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Articles 1 - 30 of 46
Full-Text Articles in Engineering
Supporting Compliance Of Occupational Safety And Health Requirements - European Labour Inspection Systems Of Sanctions And Standardised Measures, Victor Hrymak
Articles
European legislation for occupational safety and health (OSH) is based on the prevention of accidents and ill health. Apart from European directives, all Member States have national laws and strategies and expect enterprises to implement this preventative ethos, and thereby ensure adequate performance in OSH. Labour Inspectorates monitor and if necessary enforce these laws by deploying individual Labour Inspectors to chosen enterprises. If workplace safety and health conditions are found to be substandard, Labour Inspectors are expected to improve the situation using persuasion and, if necessary, their authority to compel enterprises through specific sanction powers. Bruhn (2009) describes this interaction …
Current Topics In Technology-Enabled Stroke Rehabilitation And Reintegration: A Scoping Review And Content Analysis, Katryna Cisek
Current Topics In Technology-Enabled Stroke Rehabilitation And Reintegration: A Scoping Review And Content Analysis, Katryna Cisek
Articles
Background. There is a worldwide health crisis stemming from the rising incidence of various debilitating chronic diseases, with stroke as a leading contributor. Chronic stroke management encompasses rehabilitation and reintegration, and can require decades of personalized medicine and care. Information technology (IT) tools have the potential to support individuals managing chronic stroke symptoms. Objectives. This scoping review identifies prevalent topics and concepts in research literature on IT technology for stroke rehabilitation and reintegration, utilizing content analysis, based on topic modelling techniques from natural language processing to identify gaps in this literature. Eligibility Criteria. Our methodological search initially identified over 14,000 …
Walkable Neighborhoods: Linkages Between Place, Health, And Happiness In Younger And Older Adults, Kevin M. Leyden, Michael J. Hogan, Lorraine D'Arcy, Brendan Bunting, Sebastiaan Bierema
Walkable Neighborhoods: Linkages Between Place, Health, And Happiness In Younger And Older Adults, Kevin M. Leyden, Michael J. Hogan, Lorraine D'Arcy, Brendan Bunting, Sebastiaan Bierema
Articles
Problem, research strategy, and findings: We examined whether living in a walkable neighborhood influenced the happiness of younger and older city residents. The data for this study came from a comprehensive household population survey of 1,064 adults living in 16 neighborhoods in Dublin City (Ireland) and its suburbs. We used multigroup structural equation modeling to analyze the direct and indirect effects of walkability on happiness, mediated by health, trust, and satisfaction with neighborhood appearance. We found living in a walkable neighborhood was directly linked to the happiness of people aged 36 to 45 (p¼.001) and, to a lesser extent, those …
The Future Of Clinical Trials Of Myopia Control, Mark A. Bullimore, Noel A. Brennan, Daniel I. Flintcroft
The Future Of Clinical Trials Of Myopia Control, Mark A. Bullimore, Noel A. Brennan, Daniel I. Flintcroft
Articles
In the field of myopia control, effective optical or pharmaceutical therapies are now available to patients in many markets. This creates challenges for the conduct of placebo-controlled, randomised clinical trials, including ethics, recruitment, retention, selective loss of faster progressors and non-protocol treatments: 1. Ethics: It is valid to question whether withholding treatment in control subjects is ethical. 2. Recruitment: Availability of treatments is making recruitment into clinical trials more difficult. 3. Retention: If masking is not possible, parents may immediately withdraw their child if randomised to no treatment. 4. Selective loss: Withdrawal of fast progressors in the control group leading …
Monitoring And Modelling The Glutamine Metabolic Pathway: A Review And Future Perspectives, Zohreh Mirveis, Paul Cahill, Nitin Patel, Hugh Byrne
Monitoring And Modelling The Glutamine Metabolic Pathway: A Review And Future Perspectives, Zohreh Mirveis, Paul Cahill, Nitin Patel, Hugh Byrne
Articles
In this review, the contribution of NMR to the metabolomics field will be discussed—particularly as it relates to cancer and drug metabolism research. An overview of the typical NMR metabolomic experiment will be presented while emphasizing important caveats ranging from experimental design to data interpretation.
