering: Culminating Experience Project Reports

This FPE 596 culminating project report was developed to meet the requirements for completion of the Fire Protection Master’s Program at Cal Poly. The report is intended to provide a detailed understanding of fire and building code requirements as well as describe both prescriptive and performance based approaches to human behavior in fire scenarios, building evacuation strategies, egress design and tenability analysis. An overall determination will be made to evaluate if the building provides the expected levels of safety for building occupants from fire.

The office building #211 was designed and constructed to be compliant with the International Building Code …

Mount Sac Gym & Aquatics Center: Fire & Life Safety Report, Alex Hoeft

Fire Protection Engineering: Culminating Experience Project Reports

This report has been prepared to review and analyze the Fire and Life Safety status of the proposed Gym & Aquatics building at Mt. San Antonio College. This was done using two methods: prescriptive and performance based. The prescriptive section examines the explicitly code-mandated requirements for the building and the performance-based section examines implicit requirements for the building based on the goals presented in the Life Safety Code, NFPA 101.

The subject building is a 147,000 square foot, two-story, steel-framed athletics complex occupied primarily for assembly and business uses. The structure has an indoor and outdoor component with two gymnasiums …

Existing Multipurpose Assembly Building, Garrett Mitchell Pelton

Fire Protection Engineering: Culminating Experience Project Reports

This report contains the compliance and life safety review of a multi-purpose assembly use building located in Denver, Colorado. The analysis contained within analyzes the prescriptive requirements of the structure as it stands today and then later reviews an alternative approach utilizing a performance based analysis. Due to this determination the building is evaluated as is and it is noted there are particular features that as a newly constructed building would require a different compliance approach.

This building was originally constructed in 1965 and has undergone two major additions. The East addition added the entire lower level in 1978 and …

Grange Insurance Audubon Center-Fire Protection Life Safety Report, Gabriel Levy

Fire Protection Engineering: Culminating Experience Project Reports

This technical approach narrative presents the intent and methodology of the Fire Protection and Life Safety systems for the Grange Insurance Audubon Center located at 505 W Whittier St. Columbus OH 43215. The primary goal of the structure is to provide life and property protection in a fire scenario while taking into account the costs of implementing the criterion and risks associated with the facility. This will be achieved through the appropriate application of requirements listed in the 2015 International Building Code (IBC) and the International Fire Code (IFC) as adopted by the City of Columbus, Ohio, and any reference …

Jack E Brown Chemical Engineering Building At Texas A&M University, Daniel Higdon

Fire Protection Engineering: Culminating Experience Project Reports

The Jack E Brown Chemical Engineering building at Texas A&M is located in College Station, TX. While this building is dedicated to chemical engineering, it serves many different departments as they use the lecture halls on the first floor. It was built and opened in 2004 and has 206,500 square feet with 7 stories. The building consists of multiple labs as well as study hall rooms, computer labs, offices, and the normal MEP/storage rooms. Jack E Brown building is one of the foremost buildings of the Texas A&M engineering quadrant and is further proof that Texas A&M desires to keep …

Numerical Implementation And Validation Of A Viscoelastic-Plastic Material Model For Predicting Curing Induced Residual Stresses In Adhesive Bonded Joints, Akshat Agha, Fadi Abu-Farha

Publications

One of the main challenges in the joining of multi-material components is the assessment of the nature and magnitude of the residual stresses developing in the adhesive bond during the heat curing manufacturing process. Numerical modeling of these residual stresses can provide insights for making informed decisions related to (i) material substrate properties; (ii) adhesive properties i.e., low, medium, or high stiffness; (iii) bondline geometry i.e., bondline width and bead thickness; (iv) curing cycle characteristics; and (v) fixation design i.e., type, spacing, the number of joints. This work presents a cure history-dependent viscoelastic-plastic material description for the modeling of adhesive …

Factors Influencing The Popularity Of Animation Series And Movies Among Chinese Audience On Online Video Websites, Shengyi Chen

Fordham Dissertations and Theses

Since 2010, online video platforms and computer animation technologies have been developing at an accelerated speed around the world. More and more animation works were produced by computers and then broadcast through new media, especially the online video platforms. With the help of computer technologies and the promotional effect of new media platforms, animation, a traditional art form, is gaining popularity among the youth around the world.

