Engineering Commons^™

Biomineralization And Biocompatibility Studies Of Bone Conductive Scaffolds Containing Poly(3,4-Ethylenedioxythiophene):Poly(4-Styrene Sulfonate) (Pedot:Pss), Mostafa Yazdimamaghani, Mehdi Razavi, Masoud Mozafari, Daryoosh Vashaee, Hari Kotturi, Lobat Tayebi

Chemical and Biochemical Engineering Faculty Research & Creative Works

Considering the well-known phenomenon of enhancing bone healing by applying electromagnetic stimulation, manufacturing conductive bone scaffolds is on demand to facilitate the delivery of electromagnetic stimulation to the injured region, which in turn significantly expedites the healing procedure in tissue engineering methods. For this purpose, hybrid conductive scaffolds composed of poly(3,4-ethylenedioxythiophene), poly (4-styrene sulfonate) (PEDOT:PSS), gelatin (Gel), and bioactive glass (BaG) were produced employing freeze drying technique. Concentration of PEDOT:PSS were optimized to design the most appropriate conductive scaffold in terms of biocompatibility and cell proliferation. More specifically, scaffolds with four different compositions of 0, 0.1, 0.3 and 0.6 % …

Supervised Machine Learning For Classification Of The Electrophysiological Effects Of Chronotropic Drugs On Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes, Christopher Heylman, Rupsa Datta, Agua Sobrino, Steven George, Enrico Gratton

Biomedical Engineering

Supervised machine learning can be used to predict which drugs human cardiomyocytes have been exposed to. Using electrophysiological data collected from human cardiomyocytes with known exposure to different drugs, a supervised machine learning algorithm can be trained to recognize and classify cells that have been exposed to an unknown drug. Furthermore, the learning algorithm provides information on the relative contribution of each data parameter to the overall classification. Probabilities and confidence in the accuracy of each classification may also be determined by the algorithm. In this study, the electrophysiological effects of β–adrenergic drugs, propranolol and isoproterenol, on cardiomyocytes derived from …

Analyzing General-Purpose Computing Performance On Gpu, Fanfu Meng

Master's Theses

ABSTRACT

Analyzing General-Purpose Computing Performance on GPU

Graphic Processing Unit (GPU) has become one of the most important components in modern computer systems. GPUs have evolved from a single -purpose graphic rendering hardware to a powerful processor that is capable of handling many different kinds of computing tasks. However, GPUs don’t perform well on every application, and it takes a lot of design effort to get good performance on a GPU.

This thesis aims to investigate the relative performance of a GPU vs. CPU. Design effort is held minimum for both CPU implementations and GPU implementations. Matrix multiplication, Advance Encryption …

Studying The Optimum Design Of Automotive Thermoelectric Air Conditioning, Alaa Attar

Dissertations

The remarkable amount of research being conducted on thermoelectrics gives the impression that this technology will have a bright future in power generation and temperature control systems. At the present time, thermoelectrics is applied widely for temperature control, but has not yet replaced conventional air-conditioning systems due to its lower performance. Currently, approximately 10% of annual vehicle fuel consumption corresponds to the air-conditioning system used to cool the vehicle cabin. Conventional air-conditioning systems cool the entire cabin; however, about 73% of a vehicle’s mileage occurs while the driver is the only occupant. These facts indicate the need for a single …

Application Of Starch-Based Nanoparticle Colloidal Dispersion In Curtain Coating, Ting Chen

Dissertations

In this research, a conventional petro-based latex was partially replaced with a biobased latex in a curtain coating. A common petro-based rheology modifier used in curtain coatings, which is relatively costly and difficult to disperse, was also replaced with two inorganic rheology modifiers. The influence of these materials on coating rheology and curtain stability was thoroughly examined.

In the rheological study, the interactions between biopolymer nanoparticles and inorganic rheology modifiers were found to improve the rheological properties of the biobased latex coatings. Changes in the rheological properties of the coatings were found to depend on the type of rheology modifier …

Numerical Simulation And Modeling Of Combustion In Scramjets, Ryan James Clark

Dissertations

In the last fifteen years the development of a viable scramjet has quickly approached the following long term goals: responsive sub-orbital space access; long-range, prompt global strike; and high-speed transportation. Nonetheless, there are significant challenges that need to be resolved. These challenges include high skin friction drag and high heat transfer rates, inherent to vehicles in sustained, hypersonic flight. Another challenge is sustaining combustion. Numerical simulation and modeling was performed to provide insight into reducing skin friction drag and sustaining combustion.