Machine-Learning-Based Head Impact Subtyping Based On The Spectral Densities Of The Measurable Head Kinematics, Xianghao Zhan, Yiheng Li, Yuzhe Liu, Nicholas J. Cecchi, Samuel J. Raymond, Zhou Zhou, Hossein Vahid Alizadeh, Jesse Ruan, Saeed Barbat, Stephen Tiernan, Olivier Gevaert, Michael M. Zeineh, Gerald A. Grant, David B. Camarillo
Machine-Learning-Based Head Impact Subtyping Based On The Spectral Densities Of The Measurable Head Kinematics, Xianghao Zhan, Yiheng Li, Yuzhe Liu, Nicholas J. Cecchi, Samuel J. Raymond, Zhou Zhou, Hossein Vahid Alizadeh, Jesse Ruan, Saeed Barbat, Stephen Tiernan, Olivier Gevaert, Michael M. Zeineh, Gerald A. Grant, David B. Camarillo
Articles
Traumatic brain injury can be caused by head impacts, but many brain injury risk estimation models are not equally accurate across the variety of impacts that patients may undergo and the characteristics of different types of impacts are not well studied. We investigated the spectral characteristics of different head impact types with kinematics classification. Methods: Data was analyzed from 3,262 head impacts from lab reconstruction, American football, mixed martial arts, and publicly available car crash data. A random forest classifier with spectral densities of linear acceleration and angular velocity was built to classify head impact types (e.g., football, car crash, …
Understanding And Predicting Cognitive Improvement Of Young Adults In Ischemic Stroke Rehabilitation Therapy, Helard Becerra Martinez, Katryna Cisek, Alejandro Garcia-Rudolph, John Kelleher, Andrew Hines
Understanding And Predicting Cognitive Improvement Of Young Adults In Ischemic Stroke Rehabilitation Therapy, Helard Becerra Martinez, Katryna Cisek, Alejandro Garcia-Rudolph, John Kelleher, Andrew Hines
Articles
Accurate early predictions of a patient's likely cognitive improvement as a result of a stroke rehabilitation programme can assist clinicians in assembling more effective therapeutic programs. In addition, sufficient levels of explainability, which can justify these predictions, are a crucial requirement, as reported by clinicians. This article presents a machine learning (ML) prediction model targeting cognitive improvement after therapy for stroke surviving patients. The prediction model relies on electronic health records from 201 ischemic stroke surviving patients containing demographic information, cognitive assessments at admission from 24 different standardized neuropsychology tests (e.g., TMT, WAIS-III, Stroop, RAVLT, etc.), and therapy information collected …
Gated Deep Reinforcement Learning With Red Deer Optimization For Medical Image Classification, Narayanan Ganesh, Sambandan Jayalakshmi, Rama Chandran Narayanan, Miroslav Mahdal, Hossam Zawbaa, Ali Wagdy Mohamed
Gated Deep Reinforcement Learning With Red Deer Optimization For Medical Image Classification, Narayanan Ganesh, Sambandan Jayalakshmi, Rama Chandran Narayanan, Miroslav Mahdal, Hossam Zawbaa, Ali Wagdy Mohamed
Articles
The brain is one of the most important and complex organs in the body, consisting of billions of individual cells. Uncontrolled growth and expansion of aberrant cell populations within or around the brain are the main causes of brain tumors. These cells have the potential to harm healthy cells and impair brain function [1]. Tumors can be detected using medical imaging techniques, which are considered the most popular and accurate way to classify different types of cancer, and this procedure is even more crucial as it is noninvasive [2]. Magnetic resonance imaging (MRI) is one such medical imaging technique that …
Enhancing The Prediction For Shunt‑Dependent Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage Using A Machine Learning Approach, Dietmar Frey, Adam Hilbert, Anton Früh, Vince Istvan Madai, Tabea Kossen, Julia Kiewitz, Jenny Sommerfeld, Peter Vajkoczy, Meike Unteroberdörster, Esra Zihni, Sophie Charlotte Brune, Stefan Wolf, Nora Franziska Dengler
