Engineering Commons^™

Multifunctional Pvdf Ionogels With Magnetic Nanoparticles For Electroactive And Magnetic Actuation, Alfredo Carrillo Valverde

Chemical Engineering Undergraduate Honors Theses

The fast development of compact and multifunctional electronics has driven interest in smart materials capable of responding to multiple stimuli. Ionogels, polymers that have been swollen with ionic liquids (IL), offer several favorable electrochemical and thermal properties due to their intrinsic ion conductivity, wide electrochemical window, non-flammability, and high thermal stability. However, their poor mechanical properties (e.g., modulus and strength) limit their use in applications. In this work, multifunctional PVDF ionogel composites were made by blending magnetically responsive iron oxide nanoparticles (Fe₃O₄ MNPs) into the polymer matrix. The influence of MNP concentration (9-21 wt%) on composition, ionic …

Using Gaussian Process Regression To Learn Thermodynamic Equations Of State With Uncertainty Quantification, Austen T. Lee

Chemical Engineering Undergraduate Honors Theses

This study investigates the use of derivative-informed Gaussian Process (GP) models to estimate thermodynamic behavior across temperature and density by building a Helmholtz-based equation of state. Argon, a stable monatomic gas, was chosen as a case study within the vapor region. The GP model was trained using values of experimentally measurable properties found by taking first and second derivatives of the original potential function. Results show that while the GP model offered uncertainty quantification and informed thermodynamic behavior, it predicted values that deviated from the ground truth depending on the property. The model exhibited high confidence in regions with substantial …

Development And Validation Of A Computational Fluid Dynamics Model Using Wind Tunnel Experiments, Savanah G. Godwin

Chemical Engineering Undergraduate Honors Theses

A gas release computational fluid dynamics model was developed and validated using a previous wind tunnel experiment conducted by Daniel Williams. This simulation was modeled using CHEM software, and based on experimental conditions used in the University of Arkansas’ Chemical Hazard Research Center’s wind tunnel. These include ultra-low wind speeds, working in the atmospheric boundary layer, and using finite release durations with a neutrally buoyant gas. The simulation was developed in two phases: inflow and release. The inflow phase consisted of the development of the atmospheric boundary layer. The data from the simulation aligned well with the wind tunnel data. …

Experimental Study Of Novel Bcsa Scc Repair Materials And Implications On Corrosion In Bcsa Concrete Structures, Elizabeth S.M. Poblete

Graduate Theses and Dissertations

Some current building codes for structural concrete allow the use of alternative cement concrete if their structural, durability, and fire performance can be shown to be comparable to portland cement (PC) concrete. One such alternative cement, belitic calcium sulfoaluminate (BCSA) cement, is a promising standalone replacement for portland cement given its lower global warming potential (GWP), fast setting time, and high early age compressive strength. These properties also make it an ideal repair material. But repair materials often need to be highly flowable and easy to consolidate and their performance when used to repair PC concrete structures must be understood. …

Effects Of Thermal Interface Materials On Thermal Conductivity Measurement Using A Modified Astm D5470 Thermal Resistance Tester, Chinmaya Joshi

Mechanical Engineering Undergraduate Honors Theses

In this paper, we have investigated the effect of thermal interface materials (TIMs) on the accuracy and uncertainty of thermal conductivity measurements. A modified ASTM D5470 thermal resistance tester (TRT) is developed to measure the out-of-plane thermal conductivity of pyrolytic graphite (PG) and grade 2 titanium (TiG2) with and without TIMs. Compared to the ASTM D5470 standard, this modified design uses three thermocouples per side to support regressive analysis and explores the use of TIMs.s Nine PG samples and four TiG2 samples of varying thickness have been tested to obtain thermal resistance as a function of sample thickness. The steady-state …

Identifying Novel Molecular Targets To Induce Ferroptosis In Drug-Tolerant Cancer Cells Through Computational Modeling, Haris J. Rana

Biological Sciences Undergraduate Honors Theses

Ferroptosis is an iron-dependent, reactive oxygen species (ROS)-driven form of regulated cell death in which the cell membrane is degraded by lipid peroxidation. It is regulated by multiple enzymes, such as glutathione peroxidase 4 (GPX4), which prevents membrane degradation by reducing lipid peroxides and protecting cells from oxidative damage. When inhibitors like RSL3 target GPX4, lipid peroxides build up, and toxic ROS compromises membrane integrity. Traditional anticancer treatments, such as most chemotherapies, aim to eliminate tumor cells by damaging DNA and triggering apoptosis. However, resistance to apoptosis is a “hallmark of cancer,” often resulting in treatment failure. As a distinct …

