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Articles 5671 - 5700 of 6303
Full-Text Articles in Engineering
Creating A Learning Environment That Supports Innovation And Deep Learning In Geotechnical Engineering, Glenn W. Ellis
Creating A Learning Environment That Supports Innovation And Deep Learning In Geotechnical Engineering, Glenn W. Ellis
Engineering: Faculty Publications
No abstract provided.
Characterization Of Deep Levels In N-Type And Semi-Insulating 4h-Sic Epitaxial Layers By Thermally Stimulated Current Spectroscopy, P. G. Muzykov, Ramesh Madhu Krishna, K. C. Mandal
Characterization Of Deep Levels In N-Type And Semi-Insulating 4h-Sic Epitaxial Layers By Thermally Stimulated Current Spectroscopy, P. G. Muzykov, Ramesh Madhu Krishna, K. C. Mandal
Faculty Publications
No abstract provided.
Metallic Patterning Using An Atomic Force Microscope Tip And Laser-Induced Liquid Deposition, Carlos Andrés Jarro Sanabria
Metallic Patterning Using An Atomic Force Microscope Tip And Laser-Induced Liquid Deposition, Carlos Andrés Jarro Sanabria
Theses and Dissertations--Electrical and Computer Engineering
The development of nanoscale patterns has a vast variety of applications going from biology to solid state devices. In this research we present a new direct patterning technique in which laser photoreduction of silver from a liquid is controlled by a scanning atomic force microscope tip. While pursuing the formation of patterns using the plasmonic field enhancement of an electromagnetic wave incident on a metallic Atomic Force Microscope (AFM) tip, our group discovered that contrary to expectations, the tip suppresses, rather than enhances, deposition on the underlying substrate, and this suppression persists in the absence of the tip. Experiments presented …
Feedback Control For Electron Beam Lithography, Yugu Yang
Feedback Control For Electron Beam Lithography, Yugu Yang
Theses and Dissertations--Electrical and Computer Engineering
Scanning-electron-beam lithography (SEBL) is the primary technology to generate arbitrary features at the nano-scale. However, pattern placement accuracy still remains poor compared to its resolution due to the open-loop nature of SEBL systems. Vibration, stray electromagnetic fields, deflection distortion and hysteresis, substrate charging, and other factors prevent the electron-beam from reaching its target position and one has no way to determine the actual beam position during patterning with conventional systems. To improve the pattern placement accuracy, spatial-phase-locked electron-beam lithography (SPLEBL) provides feedback control of electron-beam position by monitoring the secondary electron signal from electron-transparent fiducial grids on the substrate. While …
Tracking Articulator Movements Using Orientation Measurements, An Ji, Michael T. Johnson, Jeffrey J. Berry
Tracking Articulator Movements Using Orientation Measurements, An Ji, Michael T. Johnson, Jeffrey J. Berry
Speech Pathology and Audiology Faculty Research and Publications
This paper introduces a new method to track articulator movements, specifically jaw position and angle, using 5 degree of freedom (5 DOF) orientation data. The approach uses a quaternion rotation method to accomplish this jaw tracking during speech using a single senor on the mandibular incisor. Data were collected using the NDI Wave Speech Research System for one pilot subject with various speech tasks. The degree of jaw rotation from the proposed approach is compared with traditional geometric calculation. Results show that the quaternion based method is able to describe jaw angle trajectory and gives more accurate and smooth estimation …
Sensing Through The Continent: Towards Monitoring Migratory Birds Using Cellular Sensor Networks, David Anthony, William P. Bennett, Mehmet C. Vuran, Matthew B. Dwyer, Sebastian Elbaum, Anne Lacy, Mike Engels, Walter Wehtje
Sensing Through The Continent: Towards Monitoring Migratory Birds Using Cellular Sensor Networks, David Anthony, William P. Bennett, Mehmet C. Vuran, Matthew B. Dwyer, Sebastian Elbaum, Anne Lacy, Mike Engels, Walter Wehtje
