Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Electrical and Computer Engineering (2204)
- Aerospace Engineering (1773)
- Mechanical Engineering (1702)
- Civil and Environmental Engineering (1335)
- Operations Research, Systems Engineering and Industrial Engineering (1286)
-
- Physical Sciences and Mathematics (1119)
- Computer Engineering (730)
- Operational Research (598)
- Chemical Engineering (535)
- Biomedical Engineering and Bioengineering (528)
- Computer Sciences (503)
- Materials Science and Engineering (432)
- Signal Processing (427)
- Aviation (412)
- Electrical and Electronics (404)
- Civil Engineering (293)
- Business (282)
- Physics (252)
- Systems Engineering (247)
- Construction Engineering and Management (241)
- Navigation, Guidance, Control and Dynamics (233)
- Environmental Engineering (222)
- Other Operations Research, Systems Engineering and Industrial Engineering (218)
- Nuclear Engineering (208)
- Engineering Science and Materials (202)
- Aerodynamics and Fluid Mechanics (189)
- Digital Communications and Networking (180)
- Electromagnetics and Photonics (167)
- Space Vehicles (165)
- Institution
-
- Air Force Institute of Technology (5086)
- Brigham Young University (2410)
- University of South Carolina (1055)
- Virginia Commonwealth University (693)
- Florida Institute of Technology (690)
-
- Rowan University (360)
- University of Texas Rio Grande Valley (320)
- Mississippi State University (261)
- American University in Cairo (213)
- University of Arkansas Little Rock (134)
- SASTRA Deemed to be University (133)
- University for Business and Technology in Kosovo (110)
- University of North Dakota (16)
- Illinois State University (12)
- Columbus State University (11)
- City University of New York (CUNY) (4)
- Nova Southeastern University (1)
- Pepperdine University (1)
- Keyword
-
- #antcenter (293)
- Machine learning (127)
- Optimization (124)
- #csra (106)
- FPGA (94)
-
- Simulation (80)
- Machine Learning (79)
- Additive manufacturing (72)
- Modeling (71)
- UAV (69)
- Applied sciences (64)
- Computer vision (64)
- Global Positioning System (63)
- Image processing (62)
- Remote sensing (59)
- Deep learning (55)
- Algorithms (53)
- Kalman filtering (51)
- Microelectromechanical systems (51)
- Decision making (50)
- Flight control (48)
- Drone aircraft (47)
- Target acquisition (47)
- #afcec (46)
- Compliant mechanisms (46)
- Synthetic aperture radar (46)
- Combustion (45)
- Composite materials (45)
- Signal processing (45)
- Engineering, Chemical Engineering (44)
- Publication Year
Articles 3841 - 3870 of 11510
Full-Text Articles in Engineering
Curbside Antenna To Vehicle Path Loss Measurements And Modeling In Three Frequency Bands, Patrick Murphy
Curbside Antenna To Vehicle Path Loss Measurements And Modeling In Three Frequency Bands, Patrick Murphy
Theses and Dissertations
V2V and V2I systems have been an increasingly important topic of study in recent years. Future V2I systems could involve antennas near or on the curb at intersections or on the ground along highways. To this end the curbside antenna to vehicle channel has not been studied very much. The scope of this thesis is to develop initial models for the path loss for examples of this channel. This was done through a measurement campaign where the transmitting antenna is located on the ground near the road and the receiver is in a vehicle driving towards the transmitter. The vehicle …
Modeling Particle Dispersal In Bedload Dominated Settings, Sanaz Borhani
Modeling Particle Dispersal In Bedload Dominated Settings, Sanaz Borhani
Theses and Dissertations
Tracer particles are used to study bedload transport in gravel bed rivers. One of the advantages associated with their use is that they allow for direct measurements of particle entrainment rates in bedload transport and particle displacement. The main issue in field studies with tracer particles is the difference between tracer short term and long term behavior. This difference is due to the fact that particles undergo vertical mixing or move to less active locations such as bars or even floodplains. For these reasons the mean tracer velocity decreases over time. This phenomenon has been called tracer slowdown and it …
The Study Of Flow Hydrodynamics And Transport Processes Over Mixed Bedrock-Alluvial Reaches, Mohammad Sadegh Jafarinik
The Study Of Flow Hydrodynamics And Transport Processes Over Mixed Bedrock-Alluvial Reaches, Mohammad Sadegh Jafarinik
Theses and Dissertations
