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Full-Text Articles in Engineering

Characterization Of Time-Variant And Time-Invariant Assessment Of Suicidality On Reddit Using C-Ssrs, Manas Gaur, Vamsi Aribandi, Amanuel Alambo, Ugur Kursuncu, Krishnaprasad Thirunarayan, Jonathan Beich, Jyotishman Pathak, Amit Sheth May 2021

Characterization Of Time-Variant And Time-Invariant Assessment Of Suicidality On Reddit Using C-Ssrs, Manas Gaur, Vamsi Aribandi, Amanuel Alambo, Ugur Kursuncu, Krishnaprasad Thirunarayan, Jonathan Beich, Jyotishman Pathak, Amit Sheth

Publications

Suicide is the 10th leading cause of death in the U.S (1999-2019). However, predicting when someone will attempt suicide has been nearly impossible. In the modern world, many individuals suffering from mental illness seek emotional support and advice on well-known and easily-accessible social media platforms such as Reddit. While prior artificial intelligence research has demonstrated the ability to extract valuable information from social media on suicidal thoughts and behaviors, these efforts have not considered both severity and temporality of risk. The insights made possible by access to such data have enormous clinical potential - most dramatically envisioned as a trigger ...


Designing And Testing Of A System For Aerosolization And Recovery Of Viable Porcine Reproductive And Respiratory Syndrome Virus (Prrsv): Theoretical And Engineering Considerations, Peiyang Li, Jacek A. Koziel, Jeffrey J. Zimmerman, Steven J. Hoff, Jianqiang Zhang, Ting-Yu Cheng, Wannarat Yim-Im, Myeongseong Lee, Baitong Chen, William S. Jenks May 2021

Designing And Testing Of A System For Aerosolization And Recovery Of Viable Porcine Reproductive And Respiratory Syndrome Virus (Prrsv): Theoretical And Engineering Considerations, Peiyang Li, Jacek A. Koziel, Jeffrey J. Zimmerman, Steven J. Hoff, Jianqiang Zhang, Ting-Yu Cheng, Wannarat Yim-Im, Myeongseong Lee, Baitong Chen, William S. Jenks

Agricultural and Biosystems Engineering Publications

Porcine reproductive and respiratory syndrome virus (PRRSV) infections cause significant economic losses to swine producers every year. Aerosols containing infectious PRRSV are an important route of transmission, and proper treatment of air could mitigate the airborne spread of the virus within and between barns. Previous bioaerosol studies focused on the microbiology of PRRSV aerosols; thus, the current study addressed the engineering aspects of virus aerosolization and collection. Specific objectives were to (1) build and test a virus aerosolization system, (2) achieve a uniform and repeatable aerosol generation and collection throughout all replicates, (3) identify and minimize sources of variation, and ...


Water Exchange Rate Across The Blood-Brain Barrier Is Associated With Csf Amyloid-Β 42 In Healthy Older Adults, Brian T. Gold, Xingfeng Shao, Tiffany L. Sudduth, Gregory A. Jicha, Donna M. Wilcock, Elayna R. Seago, Danny J. J. Wang May 2021

Water Exchange Rate Across The Blood-Brain Barrier Is Associated With Csf Amyloid-Β 42 In Healthy Older Adults, Brian T. Gold, Xingfeng Shao, Tiffany L. Sudduth, Gregory A. Jicha, Donna M. Wilcock, Elayna R. Seago, Danny J. J. Wang

Sanders-Brown Center on Aging Faculty Publications

INTRODUCTION: We tested if water exchange across the blood-brain barrier (BBB), estimated with a noninvasive magnetic resonance imaging (MRI) technique, is associated with cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and neuropsychological function.

METHODS: Forty cognitively normal older adults (67–86 years old) were scanned with diffusion‐prepared, arterial spin labeling (DP‐ASL), which estimates water exchange rate across the BBB (kw). Participants also underwent CSF draw and neuropsychological testing. Multiple linear regression models were run with kw as a predictor of CSF concentrations and neuropsychological scores.

RESULTS: In multiple brain regions, BBB kw was positively associated ...


