Engineering Commons^™

Development And Applications Of In-Vitro And In-Silico Models Of The Cardiovascular System To Study The Effects Of Mechanical Circulatory Support., Moustafa Meki

Electronic Theses and Dissertations

Cardiovascular diseases (CVDs) are the leading cause of mortality globally. With ongoing interest in CVDs treatment, preclinical models for drug/therapeutic development that allow for fast iterative research are needed. Owing to the inherent complexity of the cardiovascular system, current in-vitro models of the cardiovascular system fail to replicate many of the physiological aspects of the cardiovascular system. In this dissertation, the main concern is with heart failure (HF). In advanced HF, patients may receive Left Ventricular Assist Devices (LVADs) as a bridge to transplant or destination therapy. However, LVADs have many limitations, including inability to adapt to varying tissue demand …

Mapping Three Dimensional Interactions Between Biomolecules And Electric Fields., Joseph Patrick Brian P.E.

Electronic Theses and Dissertations

Electroporation is a technique that induces the formation of open pores in cell membranes by the application of an electric field. Electroporation is widely practiced in research and clinical work for transfection of genetic sequences and drug molecule transport through the membrane barrier. However, a full theoretical explanation of the molecular mechanisms and thermodynamics responsible for pore formation, structure, and longevity does not yet exist. Advances in molecular dynamics simulations have enabled theoretical studies of electroporation with previously unobtainable fidelity spanning biologically relevant timescales. All-atom simulations utilizing the recently developed method of computational electrophysiology demonstrate that pore size correlates to …

Simulation Of Fracture Strength Improvements Of A Human Proximal Femur Using Finite Element Analysis., Waleed Ebraheem Alim

Electronic Theses and Dissertations

The most common hip fracture in the elderly occurs as a result of a fall to the side with impact over the greater trochanter resulting in a fracture of the proximal femur. The fracture usually involves the femoral neck or the intertrochanteric region. It has recently been determined that the fracture crack of a hip fracture typically initiates on the superior-lateral cortex of the femoral neck and then propagates across the femoral neck, resulting in a complete fracture. The strength of the superior-lateral cortex of the femoral neck is likely determined by the combined properties of the generally thin cortex …

Design Of An Ice-Class Propeller For The Mv Yahtse, An Icebreaking, Car And Cargo, Roro Ferry, Mara Kramer

Senior Honors Theses

During early-stage ship design, a propulsion system must be matched with data from a resistance and propulsion analysis to determine the propulsion power required for the vessel to run at its design speed. Typically, this process is completed within NavCAD; however, NavCAD does not have a method to calculate icebreaking resistance or design a propeller to meet the ice-class criteria stipulated by the International Association of Classification Societies (IACS). This paper displays and discusses Python scripts written to complete the resistance and propulsion analysis, propeller optimization, and propeller structural design meeting IACS criteria for an icebreaking, RoRo car and cargo …

Sensor-Based Nitrogen Management On Non-Irrigated Corn Based Systems In Nebraska, Samantha L. Teten

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Optimizing nitrogen (N) fertilizer applications in corn to reduce environmental impacts while maintaining producer profitability remains a challenge due to spatial and temporal variability in crop yield potential and soil N dynamics. In response to these challenges, active crop canopy sensors and imagery systems have been studied to test the performance of vegetative index-based N management, but adoption has been low. There is also a lack of field-scale research evaluating this technology in water-limiting environments.

The evaluation of two sensor-based N management techniques was completed at nine non-irrigated sites in Eastern Nebraska. The first sensor-based N management technique evaluated an …

Improving The Impingement Cold Plate Thermal Design Using Numerical And Analytical Approach, Reuben Joshua Madhuker

Mechanical and Aerospace Engineering Theses - Archive

Conventional cooling methods for an IC chip uses heat spreader to transfer heat from the chip end of the spreader to the opposite end of the spreader which then uses air or water to remove heat and thereby maintaining the overall temperature. Unfortunately, the heat spreader itself has constraints such as conduction resistance which adds the heat spreader inefficiency. But if we increase the area exposed to the cooling end then this can be improved. This is done by introducing channels at that end. These channels act as fins which give a better shot at cooling the system temperature. These …

