Engineering Commons^™

Estimating Fluid Local Velocity Within A Novel 3d Collagen Matrix Perfusion System, Ana M. Villanueva, Sherry L. Voytik, Kevin P. Buno

The Summer Undergraduate Research Fellowship (SURF) Symposium

Traditional cell culture, performed on flat surfaces under static conditions, does not accurately represent physiologic conditions. As an alternative, groups have applied interstitial fluid flow (0.1-2.0 µm/s) through a 3D cell-embedded extracellular matrix (ECM). Cells sense the flow via mechanotransduction, a process by which cells sense mechanical forces and resultantly respond with biochemical signaling. Previous work demonstrates enhanced cell morphogenesis under interstitial flow conditions. However, fluid flow is poorly described within these systems, stressing the need for a well-characterized 3D interstitial flow system. Understanding fluid mechanics within a perfusion system will help elucidate cellular response to flow-induced mechanical forces.

The …

Tumor-Microenvironment-On-Chip To Mimic Tumor Heterogeneity, Victoria Noe-Kim, Altug Ozcelikkale, Bumsoo Han

The Summer Undergraduate Research Fellowship (SURF) Symposium

Ductal Carcinoma In Situ (DCIS) is a non-invasive cancer that forms around breast milk ducts that can potentially progress into invasive breast cancer if untreated. Lack of models to study its diverse pathophysiology and differential response to treatments poses a challenge to develop standard treatment modalities with improved therapeutic outcomes. The traditional in vitro models such as cell monolayer are convenient but insufficient to represent the physiological characteristics of DCIS tumor microenvironment and often fail to predict clinical outcomes. The animal models effectively simulate the in vivo environment but also lack the ability to control the environmental parameters to match …

Simulation Of Bio-Inspired Porous Battery Electrodes, Raju Gupta, R. Edwin Garcia, Rui Tu

The Summer Undergraduate Research Fellowship (SURF) Symposium

Advancement of technology has led to the increase in use of electronic devices. However, longer life of the rechargeable battery used in electronic devices is one of the biggest issue and demand in the world of electronic devices at present. Battery's performance is affected by the orientation, arrangement, shape and size, and porosity of the materials out of which battery electrodes are made. The goal of this project is to develop a set of numerical libraries that allow developing material micro structures that will allow increasing the performance of rechargeable batteries. We focused on the development of an algorithm that …

Development Of Combined Dual-Pump Vibrational And Pure-Rotational Coherent Anti-Stokes Raman Scattering (Dpvcars And Prcars) System, Shenli Yuan, Aman Satija, Robert Lucht

The Summer Undergraduate Research Fellowship (SURF) Symposium

Coherent anti-Stokes Raman scattering (CARS) [1,2] is a spatially-resolved, time-resolved spectroscopic technique for quantitative measurements in reacting flows [3 – 6]. This work demonstrates a combination of N₂/O₂/CO₂ dual-pump vibrational coherent anti-Stokes Raman scattering (DPVCARS) system and two-beam pure-rotational coherent anti-Stokes Raman scattering (PRCARS) system. It is based on the previous development of combined VCARS and PRCARS system which was used to obtain temperature measurements in non-premixed H₂-air flames. The new combined system will be used to measure the temperature profiles and major species concentrations such as N₂/O₂/CO_{2 …}

Crack Propagation Simulation Tool, Nilofer Rajpurkar, Hojin Kim, Alejandro Strachan

The Summer Undergraduate Research Fellowship (SURF) Symposium

In the massively engineered world that exists today, understanding material behavior is of paramount importance in caring for human safety in design. Molecular dynamic simulations on crack propagation through materials allow visualization of material behavior under stress. The tool, developed by the nanoHUB group as a part of the Network for Computational Nanotechnology at Purdue University, makes performing such simulations accessible to undergraduate students, highly qualified researchers, and all those in between. First, the input deck for the simulation parameters was simplified from the complex, language-specific code into a simple, user-friendly Graphic User Interface (GUI). Several interesting example cases were …