Research efforts on mixed bedrock-alluvial rivers primary focused on the bedrock incision and very few studies investigated the alluvial morphodynamics of such systems. To the best of my knowledge none of these models have been considered the spatial variability of the sediment grain size of the bed surface in mixed bedrock-alluvial reaches and very few models focused on the spatial changes in alluvial cover within these reaches. Furthermore, a perusal of the literature on mixed bedrock-alluvial river morphodynamics reveals that very little information is available on 1) bedform geometry and flow resistances and 2) sediment sorting patterns in presence of …
Experimental Analysis Of The Automated Fiber Placement Manufacturing Parameters For High And Low Tack Prepreg Material, Anis Baz Radwan
Experimental Analysis Of The Automated Fiber Placement Manufacturing Parameters For High And Low Tack Prepreg Material, Anis Baz Radwan
Theses and Dissertations
Automated Fiber Placement (AFP) is a flexible but complex manufacturing technique which is used to layup carbon fiber tows into flat or curved structures. That could be achieved through linear and steered paths of fibers. The quality of AFP layup is highly dependent on the manufacturing process parameters such as layup temperature, tow feedrate, compaction force, and tow tension. Understanding how those parameters affect the process is crucial for achieving the desirable quality and productivity. For this work, an experimental investigation is carried out to determine the processing window that yields optimal quality for two types of material: High tack …
Impact Of Cycloalkanes On Ignition Propensity Measured As Derived Cetane Number In Multi-Component Surrogate Mixtures, Dalton Odell Carpenter
Impact Of Cycloalkanes On Ignition Propensity Measured As Derived Cetane Number In Multi-Component Surrogate Mixtures, Dalton Odell Carpenter
Theses and Dissertations
Cycloalkanes are one type of hydrocarbons present in real jet fuels. The distinct cyclic structure of the cyclo-alkanes impacts the chemical kinetic behavior differently compared to n- and iso-alkanes. At high temperatures, thermal decomposition reactions dominate, producing n-alkyl radicals similar to the oxidation reactions of n-alkanes thus promoting the reactivity. Whereas in low temperatures, the presence of the ring structure essentially suppresses the formation of alkylhydroperoxy radicals (QOOH) from alkylperoxy radicals (RO2), thus exhibiting similar reactivity to iso-alkanes. In previous generations of surrogate fuels, the cyclo-alkane functional group were largely ignored due to low levels of cycloalkanes in traditional jet …
Liquid Phase Modeling In Heterogeneous Catalysis, Mohammad Shamsus Saleheen
Liquid Phase Modeling In Heterogeneous Catalysis, Mohammad Shamsus Saleheen
Theses and Dissertations
Conversion of lignocellulosic biomass into transportation fuels or commodity and specialty chemicals will be an important and fast-growing industry within the United States over the coming decades. Its growth will be driven by a variety of factors, including increased energy demands, environmental considerations, national security, and government mandates. To achieve the desired energy efficiency and economic impact, the emerging biorefining industries need novel heterogeneous catalysts with exceptional activity, selectivity, and stability. Catalytic materials developed in the petrochemical industries are generally not suitable for processing highly functionalized feedstocks typical of the biorefinery landscape. Due to the characteristics of this biomass feedstock …
3d Topology Optimization Of Spatially Reinforced Composites, Luis G. Bahamonde Jácome
3d Topology Optimization Of Spatially Reinforced Composites, Luis G. Bahamonde Jácome
Theses and Dissertations
Topology optimization is a numerical design tool used to generate structural concepts that present optimal load paths for a given set of functional requirements. This functional generative design capability has been used to lightweight high performance structures with 1D, 2D and 3D stress states. On the other hand, fiber-reinforced composites are the perfect candidate material to use in high performance structures due to the tailorability of their stiffness and strength properties. Although numerical tools that simultaneously tailor the composite material properties while optimizing the structural topology exist, these tools are inherently limited to 1D and 2D stress states.
