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University of Nebraska - Lincoln
Department of Biological Systems Engineering: Dissertations and Theses
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Engineering Of Microparticle Encapsulated Antioxidant To Mitigate Oxidative Stress In Vitro And In Vivo, Kayla Ney
Department of Biological Systems Engineering: Dissertations and Theses
Chronic low back pain (cLBP) is one of the leading causes of years lived with disability in the United States. Current treatments for cLBP have variable results across the patient population, and many patients struggle to find consistent relief. Most current treatments focus on the symptom of pain, not the root cause. In painful degenerated discs, oxidative stress and inflammation function in a vicious cycle and perpetuate degeneration, damage, and pain. Therefore, oxidative stress and inflammation are important targets in addressing the source of pain. This work characterizes an antioxidant, BuOE, encapsulated in a chondroitin sulfate microparticle as a novel …
Alginate Hydrogels As Three-Dimensional Scaffolds For In Vitro Culture Models Of Growth Plate Cartilage Development And Porcine Embryo Elongation, Taylor D. Laughlin
Alginate Hydrogels As Three-Dimensional Scaffolds For In Vitro Culture Models Of Growth Plate Cartilage Development And Porcine Embryo Elongation, Taylor D. Laughlin
Department of Biological Systems Engineering: Dissertations and Theses
The establishment of in vitro culture models utilizes tissue engineering principles to design functional mimics of in vivo environments in vitro. Advantages for the use of in vitro culture models include ethical alleviation of animal models for therapeutic testing, cost efficiency, and a greater ability to study specific mechanisms via a systematic, ground-up approach to development. In this thesis, alginate hydrogels are utilized in the development of in vitro culture models of porcine embryo elongation and growth plate cartilage development. First, the effect of scaffold and modifications to the scaffold were explored in both projects. In order to modulate …