Engineering Commons^™

Diagnostic Sequence Detection Against A Complex Background Using A Dna Molecular Computation Framework, Adan Leon Myers Y Gutierrez

Nanoscience and Microsystems ETDs

Diagnostic assays are designed to detect a unique analyte profile in a disease of interest. Nucleic acids contain an information-dense sequence, and thus are ideal candidates for unique analytes. The gold-standard of nucleic-acid-based detection is PCR which has high sensitivity, but involves time, expertise, and cost. DNA molecular logic technology holds much promise as an alternative molecular detection method due to the potential to save cost and expertise, while also achieving a high sensitivity. However, nucleic acid detection in biomedical applications carries with it the difficulty of choice of appropriate sequence and potential biological sample background.

This work describes the …

Thwarting Adversaries With Randomness And Irrationality, Abhinav Aggarwal

Computer Science ETDs

Distributed systems are ubiquitous today: from the Internet used by billions of people around the world to the small scale IoT devices. With this rapidly increasing need to perform computation at scales larger than ever before, comes the need to ensure resilience to adversarial failures so that these systems can continue to behave as intended even when some malicious tampering happens.

In this dissertation, we explore the power of randomness and the difficulty of rationally approximating the Golden Ratio to thwart adversarial behavior in two different problems in distributed computing: interactive communication and robust collaborative search. While randomness helps with …

An Investigation Of Runoff Sources To Headwater Streams And Implications For Hydropower Projects Using Stable Isotope Analyses, Paulina Lima

Civil Engineering ETDs

The purpose of this research is to investigate the predominant sources and processes that influence runoff in the watersheds that interact with hydraulic structures in different climate systems. The predominant sources in three basins were analyzed: The San Juan-Chama River System in the USA, the Manduriacu, and Coca Codo Sinclair hydropower systems in Ecuador. This field study is based on the identification of the predominant sources in the watershed by the comparison of the isotopic signature between the seasonal variation of water sources to the surface water samples in different stream order tributaries. The results exposed that there are three …

Organic/Inorganic Interfacial Interactions Affecting Metal Reactivity: Water Treatment And Sensor Applications, Mohamed Nabil Shaikh

Civil Engineering ETDs

The aim of this dissertation was to investigate the interactions occurring at the organic – inorganic interface between solid media and aqueous contaminants for water treatment and sensor applications. The gaps in current literature on these interfacial organic-inorganic interactions must be bridged in order to develop advanced water treatment and monitoring technologies for improving water quality and thus, restore and protect the contaminated water resources. As a part of this dissertation, manganese oxides-based composites and electrospun polymer mats were developed and investigated for gaining mechanistic insights of organic (bisphenol A and acetaminophen) and inorganic (uranium) contaminants removal, respectively. These reactions …

Effects Of Coefficient Of Thermal Expansion On Unbonded Concrete Overlay Design And Performance, Gauhar Sabih

Civil Engineering ETDs

With the deterioration of highway pavements across the country, more emphasis is being laid on the rehabilitation of existing pavements. Unbonded concrete overlay (UBCO) is a cost-effective technique used to rehabilitate damaged concrete pavements. The design and performance of UBCO rely on various properties of concrete, of which coefficient of thermal expansion (CTE) is an important one. Concrete CTE has a direct impact on the design and performance of rigid pavements and overlays. CTE regulates the magnitude of curling and related stresses that impact the performance of overlays with regards to cracking, faulting and pavement roughness. Previous research revealed that …

Tailored Frequency Comb Structures And Their Sensing Applications, James Hendrie

Optical Science and Engineering ETDs

The focus of this dissertation is the development and investigation of nested cavity mode-locked lasers and their resultant tailored frequency combs. A nested cavity is made up of two cavities, known as parents. One parent is a larger, active, 100MHz Ti:Saph oscillator and the other is a smaller, passive, 7GHz Fabry-Perot Etalon (FPE). Unlike standard frequency combs that are continuous, a tailored comb’s teeth are distributed in equally spaced groups where the center of each group corresponds to the resonance of the FPE and the side bands are determined by the resonances of the Ti:Saph. This unique coupling of the …

Assessment Of The Biocompatibilty, Stability, And Suitability Of Natural And Synthetic Polymers And Drugs In The Fda Approval Process, Phuong Anh Hoang Nguyen

