Engineering Commons^™

Nitrocellulose Paper Based Microfluidic Platform Development And Surface Functionalization With Anti-Ige Aptamers, Jennifer Guerin Ward

Master's Theses

The purpose of this thesis project was to demonstrate the ability to utilize the capabilities of aptamers so that they may act as capture reagents for paper microfluidic devices. Several characterization experiments were conducted as a precursor before the final experimentation was performed. Paper characterization, manufacturing protocols for printing and heating, as well as 3D chip fabrication were all performed and analyzed. The results confirmed that the control of fluid through a 3D microfluidic device based in nitrocellulose is possible.

For the biochemistry portion of this thesis report, antibodies and aptamers were chosen to react with IgE, an antibody that …

Energy Harvesting From Elliptical Machines: Dc-Dc Converter Design Using Sepic Topology, Martin Kou

Master's Theses

Cal Poly’s ongoing Energy Harvesting from Exercise Machines (EHFEM) project is a very convenient and cost-effective way for generating DC power from physical exercise and sending it back to the electrical grid as AC power, providing a renewable energy source for the future. The EHFEM project consists of numerous subprojects involving converting different types of exercise machines for power generation. This project is a continuation of one of the previous subprojects, specifically involving an elliptical machine, and focuses on improving system functionality at different machine settings without altering the elliptical user’s experience by selecting a new DC-DC converter design, while …

Improvement Of Statistical Process Control At St. Jude Medical's Cardiac Manufacturing Facility, Christopher Lance Edwards

Master's Theses

Sig sigma is a methodology where companies strive to reproduce results ending up having a 99.9996% chance their product will be void of defects. In order for companies to reach six sigma, statistical process control (SPC) needs to be introduced. SPC has many different tools associated with it, control charts being one of them. Control charts play a vital role in managing how a process is behaving. Control charts allow users to identify special causes, or shifts, and can therefore change the process to keep producing good products, free of defects.

There are many factories and manufacturing facilities having implemented …

Impedance Sensing Of N2a And Astrocytes As Grounds For A Central Nervous System Cancer Diagnostic Device, Fraser Traves Smith Grove

Master's Theses

This thesis utilizes previously described manufacturing and design techniques for the creation of a PDMS-glass bonded microfluidic device, capable of electrochemical impedance spectroscopy (EIS). EIS has been used across various fields of research for different diagnostic needs. The major aim of this thesis was to capture cancerous and non-cancerous cells between micron sized electrodes within a microfluidic path, and to complete analysis on the measured impedances recorded from the two differing cell types. Two distinct ranges of impedance frequency were analyzed – the α dispersion range, which quantifies the impedance of the membranes of the cells of interest, and the …

Lottery Scheduling In The Linux Kernel: A Closer Look, David Zepp

Master's Theses

This paper presents an implementation of a lottery scheduler, presented from design through debugging to performance testing. Desirable characteristics of a general purpose scheduler include low overhead, good overall system performance for a variety of process types, and fair scheduling behavior. Testing is performed, along with an analysis of the results measuring the lottery scheduler against these characteristics. Lottery scheduling is found to provide better than average control over the relative execution rates of processes. The results show that lottery scheduling functions as a good mechanism for sharing the CPU fairly between users that are competing for the resource. While …

A Proposed Control Solution For The Cal Poly Wind Energy Capture System, Kent R. Burnett

Master's Theses

The focus of this thesis is to research, analyze, and design a reliable and economical control system for the Cal Poly Wind Energy Capture System (WECS). A dynamic permanent magnet generator model is adopted from [1] and [2] and combined with an existing wind turbine model to create a non-linear time varying model in MATLAB. The model is then used to analyze potentially harmful electrical disturbances, and to define safe operating limits for the WECS. An optimal operating point controller utilizing a PID speed loop is designed with combined optimization criteria and the final controller design …

A Model Predictive Control Approach To Roll Stability Of A Scaled Crash Avoidance Vehicle, Nikola John Linn Noxon