School of Computing: Conference and Workshop Papers
This paper presents CraneTracker, a novel sensor platform for monitoring migratory birds. The platform is designed to monitor Whooping Cranes, an endangered species that conducts an annual migration of 4, 000 km between southern Texas and north-central Canada. CraneTracker includes a rich set of sensors, a multi-modal radio, and power control circuitry for sustainable, continental-scale information delivery during migration. The need for large-scale connectivity motivates the use of cellular technology in low-cost sensor platforms augmented by a low-power transceiver for ad-hoc connectivity. This platform leads to a new class of cellular sensor networks (CSNs) for time-critical and mobile sensing applications. …
Tuning Of The Size And The Lattice Parameter Of Ion-Beam Synthesized Pb Nanoparticles Embedded In Si, Huan Wang, J. Cuppens, E. Biermans, S. Bals, Lucia Fernandez-Ballester, K. O. Kvashnina, W. Bras, M. J. Van Bael, K. Temst, A. Vantomme
Tuning Of The Size And The Lattice Parameter Of Ion-Beam Synthesized Pb Nanoparticles Embedded In Si, Huan Wang, J. Cuppens, E. Biermans, S. Bals, Lucia Fernandez-Ballester, K. O. Kvashnina, W. Bras, M. J. Van Bael, K. Temst, A. Vantomme
Department of Engineering Mechanics: Faculty Publications
The size and lattice constant evolution of Pb nanoparticles (NPs) synthesized by high fluence implantation in crystalline Si have been studied with a variety of experimental techniques. Results obtained from small-angle x-ray scattering showed that the Pb NPs grow with increasing implantation fluence and annealing duration. The theory of NP growth kinetics can be applied to qualitatively explain the size evolution of the Pb NPs during the implantation and annealing processes. Moreover, the lattice constant of the Pb NPs was evaluated by conventional x-ray diffraction. The lattice dilatation was observed to decrease with increasing size of the Pb NPs. Such …
Experimental Testing And Finite-Element Modeling To Evaluate The Effects Of Aggregate Angularity On Bituminous Mixture Performance, Leonardo T. Souza, Yong-Rak Kim, Flavio V. Souza, Leandro S. Castro
Experimental Testing And Finite-Element Modeling To Evaluate The Effects Of Aggregate Angularity On Bituminous Mixture Performance, Leonardo T. Souza, Yong-Rak Kim, Flavio V. Souza, Leandro S. Castro
Department of Engineering Mechanics: Faculty Publications
This study evaluates the effects of aggregate angularity in bituminous mixtures. Previous studies have predominantly focused on the effects of aggregate angularity on the resistance to permanent deformation, while little work has investigated the role of aggregate angularity related to mixture volumetrics and fatigue fracture performance. To investigate the effect of aggregate angularity on mixture performance and characteristics, five mixes with different combinations of coarse and fine aggregate angularity are evaluated by performing the uniaxial static creep test and the indirect tensile fracture energy test. The asphalt pavement analyzer test is also performed with five-year field project mixtures. Fracture energy …
Real-Time Optimal Participation Of Wind Power In An Electricity Market, Ting Dai, Wei Qiao, Liyan Qu
Real-Time Optimal Participation Of Wind Power In An Electricity Market, Ting Dai, Wei Qiao, Liyan Qu
Department of Electrical and Computer Engineering: Faculty Publications
While integrating wind power into the electricity market can reduce the operational and fuel costs of the power system, it also increases the imbalance cost and the need for reserve. Due to this contradictory, there is a need for planning the amount of wind power in the power system. This paper proposes a model to determine the real-time optimal participation of wind power in an electricity market. This model assumes that the system operator will regulate the participation level of the wind power due to the increasing cost of reserve. Case studies are presented to demonstrate the use of the …
