Engineering Commons^™

Optimal Battery Operations And Design Considering Capacity Fade Mechanisms, Bharatkumar Suthar

McKelvey School of Engineering Graduate Student Theses & Dissertations

Safely and capacity fade are the key issues that restrict the use of the lithium-ion battery for many applications. These issues are being tackled in a variety of ways. This dissertation focuses on using detailed continuum-level electrochemical models to study transport, kinetics, and mechanical processes in the lithium-ion batteries. These models can be used to quantify the effect of capacity fade mechanisms (side reactions and mechanical degradation) and improve the safety aspects of the lithium ion batteries. Three capacity-fade mechanisms—solid electrolyte interface side reaction, lithium-plating side reaction and mechanical degradation due to intercalation-induced stresses—are considered in the dissertation. Monitoring and …

Spontaneous Firing Of Sensory Neurons Modulates The Gain In The Downstream Circuit Of A Simple Olfactory System, Matthew O'Neill

McKelvey School of Engineering Graduate Student Theses & Dissertations

In locusts and other insects, odorants are transduced into electrical signal by the olfactory receptor neurons and transmitted to central circuits for further processing. Previous studies have shown that exogenous variables (e.g., flow rates, humidity, temperature, odor mixtures, etc.) can influence the responses of the sensory neurons and therefore modulate the central circuits. However, how the sensory neuron activity is manipulated to achieve adaptive gain control in the following circuit is yet to be understood. It is possible that the magnitude of the stimulus-evoked response in the receptor neurons, their spontaneous activity, or both of these factors can change how …

Shape Optimization Of Busemann-Type Biplane Airfoil For Drag Reduction Under Nonlifting And Lifting Conditions Using Genetic Algorithms, Yi Tian

McKelvey School of Engineering Graduate Student Theses & Dissertations

The focus of this thesis is on the shape optimization of the Busemann-type biplane airfoil for drag reduction under both nonlifting and lifting conditions using genetic algorithms. The concept of the Busemann-type biplane airfoil was first introduced by Adolf Busemann in 1935. Under its design condition at a specific supersonic flow speed, the Busemann biplane airfoil eliminates all wave drag due to its symmetrical biplane configuration; however it produces zero lift. Previous research has shown that the original Busemann biplane airfoil design has a poor performance under off-design conditions as well. In order to solve this problem of zero lift …

Process And Reactor Level Simulations Of Calcium Looping Combustion, Wei Dai

McKelvey School of Engineering Graduate Student Theses & Dissertations

Calcium looping (CaL) is a recent technology for carbon capture from coal fired power plants which consumes less energy than other approaches such as oxy-fuel. In the first part of this thesis, a system level model is developed in ASPEN PLUS to calculate the energy penalty of introducing Calcium looping in a coal fired power plant. Several simplifications and assumptions are made to model the Calcium looping process. The relationship between the energy penalty due to CaL and carbon capture efficiency is used to validate the process model for both pre-combustion CaL and post-combustion CaL; it agrees well with the …

System Level And Reactor Level Simulations Of Chemical Looping Combustion And Chemical Looping With Oxygen Uncoupling, Xiao Zhang

McKelvey School of Engineering Graduate Student Theses & Dissertations

No abstract provided.

Sustained Dual Drug Delivery Of Anti-Inhibitory Molecules For Spinal Cord Injury Treatment, Thomas Wilems

McKelvey School of Engineering Graduate Student Theses & Dissertations

Regeneration of lost synaptic connections following spinal cord injury (SCI) is limited due to local ischemia, cell death, and an excitotoxic environment, which leads to the development of an inhibitory glial scar surrounding a cystic cavity. Myelin-associated inhibitors (MAIs) and chondroitin sulfate proteoglycans (CSPGs) are major inhibitors to axon growth inhibition found within the glial scar and limit functional recovery. The NEP1-40 peptide competitively binds the Nogo receptor and partially blocks inhibition from MAIs, while chondroitinase ABC (ChABC) enzymatically digests CSPGs, which are upregulated at the site of injury. The first part of this work develops drug delivery systems which …

Growth Factor Gradient Formation And Release From Peg Microspheres For Nerve Regeneration., Jacob Roam