Master's Theses

In this paper, a roll stability controller (RSC) is presented based on an eight degree of freedom dynamic vehicle model. The controller is designed for and tested on a scaled vehicle performing obstacle avoidance maneuvers on a populated test track. A rapidly-exploring random tree (RRT) algorithm is used for the vehicle to execute a trajectory around an obstacle, and examines the geographic, non-homonymic, and dynamic constraints to maneuver around the obstacle. A model predictive controller (MPC) uses information about the vehicle state and, based on a weighted performance measure, generates an optimal trajectory around the obstacle. The RSC uses the …

Small-Scale Solar Central Receiver System Design And Analysis, Daniel Murray

Master's Theses

This thesis develops an analytical model of a small-scale solar central receiver power plant located at the California Polytechnic State University in San Luis Obispo, California at 35.28° N, 120.66° W. The model is used to analyze typical energy output at any time during the year. The power plant is designed to produce an output of 100 kW electrical power, and is supplemented by the combustion of natural gas. Methodologies for determining the proper size and layout of heliostats, optimal tower height, receiver size, and turbine engine selection are developed. In this specific design, solar shares of up to 73.2% …

Cuda Web Api Remote Execution Of Cuda Kernels Using Web Services, Massimo J. Becker

Master's Theses

Massively parallel programming is an increasingly growing field with the recent introduction of general purpose GPU computing. Modern graphics processors from NVIDIA and AMD have massively parallel architectures that can be used for such applications as 3D rendering, financial analysis, physics simulations, and biomedical analysis. These massively parallel systems are exposed to programmers through in- terfaces such as NVIDIAs CUDA, OpenCL, and Microsofts C++ AMP. These frame- works expose functionality using primarily either C or C++. In order to use these massively parallel frameworks, programs being implemented must be run on machines equipped with massively parallel hardware. These requirements limit …

Cubesat Mission Planning Toolbox, Brian Castello

Master's Theses

We are in an era of massive spending cuts in educational institutions, aerospace companies and governmental entities. Educational institutions are pursuing more training for less money, aerospace companies are reducing the cost of gaining ight heritage and the government is cutting budgets and their response times. Organizations are accomplishing this improved efficiency by moving away from large-scale satellite projects and developing pico and nanosatellites following the CubeSat specifications. One of the major challenges of developing satellites to the standard CubeSat mission requirements is meeting the exceedingly tight power, data and communication constraints.

A MATLAB toolbox was created to assist the …

Prediction Of Articular Cartilage Remodeling During Dynamic Compression With A Finite Element Model, Kevin Akira Yamauchi

Master's Theses

First, an in vitro growth experiment was performed to test the hypothesis that applying dynamic unconfined compression during culture produces het- erogeneous remodeling in newborn bovine articular cartilage explants. Het- erogeneous measures of cartilage microstructure were obtained by biochemical assays and quantified polarized light microscopy. Significant differences were measured between the GAG content in the inner and outer portions of the sam- ples stimulated with dynamic unconfined compression. The COL fiber network was found to be more highly aligned in the inner portion of the sample than in the peripheral region.

Next, a poroelastic finite element model with a remodeling …

Application Of A Heuristic Method To A Water Distribution System For Determining Optimal Water Quality Monitoring Locations, Lawrence David Johnson

Master's Theses

Although regulations and requirements for water quality source monitoring have increased, drinking water distribution systems can still be considered vulnerable to purposeful or accidental contamination.