Computational Analysis And Classification Of Shg Images Of Cancerous Pancreatic Tissue Based On Collagen Fiber Alignment, Gerren Welch May 2021

Computational Analysis And Classification Of Shg Images Of Cancerous Pancreatic Tissue Based On Collagen Fiber Alignment, Gerren Welch

Honors College

Pancreatic cancer is a deadly disease, with a low five-year survival rate partly due to the difficulty in diagnosing the cancer early in its development, as it shares symptoms with more common and less lethal conditions. Using Second Harmonic Generation (SHG) microscopy and computer analysis, our knowledge of the biophysics of the pancreatic tumor microenvironment increases which may lead to the development of more effective therapies. In collaboration with Maine Medical Center Research Institute (MMCRI), we have identified 20 pancreatic cancer patients. In these 20 pancreatic cancer patients, Dr. Jones, a pathologist at MMCRI has identified normal adjacent pancreas, fibrotic ...


Bibliometric Analysis Of Emerging Technologies In The Field Of Computer Science Helping In Ovarian Cancer Research, Sonali Kothari Dr., Anvita Gupta, Muskaan Agrawal Agrawal, Kajal Jaggi, Adhiraj Dev Goswami, Ketan Kotecha, M. Karthikeyan Dr., Vijayshri Khedkar Apr 2021

Bibliometric Analysis Of Emerging Technologies In The Field Of Computer Science Helping In Ovarian Cancer Research, Sonali Kothari Dr., Anvita Gupta, Muskaan Agrawal Agrawal, Kajal Jaggi, Adhiraj Dev Goswami, Ketan Kotecha, M. Karthikeyan Dr., Vijayshri Khedkar

Library Philosophy and Practice (e-journal)

This study is carried out to provide an analysis of the literature available at the intersection of ovarian cancer and computing. A comprehensive search was conducted using Scopus database for English-language peer-reviewed articles. The study administers chronological, domain clustering and text analysis of the articles under consideration to provide high-level concept map composed of specific words and the connections between them.


The Clinical Review Committee: Impact Of The Development Of In Vitro Diagnostic Tests For Sars-Cov-2 Within Radx Tech, Matthew L. Robinson, Laura L. Gibson, David D. Mcmanus Apr 2021

The Clinical Review Committee: Impact Of The Development Of In Vitro Diagnostic Tests For Sars-Cov-2 Within Radx Tech, Matthew L. Robinson, Laura L. Gibson, David D. Mcmanus

Open Access Publications by UMMS Authors

The NIH Rapid Acceleration of Diagnostics (RADx SM ) Tech Program was created to speed the development, validation, and commercialization of innovative point-of-care (POC) and home-based tests, and to improve clinical laboratory tests, that can directly detect SARS-CoV-2. Leveraging the experience of the Point-of-Care Technologies Research Network, a Clinical Review Committee (CRC) composed of clinicians, bioengineers, regulatory experts, and laboratorians was created to provide structured feedback to SARS-CoV-2 diagnostic innovators. The CRC convened 53 meetings with 49 companies offering SARS-CoV-2 tests in POC and reference laboratory formats as well as collection materials. The CRC identified common barriers to device design finalization ...


The Radx Tech Test Verification Core And The Acme Poct In The Evaluation Of Covid-19 Testing Devices: A Model For Progress And Change, Eric J. Nehl, Karl J. Simin, Nathaniel Hafer, David D. Mcmanus Apr 2021

The Radx Tech Test Verification Core And The Acme Poct In The Evaluation Of Covid-19 Testing Devices: A Model For Progress And Change, Eric J. Nehl, Karl J. Simin, Nathaniel Hafer, David D. Mcmanus

Open Access Publications by UMMS Authors

Faced with the COVID-19 pandemic, the US system for developing and testing technologies was challenged in unparalleled ways. This article describes the multi-institutional, transdisciplinary team of the “RADx SM Tech Test Verification Core” and its role in expediting evaluations of COVID-19 testing devices. Expertise related to aspects of diagnostic testing was coordinated to evaluate testing devices with the goal of significantly expanding the ability to mass screen Americans to preserve lives and facilitate the safe return to work and school. Focal points included: laboratory and clinical device evaluation of the limit of viral detection, sensitivity, and specificity of devices in ...