McKelvey School of Engineering Graduate Student Theses & Dissertations

Many biological processes depend on concentration gradients in signaling molecules. Thus, introduction of spatial patterning of proteins, while retaining activity and releasability, will be critical for the field of regenerative medicine. In particular, the area of nerve regeneration is in need of innovations to improve outcomes. Only about 25% of surgical patients with peripheral nerve damage (~200,000 surgical interventions performed each year) regain full motor function with less than 3% regaining sensation. The use of nerve guidance conduits (NGC’s) which are filled with biomimetic scaffolds is one treatment being explored. These scaffolds, however, lack the spatial patterning of proteins found …

Photoacoustic Microscopy And Photoacoustic Computed Tomography Using High-Frequency Linear Array Ultrasonic Transducers, Guo Li

McKelvey School of Engineering Graduate Student Theses & Dissertations

Photoacoustic tomography (PAT) is a highly promising imaging technology which forms images by detecting the induced pressure waves resulting from pulsed light absorption in biological tissues. Because the excitation source is light, PAT is a very safe, non-ionizing, and non-carcinogenic imaging technology. In biomedicine, PAT has the unique advantage of probing endogenous optical absorbers at different length scales with 100% relative sensitivity. With such scalability, PAT can image anatomical, functional, metabolic, molecular, and genetic contrasts of vasculature, hemodynamics, oxygen metabolism, biomarkers, and gene expression. Among several implementations of PAT, optical-resolution photoacoustic microscopy (OR-PAM) and photoacoustic computed tomography (PACT) are two …

High Resolution Multi-Parametric Diagnostics And Therapy Of Atrial Fibrillation: Chasing Arrhythmia Vulnerabilities In The Spatial Domain, Sarah Gutbrod

McKelvey School of Engineering Graduate Student Theses & Dissertations

After a century of research, atrial fibrillation (AF) remains a challenging disease to study and exceptionally resilient to treatment. Unfortunately, AF is becoming a massive burden on the health care system with an increasing population of susceptible elderly patients and expensive unreliable treatment options. Pharmacological therapies continue to be disappointingly ineffective or are hampered by side effects due to the ubiquitous nature of ion channel targets throughout the body. Ablative therapy for atrial tachyarrhythmias is growing in acceptance. However, ablation procedures can be complex, leading to varying levels of recurrence, and have a number of serious risks. The high recurrence …

Intraurban Spatiotemporal Variability Of Ambient Air Pollutants Across Metropolitan St. Louis, Li Du

McKelvey School of Engineering Graduate Student Theses & Dissertations

Ambient air monitoring networks have been established in the United States since the 1970s to comply with the Clean Air Act. The monitoring networks are primarily used to determine compliance but also provide substantive support to air quality management and air quality research including studies on health effects of air pollutants. The Roxana Air Quality Study (RAQS) was conducted at the fenceline of a petroleum refinery in Roxana, Illinois. In addition to providing insights into air pollutant impacts from the refinery, these measurements increased the St. Louis area monitoring network density for gaseous air toxics and fine particulate matter (PM2.5) …

Synthesis Of Clickable Poly(Ethylene Glycol) Derivatives For Fabrication Of Modular Microsphere-Based Scaffolds To Promote Vascularization, Peter Nguyen

McKelvey School of Engineering Graduate Student Theses & Dissertations

Vascularization plays an important role in supporting transplanted tissues and cells in tissue engineering applications. Most tissues require access to blood vessels for the delivery of oxygen and nutrients, as well as the removal of carbon dioxide and cellular waste products. Without an adequate blood supply, cells within tissue-engineered constructs and scaffolds lose viability and fail to perform their intended functions. The goal of this dissertation was to design scaffolds that can promote vascularization of biomaterial implants for biomedical applications. In order to accomplish this goal, clickable poly(ethylene glycol) (PEG) derivatives were synthesized in order to fabricate modular microsphere-based scaffolds …

Directed Differentiation And Characterization Of Spinal V3 Interneurons From Mouse Embryonic Stem Cells, Hao Xu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Neuronal populations involved in locomotion controlling central pattern generators within the spinal cord hold great potential for spinal cord injury therapy. Spontaneous recovery in rodent models suggests that a population that can reorganize around an injury site could be useful for functional recovery therapeutics after spinal cord injury. The glutamatergic, commissural, long-extending V3 interneurons shown to balance locomotor rhythm regularity and robustness within central pattern generators in vivo are both an ideal population for spinal cord injury therapeutics and a vital population to study as a part of locomotor circuitry. Unfortunately, due to the scarcity of these cells in the …