At the same time, animation producers often face a very real and challenging task – to decide whether to invest money in an animation program only with the script, a crude character …

Monofacial Vs Bifacial Solar Photovoltaic Systems In Snowy Environments, Koami Soulemane Hayibo, Aliaksei Petsiuk, Pierce Mayville, Laura Brown, Joshua M. Pearce

Electrical and Computer Engineering Publications

There has been a recent surge in interest in the more accurate snow loss estimates for solar photovoltaic (PV) systems as large-scale deployments move into northern latitudes. Preliminary results show bifacial modules may clear snow faster than monofacial PV. This study analyzes snow losses on these two types of systems using empirical hourly data including energy, solar irradiation and albedo, and open-source image processing methods from images of the arrays in a northern environment in the winter. Projection transformations based on reference anchor points and snowless ground truth images provide reliable masking and optical distortion correction with fixed surveillance cameras. …

New Advances In Fluid–Structure Interaction, Wenli Chen, Zifeng Yang, Gang Hu, Haiquan Jing, Junlei Wang

Mechanical and Materials Engineering Faculty Publications

Fluid–structure interactions (FSI) play a crucial role in the design, construction, service and maintenance of many engineering applications, e.g., aircraft, towers, pipes, offshore platforms and long-span bridges. The old Tacoma Narrows Bridge (1940) is probably one of the most infamous examples of serious accidents due to the action of FSI. Aircraft wings and wind-turbine blades can break because of FSI-induced oscillations. To alleviate or eliminate these unfavorable effects, FSI must be dealt with in ocean, coastal, offshore and marine engineering to design safe and sustainable engineering structures. In addition, the act of wind on plants and its resultant wind-induced motions …

Engineering Hydrogels For Delivery Of Therapeutic Proteins, Francesca Briggs, Daryn Browne

Bioengineering Senior Theses

In this project, we investigate how innate hydrogel properties can be leveraged for controlled protein drug release platforms. Therapeutic proteins have many valuable applications within the medical field, however, professionals often face many obstacles with obtaining controlled drug release. This paper analyzes how the manipulation of hydrogel properties can improve protein drug release rates. We started these investigations by varying hydrogel concentrations since we saw that this affects the release of small molecules. Additionally, we wanted to see what the addition of a second hydrogel network would do to protein release rates. These experiments concluded that raising polymer concentrations and …

Poly(Adr-Ribose) Polymerase 14-Specific Inhibitor For Hepatocellular Carcinoma, Clarissa Silvers, Colin Sim

Bioengineering Senior Theses

Poly (ADP-ribose) polymerases, PARPs, are comprised of a family of 17 human enzymes that share a conserved catalytic domain that transfers ADP-ribose from nicotinamide adenine dinucleotide (NAD+) to target proteins. While significant proteomic-based efforts in the field have uncovered a host of potential targets for each of the various active PARP enzymes, an outstanding question remains as to what extent proximal versus distal interactions with the protein substrates govern target selection. In this work, we describe the use of tandem mass spectrometry to identify specific residues that are auto-modified in both PARP14 and PARP15 as well as their preferred modification …

Wearable Health Sensor, George Kouretas, Kelley Mccarroll

Bioengineering Senior Theses

The COVID-19 pandemic has significantly impacted several populations, partially due to the lack of access to basic health care amenities, and emphasized the need for continuous telehealth monitoring of relevant biometric vitals. This need is further emphasized through research that has suggested that simple biometric vitals, including heart rate (HR), blood oxygen saturation rate (SpO2), and temperature, are relevant biomarkers for early disease diagnosis. The project aims to address this need through the design wearable health platform that uses novel, non-invasive techniques to monitor biometrics with the eventual goal to provide user insights into current health status and identify early …

Improving Pain Assessment Using Vital Signs And Pain Medication For Patients With Sickle Cell Disease: Retrospective Study, Swati Padhee, Gary K. Nave Jr, Tanvi Banerjee, Daniel M. Abrams, Nirmish Shah

Computer Science and Engineering Faculty Publications

Background: Sickle cell disease (SCD) is the most common inherited blood disorder affecting millions of people worldwide. Most patients with SCD experience repeated, unpredictable episodes of severe pain. These pain episodes are the leading cause of emergency department visits among patients with SCD and may last for several weeks. Arguably, the most challenging aspect of treating pain episodes in SCD is assessing and interpreting a patient's pain intensity level. Objective: This study aims to learn deep feature representations of subjective pain trajectories using objective physiological signals collected from electronic health records. Methods: This study used electronic health record data collected …