A Model-Based Approach To Predict Neuromuscular Control Patterns That Minimize Acl Forces During Jump Landing, Dieter Heinrich, Antonie J. Van Den Bogert, Robert Csapo, Werner Nachbauer

Mechanical Engineering Faculty Publications

Jump landing is a common situation leading to knee injuries involving the anterior cruciate ligament (ACL) in sports. Although neuromuscular control is considered as a key injury risk factor, there is a lack of knowledge regarding optimum control strategies that reduce ACL forces during jump landing. In the present study, a musculoskeletal model-based computational approach
is presented that allows identifying neuromuscular control patterns that minimize ACL forces during jump landing. The approach is demonstrated for a jump landing maneuver in downhill skiing, which is one out of three main injury mechanisms in competitive skiing.

Realization Of Compact Electrochemical Sensing Systems On A Board And A Chip For A High-Density Sensor Array, Hyusim Park

Electrical Engineering Dissertations - Archive

The sensitive and cost-effective electrochemical sensors based on various classes of nanocomposites fabricated by different methods for the detection of target chemicals. Its application is boundless from reactive monitoring of food additives, human health to environmental safety. In proportion to electrochemical sensor’s usages, the researchers’ interests in electrochemical sensing system have been grown, especially in portable system to satisfy many of the requirements for on-site and in-situ measurements. The electrochemical sensing system is consisted of sensor and electric readout circuit. The one of the most efficient way to carry out the reading of a set of electrochemical sensors for portable …

Data-Driven Decision Making And Control Of Rational Agents, Patrik Kolaric

Electrical Engineering Dissertations - Archive

This dissertation studies the problem of data-driven optimal decision making. The 4main contributions of this work are listed here. First, we develop a model-based and data-driven techniques for learning the cost of an Ex-pert agent. This ties fields of Inverse Optimal Control and Inverse Reinforcement Learning and represents a first data-driven algorithm of this kind in the control community. Next, we have developed optimally adaptive dynamic control allocation mechanism that optimally re-configures redundant actuators in a model-free fashion, that is, based on collected data. This work pushed the multiple frontiers of control allocation research, since state-of-the-art control allocation was Next, …

Monitoring Fgf1-Treated Skin Wounds With Label-Free Multiphoton Microscopy, Gianna Busch

Biomedical Engineering Undergraduate Honors Theses

Chronic skin wounds pose a significant threat to public health, affecting as many as 5.5 million people in the United States every year and costing the healthcare system $10 billion annually^1,2. These wounds are associated with prolonged inflammation, poor vascularization, increased infection risk, and high mortality rates^3,4. There is significant interest in developing and testing a variety of biologics to promote wound healing. However, quantitative evaluations of healing are typically limited to measurements of wound size, and there is a critical need to develop quantitative biomarkers sensitive to different aspects of the healing process. Label-free multiphoton …

Mapping The Domain Of Rna Helicase Ddx1 That Interacts With The Ns1 Of Influenza A Viruses, Elise Wyatt

Biomedical Engineering Undergraduate Honors Theses

Of the known influenza virus strains, influenza A viruses (IAVs) are the most catastrophic due to their highly contagious nature and possibly life-threatening symptoms. IAVs invade a host cell and enter the nucleus where they use the cell’s nuclear machinery for replication of their viral RNA genome which is then exported to neighboring cells to establish a productive infection. Host pathogen recognition receptors (PRRs) respond to viral infection by signaling the cell to produce type I interferons (IFNs) to fight the foreign invader. Non-structural protein 1 (NS1) of IAVs, a major component in the regulation of viral replication, opposes host …

Developing Aligned Nerve Scaffolds In A 3d Type-I Collagen Gel, Gabriel David

Biomedical Engineering Undergraduate Honors Theses

Despite significant progress in the field of peripheral nerve repair, clinical success is still limited, leaving millions to suffer from peripheral neuropathy with billions spent every year for treatment. Nerve repair methods that are capable of maximizing the regenerative properties of peripheral nerves are greatly desired in the field of medical science. This research aims to fill the gap between modern methods and the future of nerve repair by creating type-I collagen scaffolds with aligned degradation pores that will assist and nurture nerves growing through them. This is achieved by incorporating adipose stem cells into type-I collagen hydrogels and aligning …