Using Fluorescence – Polarization Endoscopy In Detection Of Precancerous And Cancerous Lesions In Colon And Pancreatic Cancer, Tauseef Charanya

McKelvey School of Engineering Graduate Student Theses & Dissertations

Colitis-associated cancer (CAC) arises from premalignant flat lesions of the colon, which are difficult to detect with current endoscopic screening approaches. We have developed a complementary fluorescence and polarization reporting strategy that combines the unique biochemical and physical properties of dysplasia and cancer for real time detection of these lesions. Utilizing a new thermoresponsive sol-gel formulation with targeted molecular probe allowed topical application and detection of precancerous and cancerous lesions during endoscopy. Incorporation of nanowire-filtered polarization imaging into NIR fluorescence endoscopy served as a validation strategy prior to obtaining biopsies.

In order to reduce repeat surgeries arising from incomplete tumor …

Online Modeling And Tuning Of Parallel Stream Processing Systems, Jonathan Curtis Beard

McKelvey School of Engineering Graduate Student Theses & Dissertations

Writing performant computer programs is hard. Code for high performance applications is profiled, tweaked, and re-factored for months specifically for the hardware for which it is to run. Consumer application code doesn't get the benefit of endless massaging that benefits high performance code, even though heterogeneous processor environments are beginning to resemble those in more performance oriented arenas. This thesis offers a path to performant, parallel code (through stream processing) which is tuned online and automatically adapts to the environment it is given. This approach has the potential to reduce the tuning costs associated with high performance code and brings …

Spectrum Management Using Markov Decision Processes, John Leo Meier

McKelvey School of Engineering Graduate Student Theses & Dissertations

Abstract: The advent of cognitive radio technology has enabled dramatically more options in the use of RF spectrum, allowing multiple transmitters to effectively share spectrum in ways that were previously unavailable (either due to technical limitations or regulatory restrictions). In this dissertation, we investigate approaches to managing RF spectrum use, with a focus on combining multiple control decisions in a mutually beneficial manner.

Our approach to making spectrum management decisions is grounded in Markov decision theory, which has a rich formal foundation and is frequently used to guide decision making in other disciplines. Here, we develop a set of Markov …

Bio-Inspired Multi-Spectral Imaging Sensors And Algorithms For Image Guided Surgery, Shengkui Gao

McKelvey School of Engineering Graduate Student Theses & Dissertations

Image guided surgery (IGS) utilizes emerging imaging technologies to provide additional structural and functional information to the physician in clinical settings. This additional visual information can help physicians delineate cancerous tissue during resection as well as avoid damage to near-by healthy tissue. Near-infrared (NIR) fluorescence imaging (700 nm to 900 nm wavelengths) is a promising imaging modality for IGS, namely for the following reasons: First, tissue absorption and scattering in the NIR window is very low, which allows for deeper imaging and localization of tumor tissue in the range of several millimeters to a centimeter depending on the tissue surrounding …

Application Of Wray-Agarwal Model To Turbulent Flow In A 2d Lid-Driven Cavity And A 3d Lid-Driven Box, Hakop J. Nagapetyan

McKelvey School of Engineering Graduate Student Theses & Dissertations

In this thesis, various turbulence models are used for simulating internal vortical flow, both turbulent and laminar, with large recirculation by considering the flow in a 2-D lid-driven square cavity and a 3-D lid driven cubic box. The accuracy of the newly developed Wray-Agarwal (WA) one equation turbulence model is compared against two well-known industry standard turbulence models; the Spalart-Allmaras (SA) and the Shear-Stress-Transport (SST) k-ω models. The simulations are performed by numerically solving the Reynolds-Averaged Navier-Stokes (RANS) equations in conjunction with WA, SA and SST k-ω models and comparing the results with the available experimental data and Large Eddy …

Optimization Of Blalock-Taussig Shunt And Anastomotic Geometry For Vascular Access Fistula Using A Genetic Algorithm, Guangyu Bao

McKelvey School of Engineering Graduate Student Theses & Dissertations

Blalock-Taussig (BT) shunts are used for defects that affect the flow of blood from the right ventricle, through the pulmonary artery, and to the lungs. Arteriovenous (AV) fistula is one type of vascular access which is a surgically created vein used to remove and return blood during hemodialysis. Plastic grafts used in the above two reconstructions may result in areas of non-physiologic flow in the grafts leading to risk of stenosis (blocked area) and thrombosis, which is the single major cause for access morbidity. The focus of this thesis is to study BT shunts and anastomoses models using Computational Fluid …