Enhancing The Prediction For Shunt‑Dependent Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage Using A Machine Learning Approach, Dietmar Frey, Adam Hilbert, Anton Früh, Vince Istvan Madai, Tabea Kossen, Julia Kiewitz, Jenny Sommerfeld, Peter Vajkoczy, Meike Unteroberdörster, Esra Zihni, Sophie Charlotte Brune, Stefan Wolf, Nora Franziska Dengler
Articles
Early and reliable prediction of shunt-dependent hydrocephalus (SDHC) after aneurysmal subarachnoid haemorhage (a SAH) may decrease the duration of in-hospital stay and reduce the risk of catheter-associated meningitis. Machine learning (ML) may improve predictions of SDHC in comparison to traditional non-ML methods. ML models were trained for CHESS and SDASH and two combined individual feature sets with clinical, radiographic, and laboratory variables. Seven different algorithms were used including three types of generalized linear models (GLM) as well as a tree boosting (Cat Boost) algorithm, a Nave Bayes (NB) classifier, and a multilayer perceptron (MLP) artificial neural net. The discrimination of …
Portable Hepa Filtration Successfully Augments Natural-Ventilation-Mediated Airborne Particle Clearance In A Legacy Design Hospital Ward, Mehael Fennelly, S. Hellebust, J. Wenger, D. O'Connor, G.W. Griffith, B.J. Plant, A.P.C. Microbiome Institute
Portable Hepa Filtration Successfully Augments Natural-Ventilation-Mediated Airborne Particle Clearance In A Legacy Design Hospital Ward, Mehael Fennelly, S. Hellebust, J. Wenger, D. O'Connor, G.W. Griffith, B.J. Plant, A.P.C. Microbiome Institute
Articles
As the severe acute respiratory syndrome coronavirus-2 pandemic has proceeded, ventilation has been recognized increasingly as an important tool in infection control. Many hospitals in Ireland and the UK do not have mechanical ventilation and depend on natural ventilation. The effectiveness of natural ventilation varies with atmospheric conditions and building design. In a challenge test of a legacy design ward, this study showed that portable air filtration significantly increased the clearance of pollutant aerosols of respirable size compared with natural ventilation, and reduced spatial variation in particle persistence. A combination of natural ventilation and portable air filtration is significantly more …
Exploring The Impact Of Noise And Degradations On Heart Sound Classification Models, Davoud Shariat Panah, Andrew Hines, Susan Mckeever
Exploring The Impact Of Noise And Degradations On Heart Sound Classification Models, Davoud Shariat Panah, Andrew Hines, Susan Mckeever
Articles
The development of data-driven heart sound classification models has been an active area of research in recent years. To develop such data-driven models in the first place, heart sound signals need to be captured using a signal acquisition device. However, it is almost impossible to capture noise-free heart sound signals due to the presence of internal and external noises in most situations. Such noises and degradations in heart sound signals can potentially reduce the accuracy of data-driven classification models. Although different techniques have been proposed in the literature to address the noise issue, how and to what extent different noise …
Assessing The Impact Of Contact Tracing With An Agent-Based Model For Simulating The Spread Of Covid-19: The Irish Experience, Elizabeth Hunter, Sudipta Saha, Jwenish Kumawat, Ciara Carroll, John Kelleher, Claire Buckley, Conor Mcaloon, Patricia Kearney, Michelle Gilbert, Greg Martin
Assessing The Impact Of Contact Tracing With An Agent-Based Model For Simulating The Spread Of Covid-19: The Irish Experience, Elizabeth Hunter, Sudipta Saha, Jwenish Kumawat, Ciara Carroll, John Kelleher, Claire Buckley, Conor Mcaloon, Patricia Kearney, Michelle Gilbert, Greg Martin
Articles
Contact tracing is an important tool in managing infectious disease outbreaks and Ireland used a comprehensive contact tracing program to slow the spread of COVID-19. Although the benefits of contact tracing seem obvious, it is difficult to estimate the actual impact contact tracing has on an outbreak because it is hard to separate the effects of contact tracing from other behavioural changes or interventions. To understand the impact contact tracing had in Ireland, we used an agent-based model that is designed to simulate the spread of COVID-19 through Ireland. The model uses real contact tracing data from the first year …