This work …
Mechanical Characterization And Non-Destructive Evaluation Of SicF/SicM Composites For Nuclear Applications, Donald J. Mccleeary
Mechanical Characterization And Non-Destructive Evaluation Of SicF/SicM Composites For Nuclear Applications, Donald J. Mccleeary
Theses and Dissertations
The SiCf/SiCm composite material is a promising candidate for accident tolerant fuel cladding in light water reactors and for structural elements in high temperature reactors. The material demonstrates exceptional toughness when compared to monolithic ceramics. It is critical to characterize the mechanical behavior, internal damage and ultimate strength of these composites under relevant loading conditions. In this thesis, the author developed and improved several mechanical characterization and non-destructive evaluation methods and applied them to SiCf/SiCm composites. Impulse excitation (IE) analysis of damaged SiCf/SiCm composite disks following controlled impact testing shows a …
Development Of An Automated Fiber Placement Process For The Fabrication Of Thermoplastic Composite Laminates, Anthony M. Sabido
Development Of An Automated Fiber Placement Process For The Fabrication Of Thermoplastic Composite Laminates, Anthony M. Sabido
Theses and Dissertations
An automated fiber placement process is desired for manufacturing variable-stiffness thermoplastic composite laminates. By developing such a composite laminate, it is possible to take advantage of the tunable performance increases that are achievable by spatially steering individual tows. In addition, using a thermoplastic polymer as the matrix material has many advantages: a high toughness, ability to employ thermoplastic joining processes that do not require adhesives, long storage life, and lacks the need to be refrigerated. This process was experimentally developed, where the effect of various process parameters on the quality of the laminate were evaluated. An experimental AFP head was …
Damping In Transient Pressurized Flows, Sahad Salim Elyass Khilqa
Damping In Transient Pressurized Flows, Sahad Salim Elyass Khilqa
Theses and Dissertations
Piping systems are commonly designed to withstand the first transient pressure peak, which is unaffected by dissipation. However, for multiple operations of control equipment, e.g., pump start-up following pump shutdown, load acceptance following load rejection on hydraulic turbines, etc., an accurate prediction of the dissipation of pressure oscillations is needed to determine a suitable time for the second operation. For this purpose, a method is presented to compute the dissipation of pressure oscillations in piping system following a simple procedure used for computing the dissipation of vibrations of bridges and other structures. Similar to structural engineering, this method is simple …
Surrogate Formulation Based On Chemical Functional Group Analysis, Stuart Nates
Surrogate Formulation Based On Chemical Functional Group Analysis, Stuart Nates
Theses and Dissertations
Chemical kinetic characteristics of real fuels exhibit high-dimensional complexity due to the excessive number of molecules and molecular classes. As a method of projecting this high-dimensional complexity, which is pertinent to real fuels, to the low-dimensional description, either a surrogate approach or detailed experiments have been utilized, can guide the construction of chemical kinetic models for real fuel. Although the validity of the surrogate approach has been extensively demonstrated by a wide range of canonical experiments for whole fuel/air mixtures, the use of empirical fuel property indicators still worries whether or not the surrogate mixture truly captures the more complex …
Too Agile? - Devops Software Development Challenges In A Military Environment, Burl T. Kenner Iii
Too Agile? - Devops Software Development Challenges In A Military Environment, Burl T. Kenner Iii
Theses and Dissertations
Agile and DevOps software development processes now represent proven, commonly accepted models in commercial industry. For DoD military environments however, empowering teams of software developers and end user operators to build, test and release solutions without direct oversight and management of leadership is a brand new experience. In 2017, a DoD software acquisitions revolution occurred when approval was granted to scrap the former ineffective, cost prohibitive process and initiate the agile DevOps model. After one year since its introduction, this paper may represent the very first look at how well this nontraditional process is working out in a military command …
Enabling High Energy Density Aluminum Anodes For Alkaline Batteries, Xinyi Zhao
Enabling High Energy Density Aluminum Anodes For Alkaline Batteries, Xinyi Zhao
Theses and Dissertations
Zn-MnO2 primary alkaline batteries stood out immediately among all batteries after it was introduced in the late 1980s and has attracted world-wide attention. These batteries have dominated the portable power market for decades as a highly effective energy storage system with high energy density, long life and low self-discharge, dependable safety and other superiorities.