Entry Flow And Heat Transfer Of Laminar And Turbulent Forced Convection Of Nanofluids In A Pipe And A Channel, Yihe Huang

McKelvey School of Engineering Graduate Student Theses & Dissertations

This thesis presents a numerical investigation of laminar and turbulent fluid flow and convective heat transfer of nanofluids in the entrance and fully developed regions of flow in a channel and a pipe. In recent years, nanofluids have attracted attention as promising heat transfer fluids in many industrial processes due to their high thermal conductivity. Nanofluids consist of a suspension of nanometer-sized particles of higher thermal conductivity in a liquid such as water. The thermal conductivity of nanoparticles is typically an order-of-magnitude higher than the base liquid, which results in a significant increase in the thermal performance of the nanofluid …

The Edge Group Coloring Problem With Applications To Multicast Switching, Jonathan Turner

All Computer Science and Engineering Research

This paper introduces a natural generalization of the classical edge coloring problem in graphs that provides a useful abstraction for two well-known problems in multicast switching. We show that the problem is NP-hard and evaluate the performance of several approximation algorithms, both analytically and experimentally. We find that for random χ-colorable graphs, the number of colors used by the best algorithms falls within a small constant factor of χ, where the constant factor is mainly a function of the ratio of the number of outputs to inputs. When this ratio is less than 10, the best algorithms produces solutions that …

Gold Nanostructures For Sensing And Functional Bioimaging, Maximilian Y. Fei

McKelvey School of Engineering Graduate Student Theses & Dissertations

Gold nanostructures offer an extremely promising path forward in the fields of imaging and sensing because of their unique optical and chemical properties. Here, we demonstrate that plasmonic nanostructures can be employed as nanoscale transducers to monitor the growth and phase transitions in ultrathin polymer films. In particular, gold nanorods with high refractive index sensitivity (~150 nm / refractive index unit (RIU)) were employed to probe the growth and swelling of polyelectrolyte multilayers (PEM). By comparing the wavelength shift and extinction intensity of the localized surface plasmon resonance (LSPR) of the gold nanorods coated with PEM in air and water, …

Human Ipsilateral Motor Physiology And Neuroprosthetic Applications In Chronic Stroke, David Thomas Bundy

McKelvey School of Engineering Graduate Student Theses & Dissertations

Improving the recovery of lost motor function in hemiplegic chronic stroke survivors is a critical need to improve the lives of these patients. Over the last several decades, neuroprosthetic systems have emerged as novel tools with the potential to restore function in a variety of patient populations. While traditional neuroprosthetics have focused on using neural activity contralateral to a moving limb for device control, an alternative control signal may be necessary to develop brain-computer interface (BCI) systems in stroke survivors that suffer damage to the cortical hemisphere contralateral to the affected limb. While movement-related neural activity also occurs in the …

Photonic Molecules Formed By Ultra High Quality Factor Microresonator For Light Control, Bo Peng

McKelvey School of Engineering Graduate Student Theses & Dissertations

Whispering-gallery-mode (WGM) optical microresonators with micro-scale mode volumes and high quality factors have been widely used in different areas ranging from sensing, quantum electrodynamics (QED), to lasing and optomechanics. Due to the ultra-high Q and the tight spatial confinement, the cavity provides high intra-cavity field intensity and long interaction time, which enhances the interaction between light and materials. This feature makes WGM microresonator a great candidate for low-threshold nonlinear processes, cavity optomechanics, signal processing, and sensor with ultra-high sensitivity. Also, modification of the modes in these resonators has been of considerable interest for their potential applications and underlying physics. Two …

Probing Mechanical Forces In Flagella By Manipulation Of Media Viscosity And Axonemal Structure, Kate Wilson

McKelvey School of Engineering Graduate Student Theses & Dissertations

Cilia and flagella are subcellular organelles used to generate fluid flow or propel the cell. These long cylindrical structures are composed of cytoskeletal elements activated by the unidirectional motor protein dynein. Cilia and flagella are crucial to a number of physiological functions, yet the specific mechanisms of dynein activation and coordination remain unclear. This work investigates the response of the flagellum of Chlamydomonas reinhardtii to increased mechanical loading achieved by variation of media viscosity, and to structural changes achieved by genetic manipulation. Effects of these perturbations are quantified using high spatiotemporal resolution recordings; the results demonstrate mutation-specific changes to the …