Biomedical Engineering ETDs

Regulation of the development, production, marketing, and sales of medical pharmaceuticals and devices in the United States fall under the regulatory functions of the Food and Drug Administration (FDA). The current FDA approval process takes an average of 10 years from start to completion, and costs over $100 million. As a result, companies use many different methods to find additional use of their drugs through marketing directly to the physician, or recycling of previously approved drug moieties. In this work, an evaluation of the in vitro and ex vivo biocompatibility of polymers and drugs in different phases of FDA approval …

Optimal Control Strategies For Complex Biological Systems, Afroza Shirin

Mechanical Engineering ETDs

To better understand and to improve therapies for complex diseases such as cancer or diabetes, it is not sufficient to identify and characterize the interactions between molecules and pathways in complex biological systems, such as cells, tissues, and the human body. It also is necessary to characterize the response of a biological system to externally supplied agents (e.g., drugs, insulin), including a proper scheduling of these drugs, and drug combinations in multi drugs therapies. This obviously becomes important in applications which involve control of physiological processes, such as controlling the number of autophagosome vesicles in a cell, or regulating the …

Detection And Remodeling Of Toxic Amyloid Aggregates By Novel Conjugated Polyelectrolytes, Adeline Marianne Fanni

Biomedical Engineering ETDs

The abnormal misfolding and aggregation of intrinsically disordered proteins into ordered fibrillar amyloid aggregates is recognized as a common pathological event in neurodegenerative disorders (ND) such as Alzheimer’s and Parkinson’s diseases. The key role of fibrillar and pre-fibrillar aggregates in ND makes them ideal biomarkers to better understand disease progression but also for early disease detection and therapeutic intervention. The work described herein was conducted to gain a better understanding of amyloid interaction to lipid membrane and its role in peptide toxicity. This research was also focused on evaluating the fluorescent probe, oligomeric p-phenylene ethynylene (OPE), as an amyloid …

A Machine Learning Based Framework For Load Forecasting And Optimal Operation Of Power Systems With Distributed Generation, Tairen Chen

Electrical and Computer Engineering ETDs

The fast development and wide utilization of distributed generations (DGs), such as Photovoltaic panels and wind turbines, provide environmentally friendly renewable energy. However, inappropriate operation, sizing, and placement of DGs could increase the power losses and reduce the stability of the power network. Load forecasting is critical to the electrical utilities to schedule power generation and distribution. In this dissertation, a framework is proposed for load forecasting and optimal operation of power system with DGs in the distribution feeder-level.

In the first part, a nonparametric method, the Bayesian Additive Regression Trees (BART), is introduced for day-ahead peak load forecasting. The …

Pixelated Gasb Membranes For Photovoltaics: Fabrication And Structure-Property Relationships, Vijay Saradhi Mangu

Electrical and Computer Engineering ETDs

In this thesis, I present a reliable and efficient approach to heterogeneous integration of single-crystalline GaSb semiconductors with highly mismatched materials. The mismatch may refer to the crystalline structure and the thermal expansion coefficient of single-crystalline GaSb and the other materials of interest. The strategy of hetero-integration relies on epitaxial lift-off. This approach prevents the formation of extended structural defects that are detrimental to the performance of optoelectronic devices and preserves GaSb growth substrates for potential reuse.

Within my research work, I have overcome some outstanding challenges of epitaxial lift-off of GaSb, and I have demonstrated the operation of single-crystalline …

Reducing Threading Dislocation In Gasb Epilayer Grown On Gaas Substrate For Photovoltaic And Thermophotovoltaic Application, Ahmad Mansoori

Optical Science and Engineering ETDs

GaSb based photovoltaic devices have been demonstrated on GaAs substrates by an inducing interfacial array of 90° misfit dislocations. Despite the beneficial qualities of the highly stable 90° misfit dislocation, there is a significant density of residual threading dislocations in the GaSb layer, resulting in the degradation of the electrical performance of such photovoltaic cells compared to lattice matched devices. We aim to reduce threading dislocation density by optimizing growth temperature and by using an AlSb dislocation filtering layer. The growth temperature optimization results in a reduction of the threading dislocation density to 1.3 × 10⁸ cm⁻². …

Application Of Cation Exchange And Nanofiltration To Treat Flue Gas Desulfurization Wastewater, Ayush R. Shahi

Civil Engineering ETDs

Application of Cation Exchange and Nanofiltration to Treat Flue Gas Desulfurization Wastewater

Ayush Raj Shahi

Bachelor’s in engineering in Civil Engineering

Master of Science in Civil Engineering

ABSTRACT

Flue gas emitted from coal-fired power plants is one of the major sources of sulfur and nitrogen oxides emissions to the atmosphere. Flue-gas desulfurization (FGD) is a pollution prevention method that is employed to meet regulatory requirements using scrubbers.