Forecasting Covid-19 Cases Using Dynamic Time Warping And Incremental Machine Learning Methods, Luis Miralles-Pechuán, Ankit Kumar, Andres L. Suarez-Cetrulo
Forecasting Covid-19 Cases Using Dynamic Time Warping And Incremental Machine Learning Methods, Luis Miralles-Pechuán, Ankit Kumar, Andres L. Suarez-Cetrulo
Articles
The investment of time and resources for developing better strategies is key to dealing with future pandemics. In this work, we recreated the situation of COVID-19 across the year 2020, when the pandemic started spreading worldwide. We conducted experiments to predict the coronavirus cases for the 50 countries with the most cases during 2020. We compared the performance of state-of-the-art machine learning algorithms, such as long-short-term memory networks, against that of online incremental machine learning algorithms. To find the best strategy, we performed experiments to test three different approaches. In the first approach (single-country), we trained each model using data …
Advances In 3d Culture Systems For Therapeutic Discovery And Development In Brain Cancer, Janith Wanigasekara, Patrick J. Cullen, Paula Bourke, Brijesh Tiwari, James F. Curtin
Advances In 3d Culture Systems For Therapeutic Discovery And Development In Brain Cancer, Janith Wanigasekara, Patrick J. Cullen, Paula Bourke, Brijesh Tiwari, James F. Curtin
Articles
This review focuses on recent advances in 3D culture systems that promise more accurate therapeutic models of the glioblastoma multiforme (GBM) tumor microenvironment (TME), such as the unique anatomical, cellular, and molecular features evident in human GBM. The key components of a GBM TME are outlined, including microbiomes, vasculature, extracellular matrix (ECM), infiltrating parenchymal and peripheral immune cells and molecules, and chemical gradients. 3D culture systems are evaluated against 2D culture systems and in vivo animal models. The main 3D culture techniques available are compared, with an emphasis on identifying key gaps in knowledge for the development of suitable platforms …
Advancing Ubiquitous Collaboration For Telehealth - A Framework To Evaluate Technology-Mediated Collaborative Workflow For Telehealth, Hypertension Exam Workflow Study, Christopher Bondy Ph.D., Linlin Chen Ph.D, Pamela Grover Md, Pengcheng Shi Ph.D
Advancing Ubiquitous Collaboration For Telehealth - A Framework To Evaluate Technology-Mediated Collaborative Workflow For Telehealth, Hypertension Exam Workflow Study, Christopher Bondy Ph.D., Linlin Chen Ph.D, Pamela Grover Md, Pengcheng Shi Ph.D
Articles
Healthcare systems are under siege globally regarding technology adoption; the recent pandemic has only magnified the issues. Providers and patients alike look to new enabling technologies to establish real-time connectivity and capability for a growing range of remote telehealth solutions. The migration to new technology is not as seamless as clinicians and patients would like since the new workflows pose new responsibilities and barriers to adoption across the telehealth ecosystem. Technology-mediated workflows (integrated software and personal medical devices) are increasingly important in patient-centered healthcare; software-intense systems will become integral in prescribed treatment plans [1]. My research explored the path to …
Childminding Professionalism And Professionalisation In Ireland: A Different Story, Miriam O'Regan, Ann Marie Halpenny, Noirin Hayes
Childminding Professionalism And Professionalisation In Ireland: A Different Story, Miriam O'Regan, Ann Marie Halpenny, Noirin Hayes
Articles