Imbalance Fault Detection Of Direct-Drive Wind Turbines Using Generator Current Signals, Xiang Gong, Wei Qiao
Imbalance Fault Detection Of Direct-Drive Wind Turbines Using Generator Current Signals, Xiang Gong, Wei Qiao
Department of Electrical and Computer Engineering: Faculty Publications
Imbalance faults constitute a significant portion of all faults in wind turbine generators (WTGs). WTG imbalance fault detection using generator current measurements has advantages over traditional vibration-based methods in terms of cost, implementation, and system reliability. However, there are challenges in using current signals for imbalance fault detection due to low signal-to-noise ratio of the useful information in current signals and non-stationary characteristic frequencies of imbalance faults. This paper proposes a method of using generator stator currents for imbalance fault detection of direct-drive WTGs. In the proposed method, the variable shaft rotating frequency of a WTG is estimated from one …
Power Semiconductor Devices, Jerry Hudgins, Rik W. De Doncker
Power Semiconductor Devices, Jerry Hudgins, Rik W. De Doncker
Department of Electrical and Computer Engineering: Faculty Publications
Historically, Power Semiconductor devices have been divided into three broad categories: diodes, transistors, and thyristors. Although modern devices can be classified in this way, there is an increasing overlap in device design and function. Also semiconductors, such as silicon carbide (SiC), gallium nitride (GaN), and other materials, as well as novel device designs have increased the suitability and broadened the applications of semiconductor switches in megawatt (MW) power conversion circuits and systems.
Modern Transistors
Transistors include the traditional power bipolar (nonsilicon materials being considered for the future), power metal-oxide-semiconductor field-effect transistors (MOSFETs), and hybrid devices that have some aspect of …
A Series-Connected Self-Reconfigurable Multicell Battery Capable Of Safe And Effective Charging/Discharging And Balancing Operations, Taesic Kim, Wei Qiao, Liyan Qu
A Series-Connected Self-Reconfigurable Multicell Battery Capable Of Safe And Effective Charging/Discharging And Balancing Operations, Taesic Kim, Wei Qiao, Liyan Qu
Department of Electrical and Computer Engineering: Faculty Publications
Bidirectional DC/DC converters are commonly used for charging and discharging multicell batteries under various modes, such as Pulsed Current (PC), Constant Current (CC), and Constant Current Constant Voltage (CCCV). The charge and discharge are usually terminated by the converters when battery voltages reach some threshold values. However, cell state imbalance is commonly present in traditional multicell batteries, which reduces the available capacities of the batteries in certain charge/discharge cycles and shortens the life cycles of the batteries. To solve this problem, this paper proposes a series-connected, self-reconfigurable, multicell battery with a bidirectional DC/DC converter capable of safe and effective charging, …
Analysis Of Π-Phase-Shifted Fiber Bragg Gratings For Ultrasonic Detection, Tongqing Liu, Ming Han
Analysis Of Π-Phase-Shifted Fiber Bragg Gratings For Ultrasonic Detection, Tongqing Liu, Ming Han
Department of Electrical and Computer Engineering: Faculty Publications
Using numerical simulations, we investigated the responses of the π-phase-shifted fiber Bragg gratings (πFBGs) impinged by pressure ultrasonic waves. The effect of the grating length, grating refractive index modification depth, and ultrasonic frequency on the wavelength sensitivity and intensity sensitivity of the πFBG ultrasonic sensor for ultrasonic waves of different wavelengths was analyzed. The directivity of a πFBG sensor was also studied. Our analysis revealed several unique πFBG response characteristics and will be useful in the design and optimization of fiber-optic ultrasonic sensors that use a πFBG as the sensing element.