FGD wastewater contains high concentrations of dissolved salts which limit options for recycling and reuse. This thesis focused on treating FGD wastewater with a combination of ion exchange (IX), precipitation, and nanofiltration (NF) …

Identification Of The Corona Point In Point-To-Plane Geometries In Atmospheric Air, Leonardo Rossetti

Electrical and Computer Engineering ETDs

The minimum sustaining electric field for streamer propagation is directly correlated to the minimum electric field at the corona point. Corona is a product of non-uniform electric fields; the onset of corona occurs before electrical breakdown. As electric fields become increasingly uniform the required field strength to produce corona is increased as well. The field uniformity can be increased until a critical point in which electrical breakdown coincides with the onset of a positive corona, this is known as the corona point.

An experimental setup with a point to plane configuration allows precise changes in electric field uniformity, by gradually …

Experimental Investigation Of Steady-State And Transient Flow Boiling Critical Heat Flux, Soon Kyu Lee

Nuclear Engineering ETDs

The Critical Heat Flux (CHF) causes a rapid reduction of heat transfer coefficient with a rapid increase of cladding temperature, which may induce physical failure of the heated material. Understanding CHF phenomena and reliable prediction of the boiling behavior are needed to design a heat transfer system including nuclear reactors. Due to the complex nature of CHF, it is still an active research topic of interest. With an increasing interest in Accident Tolerant Fuel (ATF), CHF of ATF is essential topic of study for the detailed design of the fuel – cladding element and for the reactor safety analysis.

In …

Application Of Cation Exchange And Nanofiltration To Treat Flue Gas Desulfurization Wastewater, Ayush R. Shahi

Civil Engineering ETDs

Flue gas emitted from coal-fired power plants is one of the major sources of sulfur and nitrogen oxides emissions to the atmosphere in the world today. Although coal use has decreased, it is still a major contributor to such emissions. The Clean Air Act in the United States established regulations for coal-fired power plants to limit SO_x and NO_x emissions into the atmosphere. To meet regulatory requirements, power plants have been using scrubbers to limit their air emissions. Flue-gas desulfurization (FGD) is a pollution prevention method that is employed to limit sulfur dioxide emissions directly in the environment …

Evaluating Sustainable & Equitable Financing For Pedestrian Infrastructure Maintenance And How The Quality Of Pedestrian Infrastructure Affects The Choice To Walk, Alexis Corning Padilla

Civil Engineering ETDs

In many communities, pedestrian infrastructure is poorly maintained. One challenge is finding sustainable and equitable funding since many municipalities across the country require adjacent property to maintain and repair sidewalks adjacent to their property. These policies are difficult to enforce, may place a high cost on lower-income households, and may be partly responsible for the poor condition of many sidewalks. Therefore, in the first part of this research, we evaluated three alternatives for financing the maintenance of sidewalks in Albuquerque, New Mexico: increasing the gross receipts tax, the gasoline excise tax, or the property tax. We concluded that any of …

An Efficient Multiple-Place Foraging Algorithm For Scalable Robot Swarms, Qi Lu

Computer Science ETDs

Searching and collecting multiple resources from large unmapped environments is an important challenge. It is particularly difficult given limited time, a large search area and incomplete data about the environment. This search task is an abstraction of many real-world applications such as search and rescue, hazardous material clean-up, and space exploration. The collective foraging behavior of robot swarms is an effective approach for this task. In our work, individual robots have limited sensing and communication range (like ants), but they are organized and work together to complete foraging tasks collectively. An efficient foraging algorithm coordinates robots to search and collect …

Post-Polymerization Modification Of Kapton Using Electron Beam Irradiation, Luis A. Hernandez