Cross Domain Iw Threats To Sof Maritime Missions: Implications For U.S. Sof, Gary C. Kessler, Diane M. Zorri

Publications

As cyber vulnerabilities proliferate with the expansion of connected devices, wherein security is often forsaken for ease of use, Special Operations Forces (SOF) cannot escape the obvious, massive risk that they are assuming by incorporating emerging technologies into their toolkits. This is especially true in the maritime sector where SOF operates nearshore in littoral zones. As SOF—in support to the U.S. Navy— increasingly operate in these contested maritime environments, they will gradually encounter more hostile actors looking to exploit digital vulnerabilities. As such, this monograph comes at a perfect time as the world becomes more interconnected but also more vulnerable.

Engineering Controls For Bioaerosols In Non-Industrial/Non-Healthcare Settings, David Krause, Cheri Marcham, Bill Mele, Jack Springston, Rob Strode, Donald Weekes, Neil J. Zimmerman

Publications

The list of disease pathogens that can be transmitted in the air is extensive. This list includes the common cold, SARS, measles, Hansen’s disease (leprosy), polio, influenza, Legionella (Legionnaires’ disease and Pontiac fever), and tuberculosis (TB). TB, SARS-CoV-1, avian influenza, varicella, and now SARS-CoV-2 all have received public notice due not only to their known or assumed ability to be transmitted in the air rapidly from one individual to another, but also for their virulence. Other bioaerosols that can be transmitted through the air include bacteria, fungal spores and fragments, dust mites, and pollen. This document was developed to address …

Thruster Communication For Subsurface Environments; Turning Waste Noise Into Useful Data, Stephen Cronin

Doctoral Dissertations and Master's Theses

Acoustic communication serves as one of the primary means of wirelessly communicating underwater. Whereas much of the developments in the field of wireless communication have focused on radio frequency technology, water highly absorbs radio waves rendering the link not feasible for most all subsurface operations. While acoustic links have enabled new capabilities for systems operating in this challenging environment, it has yet to reach the commodity availability of radio systems, meaning that an entire class of small, low-cost systems have been unable to make use of these links. The systems in question are primarily autonomous underwater vehicles (AUVs), as they …

Air Traffic Controllers’ Occupational Stress And Performance In The Future Air Traffic Management, Hui Wang

Doctoral Dissertations and Master's Theses

As demand for unmanned aerial vehicle (UAV) operations increases, it is vital to understand its effects on air traffic controllers and the safety of the national airspace system. This study’s primary purpose is to determine how UAVs that operate in controlled airspace would influence air traffic controllers’ occupational stress and performance. In a within-subject experimental research design, 24 participants sampled from a university’s undergraduate Air Traffic Management (ATM) program completed three different air traffic control (ATC) scenarios on an en route ATC simulation system. The degree of UAV automation and control were varied in each scenario. The participants’ stress levels, …

Gold Standards Training And Evaluator Calibration Of Pilot School Check Instructors, Paul M. Cairns

Doctoral Dissertations and Master's Theses

A key component of air carrier advanced qualification programs is the calibration and training of instructors and evaluators and assurance of reliable and valid data in support of such programs. A significant amount of research is available concerning the calibration of air carrier evaluators, but no research exists regarding the calibration of pilot school check instructors. This study was designed to determine if pilot school check instructors can be calibrated against a gold standard to perform reliable and accurate evaluations. Calibration followed the principles and theories of andragogy and adult learning and teaching, including emphasis on the cognitive domain of …

Computational Investigation Of Perforated Plate Film Cooling Utilizing Conjugate Heat Transfer, Jonathan Sippel

Doctoral Dissertations and Master's Theses

The accuracy of modern state-of-practice computational fluid dynamics approaches in predicting the cooling effectiveness of a perforated plate film-cooling arrangement is evaluated in ANSYS Fluent. A numerical investigation is performed using the Reynolds Averaged Navier Stokes equations and compared to NASA Glenn’s available Turbulent Heat Flux 4 experimental measurements collected as a part of the Transformational Tools and Technologies Project. A multiphysics approach to model heat conduction through the solid geometry is shown to offer significant improvements in wall temperature and film effectiveness prediction accuracy over the standard adiabatic wall approach. Additionally, localized gradient-based grid adaption is analyzed using the …