Numerical simulation was used to investigate boundary layer combustion, which has been shown to reduce skin friction drag. The …

Development Of A Capacity Deployment Model For Disrupted Supply Chain Networks, James D. Burns

Dissertations

The increasing complexity of modern supply chains is widely accepted as one of the many drivers of risk that can leave organizations vulnerable to the effects of a disruption. This acceptance has contributed to an emerging interest in Supply Chain Resilience in the literature. Resilient supply chains are able to both resist the effects of a disruption and recover efficiently if the disruption is severe. This new body of literature is still in a formative phase and has thus far focused on defining Supply Chain Resilience, proposing frameworks for its implementation, exploring factors that contribute to resilience, and investigating methods …

Novel Software Defined Radio Architecture With Graphics Processor Acceleration, Lalith Narasimhan

Dissertations

Wireless has become one of the most pervasive core technologies in the modern world. Demand for faster data rates, improved spectrum efficiency, higher system access capacity, seamless protocol integration, improved security and robustness under varying channel environments has led to the resurgence of programmable software defined radio (SDR) as an alternative to traditional ASIC based radios. Future SDR implementations will need support for multiple standards on platforms with multi-Gb/s connectivity, parallel processing and spectrum sensing capabilities. This dissertation implemented key technologies of importance in addressing these issues namely development of cost effective multi-mode reconfigurable SDR and providing a framework to …

Creating A Highway Information System For Safety Roadway Features, Brian K. Howell, Kenneth R. Agent, Eric Green

Kentucky Transportation Center Research Report

Roadway departures are the leading cause of roadside fatalities. The Kentucky Transportation Cabinet (KYTC) has undertaken a number of roadside safety measures to reduce roadway departures. Specifically, KYTC has installed several low-cost, systemic roadway safety treatments to Kentucky’s roadways in recent years. These treatments include cable barriers, high friction surface treatments, rumble stripes, and Safety Edges. KYTC has installed approximately 44 cable barrier systems over 265 miles of roadway,112 HFST applications over 20 miles of roadway, 750 rumble stripe installations over 2,500 miles of roadway, and 147 Safety Edge treatments on 580 miles of roadway. The project team developed a …

Understanding The Automotive Pedal Usage And Foot Movement Characteristics Of Older Drivers, Yubin Xi

All Dissertations

The purpose of this study was to understand the pedal usage characteristics of older drivers in various driving tasks using an instrumented vehicle. This study stemmed from the prevalence of the pedal application errors (PAEs) and the older drivers’overrepresentation in crashes caused by PAEs.

With the population increasing and becoming older, it is estimated that in 2020 there will be 40 million drivers over the age of 65 in the United States. Compared with their younger counterparts, older drivers are facing declining cognitive and physical abilities, such as impaired vision, slower reaction time and diminishing range of limb motion. Because …

Simulation Of Lateral Migration And Sedimentation Of A Flexible Fiber In A Vertical Weak Shear Flow, Ali Ibrahim Neamah Neamah

Masters Theses

This research is a thorough numerical investigation and critical analysis of lateral migration of a deformable particle settling in a vertical weak shear flow. Under the vertical weak shear fluid, the deformable particle may move either to the coagulation area, or the dispersion area, depending on Reynolds numbers, shear Reynolds number, fiber flexibility, and aspect ratio. In this study, a lattice Boltzmann equation is used to solve Navier-Stokes equation and a flexible particle method is employed to attack the problem of motion of a flexible fiber. A bounce-back rule is used to deal with moving boundaries interacting with fluids. Several …

A Parabolized Navier-Stokes Method For Wind Farm Applications, Anshul Mittal

Masters Theses and Doctoral Dissertations

Fluid flow simulations play an important role in the wind industry. With the development of large wind farms, flow simulations through an entire wind farm are becoming a necessity. These are required for designing the layout of new wind farms in the development stage and for forecasting power production from the existing ones for operational purposes. Conventional Navier-Stokes simulations (commonly referred to as CFD simulations) are computationally very expensive since they require a supercomputer with runtimes of several weeks. A Parabolized Navier-Stokes (PNS) method is developed and implemented in this study. The developed PNS method requires less stringent approximations as …