Minimizing Uncovered Triples: An Integer Programming Approach To College Football Conference Scheduling, Caleb Mallett

Industrial Engineering Undergraduate Honors Theses

Collegiate football teams often compete in groups of 8-20 teams known as conferences. One such conference, the Atlantic Coastal Conference (ACC), added three new schools for the 2024-25 season, bringing their total to 17 teams. Currently, each ACC team plays eight games against others within the ACC. At the season’s conclusion, the two ACC teams with the best intraconference record compete in a conference championship game. With 17 total teams each playing eight games, the ACC could have a three-way tie for the best record where none of top the three teams play one another. To avoid this situation, we …

Developing 3d-Printed Packaging To Protect Biodegradable Sensors Used For Large-Scale, Efficient Water Quality Monitoring, Han L. Siew

Industrial Engineering Undergraduate Honors Theses

Freshwater degradation due to human activities costs the United States over $2.2 billion annually, highlighting the urgent need for improved water quality monitoring methods. Traditional water sampling techniques are labor-intensive, time-consuming, and reliant on single-use plastics that contribute to environmental pollution. This research aims to address these issues by developing 3D-printed biodegradable sensor packaging for unmanned aerial vehicle (UAV)-assisted water sampling. By utilizing biodegradable materials, the research seeks to create an eco-friendly solution that ensures sensor durability while reducing negative environmental impact. The study will involve adjusting the packaging design to withstand UAV deployment by testing and improving the resistance …

Examining The Effects Of Quercetin On Phenotypic Characteristics Of Human Mesenchymal Stem Cells, Thomas M. Needy

Biomedical Engineering Undergraduate Honors Theses

Introduction A significant obstacle to mesenchymal stem cell (MSC) potency and therapeutic utility is in vitro senescence, an irreversible cessation of replication associated with age-related complications. Senolytic drugs, such as quercetin, may be helpful in selectively culling senescent cells while leaving non-senescent cells unaffected, thereby increasing potency of high-passage MSCs.

Methods The phenotypic, genotypic, and immunomodulatory effects of quercetin were assessed using in vitro models. Senescent cells, created through repeated subculturing of MSCs in vitro, and non-senescent cells were treated with 10 μM quercetin, differentiated into osteocytes, adipocytes, and chondrocytes, and analyzed to observe the effect of quercetin.

Results Quercetin …

Preclinical Development Of Genome Editing To Treat Duchenne Muscular Dystrophy By Exon Skipping, Made Harumi Padmaswari, Shilpi Agrawal, Christopher E. Nelson

Biomedical Engineering Faculty Publications and Presentations

Duchenne muscular dystrophy (DMD) is caused by loss-of-function mutations to the gene encoding dystrophin. Restoring the reading frame of dystrophin by removing internal out-of-frame exons may address symptoms of DMD. Therefore, the principle of exon skipping has been at the center stage in drug development for Duchenne muscular dystrophy (DMD) over the past two decades. Antisense oligonucleotides (AONs) have proven effective in modulating splicing sites for exon skipping, resulting in the FDA approval of several drugs using this technique in recent years. However, due to the temporary nature of AON, researchers are actively exploring genome editing as a potential long-term, …

Survival Signature Estimation Using Optimization And Monte-Carlo Simulation For K ≥ 3 Classes Of Nodes On Two-Terminal Networks, Md Sazid Rahman

Graduate Theses and Dissertations

This research develops an efficient approach to estimating survival signatures for two-terminal networks with more than two classes of components. Recently, the survival signature has gained substantial attention in the literature on network reliability estimation due to its unique separability property, which enables passing the network topology information independent of the failure distribution of the components. Following recent results from the literature, estimating the two-terminal survival signature by Monte Carlo simulation entails solving a multi-objective maximum capacity path problem on a two-terminal network in each replication. We adapt a multi-objective Dijkstra’s algorithm from the literature to construct the set of …

Vision-Based Multimodal Frameworks For Human Behavioral Analysis: Applications In Group Activity Understanding And Public Health, Naga Venkata Sai Raviteja Chappa

Graduate Theses and Dissertations

Group Activity Recognition (GAR) has emerged as a crucial problem in computer vision, with wide-ranging applications in sports analysis, video surveillance, and social scene understanding. Unlike traditional action recognition focused on individuals, GAR requires understanding complex spatiotemporal relationships between multiple actors, their interactions, and the broader context in which these activities occur. This complexity introduces unique challenges, including the need for accurate actor localization, modeling of inter-actor dependencies, and understanding of temporal evolution in group behaviors. While recent advances have shown promise, existing approaches often rely heavily on extensive annotations such as ground-truth bounding boxes and action labels, creating significant …