This research focussed on documenting the praxis and paedagogy of paid, professional childminding (family childcare/day care) in Ireland. It explored professionalism and professionalisation among childminders in the context of the evolving understanding of professionalism in Early Childhood Education and Care (ECEC) nationally and internationally. The research was conducted within the framework of Ecocultural Theory (ECT) on the eve of mandatory regulation of childminding against the backdrop of Irish ECEC policy. A mixed method approach was adopted, using the Ecocultural Family Interview for Childminders (EFICh), including participants’ photographs, case study surveys, researcher field notes and holistic ratings. We present findings related …
Os-Walk-Eu: An Open-Source Tool To Assess Health-Promoting Residential Walkability Of European City Structures, Stefan Fina, Christian Gerten, Brian Pondi, Lorraine D'Arcy, Niamh O' Reilly, David Sousa Vale, Mauro Pereira, Samuele Zilio
Os-Walk-Eu: An Open-Source Tool To Assess Health-Promoting Residential Walkability Of European City Structures, Stefan Fina, Christian Gerten, Brian Pondi, Lorraine D'Arcy, Niamh O' Reilly, David Sousa Vale, Mauro Pereira, Samuele Zilio
Articles
Introduction This paper introduces OS-WALK-EU, a new open-source walkability assessment tool developed specifically for urban neighbourhoods and using open-source spatial data. A free and open-source tool, OS-WALK-EU is accessible to the general public. It uses open data available worldwide and free online services to compute accessibility, while at the same time allowing users to integrate local datasets if available. Based on a review of existing measurement concepts, the paper adopts dimensions of walkability that were tested in European city environments and explains their conceptualization for software development. We invite the research community to collaboratively test, adopt and use the tool …
Design And Development Of Magnetic Iron Core Gold Nanoparticle-Based Fluorescent Multiplex Assay To Detect Salmonella, Xinyi Zhao
Articles
Salmonella is a bacterial pathogen which is one of the leading causes of severe illnesses in humans. The current study involved the design and development of two methods, respectively using iron oxide nanoparticle (IONP) and iron core gold nanoparticle (ICGNP), conjugated with the Salmonella antibody and the fluorophore, 4-Methylumbelliferyl Caprylate (4-MUCAP), used as an indicator, for its selective and sensitive detection in contaminated food products. Twenty double-blind beverage samples, spiked with Salmonella enteritidis, Staphylococcus aureus, and Escherichia coli, were prepared in sterile Eppendorf® tubes at room temperature. The gold layer and spikes of ICGNPs increased the surface areas. The ratio …
Exploring The Concept Of The Digital Educator During Covid-19, Fernando Jimenez, Gracia Sanchez, Jose Palma, Luis Miralles-Pechuán, Juan A. Botia
Exploring The Concept Of The Digital Educator During Covid-19, Fernando Jimenez, Gracia Sanchez, Jose Palma, Luis Miralles-Pechuán, Juan A. Botia
Articles
T In many machine learning classification problems, datasets are usually of high dimensionality and therefore require efficient and effective methods for identifying the relative importance of their attributes, eliminating the redundant and irrelevant ones. Due to the huge size of the search space of the possible solutions, the attribute subset evaluation feature selection methods are not very suitable, so in these scenarios feature ranking methods are used. Most of the feature ranking methods described in the literature are univariate methods, which do not detect interactions between factors. In this paper, we propose two new multivariate feature ranking methods based on …
A Magnetic Nanoparticle-Doped Photopolymer For Holographic Recording, Muhammad Irfan, Suzanne Martin, Muhammad Ahmed Obeidi, Scott Miller, Frank Kuster, Dermot Brabazon, Izabela Naydenova
A Magnetic Nanoparticle-Doped Photopolymer For Holographic Recording, Muhammad Irfan, Suzanne Martin, Muhammad Ahmed Obeidi, Scott Miller, Frank Kuster, Dermot Brabazon, Izabela Naydenova
Articles