Numerical Simulation And Optimization Of Carbon Dioxide Utilization For Enhanced Oil Recovery From Depleted Reservoirs, Razi Safi

McKelvey School of Engineering Graduate Student Theses & Dissertations

Due to concerns about rising CO₂ emissions from fossil fuel power plants, there has been a strong emphasis on the development of a safe and economical method for Carbon Capture Utilization and Storage (CCUS). One area of current interest in CO₂ utilization is the Enhanced Oil Recovery (EOR) from depleted reservoirs. In an Enhanced Oil Recovery system, a depleted or depleting oil reservoir is re-energized by injecting high-pressure CO₂ to increase the recovery factor of the oil from the reservoir. An additional benefit beyond oil recovery is that the reservoir could also serve as a long-term storage …

Effects Of Biomass Moisture Content On Volatile Flame Length During Cofiring With Coal, Matthew Pollard

McKelvey School of Engineering Graduate Student Theses & Dissertations

Cofiring biomass with coal can contribute to meeting Renewable Portfolio Standards (RPS) and reduce pollutant emissions. The physical characteristics and composition of biomass can vary significantly, which can affect the combustion characteristics. When cofiring biomass with coal, these differences can impact the structure of the volatile flame, the region where combustion of volatiles dominates. The length and location of the volatile flame is important to flame stability and determines the location and extent of volatile release. This has an effect on pollutant emissions, such as NOx (nitrogen oxides). Previously, the effects of parameters such as cofiring ratio, particle size, and …

Development Of Nanofiber Scaffolds With Controllable Structure And Mineral Content For Tendon-To-Bone Repair, Justin Herrold Lipner

McKelvey School of Engineering Graduate Student Theses & Dissertations

Rotator cuff tears are common and lead to significant pain and disability. Effective repair of torn rotator cuff tendons requires healing of tendon to bone. Unfortunately, healing does not reproduce the structural and compositional features of the natural tendon-to-bone bone attachment that are necessary for effective load transfer, and surgical repairs often rupture.

Recent efforts for improving tendon-to-bone healing have focused on tissue engineering approaches. Scaffolds, cells, and/or growth factors are implanted at the repair site to guide the healing process and improve outcomes. To that end, a polymer-mineral tissue engineered scaffold was developed for this thesis which mimics two …

Discrete And Continuous Sparse Recovery Methods And Their Applications, Zhao Tan

McKelvey School of Engineering Graduate Student Theses & Dissertations

Low dimensional signal processing has drawn an increasingly broad amount of attention in the past decade, because prior information about a low-dimensional space can be exploited to aid in the recovery of the signal of interest. Among all the different forms of low di- mensionality, in this dissertation we focus on the synthesis and analysis models of sparse recovery. This dissertation comprises two major topics. For the first topic, we discuss the synthesis model of sparse recovery and consider the dictionary mismatches in the model. We further introduce a continuous sparse recovery to eliminate the existing off-grid mismatches for DOA …

Potential-Flow Inflow Model Including Wake Distortion And Contraction, Jianzhe Huang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Dynamic wake models have been used in real-time flight simulations for over thirty years. The models have evolved from the earliest, three-degree-of-freedom models (derived from momentum theory) to full finite-state models derived from potential flow theory by a formal Galerkin method. These models are widely used in industry, but still have some drawbacks that need to be remedied. These drawbacks include: 1.) lack of good convergence both on the disk and off the disk (one can use one or the other but not both), 2.) poor results downstream in the limit of shallow skew angles, 3.) poor convergence inside of …

Development Of 13c Fingerprint Tool And Its Application For Exploring Carbon And Energy Metabolism In Cyanobacterium Synechocystis Sp. Pcc 6803, Le You

McKelvey School of Engineering Graduate Student Theses & Dissertations

Cyanobacteria are important microbial cell factories that are widely used in the biotechnology filed nowadays. They can use light as the sole energy source to fix CO2, accumulate biomass, and produce various valuable bio-products. Engineered cyanobacterial species can uptake nutrients from wastes to further reduce the cost. Recently, it is reported that cyanobacteria will provide much higher carbon yield than heterotrophs by co-utilizing organic carbons and CO2. However, the quantitative information of such `photo-fermentation' process is still limited. Decoding the carbon metabolism of cyanobacteria during the photo-fermentation process can reveal the functional pathways, carbon distribution, and the energy requirement, all …