Characterization Of Mechanical Properties Displayed In Body Armor Ballistic Fibers, Dawei Li, Matthew Hudspeth, Weinong Wayne Chen

The Summer Undergraduate Research Fellowship (SURF) Symposium

The current body armor systems manufactured using ballistic fibers are not performing as theoretical results predict and are causing injuries. The actual maximum projectile penetration speed that the body armor can endure is significantly lower than the theoretical maximum speed, thus causing a costly build-test relationship that is not aided with modeling design efforts. The main aim of this research is to determine the maximum penetration speeds for ballistic yarns and fabrics. Secondary aim is to examine the common assumption that during transverse impact, single fiber is under pure tension and shear stress is negligible. To examine aforementioned assumption, fibers …

Doube-Pulse Laser-Induced Breakdown Spectroscopy Of Multi-Element Sample Containing Low- And High-Z Analytes, Patrick J. Skrodzki, Jason R. Becker, Prasoon K. Diwakar Ph. D., Sivanandan S. Harilal Ph. D., Ahmed Hassanein Ph. D.

The Summer Undergraduate Research Fellowship (SURF) Symposium

Laser-induced breakdown spectroscopy (LIBS) is a portable, remote, non-invasive analytical technique which effectively distinguishes neutral and ionic species for a range of low- to high-Z elements in a multi-element target. Subsequently, LIBS holds potential in special nuclear material (SNM) sensing and nuclear forensics requiring minimal sample preparation and detecting isotopic shifts which allows for differentiation in SNM (namely U) enrichment levels. Feasible applications include not only nonproliferation and homeland security but also nuclear fuel prospecting and industrial safeguard endorsement. Elements of higher mass with complex atomic structures, such as U, however, result in crowded emission spectra with LIBS, and characteristic …

Motion Control Of Robotic Arm With Command Shaping Method, Yumeng Wu, Peter H. Meckl, Alok Agrawal

The Summer Undergraduate Research Fellowship (SURF) Symposium

In the manufacturing industry, lots of rapid point-to-point motion is required while the residual vibration is unfavorable. Residual vibrations caused by flexible elements are limiting the performance of mechanical system, especially when the system needs to make rapid point-to-point motion. As proved in earlier studies, avoiding natural frequencies of the mechanical system reduces the residual vibrations. This work is based on a non-linear, two-link flexible jointed robot with configuration dependent resonance. Command shaping method consisting different combinations of base functions and weighting factors are compared in this work. The compatibility of command shaping with classical feedback control structure allows a …

Vast 2014, Challenge One: Event Analysis Within Big Data, Isaac C. Sheeley, Jieqiong Zhao, Jing Xia, Shehzad Afzal, Joseph Christopher, David Ebert Dr.

The Summer Undergraduate Research Fellowship (SURF) Symposium

News articles and email conversation data could be very useful in the analysis of developing and ongoing events, such as preventing a potential threat or possibly even locating a missing person. There is currently no “one-size-fits-all” solution to visualizing diverse forms of datasets and their sheer sizes are far too great to efficiently analyze by brute force methods. However, using principles of Visual Analytics, it is possible to take this information overload and transform it into a useful tool to help increase the efficiency of event analysis. A visualization system was developed for email conversation networks using web technologies. An …

Optimizing Neutron Yield For Active Interrogation, Amanda M. Loveless, Allen L. Garner, Robert D. Bean, Nader Satvat

The Summer Undergraduate Research Fellowship (SURF) Symposium

Neutrons are commonly used for many applications, including active interrogation and cancer therapy. One critical aspect for active interrogation efficiency is neutron yield, which is more important for successful resolution than the energy spectrum. The typical approach for improving neutron yield entails producing more neutrons, which has motivated multiple studies using the interaction of increasingly more powerful tabletop lasers with plastic targets to generate protons or deuterons that are absorbed by another target to create neutrons [1]. Alternatively, one may use lenses to focus the neutrons to increase yield rather than simply generating more neutrons with more powerful lasers [2]. …