This study analyzes the transport of the hypothetical contaminant Cryptosporidium through the distribution system of a city with a population of 30,000 to 50,000 in an attempt to locate the optimal monitoring locations in the distribution system. Cryptosporidium was selected due to its resistance to chlorine and it’s conservative properties for vulnerability assessments. The method for selecting the optimal monitoring locations was taken from Chastain (2004) which developed and examined the method for a virtual …

A New Computational Model To Augment The Design Of Microfluidic Separations: Electric Field Assisted, Hydrodynamic Chromatography, Jeffrey D. Wells

Master's Theses

This project encompasses the implementation of a computational model to simulate the microfluidic separation of like-charged particles in a continuous flow environment. By accomplishing this task the model can be used to optimize future fractionations by tailoring the process parameters to the properties of the target particles. The primary goal of this project is to develop a vectorized code within Matlab® that captures a sufficient quantity of the physics in separations to assist with the optimization and design of microfluidic systems.

This project differs from other computational models in that it utilizes a personal computer to run the simulation in …

Spectral Shape Division Multiplexing (Ssdm): Apparatus, Transmitter, Receiver And Detection, Fausto Daniel Holguín-Sánchez

Master's Theses

Wireless communication companies require to use the frequency spectrum to operate. Both frequency licenses and infrastructure to reuse frequencies are costly resources subject to increasing demand. This work introduces a novel multiplexing method that saves spectrum called Spectral Shape Division Multiplexing (SSDM). Under certain configurations, SSDM displays higher flexibility and throughput than other spectrally efficient methods.

SSDM defines the structure of a wireless multi-carrier by software. It is similar to Orthogonal Frequency Division Multiplexing (OFDM) in that both use overlapped sub-carriers to make efficient use of allocated spectrum. However, SSDM has several advantages. Where OFDM organizes sub-carriers orthogonally, SSDM allows …

Cascaded High Voltage Converter With Variable Control For Pulsed Electric Field Applications, Emmanuel Loza

Master's Theses

Living a sustainable lifestyle while facing increasing population and decreasing natural resources has become one of humanity’s largest challenges. Locating fossil fuels is becoming more difficult while the demand for them to power our societies is ever increasing. Instead of finding more efficient methods of extracting fossil fuels, developing technologies that create renewable substitutes for fossil fuels is now the strategy. Algae biofuel matches fossil fuel performance while also meeting the criteria for renewable energy. The focus now shifts to finding methods for commercially producing algae biofuel. Therefore, the objective of this thesis is to develop a system that provides …

Real-Time Musical Analysis Of Polyphonic Guitar Audio, John E. Hartquist

Master's Theses

In this thesis, we analyze the audio signal of a guitar to extract musical data in real-time. Specifically, the pitch and octave of notes and chords are displayed over time. Previous work has shown that non-negative matrix factorization is an effective method for classifying the pitches of simultaneous notes. We explore the effect of window size, hop length, and other parameters to maximize the resolution and accuracy of the output.

Other groups have required prerecorded note samples to build a library of note templates to search for. We automate this step and compute the library at run-time, tuning it specifically …

Feasibility Study Into The Use Of 3d Printed Materials In Cubesat Flight Missions, Daniel Fluitt

Master's Theses

The CubeSat Program has provided access to space for many universities, private companies, and government institutions primarily due to the low cost of CubeSat satellite development. While these costs are orders of magnitude lower than similarly capable nano-satellite missions, they are still outside of the budgetary constraints of many potential developers including university and high school clubs. Using 3D printed plastics in the production of CubeSat structures and mechanisms presents a large cost savings opportunity that will allow these institutions to participate in the development of these satellites, expanding the educational and scientific impact of the CubeSat Program.

Five rapid …

Implementation Of A ¼ Inch Hollow Cathode Into A Miniature Xenon Ion Thruster (Mixi), David Wayne Knapp

Master's Theses

Over the last decade, miniature ion thruster development has remained an active area of research do to its low power, low thrust, and high efficiency, however, due to several technical issues; a flight level miniature ion thruster has proved elusive. This thesis covers the design, fabrication, assembly, and test of an altered version of the Miniature Xenon Ion thruster (MiXI), originally developed by lead engineer Dr. Richard Wirz, at the California Institute of Technology (Caltech). In collaboration with Dr. Wirz, MiXI-CP-V3 was developed at Cal Poly San Luis Obispo with the goal of implementing of a ¼ inch hollow cathode …