Optical Properties Of Cobalt Slanted Columnar Thin Films Passivated By Atomic Layer Deposition, Daniel Schmidt, Eva Schubert, Mathias Schubert
Optical Properties Of Cobalt Slanted Columnar Thin Films Passivated By Atomic Layer Deposition, Daniel Schmidt, Eva Schubert, Mathias Schubert
Department of Electrical and Computer Engineering: Faculty Publications
Optical properties of passivated metal slanted columnar thin films from cobalt within the visible spectral region are reported. Glancing angle deposition is utilized to grow slanted nano-columns which have been conformally coated with Al2O3 by a subsequent atomic layer deposition process. A generalized anisotropic Bruggeman effective medium approximation has been employed to analyze spectroscopic generalized ellipsometry data. The modified homogenization approach allows for determination of biaxial (monoclinic) optical and structural properties as well as fractions of three film constituents. The conformal alumina passivation layer preserves the pristine metal character of the nano-structures and prevents oxidation and aging …
Position Extraction From A Discrete Sliding-Mode Observer For Sensorless Control Of Ipmsms, Yue Zhao, Wei Qiao, Long Wu
Position Extraction From A Discrete Sliding-Mode Observer For Sensorless Control Of Ipmsms, Yue Zhao, Wei Qiao, Long Wu
Department of Electrical and Computer Engineering: Faculty Publications
Sliding-mode observers (SMOs) offer a promising solution for sensorless control of interior permanent magnet synchronous machines (IPMSMs) due to their excellent robustness to system structure and parameter uncertainty. However, in practical applications, it is challenging for an SMO to achieve a perfect estimation for the back electromagnetic force (EMF) using a finite or relatively lower sampling frequency, especially for high-speed applications. Phase shift, magnitude variation, and heavy noise in the estimated back EMF will cause unexpected errors in rotor position extraction. Thus, advanced rotor position extraction methods are needed to obtain position information from the estimated back EMF. This paper …
Compensation Algorithms For Sliding Mode Observers In Sensorless Control Of Ipmsms, Yue Zhao, Wei Qiao, Long Wu
Compensation Algorithms For Sliding Mode Observers In Sensorless Control Of Ipmsms, Yue Zhao, Wei Qiao, Long Wu
Department of Electrical and Computer Engineering: Faculty Publications
Electromechanical sensors are commonly used to obtain rotor position/speed for high-performance control of interior permanent magnet synchronous machines (IPMSMs) in vehicle systems. However, the use of these sensors increases the cost, size, weight, wiring complexity and reduces the mechanical robustness of IPMSM drive systems. These issues, together with some practical requirements, e.g., wide speed range, extreme environment temperature, and adverse loading conditions, make a sensorless control scheme desirable. This paper proposes an extended back electromotive force (EMF)-based sliding mode rotor position observer for sensorless vector control of IPMSMs. Based on filter characteristics, a robust compensation algorithm is developed to improve …
A Low-Cost, Reliable, High-Throughput System For Rodent Behavioral Phenotyping In A Home Cage Environment, Steven A. Parkison, Jay D. Carlson, Tammy R. Chaudoin, Traci A. Hoke, A. Katrin Schenk, Evan H. Goulding, Lance C. Pérez, Stephen J. Bonasera
A Low-Cost, Reliable, High-Throughput System For Rodent Behavioral Phenotyping In A Home Cage Environment, Steven A. Parkison, Jay D. Carlson, Tammy R. Chaudoin, Traci A. Hoke, A. Katrin Schenk, Evan H. Goulding, Lance C. Pérez, Stephen J. Bonasera
Department of Electrical and Computer Engineering: Faculty Publications
Inexpensive, high-throughput, low maintenance systems for precise temporal and spatial measurement of mouse home cage behavior (including movement, feeding, and drinking) are required to evaluate products from large scale pharmaceutical design and genetic lesion programs. These measurements are also required to interpret results from more focused behavioral assays. We describe the design and validation of a highly-scalable, reliable mouse home cage behavioral monitoring system modeled on a previously described, one-ofa- kind system [1]. Mouse position was determined by solving static equilibrium equations describing the force and torques acting on the system strain gauges; feeding events were detected by a photobeam …
Nonlinear Plasmonic Cloaks To Realize Giant All-Optical Scattering Switching, Christos Argyropoulos, Pai-Yen Chen, Francesco Monticone, Giuseppe D'Aguanno, Andrea Alu
Nonlinear Plasmonic Cloaks To Realize Giant All-Optical Scattering Switching, Christos Argyropoulos, Pai-Yen Chen, Francesco Monticone, Giuseppe D'Aguanno, Andrea Alu
Department of Electrical and Computer Engineering: Faculty Publications
Here we extend the reach of Fano resonant coupling by combining this concept with cloaking and plasmonic resonances in a single nonlinear nanoparticle, in order to realize giant all-optical scattering nanoswitches controlled by moderate pumping intensities. We show that a core-shell nonlinear plasmonic particle may be designed to abruptly switch from being completely cloaked to being strongly resonant, with up to a 40 dB cross-sectional difference. Self-tunable optical cloaks and resonant scatterers are envisioned for use as efficient all-optical switches and nanomemories.