Adaptive Control For Nonlinear, Time Varying Systems, John Zelina

Doctoral Dissertations and Master's Theses

It is common for aerospace systems to exhibit nonlinear, time varying dynamics. This thesis investigates the development of adaptive control laws to stabilize and control a class of nonlinear, time varying systems. Direct adaptive control architectures are implemented in order to compensate for time varying dynamics that could, for example, be caused by varying inertia resulting from fuel slosh or settling in a tank. The direct adaptive controller can also respond to external disturbances and unmodeled or nonlinear dynamics. Simulation results are presented for a prototype system that consists of two rotating tanks with time varying inertia due to the …

A Framework To Detect The Susceptibility Of Employees To Social Engineering Attacks, Hashim H. Alneami

Doctoral Dissertations and Master's Theses

Social engineering attacks (SE-attacks) in enterprises are hastily growing and are becoming increasingly sophisticated. Generally, SE-attacks involve the psychological manipulation of employees into revealing confidential and valuable company data to cybercriminals. The ramifications could bring devastating financial and irreparable reputation loss to the companies. Because SE-attacks involve a human element, preventing these attacks can be tricky and challenging and has become a topic of interest for many researchers and security experts. While methods exist for detecting SE-attacks, our literature review of existing methods identified many crucial factors such as the national cultural, organizational, and personality traits of employees that enable …

Dynamic Task Allocation In Partially Defined Environments Using A* With Bounded Costs, James Hendrickson

Doctoral Dissertations and Master's Theses

The sector of maritime robotics has seen a boom in operations in areas such as surveying and mapping, clean-up, inspections, search and rescue, law enforcement, and national defense. As this sector has continued to grow, there has been an increased need for single unmanned systems to be able to undertake more complex and greater numbers of tasks. As the maritime domain can be particularly difficult for autonomous vehicles to operate in due to the partially defined nature of the environment, it is crucial that a method exists which is capable of dynamically accomplishing tasks within this operational domain. By considering …

Analysis Of Ship Airwakes Using Modal Decomposition, Nicholas Zhu

Doctoral Dissertations and Master's Theses

The three-dimensional, unsteady, and turbulent airwake produced by a scaled model of a generic Navy ship (Simple Frigate Shape No. 2) was investigated in a low-speed wind tunnel. Stereoscopic, time-resolved particle image velocimetry (TR-PIV) measurements were made at six different crosswise planes over the flight deck region of the ship model, with and without the effect of a simulated atmospheric boundary layer (ABL).

Spatiotemporal analyses of the TR-PIV measurements were performed using modal decomposition, and the modes were decomposed further based on the frequency contents of their time dynamics. This approach allowed an inspection of the individual scales of the …

Validation Of A Two-Dimensional Clinostat Design To Provide Functional Weightlessness To Custom Gas Exchange Vessels, Collin R. Topolski

Doctoral Dissertations and Master's Theses

Understanding the impacts of microgravity on bacteria is vital for successful long duration space missions. In this environment, bacteria have been shown to become more virulent, more resistant to antibiotics and form more biofilms. To learn more about these phenomena, many experiments must be sent to the International Space Station, which is cost- and time prohibitive. Instead, the use of ground-based analogs is advantageous to define preliminary results that can later be verified with a space-based experiment. This research explored the development of an innovative 2D clinostat for simulating microgravity using bacteria. Computational fluid dynamics, standards established by previous literature …

Data-Driven Architecture To Increase Resilience In Multi-Agent Coordinated Missions, D. F.

Doctoral Dissertations and Master's Theses

The rise in the use of Multi-Agent Systems (MASs) in unpredictable and changing environments has created the need for intelligent algorithms to increase their autonomy, safety and performance in the event of disturbances and threats. MASs are attractive for their flexibility, which also makes them prone to threats that may result from hardware failures (actuators, sensors, onboard computer, power source) and operational abnormal conditions (weather, GPS denied location, cyber-attacks). This dissertation presents research on a bio-inspired approach for resilience augmentation in MASs in the presence of disturbances and threats such as communication link and stealthy zero-dynamics attacks. An adaptive bio-inspired …