Finite Element Modeling Of Ballistic Impact On A Glass Fiber Composite Armor, Dan M. Davis

Master's Theses

Finite Element Modeling of Ballistic Impact on a Glass Fiber Composite Armor

Dan Davis

Experiments measuring the ballistic performance of a commercially available fiberglass armor plate were used to guide the development of constitutive laws for a finite element model of the impact. The test samples are commercially available armor panels, made from E-glass fiber reinforced polyester rated to NIJ level III. Quasi-static tensile tests were used to establish material properties of the test panels. These properties were then used to create models in the explicit finite element code LSDYNA.

Ballistic impact testing of the panels was conducted using a …

The Characterization Of Biofilm Attachment To Metal Interfaces: Effects Of Substratum Properties, Marcel D. Mendes

Master's Theses

Bacteria are among the most abundant microorganisms on earth, and can be found in essentially every environment. When a clean surface is exposed to media containing planktonic bacteria, the bacterial cells will attach to the surface and aggregate to form what is known as a biofilm. Biofilms have been shown to negatively affect many industries including medical, industrial, and food science applications. While biofilms have been well characterized from a microbiology perspective, there has been much less research from a materials science standpoint. It is hypothesized that the material properties of the substratum (such as the micro-structure) have a significant …

Hapss, Hybrid Aircraft Propulsion System Synthesis, Michael W. Green

Master's Theses

Hybrid Aircraft Propulsion System Synthesis (HAPSS) is a computer program that sizes and analyzes pure-series hybrid electric propulsion systems for aircraft. The development of this program began during a NASA SBIR contract, in conjunction with Empirical Systems Aerospace (ESAero), with the creation of a propulsion fan design tool. Since the completion of this contract in July 2010, the HAPSS program has been expanded to combine the many aspects of a hybrid propulsion system such as the propulsive fans, electric motors, generators, and controllers, and the internal combustion engines.

This thesis describes the benefits and drawbacks of aircraft hybrid propulsion systems …

Preparation And Characterization Of Electrospun Poly(D, L-Lactide-Co-Glycolide) Scaffolds For Vascular Tissue Engineering And The Advancement Of An In Vitro Blood Brain Barrier Model, Deven Chandrakant Patel

Master's Theses

Developing an in vitro Blood Brain Barrier model that will replicate the physiological, anatomical, and functional characteristics of the native BBB has gained significant attention. Such a model would enable prediction of the penetration of CNS targeting drug candidates across the BBB, allow pre-screening and optimization strategies to be developed for new drugs and gene delivery formulations, and permit research groups to further understand how a dysfunctional BBB is involved in the pathogenesis of several neurological diseases.

The Tissue Engineering laboratory at the California Polytechnic State University, San Luis Obispo is currently in the process of developing a dynamic in …

Modal Analysis Of Composite Structures With Damping Material, Kellie Michelle Tremaine

Master's Theses

The purpose of this study is to develop an analytical solution for modal analysis of actively damped orthotropic composite plates in bending and to verify it with experimental analysis.

The analytical modal analysis solution for composite plate dynamics is derived using Euler theory. This analysis applies to structures with orthotropic lamina of uniform material properties at any lamination angle. The bending-extensional coupling can be neglected for plates that are symmetric or approximately symmetric, which allows an exact solution for natural frequency and mode shape to be obtained. An exact solution can be found for natural vibration and in general.