Boosting Optical Nonlinearities In E-Near-Zero Plasmonic Channels, Christos Argyropoulos, Pai-Yen Chen, Giuseppe D'Aguanno, Nadar Engheta, Andrea Alu
Boosting Optical Nonlinearities In E-Near-Zero Plasmonic Channels, Christos Argyropoulos, Pai-Yen Chen, Giuseppe D'Aguanno, Nadar Engheta, Andrea Alu
Department of Electrical and Computer Engineering: Faculty Publications
The anomalous transmission properties of zero-permittivity ultranarrow channels are used to boost Kerr nonlinearities and achieve switching and bistable response for moderate optical intensities. Strong field enhancement, uniform all along the channel, is a typical feature of ε-near-zero supercoupling and is shown to be particularly suited to enhance nonlinear effects. This is obtained by designing narrow apertures at cutoff in a plasmonic screen. We show that this nonlinear mechanism can significantly outperform nonlinearities in traditional Fabry-P´erot resonant gratings.
Broadband Brewster Transmission Through 2d Metallic Gratings, Khai Q. Le, Christos Argyropoulos, Nadia Mattiucci, Giuseppe D'Aguanno, Mark J. Bloemer, Andrea Alu
Broadband Brewster Transmission Through 2d Metallic Gratings, Khai Q. Le, Christos Argyropoulos, Nadia Mattiucci, Giuseppe D'Aguanno, Mark J. Bloemer, Andrea Alu
Department of Electrical and Computer Engineering: Faculty Publications
Recently, we have introduced a mechanism to achieve ultrabroadband light funnelling and total transmission through 1D narrow metallic gratings at a specific incidence angle, the so-called plasmonic Brewster angle. This phenomenon is based on impedance matching between the guided modes supported by ultranarrow linear slits and transverse-magnetic waves at oblique incidence. In this paper, we demonstrate that such phenomenon, representing the equivalent of Brewster transmission for plasmonic screens, can also occur in 2D metallic gratings of various structural forms and shapes, and that it may be made insensitive to the azimuthal, or polarization, angle u. This finding may have relevant …
Laser Induced Breakdown Spectroscopy Having Enhanced Signal-To-Noise Ratio, Dennis R. Alexander, Troy Anderson, John C. Bruce Iii
Laser Induced Breakdown Spectroscopy Having Enhanced Signal-To-Noise Ratio, Dennis R. Alexander, Troy Anderson, John C. Bruce Iii
Department of Electrical and Computer Engineering: Faculty Publications
A material can be analyzed using short pulses by applying a first pulse and a second pulse to the material in which the second pulse is delayed relative to the first pulse. The first and second pulses are directed toward a material along collinear paths, and the material is ablated using the first pulse to cause particles to be emitted from the surface of the material. The emitted particles are atomized and/or ionized using the second pulse, and the radiation from the atomized and/or ionized particles is analyzed.
Empirical Correction For Spectroscopic Ellipsometric Measurements Of Rough Or Textured Surfaces, Craig M. Herzinger, Blaine D. Johs, Mathias M. Schubert, Tino Hofmann
Empirical Correction For Spectroscopic Ellipsometric Measurements Of Rough Or Textured Surfaces, Craig M. Herzinger, Blaine D. Johs, Mathias M. Schubert, Tino Hofmann
Department of Electrical and Computer Engineering: Faculty Publications
A method of applying spectroscopic ellipsometry to arrive at accurate values of optical and physical properties for thin films on samples having rough or textured surfaces.
