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Full-Text Articles in Engineering

Histomechanical Compatibility Of Coronary Artery Bypass Grafts, Colton J. Kostelnik Oct 2022

Histomechanical Compatibility Of Coronary Artery Bypass Grafts, Colton J. Kostelnik

Theses and Dissertations

Coronary artery disease is a localized form of atherosclerosis that can severely restrict blood flow to the heart often requiring a surgical intervention known as coronary artery bypass grafting (CABG) to reestablish perfusion to this essential circulation. To some extent, the selection of the autograft tissue is at the surgeon’s discretion with factors such as stenosis location and the existing tissue’s pathological state contributing to a choice that could be deterministic in surgical outcomes. Many post-operative complications and premature graft failures originate from graft-target tissue incompatibilities and altered blood flow patterns. We hypothesize that mechanical mismatching between the graft material …


Thermodynamic Assessment Of Chromium Corrosion In The Na-K-Mg-U(Iii, Iv) Chloride Salt, Jacob Allen Yingling Oct 2022

Thermodynamic Assessment Of Chromium Corrosion In The Na-K-Mg-U(Iii, Iv) Chloride Salt, Jacob Allen Yingling

Theses and Dissertations

Thermodynamic descriptions of high-order molten chloride salt systems are essential for the development of fast molten salt reactor (MSR) technologies. However, a complete thermodynamic assessment of the essential Na-K-Mg-U(III)-U(IV) molten chloride salt with the most prevalent CrCl2 corrosion product has yet to be provided. This is remedied in the present work through application of the CALculation of PHAse Diagrams (CALPHAD) approach to the available thermodynamic data and new measurements that include differential scanning calorimetry (DSC) observations for previously unexplored two and three component chloride salt systems. Through these efforts, a unique approach was developed for the quantification of uncertainty in …


Versatile And Robust Non-Iterative Coupling Algorithm For Vehicle-Structure Interaction, Arya Datta Oct 2022

Versatile And Robust Non-Iterative Coupling Algorithm For Vehicle-Structure Interaction, Arya Datta

Theses and Dissertations

The dynamic analysis of the vehicle-structure interactions can be extremely computationally expensive. A general non-iterative coupling algorithm based on the substructure approach has been presented. It retains the advantage of the substructure approach that smaller subsystems are solved instead of a large system, which is usually solved when monolithic systems are solved. However, the advantage of using this general coupling approach is that it is non-iterative in nature, instead of the substructure approach that usually uses iterative procedure. The general coupling algorithm developed has been implemented to analyze dynamic interactions between the vehicle and the structure, both in two and …


Decellularization Strategies Of Naturally Derived Biomaterials For Tissue Engineering Applications, Julia Elizabeth Hohn Oct 2022

Decellularization Strategies Of Naturally Derived Biomaterials For Tissue Engineering Applications, Julia Elizabeth Hohn

Theses and Dissertations

In 2017, over 3.5 million peripheral vascular surgeries were performed worldwide with over 400,000 vascular repair or replacement surgeries being performed in the United States each year alone. As the number of vascular repair surgeries, including both coronary and peripheral bypass grafting procedures, continues to increase each year, these statistics indicate an urgent need for more effective and readily available replacement materials. Regenerative medicine and tissue engineering (TE) approaches, including the design, fabrication, and validation of suitable biomaterials in vitro that direct the repair and regeneration of damaged tissues, have been proposed to alleviate this problem. While advanced biomaterials have …


Uncrewed Aircraft Systems For Autonomous Infrastructure Inspection, Michail Kalaitzakis Oct 2022

Uncrewed Aircraft Systems For Autonomous Infrastructure Inspection, Michail Kalaitzakis

Theses and Dissertations

Uncrewed Aircraft Systems (UAS) are becoming increasingly popular for infrastructure inspections since they offer increased safety, decreased costs and consistent results, compared to traditional methods. However, there are still many open challenges before fully autonomous, reliable, and repeatable UAS inspections. While a UAS platform has increased mobility and can easily approach hard to reach areas, it has limited range and payload capacity and is susceptible to environmental disturbances. Therefore, current operations are limited to Visual Line of Sight (VLOS) manual inspections that usually result in just a qualitative (visual) assessment of the structure.