Mechanical Engineering ETDs

In the present study, the feasibility of chemical modification of electron-irradiated Kapton is investigated. Characterization techniques determined the changes between a pristine, electron irradiated, and a chemically treated, i.e., fluorinated, sample of Kapton. Kapton is a common material in space application as it serves as the exterior surface for space vehicles. Highly aged Kapton have significant material property changes, making them prone to electro-static discharge (ESD) damage. Understanding how Kapton material behaves under space conditions and the possibility of improving its structure and properties is of utmost important. To this end, changes to the physical properties of the material were …

Design And Fabrication Of Peel-Off And Stick Antennas, Jayakrishnan Vijayamohanan

Electrical and Computer Engineering ETDs

Antennas on multiple platforms with the capability to be reused is a novel concept in antenna technologies. This thesis explores the idea of such a flexible antenna that can be stuck on any surface using certain adhesives and be peeled off for reuse for a different purpose. This thesis specifically focuses on the application of being used on small Unmanned Aircraft Systems (sUAVs). Three basic designs are fabricated and investigated. One of them is a reconfigurable meandering monopole, consisting of a PIN diode which resonates at two different frequencies depending on the applied external voltage. A challenge that is addressed …

The Importance Of The Instantaneous Phase In Detecting Faces With Convolutional Neural Networks, Luis Armando Sanchez Tapia

Electrical and Computer Engineering ETDs

Convolutional Neural Networks (CNN) have provided new and accurate methods for processing digital images and videos. Yet, training CNNs is extremely demanding in terms of computational resources. Also, for simple applications, the standard use of transfer learning also tends to require far more resources than what may be needed. Furthermore, the final systems tend to operate as black boxes that are difficult to interpret.

The current thesis considers the problem of detecting faces from the AOLME video dataset. The AOLME dataset consists of a large video collection of group interactions that are recorded in unconstrained classroom environments. For the thesis, …

Computational Investigation Of The Interactions Between Bioactive Compounds And Biological Assemblies, Tye D. Martin

Biomedical Engineering ETDs

Small, biologically active molecules with unique properties and applications are potential solutions to a wide range of threats to global health including infectious agents and neurodegenerative disease. Experimental studies on a class of oligomeric p-phenylene ethynylenes (OPEs) have shown potential both as bioactive antimicrobials and fluorescent sensing agents for tracking amyloid-β (Aβ) aggregates found in Alzheimer’s Disease (AD). A second type of small molecule with potential applications in AD therapy, curcumin, has been found to interfere with Aβ fibril growth. Curcumin also attenuates Aβ-membrane interactions and Aβ toxicity. Our goal has been to use computational techniques to better understand the …

Verification Of Stochastic Reach-Avoid Using Rkhs Embeddings, Adam J. Thorpe

Electrical and Computer Engineering ETDs

A solution to the terminal-hitting and first-hitting stochastic reach-avoid problem for a Markov control process is presented. This solution takes advantage of a nonparametric representation of the stochastic kernel as a conditional distribution embedding within a reproducing kernel Hilbert space (RKHS). Because the disturbance is modeled as a data-driven stochastic process, this representation avoids intractable integrals in the dynamic recursion of the reach-avoid problem since the expectations can be calculated as an inner product within the RKHS. An example using a high-dimensional chain of integrators is presented, as well as for Clohessy-Wiltshire-Hill (CWH) dynamics.

Is Transportation Planning Effective? A Critical Review Of Long-Range Regional Transportation Planning In The United States, Razieh Nadafianshahamabadi

Civil Engineering ETDs

The Federal-Aid Highway Act requires urban areas with a population greater than 50,000 to create Metropolitan Planning Organizations (MPOs) to ensure that funding for transportation projects and programs are based on a continuing, cooperative, and comprehensive planning process. A major responsibility of each MPO is the creation of a long-range transportation plan (LRTP) that addresses the transportation needs of a metropolitan region over the next twenty years or more. While long-range regional transportation planning goals have grown to include a wide range of concerns and technical methods for evaluating planning scenarios have advanced substantially over the past 50 years, there …

Iii-V Nbn Focal Plane Arrays: Radiometric Characteristics As A Function Of Detector Cutoff Wavelength, Victor Darie Pepel

