Engineering Commons^™

Development, Manufacturing, And Supply Of Msd’S Ebola Vaccine, Jeffrey T. Blue

Vaccine Technology VI

Ebola was first discovered in 1976 and is a member of the filoviridae family of viruses. There are multiple strains of Ebola and infection can lead to hemorrhagic fever and death. In March 2014, a historic Ebola outbreak occurred in three Western African countries, Guinea, Liberia, and Sierra Leone. Over 28,000 cases were reported and led to more than 11,000 deaths, more than ten times the amount of cases compared to all past outbreaks combined. On August 8^th 2014, the World Health Organization declared a Public Health Emergency of International Concern (PHEIC). Merck Sharp & Dohme (MSD) partnering with …

Communications System Using Signal Modulation, William C. Barott

Publications

A communication method and system for communication utilizing modulation of digital signals, such as by targets and/or by use of low-complexity tags is presented. Targets may include any device or object that may alter signals, and tags can include a device with the ability to reflect and/or alter the properties of the signals and, in doing so, impose specific modulations on or alterations of such signals. Modulations can be sensed or detected using a receiver or receivers implementing processing algorithms derived from passive radar detection operations or other processes.

Transformative Role Of Photovoltaics In Phasing Out Alternating Current Based Grid By Local Dc Power Networks For Sustainable Global Economic Growth, Rajendra Singh, Amir A. Asif, Ganesh K. Venayagamoorthy

Publications

For sustainable global economic growth, eradication of global energy poverty and addressing climate challenges, free fuel based solar and wind energy sources are the only viable solution for electricity generation. Due to inherent advantages, photovoltaics has emerged as the major source of electrical power. Local generation of direct current (DC) power by PV and the use of batteries for storing electrical power have the potential of transforming global electricity infrastructure to address the problems faced by alternating current (AC) based centralized power generation and long haul transmission and distribution.

Bringing Electricity To Alafiarou: The Solar Microgrid Project, Nicolas Metais, Jacob Leatherberry

Electrical and Computer Engineering Senior Theses

Despite the great technological advancements and discoveries that have been made throughout the last century, 1.2 billion people still live without access to electricity, 95% of which live in Sub-Saharan Africa and developing Asia.1 In this paper, we discuss how we designed and implemented a self-sustaining, affordable and highly replicable solar microgrid in order to accelerate the electrification of rural communities in the most environmentally conscious way possible. Our project focused on developing a microgrid for a small community of 10 households in rural Benin that previously had no access to electricity. We travelled to this village in December of …

Rise Above The Flood: Bridge Building In Gambibgo, Ghana, Vanessa Diaz, Ariana Govan, Matthew Millsaps

Civil, Environmental and Sustainable Engineering Senior Theses

This thesis focuses on the design of a steel girder bridge for a rural community in Ghana, Africa. While Santa Clara Civil Engineering Senior Design Teams have been working in this community since 2008, it was not until 2013 that a project team attempted to design a pedestrian footbridge. After the 20152016 project team decided to take on the project, it became clear from talking with the Ghanaian Municipal Engineers and local community members that the steel suspension bridge proposed by the 2013 team would not meet all the needs of the community. Therefore, the team redesigned the bridge, proposing …

Heat Pipe Design For Absorption Chiller Refrigerators Powered By Cookstoves, Paola Flores, Eduardo Melendez

Mechanical Engineering Senior Theses

We developed an inexpensive refrigeration system that will operate off-grid through the use of reclaimed heat from cookstoves. The refrigerator will serve as a reliable storage unit that will maintain vaccines at a proper temperature range. This report focuses on the various components that make up our Cool Stove project. The overall system and subsystems are laid out and explained. We also address the reason why we believe this project will be beneficial to individuals in developing countries. In addition, we provide detail on the work that we have accomplished and on the results that we have achieved. We created …

Microfluidic E. Coli Detection, Kyle Pietrzyk, Scott Fukuoka, Andres Maldonado-Liu, Andy Ly

