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Articles 1 - 5 of 5
Full-Text Articles in Engineering
A Framework For Evaluating Cortical Architectural Anomalies In Temporal Lobe Epilepsy Patients, Hossein Rajali
A Framework For Evaluating Cortical Architectural Anomalies In Temporal Lobe Epilepsy Patients, Hossein Rajali
Electronic Thesis and Dissertation Repository
Focal cortical dysplasia (FCD) are localized regions of malformed cerebral cortex that are frequently associated with drug-resistant epilepsy. Currently, there is a lack of research towards providing quantitative methods for characterizing minor abnormalities in cortical architecture, hindering efforts to determine whether removal affects surgical outcome, and define potential imaging correlates. In our work, we have developed a tool to extract relevant features associated with cortical architectural abnormalities that can deal with artifacts including cortical layer distortions and morphological differences caused by cortical folding effects, and processing artifacts due to improper sectioning. This framework was applied to detect abnormalities across multiple …
Investigation Of Visual Perceptions In Parkinson's Disease And The Development Of Disease Monitoring Software, Matthew Bernardinis
Investigation Of Visual Perceptions In Parkinson's Disease And The Development Of Disease Monitoring Software, Matthew Bernardinis
Electronic Thesis and Dissertation Repository
Non-motor Parkinson’s Disease (PD) symptoms are substantial factors of PD arising throughout disease stages, yet their diagnosis and monitoring remain a challenge. Sensory abnormalities in PD occur across sensory systems and disease stages, contributing to disease-related impairments. However, the extent of symptoms is unknown, with inadequate monitoring and treatment options furthering disease management difficulties. The current work studies movement-independent visual perceptions of time, displacement and velocity in PD patients across disease stages using levodopa, deep brain stimulation (DBS), or no PD therapy. Perceptual tasks were conducted using a computer-generated graphical device designed with a focus on simplicity and flexibility. Perception …
Individual Variability Of Functional Connectivity In Resting-State And Naturalistic Fmri Paradigms, Mark O'Reilly
Individual Variability Of Functional Connectivity In Resting-State And Naturalistic Fmri Paradigms, Mark O'Reilly
Electronic Thesis and Dissertation Repository
Resting-state functional magnetic resonance imaging (fMRI) studies are criticized for their lack of control over cognitive states of individuals during observation, which may lead to increased variability in estimates of functional connectivity (FC). Engaging movies have been used in an attempt to synchronize the cognitive states of individuals during the scan, potentially reducing intersubject variability in connectivity estimates. The objective of this study was to investigate the differences in intersubject variability of FC between rest and movie conditions in a healthy cohort. The results demonstrate widespread reductions of intersubject variability of FC in the movie condition compared to the resting-state …
Quantifying The Outcomes Of A Virtual Reality (Vr)-Based Gamified Neck Rehabilitation, Shahan Salim
Quantifying The Outcomes Of A Virtual Reality (Vr)-Based Gamified Neck Rehabilitation, Shahan Salim
Electronic Thesis and Dissertation Repository
Neck pain is a major global public health concern and adds a significant financial burden to both the healthcare system as well as people suffering from it. Additionally, it presents measurement and evaluation challenges for clinicians as well as adherence challenges and treatment barriers for the patients. We have developed a virtual reality (VR)-based video game that can be used to capture outcomes that may aid in the assessment and treatment of neck pain. We investigated: (i) performance metrics of overall accuracy, accuracy based on movement difficulty, duration, and total envelope of movement; (ii) stability across sessions; (iii) accuracy across …
Fabrication And Characterization Of Collagen-Polypyrrole Constructs Using Direct-Ink Write Additive Manufacturing, Rooshan Arshad
Fabrication And Characterization Of Collagen-Polypyrrole Constructs Using Direct-Ink Write Additive Manufacturing, Rooshan Arshad
Electronic Thesis and Dissertation Repository
Current efforts in the tissue engineering field are being directed towards the creation of platforms which will facilitate in instructing cells towards biologically relevant outcomes such as stem cell differentiation and disease pathophysiology. Traditional fabrication methods serve as a limiting factor for the production of such platforms as they lack feature and geometric complexity. Additive Manufacturing (AM) offers advantage over said methods by affording designers creative freedom and great control over printed constructs. Such constructs can then be used to create appropriate models for study- ing a plethora of tissues and structures. An AM methodology for Direct-Ink Write (DIW) printing …