The …

An Investigation Of Damage Arrestment Devices On Carbon Fiber Sandwich Specimens Under Dynamic Loading, Gabriel Sabino Sanchez

Master's Theses

This research studies the effects of a damage arrestment device embedded between a carbon fiber facesheet and foam core to find whether there is an increase in the structural integrity of the sandwich composites. Experimental and theoretical finite element analyses are implemented for two different composite sandwich geometries; plates and beams. Each structure consisted of the same loading criteria and was restricted to the same vibration fixture during the experiment. An accelerometer was placed on the composite plate to record the amplitude and the natural frequencies of the composite structure. Each composite specimen is then fixed to the surface of …

Development And Characterization Of Phospholipid Encapsulated Quantum Dot Constructs For Biologic Applications, Laura C. Sparks

Master's Theses

DEVELOPMENT AND CHARACTERIZATION OF PHOSPHOLIPID ENCAPSULATED QUANTUM DOT CONSTRUCTS FOR BIOLOGIC APPLICATIONS

The American Cancer Society predicts that 577,190 cancer-related deaths and 1,638,910 newly diagnosed cases of cancer will occur in 2012. As these statistics show, cancer is a prevalent and devastating health issue; determined by the Mayo Clinic to be the second leading cause of death in the United States. Skin cancer is the most common form of cancer in the United States. In 2012 more than 68,000 Americans will be diagnosed with melanoma, 48,000 will be diagnosed with an early form of the disease that has not yet …

Flying Qualities Built-In-Test For Unmanned Aerial Systems, Alton Pak-Hin Chiu

Master's Theses

This paper presents a flying qualities built-in-test for UAS application with the scope limited to the longitudinal axis. A doublet input waveform excites the AV and both α and q are used by EUDKF to estimate the A and B matrices which are short period approximations of the system. ζ, ω, GM, PM, observability, and controllability are calculated to determine flying qualities with the results displayed to the AVO in a color-coded, easy to interpret display.

While SID algorithms have been flying in vehicles with adaptive control schemes, vehicles with other schemes (such as classical feedback) lack this built-in self …

Detecting Netflix Service Outages Through Analysis Of Twitter Posts, Cailin Cushing

Master's Theses

Every week there are over a billion new posts to Twitter services and many of those messages contain feedback to companies about their services. One company that has recognized this unused source of information is Netflix. That is why Netflix initiated the development of a system that will let them respond to the millions of Twitter and Netflix users that are acting as sensors and reporting all types of user visible outages. This system will enhance the feedback loop between Netflix and its customers by increasing the amount of customer feedback that is being received by Netflix and reducing the …

Activity Node Based Flight Software As A Benefit To Systems Engineering, Eugene Daniel Lewis

Master's Theses

This report discusses one application of a flight software design for a spacecraft in which the software executes from a database that can be managed by systems engineering. This report gives an overview of how such a software design can be developed and implemented. It also discusses why this approach is beneficial to the systems engineering program.

Light Extraction Enhancement Of Gan Based Leds Using Top Gratings, Patterned Sapphire Substrates, And Reflective Surfaces, Greg Chavoor

Master's Theses

In the last 15 years, an immense amount of research has gone into developing high efficiency Gallium Nitride based light emitting diodes (LED). These devices have become increasingly popular in LED displays and solid state lighting. Due to the large difference in refractive index between GaN and Air, a significant amount of light reflects at the boundary and does not escape the device. This drawback decreases external quantum efficiency (EQE) by minimizing light extraction. Scientists and engineers continue to develop creative solutions to enhance light extraction. Some solutions include surface roughening, patterned sapphire substrates, and reflective layers.

This study proposes …

Comparative Analysis Of Erp Emerging Technologies, Ryan Engebrethson

Master's Theses

This Master's Thesis compares technologies used in the architecture of Enterprise Resource Planning (ERP) Systems to evaluate the benefits and advantages of emerging technologies. The emerging technologies, Cloud Computing, Software as a Service (SaaS) and Multi-Tenancy, could significantly alter the current ERP space and become a primary part of ERP Systems of the future. A survey was sent to industry professionals to obtain feedback on their company's ERP Systems and to collect their comments on these new technologies. The survey results and related analysis show that Emerging Cloud ERP Systems outperform Traditional Legacy ERP Systems in all important characteristics - …