Interdisciplinary Design Senior Theses

In both developed and developing countries, there is a need for a fast diagnostic system to detect pathogens within a fluid sample. In developing a microfluidic platform, which utilizes a microfluidic chip and an optical detection method, doors may be opened for new methods of determining pathogen concentration in fluid. Most biological reactions are not instantaneous. A flow-controlling mechanism with no power requirement may be implemented in the microfluidic platform. As a proof-of-concept, our device uses a microfluidic chip, smartphone, and microlens to detect E. coli concentrations in water. The detection method is based on the latex agglutination assay which …

Potential For Alkali–Silica Reaction In Radiation Shielding Concrete Containing Special Aggregates, Daria Jóźwiak-Niedźwiedzka, Michał A. Glinicki, Karolina Gibas

International Conference on Durability of Concrete Structures

In the present study, the potential for the alkali–silica reaction (ASR) in radiation shielding concrete containing special aggregates is presented. The tests were performed on two kinds of aggregate: (1) high-density aggregate to absorb the gamma radiation (barite, magnetite, and hematite) and (2) mineral with high bound water content to attenuate the neutron flux (serpentinite). The optical microscopy in transparent light on thin sections, XRD and XRF method, was used to assess the mineral composition of aggregates. ASTM C1260 test method for potential alkali reactivity of aggregates was applied also to investigate the effect of different content and crystal size …

Aircraft Cyber Security And Information Exchange Safety Analysis For Department Of Commerce, Timothy B. Holt, Mohammad Moallemi, Linda Weiland, Matt Earnhardt, Sonya Mcmullen

Publications

The Federal Aviation Administration’s (FAA) Next Generation Air Transportation (NextGen) program is a long-term modernization and transformation of the current National Airspace System (NAS) into a more effective and coordinated decision-making system. NextGen provides a more reliable, secure, and dependable aviation capability for both users and operators ensuring more capacity, throughput, and safety. This research delineates a high-level Safety Risk Assessment (SRA) related to NextGen technologies, specifically Aircraft Communications Addressing and Reporting System (ACARS) as well as Aircraft Access to System Wide Information Management (SWIM) network (AAtS). Other communication mediums such as Mode-S or ADS-B transponder are also data exchange …

Env-617: Waste-Based Biorefineries In Developing Countries: An Imperative Need Of Time, Iqbal Mohammad Ismail, Abdul-Sattar Nizami

Canadian Society for Civil Engineering

The current world population of 7.2 billion is projected to reach up to 8.2 billion in 2025 with current annual growth rate of 1%. The Asia, Middle East, Africa and Latin America are the places, where most of this growth will occur due to rapidly growing industries and urbanization. As a consequence, the generation rate of municipal solid waste (MSW) will increase from 1.2 to 1.5 kg per capita per day in next 15 years. Globally, around 2.4 billion tons of MSW is generated every year that will reach up to 2.6 billion tons by 2025. Similarly, the energy demand …

Tra-933: Effects Of Rainfall On Control Delay And Queue At Multilane Roundabout, Stephen Olukayode Ibijola, Johnnie Ben-Edigbe

Canadian Society for Civil Engineering

The main thrust of the study is to investigate the extent of delay induced by rainfall at the roundabouts. Traffic flows at roundabout are continuous in one direction around a central island where entry flows yield to circulating flows. Based on the hypothesis that, rainfall will increase roundabout entry delay, ‘with and without’ rainfall studies were carried out at selected roundabouts in Durban, South Africa. Entry and circulating traffic flow data as well as geometric data were collected continuously at three selected sites during rainfall and dry weather conditions. Three classes of rainfall intensity were used: light rainfall with intensity < 2.5mm/h, moderate rainfall with intensity 2.5 – 10mm/h and heavy rainfall with intensity 10 – 50mm/h. Results show that entry delays increased between 11% and 22% during rainy conditions. The study concluded that heavy rainfall has a significant impact on delays and queues at roundabouts. The delay is not responsive to light and moderate rainfall intensity.