The objective of this work is to …


Digital Twins In Advanced Manufacturing To Enhance Manufacturing Efficiency, Max Kirkpatrick Oct 2022

Digital Twins In Advanced Manufacturing To Enhance Manufacturing Efficiency, Max Kirkpatrick

Theses and Dissertations

Digital Twins of manufacturing systems are an emerging tool for improvement, optimization, and monitoring of physical manufacturing systems. The idea of representing physical systems with digital depictions has been prevalent since the early days of Computer Aided Design (CAD), but recently the concept of a Digital Twin has been expanded to encapsulate more than just a digital model of a design. Instead, the Digital Twin offers a unique, comprehensive, and real-time toolset for analysis and improvement of physical systems. These tools can be used to improve system efficiency, perform “what-if” analyses, virtually commission manufacturing equipment, analyze system performance in real …


Towards Modeling Of Induction Welding Of Thermoplastic Laminates With A Mixed Finite Element Boundary Element Approach, Florentius Johannes Van Zanten Oct 2022

Towards Modeling Of Induction Welding Of Thermoplastic Laminates With A Mixed Finite Element Boundary Element Approach, Florentius Johannes Van Zanten

Theses and Dissertations

There is an increased interest in induction welding of carbon fiber reinforced thermoplastic composite laminates within the aerospace industry. Currently, optimal manufacturing process parameters (e.g., current, power, and frequency settings, coil movement speed, etc.) are determined through an experimental trial-and-error approach. To reduce the need for an experimental approach that can determine the manufacturing process parameters, which would be expensive in both time and money, accurate and computationally efficient numerical tools are desired. This research is focused on improving the existing numerical tool, WelDone, in regard to its speed and accuracy.

WelDone utilizes a hybrid element formulation that combines traditional …


Physico-Mechanical Characterization Of Prototype Earth Block Material For Constitutive Modeling, Erika Lorena Rengifo-López Oct 2022

Physico-Mechanical Characterization Of Prototype Earth Block Material For Constitutive Modeling, Erika Lorena Rengifo-López

Theses and Dissertations

The comprehensive understanding and experimental characterization of the overall compressive behavior of earth masonry block materials, such as compressed and stabilized earth blocks (CSEBs), are essential for developing analytical and numerical tools to predict the mechanical response and designing earth masonry structures. Furthermore, advancing the understanding of the extent of the influence of testing parameters on the material's response, such as specimen geometry, is a critical step towards standardization.

CSEBs are produced by compressing a mixture of soil, water, and a stabilizer (e.g., Portland cement). The heterogeneity of the material accrues from the variety of soil particle morphology and potential …


Shear Localization In The Metallic Nanolayered Composites, Shujing Dong Oct 2022

Shear Localization In The Metallic Nanolayered Composites, Shujing Dong

Theses and Dissertations

In this dissertation, the influences of layer thickness (h), interface orientation relationship (OR) and dislocation slip activities on shear band (SB) formation mechanisms was investigated by means of molecular dynamics (MD) simulations.

The effect of h and dislocation slip systems on the shear localization in Cu-FCC/Nb-BCC MNCs was studied. The strain softening observed in those samples was triggered by the SB formation. The microstructure evolutions and dislocation slips revealed that the unsymmetrical dislocation transmission across the interface induces the shear localization and promotes the SB formation. The quantitative analysis of the change in the separation distance of initially …


Supported Metal Bifunctional And Bimetallic Catalysts With Precisely Controlled Structures And Properties, Anhua Dong Oct 2022

Supported Metal Bifunctional And Bimetallic Catalysts With Precisely Controlled Structures And Properties, Anhua Dong

Theses and Dissertations

In heterogenous catalysis, metallic nanomaterials play vital roles in numerous chemical processes. However, monofunctional catalysts are greatly impeded in their applications especially in the systems including tandem and/or sequential reaction steps. Besides, the catalytic performance can also be greatly influenced by the particle size, morphology, and geometry of the surface metal atoms.