An Adaptive Algorithm For Corrupted Images, Deborah D. Duran-Herrmann, Qilin Qi, Yaoqing Lamar Yang
An Adaptive Algorithm For Corrupted Images, Deborah D. Duran-Herrmann, Qilin Qi, Yaoqing Lamar Yang
Department of Electrical and Computer Engineering: Faculty Publications (to 2015)
Noise is ever-present in communication channels and can produce devastating degradation to the images at the receiver end. In this paper, a novel approach to detecting different types of noise models in corrupted images is presented. Basically, it is a two-step process that has the ability to handle real-time applications due to its computational simplicity. The proposed algorithm handles error correction more efficiently in the second stage of processing, given a means to detect the type of noise present in the first stage. This algorithm will be verified and tested against existing methods on different noise models. Preliminary results show …
Cross-Layer Optimized Coding Mode Selection For Wireless Video Communications, Yun Ye, Song Ci, Dalei Wu
Cross-Layer Optimized Coding Mode Selection For Wireless Video Communications, Yun Ye, Song Ci, Dalei Wu
Department of Electrical and Computer Engineering: Faculty Publications (to 2015)
This paper proposed a coding mode selection method for video transmission over wireless networks. Unlike previous mode selection methods disregarding channel distortion or assuming constant packet loss rate (PLR), this method includes a cross-layer controller to collect both source and channel information. The mode selection process is formulated as a delay constrained distortion minimization problem. The three components in the resulting Lagrange cost function, namely distortion, Lagrange multiplier and packet delay, are estimated with online channel information feedback. Suboptimal coding decision and physical layer modulation and coding scheme (MCS) are determined by the controller for each packet. In our experiment, …
Coupled Electromagnetic And Heat Transfer Model For Microwave Heating In Domestic Ovens, Krishnamoorthy Pitchai, Sohan Birla, Jeyamkondan Subbiah, D. D. Jones, Harshanardhan Thippareddi
Coupled Electromagnetic And Heat Transfer Model For Microwave Heating In Domestic Ovens, Krishnamoorthy Pitchai, Sohan Birla, Jeyamkondan Subbiah, D. D. Jones, Harshanardhan Thippareddi
Department of Food Science and Technology: Faculty Publications
Microwave ovens are used extensively for heating a variety of not-ready-to-eat food products. Non-uniform heating of foods in microwave ovens is a major concern in assuring microbiological safety of such products. The non-uniform heating of foods is attributed by complex interaction of microwaves with foods. To understand this complex interaction, a comprehensive model was developed to solve coupled electromagnetic and heat transfer equations using finite-difference time-domain based commercial software. The simulation parameters, cell size, heating time step, and number of iterations for steady state electromagnetic field were optimized. The model was validated by 30 s heating profile of a cylindrical …
Moisture Damage Characterization Of Warm-Mix Asphalt Mixtures Based On Laboratory-Field Evaluation, Yong-Rak Kim, Jun Zhang, Hoki Ban
Moisture Damage Characterization Of Warm-Mix Asphalt Mixtures Based On Laboratory-Field Evaluation, Yong-Rak Kim, Jun Zhang, Hoki Ban
Department of Mechanical and Materials Engineering: Faculty Publications
This study presents laboratory evaluation integrated with field performance to examine two widely used warm-mix asphalt (WMA) approaches—foaming and emulsion technology. For a more realistic evaluation of the WMA approaches, trial pavement sections of the WMA mixtures and their counterpart hot-mix asphalt (HMA) mixtures were implemented in Antelope County, Nebraska. Field-mixed loose mixtures collected at the time of paving were transported to the laboratories to conduct various experimental evaluations of the individual mixtures. Among the laboratory tests, three (two conventional and one newly attempted) were performed to characterize moisture damage potential which is the primary focus of this study. From …