Fast And Accurate Indexing Technique For Large Multi-Biometric Data Sets, Debasis Samanta

Manipal Journal of Science and Technology

Biometric-based person identification is gaining importance and now-a-days it is required to process a large amount of biometric data in the order of millions. Therefore, the traditional approach where the identity of a query template is decided by matching the query template with all stored templates is impractical. The problem is further compounded when we have to deal with two or more biometric traits. In this paper, we propose an approach to index a large pool of multi-biometric data so that the matching process can be accomplished in a real time without compromise in accuracy of person identification. Our proposed …

Flow Meter Test Rig, Cory Davis, Emily Guss, Michael Swartz

Mechanical Engineering

As part of a fluid mechanics laboratory, there should be an experiment that demonstrates the proper use of flow meters, devices that are necessary and relevant in many fluids-related industries. In order to provide students with exposure to these types of devices and how they work, a test rig was developed with the ability to interchange a variety of flow meters in order to broaden the students’ knowledge of the different types of measuring devices. This report was also written to outline the steps taken to ensure the test rig would match a laboratory and industry setting. Additionally, it was …

Structural Calculations For Nepal Vocational Learning Center, Nicholas Petrarca

Architectural Engineering

This project goal is to build a Leadership Vocational School for youth, women, differently abled, and local leaders of rural and Kathmandu Nepal. The client for this project is an organization called Sakcham Rural Nepal and they partnered with a humanitarian organization called Journeyman International to find Architecture and Architectural Engineering students to design a safe, attractive and functional building to fit their needs.

Graph-Based Data Visualization In Virtual Reality: A Comparison Of User Experiences, Paul Andrew Sullivan

Master's Theses

Virtual reality is currently in the spotlight, attracting intense scrutiny by the press, technology companies, and consumers. After twenty years of dormancy, the technology has experienced a renaissance following advancements in both hardware and software. Most of these developments, and thus press attention, have been centered on entertainment. However, if the technology is going to continue to grow, it must be useful in a wide variety of situations. This paper explores the effectiveness of visualizing data in virtual reality in comparison to traditional presentations.

In this thesis, we present an approach to displaying data in a virtual reality environment. We …

Reservoir Sedimentation: The Economics Of Sustainability, Matthew William George

Theses and Dissertations

Despite mounting demand for a more sustainable worldwide water supply system, available reservoir capacity is relentlessly diminishing due to sedimentation. This fact, coupled with a decrease in the rate of dam construction, indicate an impending water supply dilemma. In the future, dams should be designed following a life cycle management approach rather than the typical short-sighted design life technique.Neither sustainable reservoir lifespans nor intergenerational equity is achieved through conventional cost-benefit analyses (CBA), which render all benefits and costs projected to occur more than several decades into a project as negligible. Consequently, future expenditures, including dam decommissioning or retrofitting with sediment …

Calibration Of Rapidscat Over-Land Σ0, Forrest Dayton Minor

Theses and Dissertations

RapidScat is a Ku-band radar that measures the normalized backscatter coefficient σ⁰ of the Earth's surface. Launched in 2015, it currently operates on the International Space Station. Nearly one year into its mission, RapidScat measurements began exhibiting strange behavior that is believed to be caused by a change in receiver gain. Changes in gain are compensated for during post-processing, but the measurements have a lower signal-to-noise ratio (SNR). Calibration and validation of σ⁰ measurements from this low SNR state are performed using extended land targets with various signal strengths. Study areas include the Amazon rainforest, Congo rainforest, Argentina …

Efficiency Of Chlorophyll In Gross Primary Productivity: A Proof Of Concept And Application In Crops, Anatoly A. Gitelson, Yi Peng, Andrés Viña, Timothy J. Arkebauer, James S. Schepers

Department of Agricultural and Biological Systems Engineering: Faculty Publications

One of the main factors affecting vegetation productivity is absorbed light, which is largely governed by chlorophyll. In this paper, we introduce the concept of chlorophyll efficiency, representing the amount of gross primary production per unit of canopy chlorophyll content (Chl) and incident PAR. We analyzed chlorophyll efficiency in two contrasting crops (soybean and maize). Given that they have different photosynthetic pathways (C3 vs. C4), leaf structures (dicot vs. monocot) and canopy architectures (a heliotrophic leaf angle distribution vs. a spherical leaf angle distribution), they cover a large spectrum of biophysical conditions. Our results show that chlorophyll efficiency in primary …

Calcium Phosphate As A Key Material For Socially Responsible Tissue Engineering, Vuk Uskoković, Victoria M. Wu