Acquiring And Modeling Of Si Solar Cell Transient Response To Pulsed X-Ray, Lei Pan, Praneeth Kandlakunta, Matthew Van Zile, Xuezeng Dai, Jinsong Huang, John W. Mcclory, Lei R. Cao

Faculty Publications

We report on the acquisition and modeling of the transient response of a commercial silicon (Si) solar cell using a benchtop pulsed X-ray source. The solar-cell transient output to the X-ray pulses was acquired under the dark and steady-state light illumination to mimic the practical operation of a solar cell under different light illumination levels. A solar-cell circuit model was created to develop a fundamental understanding of the transient current/voltage response of solar cell at read-out circuit level. The model was validated by a good agreement between the simulation and experimental results. It was found that the solar-cell resistance ( …

Estimating Irrigation In Rice Fields With A Water Balance Approach, Kristen Trinh

Biological and Agricultural Engineering Undergraduate Honors Theses

Global food production must increase to meet the demand associated with increased population growth, so irrigation water use will continue to rise. Therefore, it is important to monitor water usage particularly when an irrigation flowmeter is unavailable. A field water balance was created for a selection of rice fields in East-central Arkansas under observation in 2018 and 2019. From those, irrigation inputs are deduced from the water balance alone. First, each field had sensors that collected water table level (WTL) data. Next, other water inputs and outputs such as precipitation and evapotranspiration (ET) were collected from two modeled sources. The …

Low Impact Development: Low-Maintenance Design To Encourage Residential Adoption Of Sustainable Systems, Haley Ellis

Biological and Agricultural Engineering Undergraduate Honors Theses

Residential adoption of low-impact development (LID) technology can positively impact downstream watershed hydrology by reducing total volumetric discharge from the residential site. This reduction can provide economic, environmental, and social benefits for the residents as well as the community at large. Additionally, homeowners are often affected by stormwater related issues, like flooding or washout, that could be easily mitigated with a sustainably engineered LID structure or network. Engineering for sustainability often includes the blending of several objectives to provide greater overall benefit. This thesis compares the outflow characteristics of three low-maintenance residential LID design scenarios differing in rain garden soil …

Design Of Control Logic And The Human-Machine Interface For A Demonstration Plant Growth Chamber Implemented On A Programmable Logic Controller, Rachael Koehler

Biological and Agricultural Engineering Undergraduate Honors Theses

This honors thesis covers the planning, development, and implementation of system controls and human-machine interface (HMI) for a demonstration plant growth chamber. The work is a continuation of an ongoing project to be used as an educational and recruiting tool manifesting the skills acquired from the Biological and Agricultural Engineering Department at the University of Arkansas’ College of Engineering. This work includes emergency controls, overall design interface, and controls for both the aeration and lighting subsystems of the growth chamber. Overall design interface controls established included development of two user modes, Administrator and Visitor. The Administrator user will have full …

Performance And Economics Of Solar Inverters And Module Level Power Electronics In A 1 Mw Photovoltaic System, Maxwell Criswell

Biological and Agricultural Engineering Undergraduate Honors Theses

Photovoltaic solar panels convert sunlight to electricity in the form of direct current; therefore, a necessary component of every photovoltaic system is an inverter to convert the electricity to usable alternating current. There are various commercially available inverter technologies manufactured today such as microinverters, string inverters, and central inverters, as well as module level power electronic devices such as DC optimizers that are capable of improving system performance in string and central inverter systems. This thesis compares the performance and economics of five different inverter and module level power electronic systems through model simulation using Helioscope software. The five alternatives …

Phase Field Modeling Of Crack Growth In Shape Memory Ceramics, Ehsan Moshkelgosha

Boise State University Theses and Dissertations

Shape memory ceramics (SMCs) are promising candidates for actuators in extreme environments such as high temperature and corrosive applications. Despite outstanding energy dissipation, compared to metallic shape memory materials, SMCs suffer from a sudden brittle fracture. While the interaction of crack propagation and phase transformation in SMCs has been the subject of several experimental and theoretical studies, mainly at the macroscale, the fundamental understanding of the dynamic interaction of crack propagation and martensitic transformation is poorly understood. This dissertation attempts to provide a mathematical model for crack propagation in transformable zirconia to address the shortage of classical methods. This dissertation …