Flexible Microelectrode-Based Impedance Immunosensor For Rapid Detection Of E. Coli O157:H7, Sonatan Kumar Biswas

Graduate Theses and Dissertations

Abstract Food contamination poses a significant threat to public health, the economy, and human health worldwide, occurring at any stage of the food supply chain, from farm to fork. Escherichia coli 0157:H7, recognized as one of the principal causes of foodborne illness, poses a considerable risk to food safety. The primary objective of this investigation is to devise a flexible microelectrode-based immunosensor capable of swiftly identifying E. coli O157:H7 cells without the need for incubation in a pure culture environment. In the development of the biosensor, the gold electrode (composed of 50% Au) underwent an initial coating process involving 2-aminoethanethiol/cysteamine, …

Using Deep Learning And Two-Photon Excitation Fluorescence Microscopy To Predict Breast Cancer Recurrence And Response To Chemotherapy, Nicholas Powell

Graduate Theses and Dissertations

Accurate prediction of breast cancer recurrence plays a critical role in guiding treatment decisions, particularly regarding the use of systemic therapy for patients. While genomic assays such as the Oncotype DX Recurrence Score offer valuable prognostic information, they are limited in accessibility and application. The work presented in this thesis explores an imaging-based approach for the prediction of breast cancer recurrence that combines multiphoton microscopy (MPM) with deep learning to classify individual breast cancer biopsy samples by risk of recurrence. Genomic differences in tumors with different recurrence potentials may translate to distinct optical and structural information that can be captured …

Analog Low Dropout Regulator Design Within A 12nm Finfet Node, Harshdeep Singh

Graduate Theses and Dissertations

Modern ICs require the use of multiple voltage regulators to regulate power, this creates the need for analog low dropout regulator (LDO) designs in more advanced nodes such as for the 12nm FinFET process. Analog design is particularly challenging in FinFET processes due to a variety of factors, such as quantized parameters, large parasitic values and length of diffusion effects. An analog LDO was chosen for its improved power supply rejection ratio (PSRR) over digital and hybrid approach which is a key metric for voltage sensitive applications. The LDO was designed through an iterative approach to address the difficulty of …

Design And Implementation Of Asynchronous Communication In Multi-Chiplet Systems: A Comparative Study Of Pseudo-Crossbar And Bus Architectures, Matthew Clemence

Graduate Theses and Dissertations

System-on-Chip (SoC) complexity continues to present challenges in global clock distribution and power management. The Globally Asynchronous Locally Synchronous (GALS) approach addresses these issues by enabling asynchronous communication between locally synchronous chiplets. This thesis details the design and implementation of two GALS architectures employing asynchronous handshaking protocols through Multi-Threshold CMOS NULL Convention Logic (MTNCL). The first architecture, a pseudo-crossbar, uses arbiters and multiplexers/demultiplexers (MUX/DEMUX) for prioritized and dynamic communication between chiplets. The second, a bus-based approach, employs D-latches to manage communication sequentially with predetermined interrupts. This research explores the detailed implementation, functional distinctions, scalability, and integration trade-offs inherent to each …

Characterizing Heating And Resistance Properties Of Nichrome Burn Wire To Be Used In Cubesat Actuation, Noah Moix

Mechanical Engineering Undergraduate Honors Theses

This thesis investigates the use of Nichrome 60 wire as a burn wire mechanism, commonly utilized in CubeSats and other aerospace engineering applications requiring precise, single-use release systems. The experiment focused on characterizing the thermal and resistive behavior of Nichrome 60 wire under Joule heating conditions. Four wire configurations were tested: 34-gauge and 36-gauge wires, each at lengths of 1 inch and 2 inches. Each configuration was subjected to a constant current until thermal failure occurred. During testing, real-time measurements of electrical resistance and wire temperature were recorded. This data was used to generate resistance vs. temperature profiles for each …

Modeling Cell Buildup And Release In An Ultrafiltration Cartridge, Holiday B. Derosier

Chemical Engineering Undergraduate Honors Theses

While membrane filtration has improved greatly and has been incorporated into many modern practices, there isn’t much data on material exchange in and out of the lumen and how that effects the overall efficiency of the process. This data may help to accurately measure the reliability and efficiency of a filtration membrane system, which can lead to improvements in filtration sustainability, process lifespan, and product quality.