Improved Microrobotic Control Through Image Processing And Automated Hardware Interfacing, Archit R. Aggarwal, Wuming Jing, David J. Cappelleri

The Summer Undergraduate Research Fellowship (SURF) Symposium

Untethered submilliliter-sized robots (microrobots) are showing potential use in different industrial, manufacturing and medical applications. A particular type of these microrobots, magnetic robots, have shown improved performance in power and control capabilities compared to the other thermal and electrostatic based robots. However, the magnetic robot designs have not been assessed in a robust manner to understand the degree of control in different environments and their application feasibility. This research project seeks to develop a custom control software interface to provide a holistic tool for researchers to evaluate the microrobotic performance through advance control features. The software deliverable involved two main …

Population Balance Modeling Of Conjugation In Enterococcus Faecalis, Jeremy Binagia, Vu Tran, Che-Chi Shu, Doraiswami Ramkrishna

The Summer Undergraduate Research Fellowship (SURF) Symposium

In the bacteria species Enterococcus faecalis, transfer of plasmid pCF10 by conjugation between donor cells that possess sets of genes conferring drug resistance and recipient cells leads to the spread of this resistance in a population. A complex signaling molecule network is responsible for communication between recipient and donor cells. Up to this point, the nature of these signaling molecules has been modeled deterministically from the point of view of an “average” cell. While this view has been cured slightly by stochastic treatments, a model is needed that better accounts for the individual nature of each cell, each cell’s interactions …

Dynamic Response Of Textile Material Under Transverse Impact, Yuchen Zheng, Matthew C. Hudspeth, Weinong W. Chen

The Summer Undergraduate Research Fellowship (SURF) Symposium

Textile materials, such as Dyneema and Kevlar, are the major raw materials for state of the art military or personal security armor vests. However, in impact experiments, actual observed penetration speed is much lower than theoretically predicted penetration speed. Each armor vest is composed of high performance yarns which are woven together to form fabrics, which when stacked together form a vest. Understanding penetration behavior of yarns is essential to evaluate the performance of fabric, which will be useful for the design of better vests. The project is composed of three parts: static experiments, dynamic yarn experiments and dynamic fabric …

Thermo-Mechanical Modeling Of Carbon Nanotube Thermal Interfaces, Yide Wang, Sridhar Sadasivam, Timothy S. Fisher

The Summer Undergraduate Research Fellowship (SURF) Symposium

In the last decade, much research has attempted to develop a highly conducting and mechanically reliable thermal interface material. Vertically aligned carbon nanotube arrays (CNTs) is a promising thermal interface material due to the high thermal conductivity of each CNT and the mechanical compliance of CNT arrays [1].

The computational modeling of CNTs is usually at an atomistic scale; however, atomistic simulations are computationally expensive for modeling macroscopic CNT arrays used in experiments. Coarse grain simulation techniques [2] have been developed to reduce the number of degrees of freedom and hence making large scale simulations computationally tractable. The purpose of …

The Influence Of Lightweight Aggregate On Internal Curing And Its Impact On Autogenous Shrinkage Of High-Performance Concrete, Neil J. Hartman, Timothy J. Barrett, Jason Weiss

The Summer Undergraduate Research Fellowship (SURF) Symposium

In bridge deck construction high performance concrete is often desirable, however in practice it is generally susceptible to early-age shrinkage cracking resulting in an overall reduction in service life. This research seeks to assess the potential for reducing early-age shrinkage in new bridge deck construction through the use of internal curing, a process in which internal reservoirs supply water to the hydrating cement paste during the early stages of cement hydration. In North America, internal curing is typically achieved by replacing a portion of the normal fine aggregate with an expanded fine lightweight aggregate (LWA). For this study, the free …

Quantification Of Lps Eluate From Coated Microelectrode Devices, Jahrane A. Dale, Janak Gaire, Kevin J. Otto