The Radx Tech Clinical Studies Core: A Model For Academic Based Clinical Studies, Laura L. Gibson, Nisha M. Fahey, Nathaniel Hafer, John P. Broach, Bruce A. Barton, Stephenie C. Lemon, Allison Blodgett, David D. Mcmanus Apr 2021

The Radx Tech Clinical Studies Core: A Model For Academic Based Clinical Studies, Laura L. Gibson, Nisha M. Fahey, Nathaniel Hafer, John P. Broach, Bruce A. Barton, Stephenie C. Lemon, Allison Blodgett, David D. Mcmanus

Open Access Publications by UMMS Authors

The National Institutes of Health (NIH) launched the Rapid Acceleration of Diagnostics (RADx SM ) Tech initiative to support the development and commercialization of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) point-of-care test devices. The primary objective of the Clinical Studies Core (CSC) was to perform SARS-CoV-2 device studies involving diverse populations and settings. Within a few months, the infrastructure for clinical studies was developed, including a master protocol, digital study platform, data management system, single IRB, and multi-site partnerships. Data from some studies are being used to support Emergency Use Authorization of novel SARS-CoV-2 test devices. The CSC reduced ...


Quantitative Analysis Of Research On Artificial Intelligence In Retinopathy Of Prematurity, Ranjana Agrawal, Manasi Anup Agrawal, Sucheta Kulkarni, Ketan Kotecha, Rahee Walambe Apr 2021

Quantitative Analysis Of Research On Artificial Intelligence In Retinopathy Of Prematurity, Ranjana Agrawal, Manasi Anup Agrawal, Sucheta Kulkarni, Ketan Kotecha, Rahee Walambe

Library Philosophy and Practice (e-journal)

Retinopathy of Prematurity (ROP) is a disease of the eye and a potential source of blindness in low birth weight preterm infants. It is preventable if diagnosed and treated on time. Artificial Intelligence (AI) has played an important role in developing automated screening systems to assist medical experts. There are many traditional literature review articles available that focus on the scientific content of ROP-AI. The researchers also require a bibliometric analysis to become acquainted with the competing groups and new trends in this field. This paper gives a brief overview of ROP and AI systems for ROP screening with a ...


A Multi-Institutional Partnership Catalyzing The Commercialization Of Medical Devices And Biotechnology Products., Nathaniel Hafer, Bryan Buchholz, Denise Dunlap, Brennan Fournier, Scott Latham, Mary Ann Picard, Steven Tello, Laura L. Gibson, Craig M. Lilly, David D. Mcmanus Apr 2021

A Multi-Institutional Partnership Catalyzing The Commercialization Of Medical Devices And Biotechnology Products., Nathaniel Hafer, Bryan Buchholz, Denise Dunlap, Brennan Fournier, Scott Latham, Mary Ann Picard, Steven Tello, Laura L. Gibson, Craig M. Lilly, David D. Mcmanus

COVID-19 Publications by UMMS Authors

The commercialization of medical devices and biotechnology products is characterized by high failure rates and long development lead times particularly among start-up enterprises. To increase the success rate of these high-risk ventures, the University of Massachusetts Lowell (UML) and University of Massachusetts Medical School (UMMS) partnered to create key academic support centers with programs to accelerate entrepreneurship and innovation in this industry. In 2008, UML and UMMS founded the Massachusetts Medical Device Development Center (M2D2), which is a business and technology incubator that provides business planning, product prototyping, laboratory services, access to clinical testing, and ecosystem networking to medical device ...


Assistive Robotics And Their Uses During The Pandemic, Thomas Klassen, Jeremy Evert Apr 2021

Assistive Robotics And Their Uses During The Pandemic, Thomas Klassen, Jeremy Evert

Student Research

• “Assistive Robotics” defines any device that can sense, process sensory information, and perform actions that benefit people with disabilities.

• This form of technology can be used on a much higher scale with a greater number of uses.

• We have an opportunity to expand the usage of assistive robotics to help combat COVID-19.


Prosody And Attachment In Possessive Structures, Elizabeth Keeton, Katy Carlson Apr 2021

Prosody And Attachment In Possessive Structures, Elizabeth Keeton, Katy Carlson

2021 Celebration of Student Scholarship - Oral Presentations

In this project, we are studying the effect that prosodic boundaries and accent location have on attachment in an ambiguous phrase like “the daughter of the pharaoh’s advisor.” Under high possessive attachment, the phrase could mean, “There’s a daughter of the pharaoh, and we’re talking about her advisor.” If there is low possessive attachment instead, the phrase could be understood as, “There’s a pharaoh’s advisor, and we’re talking about his/her daughter.” In an auditory questionnaire, participants will listen to 24 dialogues, with the phrases preceded by the question “Who was it?” We placed ...