Design Of A New Digital Relay For Transmission Line Fault Detection, Classification And Localization Based On A New Composite Relay And Artificial Neural Network Approach, Ahmed Sabri Altaie

Masters Theses

This thesis focuses on new approach to detect, classify, and localize the fault in transmission line. Firstly, fault detection was carried out using the New Composite Relay (CR) which, has different characteristics and the ability to detect any type of fault including series faults. Secondly, fault classification was conducted using the Feed Forward Artificial Neural Network (FFANN). In addition, the fault classification led to the investigation of the best use of the FFANN. The data used come from MATLAB/SIMULINK three phase series compensated network. The results obtained using FFANN, were compared with the type of the fault that have been …

An Introduction To Defining Cost Estimates For Mechanical And Electrical Services Using The Nrm1, Charles Mitchell

Reports

Determining an accurate value for the supply and installation of mechanical and electrical services is a difficult task due to the level of specialisation and variance within this sector of the industry. The level of specialised knowledge and the ever changing technology has prevented the Quantity Surveyor from taking a firm hold on the cost estimation of these services. Cost estimates have previously been prepared by consultant services engineers or based on costs provided by these consultants.

However, employers nowadays require more cost certainty in the estimates of costs. As a direct result the New Rules of Measurement 1 (NRM1) …

Fiscal Year 2015 Fhwa-536 Report For The Kentucky Transportation Cabinet, Steven Douglas Kreis, Candice Y. Wallace, Bryan Gibson, Sarah M. Mccormack

Kentucky Transportation Center Research Report

The Federal Highway Administration (FHWA) requires state transportation agencies to submit a biennial report on local highway finances. The purpose of these reports is to provide FHWA with the data it needs to capture the financing of highway activities at the local level. Based on this information, it can identify trends in revenue, expenditures, investments, and program development, and in turn make decisions about future investments. The report, FHWA-536, asks agencies to report on four areas of local highway finance: 1) disposition of highway-user revenues; 2) revenues used for roads and streets identified by source and funding type; 3) road …

Evaluation Of Thermal Imaging Technology For Commercial Vehicle Screening, Jennifer R. Walton, Mark S. Spellman, Joseph D. Crabtree

Kentucky Transportation Center Research Report

Brake and tire violations are common problems identified through commercial vehicle inspections. Identifying and correcting these types of problems before a crash occurs can produce significant safety benefits. Thermal imaging technology can be used by commercial vehicle enforcement to screen vehicles as they approach a weigh station to determine if they may have flat tires and inoperable brakes. The vehicles do not have to be stopped at a weigh station to be screened. Kentucky currently has three stations outfitted with thermal imaging technology. The objectives of this study were to evaluate the benefits of using the thermal imaging cameras to …

Methodology Update For Estimating Volume To Service Flow Ratio, Mei Chen, Xu Zhang

Kentucky Transportation Center Research Report

Volume/service flow ratio (VSF) is calculated by the Highway Performance Monitoring System (HPMS) software as an indicator of peak hour congestion. It is an essential input to the Kentucky Transportation Cabinet’s (KYTC) key planning applications, such as highway adequacy rating. After the Federal Highway Administration (FHWA) reassessed the HPMS, the standalone HPMS software was no longer supported. This conclusion was based on the 2000 Highway Capacity Manual (HCM2000). As a result, the peak capacity and VSF estimates based on the submittal file are no longer available to KYTC. The calculation of VSF ratios requires AADT, K factor, directional factor, and …

Update Of Data For Estimating Esals, Jerry G. Pigman, R. Clark Graves, Brad W. Rister, David H. Cain, Neil Tollner

Kentucky Transportation Center Research Report

This project involved updating processing traffic characteristics data using a series of quality control and analytical programs to produce an estimate of the following parameters of interest; 1) average daily traffic, 2) percent trucks, 3) percent trucks classified as heavy/coal, 4) axles per truck, 5) axles per heavy/coal truck, 6) ESALs per truck axle, 7) ESALs per heavy/coal truck axle, and 8) total ESALs. ESAL estimation parameters used WIM data collected during 2007, 2011, and 2012–2013 (representing 41 stations); and classification data collected in 2010, 2011 and 2012 (representing 1,669 stations).