The goal of this work is to synthesize bifunctional or bimetallic nanoparticles with high metal dispersion and homogenous alloys by rational synthetic strategies to facilitate the catalyst function. Strong electrostatic adsorption (SEA) is an effective and facile methodology to produce well dispersed and uniform nanoparticles. Metal-acid bifunctional catalysts …


Mimo Antenna Systems For Wireless Handheld Devices, Ahmed H. Abdelgawwad Oct 2022

Mimo Antenna Systems For Wireless Handheld Devices, Ahmed H. Abdelgawwad

Theses and Dissertations

Mobile communications have seen tremendous growths in the last decades in the form of smartphones, watches, wireless enabled Personal Digital Assistants (PDAs) and so on. The current and future wireless communication systems require high data-rate capabilities to support high speed needs of users in modern applications. Multiple-input multiple-output (MIMO) antenna systems have become the most promising candidate to support the increased data demand. Therefore, they have emerged as an integral part of the new 5G wireless standard. One key challenge regarding MIMO systems for the handheld is to be able to successfully accommodate multiple miniature platform integrated antennas within a …


Cnn-Based Dendrite Core Detection From Microscopic Images Of Directionally Solidified Ni-Base Alloys, Xiaoguang Li Oct 2022

Cnn-Based Dendrite Core Detection From Microscopic Images Of Directionally Solidified Ni-Base Alloys, Xiaoguang Li

Theses and Dissertations

Dendrite core is the center point of the dendrite. The information of dendrite core is very helpful for material scientists to analyze the properties of materials. Therefore, detecting the dendrite core is a very important task in the material science field. Meanwhile, because of some special properties of the dendrites, this task is also very challenging. Different from the typical detection problems in the computer vision field, detecting the dendrite core aims to detect a single point location instead of the bounding-box. As a result, the existing regressing bounding-box based detection methods can not work well on this task because …


Achieving Sustainability In Urban Transit And High-Occupancy Vehicle Systems Through Emerging Technologies And Operations, Ruixiao Sun Oct 2022

Achieving Sustainability In Urban Transit And High-Occupancy Vehicle Systems Through Emerging Technologies And Operations, Ruixiao Sun

Theses and Dissertations

It is critical to reduce road transportation emissions, as it is the major source contributing to greenhouse gas emissions (GHGs) and air pollution. However, the increasing travel demand due to the rise of population and economy makes the task challenging. Mathematically, road transportation emissions can be minimized in the manner of reducing total vehicle miles traveled (VMT) and lowering vehicle emission rate. Many strategies have been proven viable for achieving transportation sustainability. For example, the total VMT can be reduced by switching low-occupancy transportation modes (i.e., driving alone) to high-occupancy transportation modes (i.e., public transit, ridesharing). The development of alternative-fuel …


Use Of Dic Measurements With Finite Element Models For Direct Heterogeneous Material Property Determination And Wrinkle Formation During Automated Fiber Placement, Sreehari Rajan Kattil Oct 2022

Use Of Dic Measurements With Finite Element Models For Direct Heterogeneous Material Property Determination And Wrinkle Formation During Automated Fiber Placement, Sreehari Rajan Kattil

Theses and Dissertations

In this work, application of DIC in combination with finite element modeling is demonstrated for efficient material characterization for complex heterogeneous materials and tow wrinkle formation during automated fiber placement.

The first part of the work describes the integration of DIC measurements with finite element models for direct property identification in heterogeneous material systems. The material property identification is based on solving partial differential equations (PDE) of equilibrium for unknown elastic material properties with known boundary conditions and full field strain data (Eg. DIC). The PDEs are solved numerically using Petrov-Galerkin finite element procedure. The classical Bubnov-Galerkin method is shown …


Impacts Of Preferential Vaporization Of Multi-Component Liquid Fuels On Near-Limit Combustion Behaviors, Seungjae Lim Oct 2022

Impacts Of Preferential Vaporization Of Multi-Component Liquid Fuels On Near-Limit Combustion Behaviors, Seungjae Lim

Theses and Dissertations

Combustion technologies used in energy conversion devices involve multi-phase and multi-component combustion behaviors associated with chemical kinetic characteristics coupled with spray dynamics. For reliable engine operation, the engine operation envelope is necessarily required to be determined by near-limit combustion behaviors such as flame flashback, lean blowout, ignition, and extinction, which are influenced by both fuel chemical and physical properties. Liquid fuels are composed of a wide range of molecular structures and weights, therefore exhibiting relatively large distillation temperature range. When fuel chemical properties change during fuel vaporization, preferential vaporization effects could play a considerable role in near-limit combustion behaviors. In …


Cyclic Response And Liquidfaction Behavior Of Gravelly Soils, Pitak Ruttithivaphanich Oct 2022

Cyclic Response And Liquidfaction Behavior Of Gravelly Soils, Pitak Ruttithivaphanich