Functionalised holograms are important for applications utilising smart diffractive optical elements for light redirection, shaping and in the development of sensors/indicators. This paper reports on holographic recording in novel magnetic nanocomposites and the observed temperature change in dry layers and liquid samples exposed to alternating magnetic field (AMF). The nanocomposite consists of N-isopropylacrylamide (NIPA)-based polymer doped with magnetic nanoparticles (MNPs), and local heating is achieved through magnetic induction. Here, volume transmission holographic gratings (VTHGs) are recorded with up to 24% diffraction efficiency (DE) in the dry layers of magnetic nanocomposites. The dry layers and liquid samples are then exposed to …
The Association Between Ambient Uvb Dose And Anca‑Associated Vasculitis Relapse And Onset, Jennifer Scott, Enock Havyarimana, Albert Navarro-Gallinad, Arthur White, Jason Wyse, Jos Van Geffen, Michiel Van Weele, Antonia Buettner, Tamara Wanigasekera, Cathal Walsh, Louis Aslett, John Kelleher, Julie Power, James Ng, Declan O’Sullivan, Lucy Hederman, Neil Basu, Mark A. Little, Lina Zgaga
The Association Between Ambient Uvb Dose And Anca‑Associated Vasculitis Relapse And Onset, Jennifer Scott, Enock Havyarimana, Albert Navarro-Gallinad, Arthur White, Jason Wyse, Jos Van Geffen, Michiel Van Weele, Antonia Buettner, Tamara Wanigasekera, Cathal Walsh, Louis Aslett, John Kelleher, Julie Power, James Ng, Declan O’Sullivan, Lucy Hederman, Neil Basu, Mark A. Little, Lina Zgaga
Articles
The aetiology of ANCA-associated vasculitis (AAV) and triggers of relapse are poorly understood. Vitamin D (vitD) is an important immunomodulator, potentially responsible for the observed latitudinal differences between granulomatous and non-granulomatous AAV phenotypes. A narrow ultraviolet B spectrum induces vitD synthesis (vitD-UVB) via the skin. We hypothesised that prolonged periods of low ambient UVB (and by extension vitD deficiency) are associated with the granulomatous form of the disease and an increased risk of AAV relapse.
Evaluating Technology-Mediated Collaborative Workflows For Telehealth, Christopher Bondy Ph.D., Pengcheng Shi, Pamela Grover Md, Vicki Hanson, Linlin Chen, Rui Li
Evaluating Technology-Mediated Collaborative Workflows For Telehealth, Christopher Bondy Ph.D., Pengcheng Shi, Pamela Grover Md, Vicki Hanson, Linlin Chen, Rui Li
Articles
Goals: This paper discusses the need for a predictable method to evaluate gains and gaps of collaborative technology-mediated workflows and introduces an evaluation framework to address this need. Methods: The Collaborative Space Analysis Framework (CS-AF), introduced in this research, is a cross-disciplinary evaluation method designed to evaluate technology-mediated collaborative workflows. The 5-step CS-AF approach includes: (1) current-state workflow definition, (2) current-state (baseline) workflow assessment, (3) technology-mediated workflow development and deployment, (4) technology-mediated workflow assessment, (5) analysis, and conclusions. For this research, a comprehensive, empirical study of hypertension exam workflow for telehealth was conducted using the CS-AF approach. Results: The CS-AF …
Synergistic Anticancer Response Of Curcumin And Piperine Loaded Lignin-G-P (Nipam-Co-Dmaema) Gold Nanogels Against Glioblastoma Multiforme, Xinyi Zhao, Bilal Javad, Daxing Cui, James Curtin, Furong Tian
Synergistic Anticancer Response Of Curcumin And Piperine Loaded Lignin-G-P (Nipam-Co-Dmaema) Gold Nanogels Against Glioblastoma Multiforme, Xinyi Zhao, Bilal Javad, Daxing Cui, James Curtin, Furong Tian
Articles
Glioblastoma multiforme (GBM) is the most aggressive and commonly diag- 11 nosed brain cancer and presents a strong resistance to routine chemotherapeutic drugs. 12 The present study involves the synthesis of Lignin-g- p (NIPAM-co-DMAEMA) gold 13 nanogel, loaded with curcumin and piperine to treat GBM. The application has three 14 functions: (1) overcome the limitations of biodistribution, (2) enhance the toxicity of an- 15 ticancer drugs against GBM, (3) identify the uptake pathway. Atom transfer radical 16 polymerization was used to synthesize the Lignin-g-PNIPAM network, crosslinked with 17 the gold nanoparticles (GNPs) to self-assemble into nanogels. The size distribution and …