The Summer Undergraduate Research Fellowship (SURF) Symposium

Penetrating microelectrode arrays have a great potential to be used as control and communication interfaces for neuroprosthetics. A persistent obstacle in the clinical implementation of microelectrode arrays is the chronic degradation of these devices, putatively due to the foreign body response. Though researchers have studied the progression of the foreign body response and the effect of anti-inflammatory drugs on the efficacy of the implant, the exact biological mechanisms of implant degradation are not fully understood. To more closely investigate the effect of the foreign body response on device degradation, neuroinflammation can be exacerbated by coating dummy electrodes implanted into mice …

Nonlinear Optical Microscopy Of Murine Abdominal Aortic Aneurysm, Katherine E. Wilson, Alexa A. Yrineo, Amelia J. Adelsperger, Hilary D. Schroeder, Delong Zhang, Jesse Zhang, Chien-Sheng Liao, Frederick W. Damen, Ji-Xin Cheng, Evan H. Phillips, Craig J. Goergen

The Summer Undergraduate Research Fellowship (SURF) Symposium

Abdominal aortic aneurysm (AAA) is a cardiovascular disease characterized by dilation and weakening of the vessel wall. AAA rupture is responsible for approximately 14,000 deaths annually in the United States [1]. Nonlinear optical (NLO) microscopy presents new possibilities for analyzing AAA tissue samples from murine models. Common NLO techniques are two-photon excitation fluorescence (TPEF), which detects the intrinsic autofluorescent properties of elastin, and second-harmonic generation (SHG), which is specific for collagen fibrils. Elastin and collagen, two major extracellular matrix components, help the aortic wall withstand internal pressure. Murine AAAs were created through 1) subcutaneous continuous systemic infusion of angiotensin II …

Designing Constructed Wetlands For Water Purification In Tanzania, Danielle Mcneely, Michael Sheehan, John Lumkes

The Summer Undergraduate Research Fellowship (SURF) Symposium

In Tanzania half of households have unsafe drinking water (Nkonya, 2010) and many diseases arise from poor water quality, including meningitis, hepatitis A and E, and salmonella (Kusiluka et al., 2004). One cost-effective way of cleaning water is by passing it through a wetland. This research is focused on simplifying the process of horizontal subsurface flow wetland construction for the villagers of Endallah. The outcome is an Excel tool that standardizes methodology for building wetlands that can then be applied to Endallah. Rainfall data from the Arusha region of Tanzania was used to make a rainfall estimation grid. From this …

Chronic Brain Stimulation Using Micro-Ecog Devices, Hayden C. Carney, Roy Lycke, Kevin J. Otto, Amelia A. Schendel, Justin Williams

The Summer Undergraduate Research Fellowship (SURF) Symposium

Recording and stimulating brain activity has had great success both as a research tool and as a clinical technique. Neural prosthetics can replace limbs, restore hearing, and treat disorders like Parkinson’s and epilepsy, but are relatively crude. Current neural prosthetic systems use penetrating electrodes to achieve high precision, but the invasive nature of these devices provoke a strong immune response that limits chronic use. (Polikov et al) In our study we evaluate micro-electrocortiographic (micro-ECoG) devices which sit under the skull and on the surface of the brain for stimulation over chronic timescales. We anticipate these devices with their less invasive …

Modeling Of Mixed Friction Interactions Occurring In Axial Piston Pumps, Andrew C. Adelsperger, Lizhi Shang, Dan Mizell, Monika Ivantysynova

The Summer Undergraduate Research Fellowship (SURF) Symposium

Axial piston pumps are integral to a variety of hydraulic systems due to their versatility and reliability, but most attempts to model them for design purposes have failed. However, software which fully models the fluid structures within these pumps, such as the FSTI gap design program, has improved significantly. Unfortunately, current discrepancies between simulated and measured friction forces on the cylinder due to the fluid drag and piston movement need to be eliminated so that more accurate simulation of these pumps in operation is possible. Friction measurements and FSTI simulation outputs were analyzed with MATLAB filters and graphs, resulting in …