Pharmacy Faculty Articles and Research

Socially responsible technologies are designed while taking into consideration the socioeconomic, geopolitical and environmental limitations of regions in which they will be implemented. In the medical context, this involves making therapeutic platforms more accessible and affordable to patients in poor regions of the world wherein a given disease is endemic. This often necessitates going against the reigning trend of making therapeutic nanoparticles ever more structurally complex and expensive. However, studies aimed at simplifying materials and formulations while maintaining the functionality and therapeutic response of their more complex counterparts seldom provoke a significant interest in the scientific community. In this review …

Investigation Into The Predictive Capability Of Macro-Economic Features In Modelling Credit Risk For Small Medium Enterprises, Kevin Mctiernan

Dissertations

This research project investigates the predictive capability of macro-economic features in modelling credit risk for small medium enterprises (SME/SMEs). There have been indications that there is strong correlation between economic growth and the size of the SME sector in an economy. However, since the financial crisis and consequent policies and regulations, SMEs have been hampered in attempts to access credit. It has also been noted that while there is a substantial amount of credit risk literature, there is little research on how macro-economic factors affect credit risk. Being able to improve credit scoring by even a small amount can have …

Developing The Greatest Blue Economy: Water Productivity, Fresh Water Depletion, And Virtual Water Trade In The Great Lakes Basin, A. L. Mayer, Stanley Mubako, Benjamin L. Ruddell

Michigan Tech Publications, Part 1

The Great Lakes basin hosts the world's most abundant surface fresh water reserve. Historically an industrial and natural resource powerhouse, the region has suffered economic stagnation in recent decades. Meanwhile, growing water resource scarcity around the world is creating pressure on water-intensive human activities. This situation creates the potential for the Great Lakes region to sustainably utilize its relative water wealth for economic benefit. We combine economic production and trade datasets with water consumption data and models of surface water depletion in the region. We find that, on average, the current economy does not create significant impacts on surface waters, …

Examining Primarily White Institutions Of Higher Education: Black Student Experience In The 1960s, Oluwashola Gbemi

Binghamton University Undergraduate Journal

A major outcome of the Civil Rights Act of 1964 was the desegregation of higher-learning institutions. Despite this, there was little change regarding the character and cultural norms of predominantly white institutions (PWIs) of higher learning. In this review of literature discussing the experiences of Black students attending PWIs during the 1960s, I argue that cultural norms such as racial discrimination yielded a detrimental impact on the success and wellbeing of African-American students. While I discuss what quality wellbeing for African-American students entails, I highlight the significance of black student unions to the wellbeing of black students. In order to …

Potential For Biofuel Production From Algae Based Wastewater Treatment In California: Can Algal Biofuels Be Cost-Competitive With Traditional Petroleum Based Diesel?, Amanda Rupiper

Master's Projects and Capstones

Neither the use of algae to clean wastewater, nor the use of photosynthetic organisms to generate biodiesel, are new concepts on their own. By combining these two processes, algal-based wastewater treatment with algal biofuel production, additional benefits can be derived, among which could be a cost-savings. In California the average estimated base production cost per gallon for algal biodiesel is $5.98/gallon. Compared to the adjusted production cost of petroleum-based diesel of $1.53/gallon, biodiesel is not cost-competitive. Coupling wastewater treatment and algal cultivation reduces the net energy use of the two processes separately and, if accounted for, greatly reduces the production …

An Exploration Of The Relationship Between The Partisan-Business Cycle And Economic Inequality Within Developed Economies, Richard O'Doherty

Dissertations

Recent contributions to the study of inequality have provided strong evidence towards the presence of an established trend, over several decades, of growing economic inequality (with a particular focus on distribution within their tails; i.e. top 10%, 1%) across countries with developed economies and indications of similar trends across developing economies. While the causality and influencing factors to these trends has widely been discussed, and has range from declining domestic growth rates as economies move towards high mass consumption states to globalisation, political decision making and policy application been referred to as both contributory or an instrument for dampening such …

Characterization Of Geolocation Accuracy Of Suomi Npp Advanced Technology Microwave Sounder Measurements, Yang Han, Fuzhong Weng, Xiaolei Zou, Hu Yang, Deron Scott