Theses and Dissertations

Cyclic response and liquefaction behavior are soil mechanisms under earthquake conditions. The study of dynamic soil response is important to evaluate soil behaviors under dynamic loading for a wide range of strains. Soil liquefaction phenomena involving a significant reduction in the strength and stiffness of saturated cohesionless soils has caused catastrophic ground failure in numerous earthquakes. Liquefaction mostly occurs in sand, but liquefaction of gravelly soil has been observed. To date, only a few studies have focused on the liquefaction of gravelly soils; hence, research data is limited. This research aims to improve the understanding of cyclic response and liquefaction …


Durability Enhancement Of Anion Exchange Membrane Based Fuel Cells (Aemfcs) And Water Electrolyzers (Aemels) By Understanding Degradation Mechanisms, Noor Ui Hassan Oct 2022

Durability Enhancement Of Anion Exchange Membrane Based Fuel Cells (Aemfcs) And Water Electrolyzers (Aemels) By Understanding Degradation Mechanisms, Noor Ui Hassan

Theses and Dissertations

The past several years have seen remarkable progress in renewable energy sources such as solar and wind, showing excellent efficiency and significant cost reduction. The intermittent nature of renewable resources requires them to be integrated with energy storage systems that can hold or convert this excess energy into other forms. Though batteries have been the most popular, it is also possible to store the energy as chemicals and fuels, such as hydrogen (H2). Hydrogen generation from water electrolysis has been receiving significant attention in recent years. Among the existing water electrolysis technologies, anion exchange membrane electrolyzers (AEMELs) are …


Applications Of Laser Liftoff Technique For Wide Bandgap Power And Flexible Electronics, Md Didarul Alam Oct 2022

Applications Of Laser Liftoff Technique For Wide Bandgap Power And Flexible Electronics, Md Didarul Alam

Theses and Dissertations

Wide bandgap (WBG) AlGaN/GaN and ultrawide bandgap (UWBG) AlGaN/AlGaN III-nitride high electron mobility transistors (HEMTs) have come a long way since their initial demonstration and are desired for a multitude of applications in deep-scaled high-frequency, high-voltage, high-current, and high-temperature power electronics. Although AlGaN/GaN HEMTs have recently become state-of-the-art in consumer electronics chargers and amplifiers, the performance of the devices is limited by severe self-heating which significantly reduce their efficacy in demanding applications that require high-current density. One strategy to reduce this self-heating effect in GaN HEMTs is to use high thermal conductivity SiC or bulk AlN substrates. While this approach …


Empirical Studies On Automated Software Testing Practices, Alireza Salahirad Oct 2022

Empirical Studies On Automated Software Testing Practices, Alireza Salahirad

Theses and Dissertations

Software testing is notoriously difficult and expensive, and improper testing carries economic, legal, and even environmental or medical risks. Research in software testing is critical to enabling the development of the robust software that our society relies upon. This dissertation aims to lower the cost of software testing without decreasing the quality by focusing on the use of automation. The dissertation consists of three empirical studies on aspects of software testing. Specifically, these three projects focus on (1) mapping the connections between research topics and the evolution of research topics in the field of software testing, (2) an assessment of …


Molten Salt Thermal Properties Database – Thermochemical Development And Thermodynamic Assessment Of Various Molten Salt Systems, Johnathon Chandler Ard Oct 2022

Molten Salt Thermal Properties Database – Thermochemical Development And Thermodynamic Assessment Of Various Molten Salt Systems, Johnathon Chandler Ard

Theses and Dissertations

The Molten Salt Thermal Properties Database – Thermochemical (MSTDB-TC) is a validated open-source database for thermochemical modeling of molten salt reactor (MSR) relevant fluoride and chloride salt systems. The database has been created and populated by leveraging available models from literature as well as completing novel system assessments. The development and contents of the MSTDB-TC v1.2 initial release are detailed along with various system assessments performed in the course of the work. The database utilizes a major strength of the CALPHAD thermodynamic modeling method. This is the ability to estimate higher-order system behavior by combining modeled lower-order systems, …


High-Throughput Computation Of Interfacial Thermal Management Of Wide-Bandgap Semiconductors, Hao-Wen Chen Oct 2022

High-Throughput Computation Of Interfacial Thermal Management Of Wide-Bandgap Semiconductors, Hao-Wen Chen