In order to achieve higher cell-level energy density, Aluminum has long been considered a very attractive anode material for alkaline batteries because of its high theoretical capacity (2980 mAh/g; 2.60 Ah/cm3) and low price. However, some early efforts to utilize aluminum anodes did …
Effect Of Tcdd, An Environmental Contaminant, On Activation Of Ahr Leading To Induction Of Myeloid Derived Suppressor Cells (Mdscs) And The Ability Of Resveratrol, A Botanical, To Neutralize This Effect, Wurood Hantoosh Neamah
Effect Of Tcdd, An Environmental Contaminant, On Activation Of Ahr Leading To Induction Of Myeloid Derived Suppressor Cells (Mdscs) And The Ability Of Resveratrol, A Botanical, To Neutralize This Effect, Wurood Hantoosh Neamah
Theses and Dissertations
Aryl hydrocarbon receptor (AhR), is a ligand-activated transcription factor that integrates environmental, dietary, microbial and metabolic cues to control various cellular processes, such as the cell cycle, epithelial barrier function, cell migration and immune function. AhR was discovered as the receptor that binds with high affinity to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and leads to numerous of toxicological outcomes. In the current study, we discovered a critical role played by AhR, following activation by TCDD, in modulating a variety of immunological functions through regulation of epigenetic and microbial pathways. Our data demonstrated that AhR activation triggers MDSC mobilization from bone marrow to peritoneal …
Role Of Epigenetic, Molecular And Cellular Pathways In The Regulation Of Inflammation, William James Becker
Role Of Epigenetic, Molecular And Cellular Pathways In The Regulation Of Inflammation, William James Becker
Theses and Dissertations
Dysregulated inflammation is at the heart of countless human diseases. Graft rejection is the process by which an organ from an incompatible donor is rejected by the recipient whose immune cells attack the foreign tissue. Colitis is an inflammatory disorder caused by undue chronic inflammation in the colon and rectum that can progress to cancer. Colitis incidence is on the rise, especially in developing nations and Asia; and the list of patients who need organ transplants grow by the day. Therapies for both graft rejection and colitis are limited to immunosuppressive drugs that leaves patients vulnerable to infection, heart disease, …
Enhancing Thermal-Hydraulic Performance Of Parallel And Counter Flow Mini-Channel Heat Sinks Utilizing Secondary Flow: A Numerical And Experimental Study, Amitav Tikadar
Theses and Dissertations
Continual growth of hydraulic and thermal boundary layers along stream wise direction in conventional straight fin mini-channel heat sink causes gradual deterioration of their thermal performance. To enhance thermal-hydraulic performance by breaking and redevelopment of the boundary layers, this research aims to introduce a novel inter-connected mini-channel sinks. Two inter-connectors were positioned transversely between two adjacent mini-channels, which segmented the flow domain into three zones. Secondary flow was generated through the inter-connectors utilizing the pressure difference of the adjacent channels resulting in hydraulic and thermal boundary layers disruption and hence enhanced thermal-hydraulic performance of the mini-channel heat sink was achieved. …
Flame Spray Pyrolysis Of Ce-Mn Solid Solutions For Catalytic Applications, Nicole Cordonnier
Flame Spray Pyrolysis Of Ce-Mn Solid Solutions For Catalytic Applications, Nicole Cordonnier
Theses and Dissertations
Flame spray pyrolysis (FSP) is a method of quickly synthesizing active particles in a flame. Precursors are dissolved in a flammable organic solvent before being sprayed into the flame environment where they rapidly burn. Particle formation occurs on the order of 10 milliseconds. FSP has been shown to be a viable method of producing materials on an industrial scale, capable of producing grams of particles per minute. Metastable structures which exist in the liquid phase, but are difficult to synthesize using traditional impregnation methods can be formed with FSP due to fast quenching times. For example, solid solutions of Ce-Zr …
Epigenetic And Purinergic Regulation Of Mast Cells Mediator Release, Zahraa Abdulmohsin Mohammed