Computer programs used to process classification data, process weight …

Viscoelastic, Fatigue Damage, And Permanent Deformation Characterization Of High Rap Bituminous Mixtures Using Fine Aggregate Matrix (Fam), Hesamaddin Nabizadeh

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Performance characteristics of bituminous mixtures play the most influential role in designing flexible pavement. These asphaltic mixtures can be considered as heterogeneous mixtures which composed of two primary components: fine aggregate matrix (FAM) phase and aggregate phase. The FAM phase acts as a critical phase in evaluating the performance characteristics including viscoelastic, fatigue damage, and permanent deformation characteristics of entire asphalt mixtures. This study evaluates the viscoelastic, fatigue damage and permanent deformation characteristics of bituminous mixtures containing 65% reclaimed asphalt pavement (RAP) by performing oscillatory torsional shear tests of cylindrical bars of FAM using a dynamic mechanical analyzer. Moreover, this …

Effects Of Sediments On Bmps For Highway Runoff Control, Matthew Garder

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Numerous studies conducted on highway stormwater runoff and its control with Best Management Practices (BMPs) indicate that sediment is the major pollutant that affects performance and longevity of BMPs. Currently, there are several knowledge gaps related to the effects of sediments on highway BMPs: a) how much sediment will be generated by a construction site by a section of highway with its surrounding watershed under different conditions; b) how sediment is intercepted by different BMPs with or without pretreatment sections; and c) what are the effects of these sediments on BMPs’ hydraulic behavior, longevity, and pollutants removal or release. The …

Phase I Evaluation Of Selected Concrete Material Models In Ls-Dyna, Bradley J. Winkelbauer

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Numerous roadside safety systems are configured with reinforced concrete materials, such as bridge railings, median barriers, and roadside parapets. These protective barrier systems are intended to safely contain and redirect errant vehicles as well as prevent impacts into hazardous fixed objects or other geometric features. The analysis and design of these structures may involve impact simulation with finite element software, like LS-DYNA, which includes multiple concrete material models. For such investigations, limited guidance is available for selecting preferred concrete material models and determining appropriate values for specific parameters. This Phase I study investigated the viability and performance of existing concrete …

Method Assessment For Microalgae Quantification In Wastewater Treatment And Biofuel Production, Kristen S. Harrison

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

There is growing interest in the use of microalgae for wastewater treatment and biofuel production. However, there is not yet a reliable, user-friendly method of quantifying the biomass and lipid production of a large sample of algae. This study aims to establish and validate new methods for green microalgae quantification using the Microplate reader and the Coulter Counter. Chlorella vulgaris was chosen as the ‘ideal’ algal species for wastewater treatment and biofuel production due to its structure, lipid production, and pollution removal ability. Three traditional quantification methods -- microscope cell count, lipid separation, and chlorophyll extraction -- were compared to …

Phospho1 Deficiency Transiently Modifies Bone Architecture Yet Produces Consistent Modification In Osteocyte Differentiation And Vascular Porosity With Ageing, Behzad Javaheri, Alessandra Carriero, Katherine Ann Staines, Y.-M. Chang, D. A. Houston, Karla J. Oldknow, José Luis Millán, Bassir N. Kazeruni, Phil L. Salmon, Sandra J. Shefelbine

Biomedical Engineering and Sciences Faculty Publications

PHOSPHO1 is one of principal proteins involved in initiating bone matrix mineralisation. Recent studies have found that Phospho1 KO mice ( Phospho1-R74X) display multiple skeletal abnormalities with spontaneous fractures, bowed long bones, osteomalacia and scoliosis. These analyses have however been limited to young mice and it remains unclear whether the role of PHOSPHO1 is conserved in the mature murine skeleton where bone turnover is limited. In this study, we have used ex-vivo computerised tomography to examine the effect of Phospho1 deletion on tibial bone architecture in mice at a range of ages (5, 7, 16 and 34. weeks of age) …

The Effect Of Recency To Human Mobility, Hugo Barbosa, Fernando B. De Lima-Neto, Alexandre Evsukoff, Ronaldo Menezes