Dynamic Blood-Brain Barrier Regulation In Mild Traumatic Brain Injury, Eoin O'Keeffe, Eoin Kelly, Yuzhe Liu, Chiara Giordano, Eugene Wallace, Mark Hynes, Stephen Tiernan, Aidan Meagher, Chris Greene, Stephanie Hughes, Tom Burke, John Kealy, Niamh Doyle, Alison Hay, Michael Farrell, Gerald A. Grant, Alon Friedman, Ronel Veksler, Michael G. Molloy, James F. Meaney, Niall Pender, David Camarillo, Colin P. Doherty, Matthew Campbell
Dynamic Blood-Brain Barrier Regulation In Mild Traumatic Brain Injury, Eoin O'Keeffe, Eoin Kelly, Yuzhe Liu, Chiara Giordano, Eugene Wallace, Mark Hynes, Stephen Tiernan, Aidan Meagher, Chris Greene, Stephanie Hughes, Tom Burke, John Kealy, Niamh Doyle, Alison Hay, Michael Farrell, Gerald A. Grant, Alon Friedman, Ronel Veksler, Michael G. Molloy, James F. Meaney, Niall Pender, David Camarillo, Colin P. Doherty, Matthew Campbell
Articles
Whereas the diagnosis of moderate and severe traumatic brain injury (TBI) is readily visible on current medical imaging paradigms (magnetic resonance imaging [MRI] and computed tomography [CT] scanning), a far greater challenge is associated with the diagnosis and subsequent management of mild TBI (mTBI), especially concussion which, by definition, is characterized by a normal CT. To investigate whether the integrity of the blood-brain barrier (BBB) is altered in a high-risk population for concussions, we studied professional mixed martial arts (MMA) fighters and adolescent rugby players. Additionally, we performed the linear regression between the BBB disruption defined by increased gadolinium contrast …
Cognitive Performance In Midlife Type 2 Diabetes: Results Form The Enbind Study, A. H. Dyer, L. Mckenna, G. Gamage, N. M. Bourke, Isabelle Killane, M. Widdowson, C. P. Woods, J. Gibney, R. Reilly, D. O'Neill, S. P. Kennelly
Cognitive Performance In Midlife Type 2 Diabetes: Results Form The Enbind Study, A. H. Dyer, L. Mckenna, G. Gamage, N. M. Bourke, Isabelle Killane, M. Widdowson, C. P. Woods, J. Gibney, R. Reilly, D. O'Neill, S. P. Kennelly
Articles
Aims: To establish the impact of uncomplicated type 2 diabetes on cognitive and neuropsychological performance in midlife. Methods: We performed a cross-sectional study of middle-aged adults with uncomplicated type 2 diabetes and a cohort of healthy control participants. General cognition was assessed using the Montreal Cognitive Assessment test and neuropsychological assessment was undertaken using a detailed neuropsychological assessment battery. Results: A total of 152 participants (102 with type 2 diabetes and 50 controls) were recruited (mean age 52 ± 8 years, 51% women). Participants with midlife type 2 diabetes were more than twice as likely to make an error on …
Harnessing Smart Technology For Private Well Risk Assessment And Communication, Tanner Hoffman, Paul Hynds, Corinne Schuster-Wallace, Sarah Dickson-Anderson, Anna Majury
Harnessing Smart Technology For Private Well Risk Assessment And Communication, Tanner Hoffman, Paul Hynds, Corinne Schuster-Wallace, Sarah Dickson-Anderson, Anna Majury
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Unregulated, privately owned water supplies, including groundwater wells, are relied upon extensively, particularly in rural and remote regions. While adequate stewardship behaviors (water testing, treatment, and maintenance) have been shown to decrease the incidence and frequency of faecal indicator organism (FIO) presence and, by extension, the risk of pathogenic ingress, contaminated private water supplies continue to constitute a significant public health risk. Recognizing that innovative approaches are needed to bolster well stewardship, this paper identifies and assesses 35 tools (smartphone and web-based applications) to better understand components, functionality, strengths, and weaknesses. Applications for both data collection and risk communication were …
Assessment Of Physicochemical Characteristics, Thermal Stability And Release Profile Of Ascorbic Acid Microcapsules Obtained By Complex Coacervation, Michele Cristina Rodrigues Da Cruz, João Luiz Andreotti Dagostin, Camila Augusto Perussello, Maria Lúcia Masson