Epigenetic And Purinergic Regulation Of Mast Cells Mediator Release, Zahraa Abdulmohsin Mohammed
Theses and Dissertations
Mast cells (MCs) are well known for their implications in allergic reactions. They are also known to have multiple functions in the innate and adaptive immune system. Their activation plays an essential role in many aspects of physiological and pathological conditions. Allergies are considered chronic conditions that affect more than 60 million people in the U.S. These diseases are driven by the activation of MCs in response to IgE-mediated antigen, rendering these cells as targets for the management of allergies and asthma. Therefore, this research considers the understanding of their activation and the regulation of their response to be an …
Machine Learning Methods For Rapid Inspection Of Automated Fiber Placement Manufactured Composite Structures, Christopher Sacco
Machine Learning Methods For Rapid Inspection Of Automated Fiber Placement Manufactured Composite Structures, Christopher Sacco
Theses and Dissertations
The advanced manufacturing capabilities provided through the automated fiber placement (AFP) system has allowed for faster layup time and more consistent production across a number of different geometries. This contributes to the modern production of large composite structures and the widespread adaptation of composites in industry in general and aerospace in particular. However, the automation introduced in this process increases the difficulty of quality assurance efforts and inspection. The AFP process can induce a number of manufacturing defects including wrinkles, twists, gaps, and overlaps. The manual identification of these defects is often laborious and requires a measure of expert knowledge. …
Experimental Methods And Techniques For Improved Biomechanical Characterization Of Diverse Murine Aortopathies, Brooks Alexander Lane
Experimental Methods And Techniques For Improved Biomechanical Characterization Of Diverse Murine Aortopathies, Brooks Alexander Lane
Theses and Dissertations
Aortopathies constitute a broad class of diseases affecting the aorta – the largest artery responsible for distributing oxygenated blood to the systemic circulation. Specifically, aortic aneurysms (AAs) are described as a focal dilation of the vascular wall exceeding 50% of the normal vessel diameter. Ultimately AAs may stabilize, dissect, or rupture, with the latter virtually ensuring mortality. Currently clinicians consider prophylactic intervention based on size and growth-rate criteria that have been estimated from large-cohort statistical analyses. These criteria, however, fail to address the underlying mechanisms. Furthermore, 13% of small-to-mid sized AAs have been found to rupture prior to meeting these …
Damage Evaluation Of Concrete Structures Using Acoustic Emission, Rafal Anay
Damage Evaluation Of Concrete Structures Using Acoustic Emission, Rafal Anay
Theses and Dissertations
The deterioration and aging of the infrastructure in the U.S. have become a crucial issue, especially for highway bridges and nuclear power plants. The reliability and safety of existing structures are affected by growing populations and limited resources. This issue has gained significant concern during the last two decades and efforts are being conducted to accelerate the improvement of nondestructive testing (NDT) and structural health monitoring (SHM) methods. Additional information regarding the condition of existing structures and the early detection of damage can aid in reducing overall maintenance costs. The studies presented in this dissertation employ acoustic emission (AE) as …
A Model For Condensation Heat Transfer In Hydrophobic-Hydrophilic Surfaces, Abdulwahab E. Alhashem
A Model For Condensation Heat Transfer In Hydrophobic-Hydrophilic Surfaces, Abdulwahab E. Alhashem
Theses and Dissertations
The primary focus of this research is to provide a validated model for a comprehensive understanding of hydrophobic-‐hydrophilic condensation on patterned-‐ hybrid surface. Establishing the model requires the modeling of fully dropwise condensation (DWC) before applying modifications to evaluate heat transfer performance of patterned-‐hybrid condensation surface.