This project aims to model the material balance within a perfusion bioreactor ultrafiltration system in MATLAB, with a focus on bioreactors and cell buildup and release from the lumen. The results of this study …

Assessing The Fate Of Antibiotic Resistance Genes In Wastewater Treatment Processes, Gunter A. Campbell

Civil Engineering Undergraduate Honors Theses

The increasing need for clean water has paved the way for the creation of systems for reusing water, such as wastewater treatment plants (“WWTPs”), to provide potable water. But in recent years, such systems have raised concerns about the distribution of antibiotic resistance genes (“ARGs”). Bacteria are adapting to antibiotics by the evolution of resistance mechanisms, such as high mutation rates and horizontal transfer. The presence of ARGs, particularly tetracycline ("tetA") resistance genes, in wastewater effluents is of concern, as they can survive treatment, spread to bodies of water, and pose a threat to human health. In this study, the …

Computer Vision In Soccer: Yolov11 Analytics Engine For Quantifying Game Strategy, Connor S. Maurer

Data Science Undergraduate Honors Theses

Single-shot object detection capabilities significantly reduce computational overhead for real-time computer vision in sports analytics at 60 FPS. YOLO11’s lightweight CNN gives promising accuracy while meeting the low-latency demand of dynamic soccer matches. As data-driven approaches take over the sport of soccer, efficient player tracking systems become critical for informing coach’s strategies. I prototype the ETL (Extract, Transform, Load) process of data collected from a single- shot detection program and evaluate its viability for estimating player fatigue. YOLO11 detects players, the ball, and other characteristics, with the output transformed by homography to estimate the positions in the real world. These …

Connecting Biological Engineering Education With Hands-On Internship Experience, Lindsey Bush

Biological and Agricultural Engineering Undergraduate Honors Theses

My honors thesis examines how my time in the biological engineering program and internship experience have prepared me for my future career. It highlights the skills I developed, the lessons I learned, and how these experiences shaped my job search and career decisions.

In my thesis, I share details about my internship. I described what I worked on, the places I visited, and the hands-on experience I gained. I talk about how my coursework provided a strong foundation and how my internship allowed me to apply those concepts in real-world engineering settings. I also discuss the technical and professional skills …

Construction And Characterization Of An Rf Anechoic Range, Logan Gentry

Electrical Engineering and Computer Science Undergraduate Honors Theses

Anechoic RF ranges are electromagnetically quiet spaces intended to provide conditions suitable for testing and classifying electronic equipment. Typically, ranges are constructed indoors, which presents a number of design challenges related to room geometry, cost, and material selection. This report describes the creation of an indoor anechoic range intended for characterization of antennas. Furthermore, the range is characterized for performance across a wide range of discrete frequencies in the UHF band according to CISPR standards, resulting in the determination of a lower frequency limit at which the room performance begins to degrade. The characterization of this range agrees with far-field …

Insert Creation To Mimic Blood Vessels In Gel Phantoms, Courtney Bloom

Biomedical Engineering Undergraduate Honors Theses

Gel phantoms are commonly used in research settings due to their ability to mimic soft tissue. Creating these phantoms usually involves 3D printing an insert, embedding it in gel, and then washing the insert out. Polyvinyl alcohol (PVA) is typically used as the insert material, but it often swells and deforms the gel during the washout process. Aquapour, a water-soluble material, was investigated as a potential replacement for PVA. Unlike PVA, Aquapour comes in a powdered form that can be mixed with water to create a castable slurry. To create molds to cast Aquapour, SolidWorks was used to design two …

Fabrication And In Vitro Biocompatibility Assessment Of Composite-Coated Magnesium Materials, Bryce Williams

Biomedical Engineering Undergraduate Honors Theses

This study provides a comparative assessment of the corrosion, morphology, and biological properties of four of the most promising coating methods for magnesium in biomedical applications, namely micro-arc oxidation (MAO), graphene oxide (GO)-containing MAO coating, MAO/sol-gel composite coating, and MAO/polycaprolactone (PCL) polymer dip coating approaches. Despite the abundance of research focused on these promising approaches, there is a notable lack of comparative studies evaluating their properties. To this end, the investigated composite coatings are ZK60+MAO, ZK60+MAO/GO, ZK60+MAO/Sol-gel, and ZK60+MAO/PCL composite coating. Several tests were used to assess various properties of the prepared groups such as in vitro corrosion characteristics, surface …