Decade Long Monitoring Of Active Galactic Nuclei With Swift, Tithi Patel, Dirk Grupe Apr 2021

Decade Long Monitoring Of Active Galactic Nuclei With Swift, Tithi Patel, Dirk Grupe

2021 Celebration of Student Scholarship - Oral Presentations

I will report decade-long monitoring campaigns with the NASA Neil-Gehrels Swift mission of about 100 Active Galactic Nuclei (AGN). Swift has started with monitoring some AGN since 2005. This long-term monitoring project has enabled us to catch AGN in extreme high and low X-ray flux states allowing to trigger follow-up observations by XMM-Newton, NuSTAR, HST. While this program has led in the past to at least one trigger per year, no AGN was found with extreme variability. I will also give a brief overview of the causes of this extreme variability.


Factors Associated The Underrepresentation Of Female Head Coaches In Intercollegiate Athletics, Chloe Whitlock, Steve Chen Apr 2021

Factors Associated The Underrepresentation Of Female Head Coaches In Intercollegiate Athletics, Chloe Whitlock, Steve Chen

2021 Celebration of Student Scholarship - Oral Presentations

Past studies had shown the underrepresentation of females in the coaching profession. The purpose of this study was to examine the contributory factors to the underrepresentation of female head coaches in intercollegiate athletics. To further examine this issue, two studies were conducted to examine the perceptions of 124 current NCAA Division-I athletic coaches and 163 high school educators. Based on collegiate coaches’ responses, the factor analysis identified four important constructs that contribute to the success of female coaches’ job obtainment. According to the results of the second study, the high school educators (n = 163) believed there were gender biases and ...


Factors For Success In Rural Tourism: A Case Study Of Eastern Kentucky, Bethany Allen, Vijay Subramaniam Apr 2021

Factors For Success In Rural Tourism: A Case Study Of Eastern Kentucky, Bethany Allen, Vijay Subramaniam

2021 Celebration of Student Scholarship - Oral Presentations

This research study examines the variables of tourism that influence a traveler’s decision when traveling in Eastern Kentucky, specifically Morehead, Kentucky. Morehead is a destination with great potential to be built into a prominent location for tourism in Kentucky. To best understand the potential of the area, the resources available and the existing tourism locations were accessed to build the foundation of this project. Successful tourism destinations around the state of Kentucky have been assessed to determine what factors contribute to their success as well as what tactics/resources the businesses use to draw people in. In comparison to ...


Changes In Consumer Market Preference And Purchase Frequency In Response To The Covid-19 Pandemic, Sean Thomas Dial Apr 2021

Changes In Consumer Market Preference And Purchase Frequency In Response To The Covid-19 Pandemic, Sean Thomas Dial

Masters Theses & Specialist Projects

Research literature throughout 2020 indicate consumer behavioral changes in response to the systemic effects of the global COVID-19 pandemic, but these studies investigate transient adaptations in consumer behaviors during the early quarantine period of the pandemic. This study intends to investigate lasting or permanent changes in consumer market preference and purchase frequency between BAM and online retail due to the effects of the pandemic. The principal investigator designed a survey for participants to estimate purchase frequencies and market preferences for apparel, electronics, groceries, and general purchases before and after the pervasive effects of the pandemic (N = 1195; n = 61). The ...


Bibliometric Analysis Of Named Entity Recognition For Chemoinformatics And Biomedical Information Extraction Of Ovarian Cancer, Vijayshri Khedkar, Charlotte Fernandes, Devshi Desai, Mansi R, Gurunath Chavan Dr, Sonali Tidke Dr., M. Karthikeyan Dr. Apr 2021

Bibliometric Analysis Of Named Entity Recognition For Chemoinformatics And Biomedical Information Extraction Of Ovarian Cancer, Vijayshri Khedkar, Charlotte Fernandes, Devshi Desai, Mansi R, Gurunath Chavan Dr, Sonali Tidke Dr., M. Karthikeyan Dr.

Library Philosophy and Practice (e-journal)

With the massive amount of data that has been generated in the form of unstructured text documents, Biomedical Named Entity Recognition (BioNER) is becoming increasingly important in the field of biomedical research. Since currently there does not exist any automatic archiving of the obtained results, a lot of this information remains hidden in the textual details and is not easily accessible for further analysis. Hence, text mining methods and natural language processing techniques are used for the extraction of information from such publications.Named entity recognition, is a subtask that comes under information extraction that focuses on finding and categorizing ...