Biomedical Engineering and Sciences Faculty Publications

In recent years, we have seen scientists attempt to model and explain human dynamics and in particular human movement. Many aspects of our complex life are affected by human movement such as disease spread and epidemics modeling, city planning, wireless network development, and disaster relief, to name a few. Given the myriad of applications, it is clear that a complete understanding of how people move in space can lead to considerable benefits to our society. In most of the recent works, scientists have focused on the idea that people movements are biased towards frequently-visited locations. According to them, human movement …

Petrology And Geochemistry Of The Harlan, Kellioka, And Darby Coals From The Louellen 7.5-Minute Quadrangle, Harlan County, Kentucky, Michelle N. Johnston, James C. Hower, Shifeng Dai, Peipei Wang, Panpan Xie, Jingjing Liu

Center for Applied Energy Research Faculty and Staff Publications

The Harlan, Kellioka, and Darby coals in Harlan County, Kentucky, have been among the highest quality coals mined in the Central Appalachians. The Middle Pennsylvanian coals are correlative with the Upper Elkhorn No. 1 to Upper Elkhorn No. 3½ coals to the northwest of the Pine Mountain thrust fault. Much of the mining traditionally was controlled by captive, steel-company-owned mines and the coal was part of the high volatile A bituminous portion of the coking coal blend. Overall, the coals are generally low-ash and low-sulfur, contributing to their desirability as metallurgical coals. We did observe variation both in geochemistry, such …

Faster Maximium Priority Matchings In Bipartite Graphs, Jonathan Turner

All Computer Science and Engineering Research

A maximum priority matching is a matching in an undirected graph that maximizes a priority score defined with respect to given vertex priorities. An earlier paper showed how to find maximum priority matchings in unweighted graphs. This paper describes an algorithm for bipartite graphs that is faster when the number of distinct priority classes is limited. For graphs with k distinct priority classes it runs in O(kmn1/2) time, where n is the number of vertices in the graph and m is the number of edges.

Estimation On Gibbs Entropy For An Ensemble, Lekhya Sai Sake

Electronic Theses, Projects, and Dissertations

In this world of growing technology, any small improvement in the present scenario would create a revolution. One of the popular revolutions in the computer science field is parallel computing. A single parallel execution is not sufficient to see its non-deterministic features, as same execution with the same data at different time would end up with a different path. In order to see how non deterministic a parallel execution can extend up to, creates the need of the ensemble of executions. This project implements a program to estimate the Gibbs Entropy for an ensemble of parallel executions. The goal is …

Signage Recognition Based Wayfinding System For The Visually Impaired, Abdullah Khalid Ahmed

Masters Theses

Persons of visual impairment make up a growing segment of modern society. To cater to the special needs of these individuals, society ought to consider the design of special constructs to enable them to fulfill their daily necessities. This research proposes a new method for text extraction from indoor signage that will help persons of visual impairment maneuver in unfamiliar indoor environments, thus enhancing their independence and quality of life.

In this thesis, images are acquired through a video camera mounted on glasses of the walking person. Frames are then extracted and used in an integrated framework that applies Maximally …

A High Performance Architecture For An Exact Match Short-Read Aligner Using Burrows-Wheeler Aligner On Fpgas, Dana Abdul Qader

Masters Theses

Due to modern DNA sequencing technologies vast amount of short DNA sequences known as short-reads is generated. Biologists need to be able to align the short-reads to a reference genome to be able to make scientific use of the data. Fast and accurate short-read aligner programs are needed to keep up with the pace at which this data is generated. Field Programmable Gate Arrays have been widely used to accelerate many data-intensive bioinformatics applications.

Burrows-Wheeler Transform has been used in the theory of string matching which has led to the development of many short-read alignment programs. This thesis presents a …

Midfield Rf Signal Detector, Dawei Zhang

Electrical Engineering

This project is part of a Master’s thesis which looks at alternative ways to measure blood glucose. The Master’s thesis uses mid-field signals in order to match impedance and therefore lose less power as they travel through flesh. The goal of this senior project is to build a receiver for those signals and give accurate RSSI (received signal strength indicator) measurements. Mid-fields were originally explored by Stanford professor Dr. Ada Poon [3] who used the signaling technique to recharge the batteries of deeply implanted devices. Devices implanted near the surface of the skin were able to have their batteries recharged …