Theses and Dissertations

As semiconductor electronics, in particular high electron mobility transistors, get hot in operation, people are trying to incorporate different semiconductor materials to solve the problem of heat dissipation to maintain the device efficiency and performance. In this master thesis, two different packages, LAMMPS and almaBTE, that are focusing on micro-scale and atomic scale respectively, are used to simulate the heat transfer process across interfaces in two different scales. In the LAMMPS simulation, the research is exploring how the location of atoms and the thickness of interfacial layers will influence the interfacial thermal conductance. On the other hand, using the almaBTE …


Fabrication Of Asymmetrical Hollow Fiber-Supported Thin Film Membranes, Stack Assembly, And Accelerated Long-Term Stability Test For Oxygen Production From Air, Myongjin Lee Oct 2022

Fabrication Of Asymmetrical Hollow Fiber-Supported Thin Film Membranes, Stack Assembly, And Accelerated Long-Term Stability Test For Oxygen Production From Air, Myongjin Lee

Theses and Dissertations

Air separation is a widely used process for oxygen production. Several separation technologies have been developed for air separation, including cryogenic distillation, swing adsorption, redox process of metal oxides, and electrochemical process. Among these technologies, electrochemical permeation process stands out as a cost-effective and simple process for pure oxygen production from air. The electrochemical permeation process employs a gas-tight membrane to permeate and separate oxygen from air directly, where the membrane conducts both ions and electrons simultaneously. Different membrane designs have been studied to obtain the improved performance for oxygen permeation, typically planar and tubular designs. Among these membrane configurations, …


Closed Form Implicitly Integrated Models For Computationally Efficient Simulation Of Power Electronics, Andrew Wunderlich Oct 2022

Closed Form Implicitly Integrated Models For Computationally Efficient Simulation Of Power Electronics, Andrew Wunderlich

Theses and Dissertations

This work describes novel closed-form, implicitly integrated (CF-implicit) models of switched-mode power converters which feature implicit integration but require no iterative numerical solving algorithm for evaluation because they are explicitly solved prior to model execution. The derived models capture the large-signal dynamic behavior of the power converters, so their use and accuracy are not limited to any one set of operating conditions. These models can be implemented in any computational environment, including directly on an existing embedded controller as a digital twin. Since no iterative solver is required, the models are highly computationally efficient and have a very predictable worst-case …


A Hybrid Experimental-Computational Study: Prediction Of Flow Fields And Full-Field Pressure Distributions On Three-Tab Asphalt Roofing Shingles Subjected To Hurricane Velocity Winds, Troy A. Myers Oct 2022

A Hybrid Experimental-Computational Study: Prediction Of Flow Fields And Full-Field Pressure Distributions On Three-Tab Asphalt Roofing Shingles Subjected To Hurricane Velocity Winds, Troy A. Myers

Theses and Dissertations

A novel hybrid experimental-computational study is performed to predict the flow fields and pressure distributions on the measured shapes of flexible, three-tab asphalt roofing shingles undergoing increasing uplift when exposed to hurricane velocity winds. StereoDIC analysis is performed to measure the transient full-field deformed shapes of full-size three-tab asphalt shingles when subjected to hurricane velocity winds for two hours. Steady state computational fluid dynamics (CFD) simulations of the shingled roof facsimile-plenum region representative of the experiments are successfully performed. The simulations are performed to predict wind loading of the uplifted shingle shapes by utilizing the measured full-field three-dimensional uplifted shapes …


Investigating The Impact Of Endothelial Dysfunction And Aging On Vascular Remodeling Using Mouse Models, Liya Du Oct 2022

Investigating The Impact Of Endothelial Dysfunction And Aging On Vascular Remodeling Using Mouse Models, Liya Du

Theses and Dissertations

Endothelial dysfunction, characterized by a reduction in the bioavailability of nitric oxide (NO), is a major factor in the initiation and progression of atherosclerosis, an age-related chronic inflammatory process in the arterial wall and the leading cause of mortality and morbidity globally. A better understanding of alterations in vascular structure and function associated with endothelial dysfunction can facilitate the early detection of atherosclerosis and the development of potential pharmaceutical interventions. This study aims to clarify the impact of endothelial dysfunction in conjunction with aging on the microstructure of aortic extracellular matrix (ECM) and to elucidate the relationship between microstructural adaptation …


Pulse Width Modulation-Based Voltage Balancing And Circulating Current Control For Modular Multilevel Converters, Md Multan Biswas Oct 2022

Pulse Width Modulation-Based Voltage Balancing And Circulating Current Control For Modular Multilevel Converters, Md Multan Biswas