Optimizing The Effects Of Yoda1 And Assessing The Effects Of Mrna Silencing Of Piezo1 Gene In Mesenchymal Stem Cells, Addison R. Mclaughlin

Biomedical Engineering Undergraduate Honors Theses

Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are capable of differentiating into various skeletal tissues, making them promising candidates for regenerative medicine. A critical factor influencing their differentiation potential is mechanosensitivity, the ability to respond to mechanical stimuli. The mechanosensitive calcium ion channel PIEZO1 has emerged as a key regulator in this process, particularly in osteogenic differentiation. This study investigated the role of PIEZO1 in MSC osteogenesis through pharmacological activation using YODA1 and gene silencing via siRNA. Human bone marrow-derived MSCs were cultured and induced for osteogenic differentiation under varying concentrations and durations of YODA1 treatment. Alizarin …

Efficacy Of Mitophagy Inhibition As A Potentiating Agent For Conventional Chemotherapy, Morghan Relich, Shelby Bess

Biomedical Engineering Undergraduate Honors Theses

Cancer is a result of uncontrolled growth and reproduction of cells. Damaged or abnormal cells grow and multiply when they should not and in turn the cells continue to proliferate and metastasize. Malignant cells rely on functional mitochondria for proliferation, metastasis, and survival. These mitochondria maintain a functional mitochondrial network through a quality control mechanism called mitophagy. Mitophagy is a conserved intracellular process to maintain quality control and remove damaged mitochondria.

Previous research has been done to examine the effects of mitophagy in tumor cells, as well as the effects of mitophagy inhibition. One focus of current research has been …

Metabolic Responses Of Adipose-Derived Stem Cells In Collagen I Hydrogels, Caroline R. King

Biological Sciences Undergraduate Honors Theses

Peripheral nerve injury affects approximately 44 in 1 million people in the United States every year and can lead to incomplete nerve recovery and loss of motor and sensory function. A significant amount of energy is required for nerve injury repair. A lack of energy allocation to the injury site hinders repair. Current treatments include hollow nerve guidance conduits, decellularized nerve grafts, and autografts. However, they are limited by factors such as donor site morbidity and sustained immunosuppressive treatments. Using three-dimensional collagen I hydrogels laden with adipose-derived stem cells (ASCs) can assist in neural regeneration. Three-dimensional collagen scaffolds aim to …

Feasibility Of Liquid Carbon Sources For Algae Growth, Brady S. Jones

Chemical Engineering Undergraduate Honors Theses

This thesis explores the use of electrochemically produced aqueous bicarbonate as a novel liquid-phase carbon source for enhancing algal biomass productivity. Targeting the freshwater microalgae Chlorella Saccharophila, the study investigates its growth response to varying bicarbonate concentrations and compares the efficacy of liquid bicarbonate delivery with traditional gaseous CO₂ bubbling methods. Results demonstrate that Chlorella Saccharophila can sustain growth solely on bicarbonate, and that bicarbonate-fed cultures yielded higher biomass than those supplied with gaseous CO₂ or hybrid systems. These findings validate the potential of bicarbonate-based carbon delivery for scalable algae cultivation, offering key advantages such as gas-free operation, improved …

Design Considerations Of A Gpu, Nicholas M. Devilliers

Electrical Engineering and Computer Science Undergraduate Honors Theses

With the current era of AI technology, the era of single instruction multiple data has become an increasingly viable solution to accelerate training. The problem is that while software to use GPUs and other hardware accelerators, designing GPUs and ASIC devices has become increasingly more expensive and there aren’t great examples of generic GPUs that anyone can use and modify. In this thesis, there are four design considerations that will be discussed and how they affect the result of a generic GPU. The four considerations that were talked about in the thesis are, word width, arithmetic type, number of stages, …

Evaluating Fly-Ash As A Sustainable Solution For Contaminant Removal From Wastewater, Calyn Wisdom

Chemical Engineering Undergraduate Honors Theses

Access to clean and safe water is an escalating global concern due to the persistent presence of toxic contaminants in aquatic environments. Among these, synthetic dyes and per- and polyfluoroalkyl substances (PFAS) represent two distinct yet significant classes of pollutants, both posing serious environmental and public health risks. Dyes in water contribute to intense coloration, elevated chemical and biological oxygen demand (COD and BOD), reduced light penetration, and disruption of aquatic ecosystems, with potential health risks to humans upon exposure. PFAS, often termed "forever chemicals," are synthetic organofluorine compounds associated with a range of adverse health effects, including endocrine disruption, …