Regularized Ridge Regression Models To Estimate Static Elastic Moduli From Wireline Measurements: Case Study From Southern Iraq, Husam H. Alkinani, Abo Taleb T. Al-Hameedi, Shari Dunn-Norman, Munir Aldin, Deepak Gokaraju, Andreina Guedez, Atheer M. Alattar

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Elastic moduli such as Young's modulus (E), Poisson's ratio (v), and bulk modulus (K) are vital to creating geomechanical models for wellbore stability, hydraulic fracturing, sand production, etc. Due to the difficulty of obtaining core samples and performing rock testing, alternatively, wireline measurements can be used to estimate dynamic moduli. However, dynamic moduli are significantly different from elastic moduli due to many factors. In this paper, correlations for three zones (Nahr Umr shale, Zubair shale, and Zubair sandstone) located in southern Iraq were created to estimate static E, K, and ν from dynamic data. Core plugs from the aforementioned three …

Specialized Safety Training And Tracking For Kytc Construction And Maintenance Personnel, Gabriel Dadi, Ashtarout Ammar, Seth Atkins, Martha Horseman

Kentucky Transportation Center Research Report

High-quality safety training is critical for educating employees in the highway construction and maintenance industry about workplace hazards and giving them tools to remove and/or minimize associated risks. But researchers and state transportation agencies have not committed enough resources to develop safety trainings that address the unique needs of this sector. This report fills in this gap for the Kentucky Transportation Cabinet (KYTC) by cataloguing safety training resources available through other state and federal transportation agencies, documenting trainings available to Cabinet staff, identifying and prioritizing training gaps, and critically evaluating the content, quality, and duration of training resources. A web-based …

Solid Thermal Storage As An Energy Storage Device In Insulated Solar Electric Cookers: Thermal Modeling And Experiment, Michael Antonio Fernandez

Physics

The use of solid thermal storage (STS) as an energy storage device in insulated solar electric cookers (ISEC) was explored using a thermal simulation before retrofitting an existing cooker without energy storage and testing it under several conditions. STS sizing, material selection, and geometry were examined from both theoretical and practical perspectives and re-examined following experimental results. Characterization of the system’s thermal interfaces and methods to improve their thermal conductivities were investigated resulting in several performance enhancements to the system.

Barrier Knockdown Test Control System For The Cal Poly Kinesiology Department, Regina M. Chapuis

Computer Engineering

The goal of this project is to design and implement a new control system for the LEDs and buttons on an existing Barrier Knockdown setup in the Cal Poly Kinesiology department. The Barrier Knockdown test is a testing apparatus in which subjects knock down a series of mechanical barriers in one of three patterns. The computer system times their reaction and movement time, and the test as a whole provides students with data to study the phenomenon of Contextual Interference. This system was previously controlled by an old computer setup that ultimately crashed. This project recreates the logic and user …

The Poly Rover Project, Eric Lei, Alla Alamsi, Neil Patel, Diego Ramos

Computer Engineering

The Polyver Project is an idea born from the curiosity of a few students who wondered what the interaction between a physical person and a rover as the host of random internet users would look like. It is also an experiment to enhance the exploration of real world sites in real time while also having the power of interaction.

The goal of the Polyver Project is to build the foundation for a system that can serve as the interface between the internet and a fleet of rovers. Each rover is equipped with at least a camera, microphone, and a speaker …

Estimation Of Joint Moments During Turning Maneuvers In Alpine Skiing Using A Three Dimensional Musculoskeletal Skier Model And A Forward Dynamics Optimization Framework, Dieter Heinrich, Antonie J. Van Den Bogert, Werner Nachbauer

Mechanical Engineering Faculty Publications

In alpine skiing, estimation of the joint moments acting onto the skier is essential to quantify the loading of the skier during turning maneuvers. In the present study, a novel forward dynamics optimization framework is presented to estimate the joint moments acting onto the skier incorporating a three dimensional musculoskeletal model (53 kinematic degrees of freedom, 94 muscles). Kinematic data of a professional skier performing a turning maneuver were captured and used as input data to the optimization framework. In the optimization framework, the musculoskeletal model of the skier was applied to track the experimental data of a skier and …