Theses and Dissertations

In the last decade, because of some key features and advantages of Modular Multilevel Converter (MMC), it is widely applied for various Medium Voltage (MV) and High Voltage (HV) power electronic interfacing applications. The structure of MMCs varies by application but in general, they are composed of multiple Sub-Modules (SMs) which each contains a floating capacitor. For the operation of MMCs, capacitor voltages are required to remain equally set. This is referred to as the balanced condition and requires a method for SM Capacitor Voltage Balancing (CVB). Connections of SMs for most of the common MMC configurations result in additional …


Experimental Investigations Of Yarn Pull-Out Behavior In Kevlar®: Influence Of Applied Metallic Coatings And Effect Of Dynamic Loading, Julie Ann Roark Oct 2022

Experimental Investigations Of Yarn Pull-Out Behavior In Kevlar®: Influence Of Applied Metallic Coatings And Effect Of Dynamic Loading, Julie Ann Roark

Theses and Dissertations

Flexible woven Kevlar® textile fabrics are widely used in protective armor applications. Yarn pull-out, comprised of yarn uncrimping (i.e., straightening) and yarn translation, is a major energy absorption mechanism during ballistic impact onto these fabrics, especially for impact velocities below the ballistic limit. Yarn pull-out is influenced by various parameters including inter-yarn friction, pull-out distance, pull-out velocity, transverse pre-tension, fiber diameter, fabric architecture, fabric waviness, fabric count and yarn modulus.

The first part of this thesis investigates yarn pull-out behavior of commercially available Kevlar® KM2+ individual yarns coated with metallic layers (copper, aluminum, aluminum nitride, silver) via a directed vapor …


Development Of Micro-Sized Algan Deep Ultraviolet Light Emitting Diodes And Monolithic Photonic Integrated Circuits, Richard Speight Floyd Iii Jul 2022

Development Of Micro-Sized Algan Deep Ultraviolet Light Emitting Diodes And Monolithic Photonic Integrated Circuits, Richard Speight Floyd Iii

Theses and Dissertations

III-Nitride materials-based visible emission LEDs have emerged as a disruptive technology in the fields of lighting,i) communications,ii,iii,iv) and displays.v,vi) Shorter wavelength LEDs in the DUV spectral region (210nm – 360nm) with ultra-wide bandgap (UWBG) AlxGa1-xN active layers are now poised to displace toxic Mercury-based light sources.vii) Over the past decade AlGaN LEDs operating in the deep ultra-violet (DUV) spectral region (200 nm < λemission < 300 nm) have been deployed in novel applications including autonomous drone-based sterilization and sanitization systems, viii) point-of-use water purification systems, ix) photo-therapeutics,x) gas sensors,xi) and non-line-of-sight (NLOS) communications.xii) Similarly, DUV light detectors using ultra-wide bandgap (UWBG) Al …


Cnn-Based Semantic Segmentation With Shape Prior Knowledge, Yuhang Lu Jul 2022

Cnn-Based Semantic Segmentation With Shape Prior Knowledge, Yuhang Lu

Theses and Dissertations

Semantic segmentation that aims at grouping discrete pixels into connected regions is a fundamental step in many high-level computer vision tasks. In recent years, Convolutional Neural Networks (CNNs) have made breakthrough progresses in public semantic segmentation benchmarks. The ability of learning from large-scale labeled datasets empowers them to generalize to unseen images better than traditional nonlearning-based methods. Nevertheless, the heavy dependency on labeled data also limits their applications in tasks where high-quality ground truth segmentation masks are scarce or difficult to acquire. In this dissertation, we study the problem of alleviating the data dependency for CNN-based segmentation with a focus …


Neurochemical, Molecular, And Behavioral Effects Of Intranasal Insulin, Jennifer Marie Erichsen Jul 2022

Neurochemical, Molecular, And Behavioral Effects Of Intranasal Insulin, Jennifer Marie Erichsen

Theses and Dissertations

Age-related cognitive decline (ARCD) is one of the most dreaded aspects of growing old and a public health concern. Unfortunately, there is currently no treatment that effectively ameliorates ARCD. In recent decades, intranasal insulin (INI) has demonstrated promising memory enhancements for rodents and individuals with Alzheimer’s disease, both in basic science research laboratories and multi-center clinical trials. Other studies have shown INI improves memory and cognition in healthy rodents and humans, indicating that INI may hold promise as a successful ARCD therapeutic. However, there is a glaring lack of evidence regarding how INI produces these effects. The goal of these …