Electrical and Computer Engineering Faculty Publications

The Advanced Technology Microwave Sounder (ATMS) onboard Suomi National Polar-orbiting Partnership satellite has 22 channels at frequencies ranging from 23 to 183 GHz for probing the atmospheric temperature and moisture under all weather conditions. As part of the ATMS calibration and validation activities, the geolocation accuracy of ATMS data must be well characterized and documented. In this study, the coastline crossing method (CCM) and the land-sea fraction method (LFM) are utilized to characterize and quantify the ATMS geolocation accuracy. The CCM is based on the inflection points of the ATMS window channel measurements across the coastlines, whereas the LFM collocates …

A Concrete Water Pasteurization Device For Third World Countries, Andrea R. Murchie

Senior Honors Projects, 2010-2019

In the rural areas of South Africa, as well as many other developing countries, people cook food and sterilize their water by heating over open fires. Many times the fires are inside of homes, which more often than not are very small. Children will often be the ones to tend to the fire, out of necessity while parents and other family members are tending to other work and needs.

The purpose of my Senior Honors Project was to design a concrete vessel that can hold water and heat the water to pasteurization (149°F) when exposed to sunlight for an extended …

Historical Trends In Mean And Extreme Runoff And Streamflow Based On Observations And Climate Models, Behzad Asadieh, Nir Y. Krakauer, Balázs M. Fekete

Publications and Research

To understand changes in global mean and extreme streamflow volumes over recent decades, we statistically analyzed runoff and streamflow simulated by the WBM-plus hydrological model using either observational-based meteorological inputs from WATCH Forcing Data (WFD), or bias-corrected inputs from five global climate models (GCMs) provided by the Inter-Sectoral Impact Model Intercomparison Project (ISI-MIP). Results show that the bias-corrected GCM inputs yield very good agreement with the observation-based inputs in average magnitude of runoff and streamflow. On global average, the observation-based simulated mean runoff and streamflow both decreased about 1.3% from 1971 to 2001. However, GCM-based simulations yield increasing trends over …

Asset Management Model For An Industrial Process Automations System In The Chemical Engineering Unit Operations Laboratory At Rose-Hulman Institute Of Technology, Megan Elaine Liebman

Graduate Theses - Chemical Engineering

In the Chemical Engineering curriculum, the Unit Operations (UO) Laboratory is recognized as the place where hands-on exposure to industrial practices occurs. Students not only examine fundamental engineering principles, but also gain knowledge of the intricacies of modern control technology. The UO Laboratory at Rose-Hulman Institute of Technology houses an industrial state-of-the-art distributed control system, which operates eleven large-scale experiments and interfaces with approximately two hundred process instruments. The size and complexity of the distributed control system and its associated equipment have grown over the past ten years and have reached a point where a systematic asset management approach is …

Nanofiltration Rejection Of Contaminants Of Emerging Concern From Municipal Water Resource Recovery Facility Secondary Effluents For Potable Reuse Applications, Steven Michael Jones

Graduate Theses and Dissertations

As reuse of municipal water resource recovery facility (WRRF) effluent becomes vital to augment diminishing fresh drinking water resources, concern exists that conventional barriers may prove deficient and the upcycling of contaminants of emerging concern (CECs) could prove harmful to human health and aquatic species if more effective and robust treatment barriers are not in place.

There are no federal Safe Drinking Water Act (SDWA) regulations in place specifically for direct potable reuse (DPR) of WRRF effluent. Out of necessity, some states are developing their own DPR reuse regulations. Currently, reverse osmosis (RO) is the default full advanced treatment (FAT) …

Chitosan As An Antiviral, Tayler Pauls

Biomedical Engineering Undergraduate Honors Theses

There is no broad-based antiviral medication available today; there are specific antivirals, for example, the antiretroviral for HIV. However, these specific antivirals are not available in each country and can be problematic for specific patients. Chitosan is proposed as a possible broad-based antiviral, which has already demonstrated antibacterial properties, antiviral properties in plants, is used for wound healing and as a hydrogel among other medical applications. The methods used are transfection of NIH-3T3 cells with GFP-adenovirus with 0.1%, 0.5%, and 1% chitosan added to virus prior to transfection. Fluorescence microscopy and flow cytometry data has validated that the use of …