Controlling Temperature Of Dc-Dc Converter Using Switching Frequency Adjustment, Sajjad Ahsan, Arsalan Mughal, Mark Rapiz

Electrical Engineering

As DC-DC converter operates under different load conditions, the amount of loss within the converter varies accordingly. Consequently the temperature of the DC-DC converter will also change based on the load demand. For PWM based DC-DC converters, one factor that contributes to the loss; thus, the increase in temperature is the switching frequency at which the converter operates. The higher the switching frequency used, the bigger the switching loss and in turn the hotter the converter. In this project, the temperature of a DC-DC converter is controlled by changing the switching frequency used by the converter. The hardware investigation used …

Hybrid Ac/Dc Light Bulb, Celina Mendez, Kristian Vincent Cruz, Nouman Baryal

Electrical Engineering

A hybrid AC/DC house aims to maximize the use of AC electricity from the utility grid and DC electricity from renewable energy sources such as roof-top solar panels. The hybrid system will therefore improve the reliability of the electrical by enabling power to be delivered to the loads even when one of the sources is not operational. One of the critical loads that every house needs is lighting. The hybrid AC/DC system should therefore be reliably facilitating the power delivery to the lighting. In this project, a localized hybrid AC/DC for LED light bulbs is designed and constructed. The hybrid …

Smartphone Control Of Rc Cars, Weston R. Fitzgerald

Electrical Engineering

The smartphone-controlled RC (remote-controlled) car is an inexpensive remote-controlled car designed to be fast and portable. Instead of manufacturing, packaging, and shipping a separate controller, the remote control is implemented in a phone application, which saves time and money in both the design process and the manufacturing process. Utilizing the user’s smartphone is more cost-effective since mobile devices are a common recurrence, and packaging fewer devices results in overall better portability of the product.

This smartphone-controlled car is speedy and intuitive to learn for typical smartphone users. The user can change the car’s speed and direction wirelessly using their phone; …

Hybrid Ac/Dc House: The Road To A Sustainable Future, Nicholas Mcadams, Luis Rodriguez

Electrical Engineering

The Hybrid AC/DC house is a sustainable alternative to preexisting residential power systems. The implementation of a DC bus in current homes will allow inefficient DC-AC and AC-DC conversions to be circumvented. This provides a direct path for current to flow to DC loads from DC sources such as solar panels to minimize power losses. In doing so, this will give users the ability to power their homes strictly from renewable sources and substantially decrease reliance on the utility. For this purpose, the hybrid AC/DC house is also designed in such a way to be entirely grid-independent to provide power …

Behind The Ear (Bte) Hearing Aid, Marco Gaitan, Jaclyn Kimoto, Lawrence Lai, Billy Pho

Electrical Engineering

The product is a Behind The Ear (BTE) hearing aid with the capability to improve the quality of life for people with mild to severe hearing loss and caters to a different consumer through bold exterior design to increase awareness of deafness and normalize hearing loss. In comparison to In The Ear (ITE) and In The Canal (ITC) hearing aids, the BTE hearing aid provides the best amplification while retaining an affordable price. Sound amplification depends on two or more directional microphones embedded in the product to give users the ability to discern the direction of incoming sound easily in …

Microgrid Energy Storage Branch, Evan Luu, Jeffrey Shieh

Electrical Engineering

The microgrid is the future for the electrical utility system. Because of this, future power engineers need to be well-versed in this topic when they go into industry. Cal Poly has created a microgrid laboratory for this very purpose. However, it is missing its battery based energy storage branch. Due to safety concerns, a traditional chemical battery is not suitable for student use. In order to maintain Cal Poly’s learn-by-doing approach, an alternative solution must be implemented. A regenerative power supply meets the criteria for student use. It is capable of simulating the sinking and sourcing capabilities of a battery …

Multi-Effect Guitar Pedal, Ryan K. Madden

Electrical Engineering

This product is a multi-effect pedal to be used with an electric guitar. This unit can distort and overdrive the weak signal from a guitar as well as add chorus, phaser, and compressor effects to the signal. Additionally, the user can choose different serial combinations of the effects, allowing full creativity and experimentation with a multitude of signal chain options. This product, having many different effects, saves space than if the effects were all individual devices. To interact with the product, there is a user interface with buttons, LEDs, and an OLED screen to allow the user to customize the …