Mitigation Of Airborne Prrsv Transmission With Uv Light Treatment: Proof-Of-Concept, Peiyang Li, Jacek A. Koziel, Jeffrey J. Zimmerman, Jianqiang Zhang, Ting-Yu Cheng, Wannarat Yim-Im, William S. Jenks, Myeongseong Lee, Baitong Chen, Steven J. Hoff Mar 2021

Mitigation Of Airborne Prrsv Transmission With Uv Light Treatment: Proof-Of-Concept, Peiyang Li, Jacek A. Koziel, Jeffrey J. Zimmerman, Jianqiang Zhang, Ting-Yu Cheng, Wannarat Yim-Im, William S. Jenks, Myeongseong Lee, Baitong Chen, Steven J. Hoff

Agricultural and Biosystems Engineering Publications

Proper treatment of infectious air could potentially mitigate the spread of airborne viruses such as porcine reproductive and respiratory syndrome virus (PRRSV). The objective of this research is to test the effectiveness of ultraviolet (UV) in inactivating aerosolized PRRSV, specifically, four UV lamps, UV-A (365 nm, both fluorescent and LED-based), “excimer” UV-C (222 nm), and germicidal UV-C (254 nm), were tested. The two UV-C lamps effectively irradiated fast-moving PRRSV aerosols with short treatment times (<2 s). One-stage and two-stage UV inactivation models estimated the UV doses needed for target percentage (%) reductions on PRRSV titer. UV-C (254 nm) dose needed for 3-log (99.9%) reduction was 0.521 and 0.0943 mJ/cm2, respectively, based on one-stage and two-stage models. An order of magnitude lower UV-C (222 nm) doses were needed for a 3-log reduction, i.e., 0 ...


Realize, Analyze, Engage (Rae): A Digital Tool To Support Recovery From Substance Use Disorder, Stephanie P. Carreiro, Melissa Taylor, Sloke Shrestha, Megan Reinhardt, Nicole Gilbertson, Premananda Indic Feb 2021

Realize, Analyze, Engage (Rae): A Digital Tool To Support Recovery From Substance Use Disorder, Stephanie P. Carreiro, Melissa Taylor, Sloke Shrestha, Megan Reinhardt, Nicole Gilbertson, Premananda Indic

University of Massachusetts Medical School Faculty Publications

Background: Substance use disorders are a highly prevalent group of chronic diseases with devastating individual and public health consequences. Current treatment strategies suffer from high rates of relapse, or return to drug use, and novel solutions are desperately needed. Realize Analyze Engage (RAE) is a digital, mHealth intervention that focusses on real time, objective detection of high-risk events (stress and drug craving) to deploy just-in-time supportive interventions. The present study aims to (1) evaluate the accuracy and usability of the RAE system and (2) evaluate the impact of RAE on patient centered outcomes.

Methods: The first phase of the study ...


Usability, Perceived Usefulness, And Shared Decision-Making Features Of The Afib 2gether Mobile App: Protocol For A Single-Arm Intervention Study, Alok Kapoor, Andreza Andrade, Anna Hayes, Kathleen M. Mazor, Carl Possidente, Kim Nolen, Rozelle Hegeman-Dingle, David D. Mcmanus Feb 2021

Usability, Perceived Usefulness, And Shared Decision-Making Features Of The Afib 2gether Mobile App: Protocol For A Single-Arm Intervention Study, Alok Kapoor, Andreza Andrade, Anna Hayes, Kathleen M. Mazor, Carl Possidente, Kim Nolen, Rozelle Hegeman-Dingle, David D. Mcmanus

Open Access Publications by UMMS Authors

BACKGROUND: The Centers for Disease Control and Prevention has estimated that atrial fibrillation (AF) affects between 2.7 million and 6.1 million people in the United States. Those who have AF tend to have a much higher stroke risk than others. Although most individuals with AF benefit from anticoagulation (AC) therapy, a significant majority are hesitant to start it. To add, providers often struggle in helping patients negotiate the decision to start AC therapy. To assist in the communication between patients and providers regarding preferences and knowledge about AC therapy, different strategies are being used to try and solve ...