Monitoring The Wall Mechanics During Stent Deployment In A Vessel, Brian Steinert, Shijia Zhao, Linxia Gu
Monitoring The Wall Mechanics During Stent Deployment In A Vessel, Brian Steinert, Shijia Zhao, Linxia Gu
Department of Mechanical and Materials Engineering: Faculty Publications
Clinical trials have reported different restenosis rates for various stent designs . It is speculated that stentinduced strain concentrations on the arterial wall lead to tissue injury, which initiates restenosis . This hypothesis needs further investigations including better quantifications of non-uniform strain distribution on the artery following stent implantation. A non-contact surface strain measurement method for the stented artery is presented in this work. ARAMIS stereo optical surface strain measurement system uses two optical high speed cameras to capture the motion of each reference point, and resolve three dimensional strains over the deforming surface. As a mesh stent is deployed …
Thickness-Shear And Thickness-Twist Modes In An Oblate Elliptical Ceramic Cylinder And Energy Trapping In Contoured Acoustic Wave Resonators, Huijing He, Jiashi Yang, Yi-Hua Huang
Thickness-Shear And Thickness-Twist Modes In An Oblate Elliptical Ceramic Cylinder And Energy Trapping In Contoured Acoustic Wave Resonators, Huijing He, Jiashi Yang, Yi-Hua Huang
Department of Mechanical and Materials Engineering: Faculty Publications
We study shear-horizontal motions of a piezoelectric ceramic cylinder with an oblate elliptical cross section and axial poling. Exact thickness-shear and thickness-twist vibration modes are obtained. These modes show energy trapping, i.e., the vibration is mainly confined near the thick, central region and decays to almost nothing near the edges. The results are useful for the understanding and design of contoured piezoelectric resonators for strong energy trapping.
Systems And Synthetic Biology Of The Vessel Wall, Jennifer Frueh, Nataly Maimari, Ying Lui, Zoltan Kis, Vikram Mehta, Negin Pormehr, Calum Grant, Emmanuel Chalkias, Mika Falck-Hansen, Sandra Bovens, Ryan M. Pedrigi, Taka Homma, Gianfillippo Coppola, Rob Krams
Systems And Synthetic Biology Of The Vessel Wall, Jennifer Frueh, Nataly Maimari, Ying Lui, Zoltan Kis, Vikram Mehta, Negin Pormehr, Calum Grant, Emmanuel Chalkias, Mika Falck-Hansen, Sandra Bovens, Ryan M. Pedrigi, Taka Homma, Gianfillippo Coppola, Rob Krams
Department of Mechanical and Materials Engineering: Faculty Publications
Atherosclerosis is intimately coupled to blood flow by the presence of predilection sites. The coupling is through mechanotransduction of endothelial cells and approximately 2000 gene are associated with this process. This paper describes a new platform to study and identify new signalling pathways in endothelial cells covering an atherosclerotic plaque. The identified networks are synthesized in primary cells to study their reaction to flow. This synthetic approach might lead to new insights and drug targets.
Nanotopographic Cell Culture Substrate: Polymer-Demixed Nanotextured Films Under Cell Culture Conditions, Jung Yul Lim, Christopher A. Siedlecki, Henry J. Donahue
Nanotopographic Cell Culture Substrate: Polymer-Demixed Nanotextured Films Under Cell Culture Conditions, Jung Yul Lim, Christopher A. Siedlecki, Henry J. Donahue
Department of Mechanical and Materials Engineering: Faculty Publications
Modulating physical cell culture environments via nanoscale substrate topographic modification has recently been of significant interest in regenerative medicine. Many studies have utilized a polymer-demixing technique to produce nanotextured films and showed that cellular adhesion, proliferation, and differentiation could be regulated by the shape and scale of the polymer-demixed nanotopographies. However, little attention has been paid to the topographic fidelity of the polymer-demixed films when exposed to cell culture conditions. In this brief article, two polymer-demixing systems were employed to assess topographic changes in polymer-demixed films after fibronectin (FN) extracellular matrix protein adsorption and after incubation in phosphate-buffered saline at …