Effect Of Twin Screw Granulator Process Parameters On Granule Attributes, Haosheng Xu, Ridade Sayin, James Litster

The Summer Undergraduate Research Fellowship (SURF) Symposium

Twin screw wet granulation has been considered as an efficient and effective technique of manufacturing granules (agglomerates made up of small particles) and has been widely applied in pharmaceutical industry. However, narrow granule size distributions are difficult to achieve. This study aims to elucidate the effect of process parameters such as liquid feed rate and screw configuration on the granule attributes through granule characterization. The methods used are sieve analysis (for size distribution), liquid distribution (determining the dye concentration in the granules) and density and porosity (percentage gas volume in the granule) analyses. A sieve shaker is used to divide …

Characterization Of Swelling Ratio And Water Content Of Hydrogels For Cartilage Engineering Applications, Emily E. Gill, Renay S.-C. Su, Julie C. Liu

The Summer Undergraduate Research Fellowship (SURF) Symposium

Due to the high prevalence of arthritis and cartilage-related injuries, tissue engineers are studying ways to grow cartilage tissue replacements. Resilin, an elastomeric protein found in insect cuticles, is known for its extraordinary resilience and elasticity. In previous studies, recombinant resilin-based hydrogels, or cross-linked protein networks, exhibited potential for use in cartilage tissue scaffolds. Our lab successfully developed resilin-based proteins with a sequence based on the mosquito gene and showed that resilin-based hydrogels possess mechanical properties of the same order of magnitude as native articular cartilage. In addition, these mechanical properties can be controlled by changing the protein concentration. To …

Thermal Properties Of Soft Nanomaterials: Materials Synthesis And Fabrication, Meng Pan, Collier Miers, Amy Marconnet, Yu Han

The Summer Undergraduate Research Fellowship (SURF) Symposium

The properties of soft nanomaterials are hard to measure exactly due to their mechanical properties and unstable shape. In particular, hydrogels are a class of cross-linked polymers that can absorb large quantities of water changing their shape under the influence of various conditions such as humidity, temperature, and pH. This research addresses the fabrication of a material that has a significant contrast in properties under different conditions (e.g. temperature, wetting, and pH) and determine the physical mechanisms of heat transfer in this nanomaterial. The hydrogels are made using a several cycles of a freeze-thaw method. The method requires soluble material. …

Solar-Combined Thermoelectric Power Generation Simulator, Hemanth Mullangi Chenchu, Kazuaki Yazawa, Je-Hyeong Bahk

The Summer Undergraduate Research Fellowship (SURF) Symposium

Photovoltaic (PV) devices are gaining popularity in harnessing solar energy as a form of sustainable energy source to generate electricity. However, these devices including tandem PV cells are limited to utilizing only high energy photons from the solar spectrum. This curtails their efficiency restricting them from being employed in mega Watts scale power generation. This study develops a software tool that allows engineers to tap into the wasted wavelengths of the spectrum by adding a thermoelectric (TE) module and a bottoming steam turbine cycle thus spreading the use of the spectrum. The tool allows investigating how power output and thus …

Simulation Of Bio-Inspired Porous Battery Separators, Yumeng Xie, Edwin Garcia, Aniruddha Jana

The Summer Undergraduate Research Fellowship (SURF) Symposium

Li-Ion rechargeable battery is one of the most-used rechargeable batteries around the industry of the world. The battery is most used in most electronic devices, electrical cars. But the battery separator is one of the mainly problem that limits the service life. If we can find the way to improve the performance of the battery separator, we can highly increase the service life of the Li-Ion battery. The goal of the project 'Simulation of Bio-Inspired Porous Battery Separators' is to generate a tool for users in order to create computer models of bio-inspired porous structures that resemble porous separators layer …

Double-Pulse Nd:Yag-Co2 Libs Excitation For Bulk And Trace Analytes, Jason R. Becker, Patrick Skrodzki, Prasoon Diwakar, Sivanandan Harilal, Ahmed Hassanein