Study Design And Data Analysis Of Artificial Pancreas Device Systems With Closed-Loop Glucose-Sensing Insulin Delivery, Sravya B. Shankara, Yujia Liu, Qingfeng Zheng, Jing Guo, Guixia Wang, Bo Zhang Feb 2021

Study Design And Data Analysis Of Artificial Pancreas Device Systems With Closed-Loop Glucose-Sensing Insulin Delivery, Sravya B. Shankara, Yujia Liu, Qingfeng Zheng, Jing Guo, Guixia Wang, Bo Zhang

Open Access Publications by UMMS Authors

Objective: The objective of this article is to provide a high-profile review and discussion on the study design and statistical analysis of pivotal clinical trials conducted to demonstrate the safety and effectiveness of closed-loop investigational artificial pancreas device systems (APDSs) in premarket approval applications.

Methods: The United States Food and Drug Administration (FDA) guidance on the content of investigational device exemption and premarket approval applications for APDSs is reviewed with special emphasis on study design and statistical analysis of the pivotal clinical trials. The two pivotal studies for the MiniMed 670G hybrid closed-loop system by Medtronic in their premarket approval ...


Development And Validation Of An Automated Algorithm To Detect Atrial Fibrillation Within Stored Intensive Care Unit Continuous Electrocardiographic Data: Observational Study, Allan J. Walkey, Syed K. Bashar, Md Billal. Hossain, Eric Y. Ding, Daniella Albuquerque, Michael Winter, Ki H. Chon, David D. Mcmanus Feb 2021

Development And Validation Of An Automated Algorithm To Detect Atrial Fibrillation Within Stored Intensive Care Unit Continuous Electrocardiographic Data: Observational Study, Allan J. Walkey, Syed K. Bashar, Md Billal. Hossain, Eric Y. Ding, Daniella Albuquerque, Michael Winter, Ki H. Chon, David D. Mcmanus

Open Access Publications by UMMS Authors

BACKGROUND: Atrial fibrillation (AF) is the most common arrhythmia during critical illness, representing a sepsis-defining cardiac dysfunction associated with adverse outcomes. Large burdens of premature beats and noisy signal during sepsis may pose unique challenges to automated AF detection.

OBJECTIVE: The objective of this study is to develop and validate an automated algorithm to accurately identify AF within electronic health care data among critically ill patients with sepsis.

METHODS: This is a retrospective cohort study of patients hospitalized with sepsis identified from Medical Information Mart for Intensive Care (MIMIC III) electronic health data with linked electrocardiographic (ECG) telemetry waveforms. Within ...


Radiation‐Induced Oral Mucositis Hamster Model Using A Linear Accelerator Enhances Clinical Relevance Of Preclinical Studies For Treatment Strategy Investigation, Carolyn T. Jordan, Emily M. Bradford, Dennis C. Cheek, Mahesh R. Kudrimoti, Craig S. Miller, Molly H. Smith, J. Zach Hilt, Thomas D. Dziubla Jan 2021

Radiation‐Induced Oral Mucositis Hamster Model Using A Linear Accelerator Enhances Clinical Relevance Of Preclinical Studies For Treatment Strategy Investigation, Carolyn T. Jordan, Emily M. Bradford, Dennis C. Cheek, Mahesh R. Kudrimoti, Craig S. Miller, Molly H. Smith, J. Zach Hilt, Thomas D. Dziubla

Radiation Medicine Faculty Publications

Translational animal models for oral mucositis (OM) are necessary to simulate and assess the bioclinical effects and response in humans. These models should simulate high levels of radiation exposure that leads to oxidative stress and inflammatory‐initiated tissue changes. Hamster models have been extensively studied to observe pathological effects of radiation exposure and help in the development of effective treatments. To successfully evaluate the potential for treatment regimens with consistency and relevance, a radiation‐induced OM hamster model was developed using a clinical linear accelerator utilized by cancer patients daily. The dose exposure to the isolated, everted cheek pouch of ...


Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction In Tauopathy, Shon A. Koren, Matthew J. Hamm, Ryan Cloyd, Sarah N. Fontaine, Emad Chishti, Chiara Lanzillotta, Jennifer Rodriguez-Rivera, Alexandria Ingram, Michelle Bell, Sara M. Galvis-Escobar, Nicholas Zulia, Fabio Di Domenico, Duc Duong, Nicholas T. Seyfried, David K. Powell, Moriel Vandsburger, Tal Frolinger, Anika M. S. Hartz, John Koren Iii, Jeffrey M. Axten, Nicholas J. Laping, Jose F. Abisambra Jan 2021

Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction In Tauopathy, Shon A. Koren, Matthew J. Hamm, Ryan Cloyd, Sarah N. Fontaine, Emad Chishti, Chiara Lanzillotta, Jennifer Rodriguez-Rivera, Alexandria Ingram, Michelle Bell, Sara M. Galvis-Escobar, Nicholas Zulia, Fabio Di Domenico, Duc Duong, Nicholas T. Seyfried, David K. Powell, Moriel Vandsburger, Tal Frolinger, Anika M. S. Hartz, John Koren Iii, Jeffrey M. Axten, Nicholas J. Laping, Jose F. Abisambra

Sanders-Brown Center on Aging Faculty Publications

Tauopathies are a group of more than twenty known disorders that involve progressive neurodegeneration, cognitive decline and pathological tau accumulation. Current therapeutic strategies provide only limited, late-stage symptomatic treatment. This is partly due to lack of understanding of the molecular mechanisms linking tau and cellular dysfunction, especially during the early stages of disease progression. In this study, we treated early stage tau transgenic mice with a multi-target kinase inhibitor to identify novel substrates that contribute to cognitive impairment and exhibit therapeutic potential. Drug treatment significantly ameliorated brain atrophy and cognitive function as determined by behavioral testing and a sensitive imaging ...


Trabecular Bone Organoid Model For Studying The Regulation Of Localized Bone Remodeling, Yongkuk Park, Eugene Cheong, Jun-Goo Kwak, Ryan Carpenter, Jae-Hyuck Shim, Jungwoo Lee Jan 2021

Trabecular Bone Organoid Model For Studying The Regulation Of Localized Bone Remodeling, Yongkuk Park, Eugene Cheong, Jun-Goo Kwak, Ryan Carpenter, Jae-Hyuck Shim, Jungwoo Lee

Open Access Publications by UMMS Authors

Trabecular bone maintains physiological homeostasis and consistent structure and mass through repeated cycles of bone remodeling by means of tightly localized regulation. The molecular and cellular processes that regulate localized bone remodeling are poorly understood because of a lack of relevant experimental models. A tissue-engineered model is described here that reproduces bone tissue complexity and bone remodeling processes with high fidelity and control. An osteoid-inspired biomaterial-demineralized bone paper-directs osteoblasts to deposit structural mineralized bone tissue and subsequently acquire the resting-state bone lining cell phenotype. These cells activate and shift their secretory profile to induce osteoclastogenesis in response to chemical stimulation ...


Effects Of Racing Surface And Turn Radius On Fatal Limb Fractures In Thoroughbred Racehorses, Michael L. Peterson, Wayne T. Sanderson, Nurlan Kussainov, Sarah Jane Hobbs, Patti Miles, Mary C. Scollay, Hilary M. Clayton Jan 2021

Effects Of Racing Surface And Turn Radius On Fatal Limb Fractures In Thoroughbred Racehorses, Michael L. Peterson, Wayne T. Sanderson, Nurlan Kussainov, Sarah Jane Hobbs, Patti Miles, Mary C. Scollay, Hilary M. Clayton

Biosystems and Agricultural Engineering Faculty Publications

North American Thoroughbred racing is conducted on three types of surfaces—dirt, turf, and synthetic. The tracks are oval, and races are run counterclockwise. The loading on right and left limbs is expected to differ as a function of turn radius, banking, surface, and gait asymmetry. Hind limbs and forelimbs also have different functions related to propulsion and turning, respectively. This study uses the Equine Injury Database for race starts from 1 January 2009 through 31 December 2014, to compare injury rates across participating North American racetracks. The data are limited to catastrophic injuries in which horses died or were ...