The model for fully DWC consists of defining expressions for heat transfer through a single drop, maximum radius of the drop and drop-‐size distribution which all are primarily based on the work in the literature. In this work the author utilized a proposed modified version of the simulation for drop-‐size distribution for fully DWC, …
Health Monitoring Of Liquid Pipelines, Mohammed Hameed Sabhan Al-Tofan
Health Monitoring Of Liquid Pipelines, Mohammed Hameed Sabhan Al-Tofan
Theses and Dissertations
The crude and refined oil, water, and other liquids are widely transported through pipelines over long distances within geographical boundaries of countries or beyond. Pipeline accidents, however, are frequent, affecting operation and reducing targeted performance. The frequency of these accidents presents a growing concern and necessitates the need for an effective health monitoring plan. This plan requires monitoring of flow conditions and warning of any changes or abnormal conditions. Abnormalities in the flow conditions include changes in the piping system performance due to defects, such as leaks and blockages. These changes can be located and quantified utilizing different approaches. Two …
Application And Evaluation Of Full-Field Surrogate Models In Engineering Design Space Exploration, Christopher Murray Thelin
Application And Evaluation Of Full-Field Surrogate Models In Engineering Design Space Exploration, Christopher Murray Thelin
Theses and Dissertations
When designing an engineering part, better decisions are made by exploring the entire space of design variations. This design space exploration (DSE) may be accomplished manually or via optimization. In engineering, evaluating a design during DSE often consists of running expensive simulations, such as finite element analysis (FEA) in order to understand the structural response to design changes. The computational cost of these simulations can make thorough DSE infeasible, and only a relatively small subset of the designs are explored. Surrogate models have been used to make cheap predictions of certain simulation results. Commonly, these models only predict single values …
Optimization And Hardware Implementation Of Syba-An Efficient Feature Descriptor, Samuel Gaylin Fuller
Optimization And Hardware Implementation Of Syba-An Efficient Feature Descriptor, Samuel Gaylin Fuller
Theses and Dissertations
Feature detection, description and matching are crucial steps in many computer vision algorithms. These rely on feature descriptors to be able to match image features across sets of images. This paper discusses a hardware implementation and various optimizations of our lab's previous work on the SYnthetic BAsis feature descriptor (SYBA). Previous work has shown that SYBA can offer superior performance to other binary descriptors, such as BRIEF. This hardware implementation on an FPGA is a high throughput and low latency solution, which is critical for applications such as: high speed object detection and tracking, stereo vision, visual odometry, structure from …
Ultra Low Latency Visual Servoing For High Speed Object Tracking Using Multi Focal Length Camera Arrays, Alexander Steven Mccown
Ultra Low Latency Visual Servoing For High Speed Object Tracking Using Multi Focal Length Camera Arrays, Alexander Steven Mccown
Theses and Dissertations
In high speed applications of visual servoing, latency from the recognition algorithm can cause significant degradation of in response time. Hardware acceleration allows for recognition algorithms to be applied directly during the raster scan from the image sensor, thereby removing virtually all video processing latency. This paper examines one such method, along with an analysis of design decisions made to optimize for use during high speed airborne object tracking tests for the US military. Designing test equipment for defense use involves working around unique challenges that arise from having many details being deemed classified or highly sensitive information. Designing tracking …
Proactive Energy Optimization In Residential Buildings With Weather And Market Forecasts, Cody Ryan Simmons
Proactive Energy Optimization In Residential Buildings With Weather And Market Forecasts, Cody Ryan Simmons
Theses and Dissertations
This work explores the development of a home energy management system (HEMS) that uses weather and market forecasts to optimize the usage of home appliances and to manage battery usage and solar power production. A Moving Horizon Estimation (MHE) application is used to find the unknown home model parameters. These parameters are then updated in a Model Predictive Controller (MPC) which optimizes and balances competing comfort and economic objectives. Combining MHE and MPC applications alleviates model complexity commonly seen in HEMS by using a lumped parameter model that is adapted to fit a high-fidelity model. HVAC on/off behaviors are simulated …
Controlling Co Dose From Corm-Loaded Electrospun Scaffolds With Diffusion-Based Modeling And Experimental Assessment Of Endothelial Cell Response, Kenyatta S. Washington
Controlling Co Dose From Corm-Loaded Electrospun Scaffolds With Diffusion-Based Modeling And Experimental Assessment Of Endothelial Cell Response, Kenyatta S. Washington