The Summer Undergraduate Research Fellowship (SURF) Symposium

Laser-induced breakdown spectroscopy [LIBS] is a commonly used technique for multi-element analyses for various applications such as space exploration, nuclear forensics, environmental analysis, process monitoring. The advantages of the LIBS technique include robustness, ease of use, field portability, and real-time, non-invasive multi-element analyses. However, in comparison to other lab based analytical techniques, it suffers from low precision and low sensitivity. In order to overcome these drawbacks, various approaches have been used, including double-pulse LIBS [DPLIBS]. Typically, various wavelength combinations of two Nd: yttrium aluminum garnet [YAG] lasers have been used for DPLIBS. However, the use of long wavelength (CO_{2 …}

Monitoring Hydroxyurea Treatment Of Sickle Cell Anemia, Adhit Ramamurthi, Jayachandran Devaraj, Doraiswami Ramkrishna

The Summer Undergraduate Research Fellowship (SURF) Symposium

Sickle cell is a hereditary disease affecting more than 100,000 people in the United States alone that causes hemoglobin in red blood cells to polymerize and turn the cell into a sickle shape, resulting in severe vaso-occlusive crises and ischemic attacks. Sickle cell patients often suffer from pain crises, with the number of pain crises linked to their prognosis, especially at a younger age. Currently, the drug hydroxyurea (HU) is used to treat the disease, with a measure of red blood cell volume (RBC MCV) as monitor for treatment progression. However, physicians have to wait atleast 120 days to identify …

Roundabout Maintenance Manual, Emily A. Bonini, Pat Conner P.E., John Haddock Phd, P.E., Yu Tian

The Summer Undergraduate Research Fellowship (SURF) Symposium

In recent years, roundabouts have been rapidly growing in popularity. As a result, many communities are installing them in their roadways; however, they are encountering difficulties in maintaining them. Uneducated workers can cause damage to roundabouts and to themselves, costing cities time and money. This project aims to create a guide for communities new to roundabouts in order to reduce damages and unnecessary maintenance costs. Data was gathered by determining the most common maintenance questions and problems along with what information was already available on roundabout maintenance. Next, agencies most experienced with roundabouts were surveyed on the best maintenance practices. …

Modeling Thermophotovoltaic Rare Earth Based Selective Emitters, Anubha Mathur, Enas Said Sakr, Peter Bermel

The Summer Undergraduate Research Fellowship (SURF) Symposium

Thermophotovoltaic (TPV) devices convert heat to electricity using thermal radiation to illuminate a photovoltaic (PV) diode. Typically, this radiation is generated by a blackbody-like emitter. Such an emission spectrum includes a broad range of wavelengths, but only higher energy photons can be converted by the PV diode, which severely limits efficiencies. Thus, introducing a selective emitter and filter to recycle unwanted photons could potentially greatly enhance performance. In this work, we consider a rare earth-doped selective emitter structure to increase the number of photons emitted above the bandgap of the photovoltaic (PV) cell, while minimizing the total power emitted below …

Design And Fabrication Of A Novel Electrospinning System For Musculoskeletal Tissue Regeneration, Carter L. Chain, Maggie R. Del Ponte, Meng Deng, Feng Yue, Shihuan Kuang

The Summer Undergraduate Research Fellowship (SURF) Symposium

Disease and injury to human tissue, especially musculoskeletal tissue, is a prevalent concern to the public, affecting millions of people each year. Current treatment options involving autografts and allografts are hindered by limited availability and risk of immunogenicity, respectively. In order to overcome these limitations, a transdisiplinary regenerative engineering strategy has emerged with a focus on the development of biomimetic scaffolds that closely mimic the properties of the native tissues. For example, the structure of muscle tissue is characterized by oriented muscle fibers. However, fabrication of aligned nanofiber structures that mimic the anisotropic organization of muscle presents significant engineering challenges. …