Electrical and Computer Engineering ETDs

Summarized here are the measured radiometric characteristics of three Infrared III-V InAsSb/AlAsSb/InAsSb-based nBn focal plane arrays (FPAs) in the SWIR to MWIR range with cutoff wavelengths of 2.85 µm, 3.3 µm and 4.2 µm at the nominal operating temperature of 150 K. Herein referred to by their respective cutoff wavelengths, the nBn detectors are characterized across the temperature range of 130 K to 180 K. The optical response and noise characteristics are examined as a function of cutoff wavelength, and a comparison of dark current density is made to HgTeCd photodiodes using the Rule ‘07 heuristic.

The 2.85 µm, 3.3 …

Tauopathies, Novel Optogenetic Tools, And The Future Of Artificial Intellience In Medicine., Jessica L. Binder

Biomedical Sciences ETDs

To this day, there is no cure for Alzheimer’s disease (AD) and related dementias (ADRD). With the daunting rise at an exponential rate of ADRD burden and related deaths, the necessity to find a new line of attack is vital. Pathological accumulation of microtubule associated protein tau in neurons is a major neuropathological hallmark of Alzheimer’s disease (AD) and related tauopathies. Attempts have been made to promote clearance of pathological tau (p-Tau) from neurons via autophagy. Transcription factor EB (TFEB) has shown to clear p-Tau from neurons via autophagy. However, sustained TFEB activation and autophagy can create burden on cellular …

Low Loading Gold Vapor Deposited Electrode For High Sensitivity As (Iii) Detection, Tybur Casuse

Civil Engineering ETDs

The objective of this thesis is to develop a method for detection of arsenite, As (III), using a thin film of gold (Au) vapor deposited onto carbon paper as an electrode. Currently, availability of drinking water arsenic (As) concentration information for rural communities is diminished due to high cost per sample analysis and limited access to analytical laboratories which can accurately determine concentrations near the 10 maximum contaminant level (MCL) set by the World Health Organization (WHO) and the US Environmental Protection Agency (EPA). The use of a minimal amount of gold aids in decreasing the cost of an electrode. …

Assessment Of Project Risks In Fast-Track Construction Projects, Claudia Garrido Martins

Civil Engineering ETDs

Fast-tracking has been extensively used to respond to demands for reduced construction project delivery times. Unique risks arising from the overlapping of activities can threaten the project. A framework is proposed to assess project risks in fast-track construction projects to better understand the intersection of fast-track, risks, and construction. The research used a commercial construction renovation project as a case study, semi-structured interviews, simulation and optimization methods to identify risks of overlapping activities, classify the risks, evaluate the impact of risks and risk mitigation actions, and optimal combinations to minimize the risk impact and mitigation costs. This study resulted in …

Characterization Of Single- And Multi-Phase Shock-Accelerated Flows, Patrick John Wayne

Mechanical Engineering ETDs

Experiments conducted in the Shock Tube Facility at the University of New Mexico are focused on characterization of shock-accelerated flows. Single-phase (gaseous) initial conditions consist of a heavy gas column of sulfur hexafluoride seeded with approximately 11% acetone gas by mass. Visualization of the image plane for gaseous initial conditions is accomplished via planar laser-induced fluorescence (PLIF) with a high-powered Nd:YAG ultraviolet laser and an Apogee Alta U-42 monochrome CCD camera, with a quantum efficiency > 90%. Multi-phase (gas-solid) initial conditions consist of glass micro-beads deposited on small 1-cm diameter discs of specific surface chemistry, mounted flush with the bottom wall …

Large Scale Electronic Health Record Data And Echocardiography Video Analysis For Mortality Risk Prediction, Alvaro Emilio Ulloa Cerna

Electrical and Computer Engineering ETDs

Electronic health records contain the clinical history of patients. The enormous potential for discovery in such a rich dataset is hampered by their complexity. We hypothesize that machine learning models trained on EHR data can predict future clinical events significantly better than current models. We analyze an EHR database of 594,862 Echocardiography studies from 272,280 unique patients with both unsupervised and supervised machine learning techniques.

In the unsupervised approach, we first develop a simulation framework to evaluate a family of different clustering pipelines. We apply the optimized approach to 41,645 patients with heart failure without providing any survival information to …