Dual-Functional Phosphorene Nanocomposite Membranes For The Treatment Of Perfluorinated Water: An Investigation Of Perfluorooctanoic Acid Removal Via Filtration Combined With Ultraviolet Irradiation Or Oxygenation, Joyner Eke, Lillian Banks, M. Abdul Mottaleb, Andrew J. Morris, Olga V. Tsyusko, Isabel C. Escobar Jan 2021

Dual-Functional Phosphorene Nanocomposite Membranes For The Treatment Of Perfluorinated Water: An Investigation Of Perfluorooctanoic Acid Removal Via Filtration Combined With Ultraviolet Irradiation Or Oxygenation, Joyner Eke, Lillian Banks, M. Abdul Mottaleb, Andrew J. Morris, Olga V. Tsyusko, Isabel C. Escobar

Internal Medicine Faculty Publications

Nanomaterials with tunable properties show promise because of their size-dependent electronic structure and controllable physical properties. The purpose of this research was to develop and validate environmentally safe nanomaterial-based approach for treatment of drinking water including removal and degradation of per- and polyfluorinated chemicals (PFAS). PFAS are surfactant chemicals with broad uses that are now recognized as contaminants with a significant risk to human health. They are commonly used in household and industrial products. They are extremely persistent in the environment because they possess both hydrophobic fluorine-saturated carbon chains and hydrophilic functional groups, along with being oleophobic. Traditional drinking water ...


Fmri Feature Extraction Model For Adhd Classification Using Convolutional Neural Network, Senuri De Silva, Sanuwani Udara Dayarathna, Gangani Ariyarathne, Dulani Meedeniya, Sampath Jayarathna Jan 2021

Fmri Feature Extraction Model For Adhd Classification Using Convolutional Neural Network, Senuri De Silva, Sanuwani Udara Dayarathna, Gangani Ariyarathne, Dulani Meedeniya, Sampath Jayarathna

Computer Science Faculty Publications

Biomedical intelligence provides a predictive mechanism for the automatic diagnosis of diseases and disorders. With the advancements of computational biology, neuroimaging techniques have been used extensively in clinical data analysis. Attention deficit hyperactivity disorder (ADHD) is a psychiatric disorder, with the symptomology of inattention, impulsivity, and hyperactivity, in which early diagnosis is crucial to prevent unwelcome outcomes. This study addresses ADHD identification using functional magnetic resonance imaging (fMRI) data for the resting state brain by evaluating multiple feature extraction methods. The features of seed-based correlation (SBC), fractional amplitude of low-frequency fluctuation (fALFF), and regional homogeneity (ReHo) are comparatively applied to ...


Biofilm And Cell Adhesion Strength On Dental Implant Surfaces Via The Laser Spallation Technique, James D. Boyd, Arnold J. Stromberg, Craig S. Miller, Martha E. Grady Jan 2021

Biofilm And Cell Adhesion Strength On Dental Implant Surfaces Via The Laser Spallation Technique, James D. Boyd, Arnold J. Stromberg, Craig S. Miller, Martha E. Grady

Statistics Faculty Publications

OBJECTIVE: The aims of this study are to quantify the adhesion strength differential between an oral bacterial biofilm and an osteoblast-like cell monolayer to a dental implant-simulant surface and develop a metric that quantifies the biocompatible effect of implant surfaces on bacterial and cell adhesion.

METHODS: High-amplitude short-duration stress waves generated by laser pulse absorption are used to spall bacteria and cells from titanium substrates. By carefully controlling laser fluence and calibration of laser fluence with applied stress, the adhesion difference between Streptococcus mutans biofilms and MG 63 osteoblast-like cell monolayers on smooth and rough titanium substrates is obtained. The ...


Improvement Of Printing Quality For Laser-Induced Forward Transfer Based Laser-Assisted Bioprinting Process Using A Cfd-Based Numerical Model, Jie Qu, Chaoran Dou, Ben Xu, Jianzhi Li, Zhonghao Rao, Andrew Tsin Jan 2021

Improvement Of Printing Quality For Laser-Induced Forward Transfer Based Laser-Assisted Bioprinting Process Using A Cfd-Based Numerical Model, Jie Qu, Chaoran Dou, Ben Xu, Jianzhi Li, Zhonghao Rao, Andrew Tsin

Mechanical Engineering Faculty Publications and Presentations

As one of the three-dimensional (3D) bioprinting techniques with great application potential, laser-induced-forward-transfer (LIFT) based laser assisted bioprinting (LAB) transfers the bioink through a developed jet flow, and the printing quality highly depends on the stability of jet flow regime. To understand the connection between the jet flow and printing outcomes, a Computational Fluid Dynamic (CFD) model was developed for the first time to accurately describe the jet flow regime and provide a guidance for optimal printing process planning. By adopting the printing parameters recommended by the CFD model, the printing quality was greatly improved by forming stable jet regime ...