Theses and Dissertations
Cardiovascular disease (CVD) accounts for one in every five deaths in the United States alone due to occlusion in small diameter (< 6 mm) vessels. The current treatment options includes bypass grafting; however, more than 30 percent of patients do not have viable saphenous veins for autologous grafting [1]. Therefore, tissue engineering is being considered as an alternative approach. The overall goals of this project were to develop a tissue engineered vascular graft with the incorporation of carbon monoxide releasing molecules (CORMs) and to determine the impacts of carbon monoxide (CO) on endothelial cells (ECs) with the goal of promoting a functional endothelium within the graft. This was accomplished through two complementary studies: investigating the impacts of CO-loaded electrospun scaffolds on ECs for cardiovascular applications and diffusion-based modeling of drug delivery of gasotransmitters from tissue engineered scaffolds. In the first study, we extended the maximum in vitro incubation time to permit better cellular attachment and proliferation with a newly-synthesized, more hydrophobic CORM (DK3) and established the impact of CORMs on EC viability and function (e.g. reactive oxygen species (ROS) products, and ROS levels). We further investigated toxicity and biocompatibility of a newly synthesized CORM (DK4) loaded within PCL thin films and nanoparticles. We concluded that the DK4 and other compounds are not toxic at doses ranging from 0 – 50 μg/mL to the ECs both within nanoparticles that can be internalized within cells. We also conducted an in vivo pilot study to determine graft biocompatibility and preliminary results showed that CORM implants maintain mechanical integrity, support blood flow, and do not show toxicity for up to six weeks. In the second study, we validated a computational model and analyzed the output of CO delivery to better understand and control local dose. For CO release, this model is necessary because of the limitations with real-time experimental analysis and the need to better understand the dose available to the cells. We demonstrated that the validated model can be used to predict drug availability to cells for a variety of scaffolds and drug molecules. Our simulated results suggest that only a fraction of the initial concentration of gasotransmitters released from fibers that enters the interstitial fluid in vivo, or culture media in vitro, will be available to cells. We also demonstrated that fiber orientation and fiber diameter are important for drug delivery, but fiber density provides even more important information. The more contact area within the fiber scaffolds is equivalent to experimental conditions with more cell attachment and spreading. These parameters are not only important for traditional tissue engineering, but also for drug delivery. Overall, these results demonstrate the feasibility of making a tissue engineered vascular graft with the incorporation of CORMs and validating he importance of computational modeling of diffusion-based transport of CO. Future work will involve performing surface modifications to enhance cell attachment and proliferation, using the developed computational model to better predict dose available to cells, and experimentally determining impact of CO dose on ECs.
Integrating A Modified Pulse Amplitude Modulation (Pam4) Scheme With Two Spatially Multiplexed Channels In Optical Fiber Communication Systems, Bilas Chowdhury
Integrating A Modified Pulse Amplitude Modulation (Pam4) Scheme With Two Spatially Multiplexed Channels In Optical Fiber Communication Systems, Bilas Chowdhury
Theses and Dissertations
A multi-input multi-output (MIMO) based optical fiber multiplexing architecture known as Spatial Domain Multiplexing (SDM) adds a new dimension to optical fiber communication systems by spatially reusing the optical frequencies. SDM allocates different spatial location for different input signals based on the input launch angles. These input signals propagate helically inside the carrier fiber. They abide total internal reflection and exit as concentric donut shaped rings while travelling the fiber. These SDM channels do not exhibit any crosstalk or intersymbol interference. SDM systems can also complement different modulation techniques such as Return to Zero (RZ), Non-Return to Zero (NRZ), and …
Survival Theory Modelling For Information Diffusion, Akshay Aravamudan
Survival Theory Modelling For Information Diffusion, Akshay Aravamudan
Theses and Dissertations
Information diffusion is the spread of information within a network. In this thesis, we model information diffusion as a survival process. We have adopted an existing algorithm called NetRate for modelling information diffusion. This model involves finding the distribution of trasmission time between two nodes in the network. We modify NetRate’s concave-down log-likelihood expression by adding partial parentage information and formulate an Expectation-Minimization (EM) algorithm to learn the parameters. We also describe a simulation scheme for NetRate inspired by point process simulation strategies. Using the assumptions of the NetRate model, we derive a a method to model popularity as a …