Assessment Of Physicochemical Characteristics, Thermal Stability And Release Profile Of Ascorbic Acid Microcapsules Obtained By Complex Coacervation, Michele Cristina Rodrigues Da Cruz, João Luiz Andreotti Dagostin, Camila Augusto Perussello, Maria Lúcia Masson
Articles
The aim of this study was to determine the physicochemical characteristics, thermal stability and release profile of ascorbic acid (AA) microcapsules obtained by complex coacervation. Gelatin and gum arabic were used as wall materials in concentrations of 2.5, 5.0 and 7.5 g% (w/v). The coacervate microcapsules were freeze-dried and assessed for physicochemical characteristics, thermal behavior and stability during 60 days of storage. The release profile was evaluated at different pH values (1.1, 2.2, 5.4, 7.4, 9.6 and 12). The encapsulation efficiency ranged from 27.3 to 93.8%. The microcapsules of AA presented good characteristics for application in food matrices, such as …
Nanostructured Materials For Food Applications: Spectroscopy, Microscopy And Physical Properties, Shubham Sharma, Swana Jaiswal, Brendan Duffy, Amit Jaiswal
Nanostructured Materials For Food Applications: Spectroscopy, Microscopy And Physical Properties, Shubham Sharma, Swana Jaiswal, Brendan Duffy, Amit Jaiswal
Articles
Nanotechnology deals with the matter of atomic or molecular scale. Other factors that define the character of a nanoparticle are its physical and chemical properties, such as surface area, surface charge, hydrophobicity of the surface, the thermal stability of the nanoparticle, and its antimicrobial activity. A nanoparticle is usually characterized by using microscopic and spectroscopic techniques. Microscopic techniques are used to characterize the size, shape, and location of the nanoparticle by producing an image of the individual nanoparticle. Several techniques, such as scanning electron microscopy (SEM), transmission electron microscopy/high resolution transmission electron microscopy (TEM/HRTEM), atomic force microscopy (AFM) and scanning …
Evaluation Of Hydrometric Network Efficacy And User Requirements In The Republic Of Ireland Via Expert Opinion And Statistical Analysis, Paul Hynds, Ahmed Nasr, Jean O'Dwyer
Evaluation Of Hydrometric Network Efficacy And User Requirements In The Republic Of Ireland Via Expert Opinion And Statistical Analysis, Paul Hynds, Ahmed Nasr, Jean O'Dwyer
Articles
Decreased funding and shifting governmental priorities have resulted in a contraction of hydrometric measurement in many regions over the past two decades. Moreover, concerns exist with respect to appropriate data usage and (transboundary) exchange, in addition to the compatibility and extent of existing hydrometric datasets. These issues are undoubtedly magnified due to enhanced data demands and increased financial pressures on network managers, thus requiring new approaches to optimising the societal benefits and overall efficacy of hydrometric information for future socio-hydrological resilience. The current study employed a quantitative cross-sectional expert elicitation of 203 respondents to collate, analyse and assess hydrometric network …
Fatigue And Damage Of Porcine Pars Interarticularis During Asymmetric Loading, Colin Bright, Stephen Tiernan, Fiona Mcevoy, Pat Kiely
Fatigue And Damage Of Porcine Pars Interarticularis During Asymmetric Loading, Colin Bright, Stephen Tiernan, Fiona Mcevoy, Pat Kiely
Articles
If the articular facets of the vertebra grow in an asymmetric manner, the developed bone geometry causes an asymmetry of loading. When the loading environment is altered by way of increased activity, the likelihood of acquiring a stress fracture may be increased. The combination of geometric asymmetry and increased activity is hypothesised to be the precursor to the stress fracture under investigation in this study, spondylolysis. This vertebral defect is an acquired fracture with 7% prevalence in the paediatric population. This value increases to 21% among athletes who participate in hyperextension sports. Tests were carried out on porcine lumbar vertebrae, …