Engineering Commons^™

Investigation On Nanoparticle Based Combination Therapy For Targeted Cancer Treatment, Muhammad Raisul Abedin

Doctoral Dissertations

“The current treatment methods in cancer are associated with toxicity in healthy tissues, partial therapeutic response, drug resistance and finally recurrence of the disease. The cancer drugs are challenged by non-specific binding, undesired toxicity in healthy cells, low therapeutic index and finally poor therapeutic outcome. In this work, a targeted nanoscale therapeutic system Antibody Drug Nanoparticle (ADN) was engineered to selectively inhibit the breast cancer cell growth with reduced toxicity in healthy cells. The ADNs were designed by synthesizing rod shaped anoparticles using pure chemotherapeutic drug and covalently conjugating a therapeutic monoclonal antibody (mAb) on the surface of the drug …

A Review Of Carbon Dioxide Adsorption To Unconventional Shale Rocks Methodology, Measurement, And Calculation, Sherif Fakher, Abdulmohsin Imqam

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Carbon dioxide (CO₂) injection has been applied extensively in hydrocarbon reservoirs for both increasing oil recovery and CO₂ storage purposes. Recently, CO₂ injection has been proposed to increase oil recovery and for CO₂ storage in shale reservoirs. During CO₂ injection in shale reservoirs, adsorption will take place on the surface of the rock, which will impact both the oil recovery and the storage capacity. This research provides a roadmap to the different types of adsorption and the adsorption measurements and calculations with emphasis on the ones most applicable during CO₂ injection in shale …

A New Type Of Crumb Rubber Asphalt Mixture: A Dry Process Design And Performance Evaluation, Feng Ma, Jiasheng Dai, Zhen Fu, Jenny Liu, Wenhao Dong, Zhen Huang

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

To obtain a crumb rubber asphalt mixture with excellent performance, this study combined trans-polyoctenamer rubber (TOR), crumb rubber, and other additives to establish a new type of crumb rubber (CRT). The objective of this study was to design and evaluate the road performance of the new type of crumb rubber asphalt mixture (CRTAM) with a skeleton dense texture through a dry process. First, the skeleton intrusion compact volume method was used to optimize the grading of coarse and fine aggregates, and the design of the CRTAM gradation was carried out through the same and unequal volume replacement grading method. Then, …

Bending Behavior And Deflection Prediction Of High-Strength Sfrc Beams Under Fatigue Loading, Dan Ying Gao, Zhi Qiang Gu, Chenglin Wu

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The experiments of high-strength steel-fiber-reinforced concrete (SFRC) beams subjected to fatigue bend loading were conducted in this work. A total of 12 beams were tested to failure, including 2 under static loading and 10 under fatigue loading. The main varying parameters of the tested beams included the stress level, fiber volume fraction, and strength of the steel reinforcement. The fatigue life, mid-span deflection, residual deflection, and crack width were measured and evaluated. The stiffness degradation of high-strength SFRC beams was analyzed. The results indicated that both the stress level and fiber volume fraction have significant influences on the fatigue life …

Modeling Of Scrap Dissolution In Molten Iron For The Case Of Heat Transfer-Controlled Process By Different Approaches And Comparison Of Their Accuracies, Ajay Kumar Shukla, Brahma Deo, D. G.C. Robertson

Materials Science and Engineering Faculty Research & Creative Works

Dissolution of steel scrap in molten iron is studied by using analytical as well as numerical approaches for the case of a heat transfer-controlled process. The approaches used are Green's function approach, quasi-static approach, integral profile method (IPM) (with parabolic profile), and finite difference methods (FDM). Application of FDM explicit and FDM implicit with fixed grid and variable grid is described. Accuracy of all the approaches is compared in terms of total dissolution time evaluated from overall heat balance criterion. The selection rule of time step and deciding the suitable approach for achieving minimum error for different operating conditions, represented …

Aging Response On The Stress Corrosion Cracking Behavior Of Wrought Precipitation-Hardened Magnesium Alloy, G. R. Argade, S. K. Panigrahi, R. S. Mishra

Materials Science and Engineering Faculty Research & Creative Works

Constant immersion testing and slow strain rate testing (SSRT) are conducted on wrought magnesium alloy in a 3.5 wt.% NaCl solution. After solution annealing (SA) at 525 °C for 8 h, the alloy was isothermally aged at 210 °C for 15 h, 48 h, and 144 h to obtain underaged (UA), peak-aged (PA), and overaged (OA) microstructures, respectively. After 32 days of constant exposure in chloride solution, the SA and UA samples showed the lowest (~ 0.10 mg cm−2 day−1) and the highest (~ 0.20 mg cm−2 day−1) weight loss, respectively. SSRT was carried out at an initial strain rate …

Direct Numerical Simulations Of Acoustic Disturbances In Various Rectangular Nozzle Configurations, Nathaniel Hildebrand, Meelan M. Choudhari, Lian Duan

Mechanical and Aerospace Engineering Faculty Research & Creative Works

We perform Direct Numerical Simulations (DNS) to study the acoustic freestream disturbances radiating from the turbulent boundary layers along the contoured nozzle walls of a hypersonic wind tunnel with a rectangular test section. To begin with, the effects of the spanwise end walls are suppressed by confining the spanwise computational domain to a finite segment of the overall nozzle cross section and by imposing periodic boundary conditions across that spanwise domain. Besides providing a building-block configuration to reveal partial effects of the enclosed acoustic environment within the wind tunnel, these computations serve as a steppingstone toward the goal of fully-3D …

Direct Numerical Simulation Of Turbulent Pressure Fluctuations Over A Cone At Mach 8, Junji Huang, Lian Duan, Katya M. Casper, Ross M. Wagnild, Neal P. Bitter

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Direct numerical simulations (DNS) were conducted to characterize the pressure fluctuations under the turbulent portion of the boundary layer over a sharp 7◦ half-angle cone at a nominal freestream Mach number of 8 and a unit Reynolds number of Reunit = 13.4 x 106/m. The axisymmetric cone geometry and the flow conditions of the DNS matched those measured in the Sandia Hypersonic Wind Tunnel at Mach 8 (Sandia HWT-8). The DNS-predicted wall pressure statistics, including the root-mean-square (r.m.s.) fluctuations and the power spectral density (PSD), were compared with those measured in the Sandia HWT-8. A good comparison between the DNS …

Environmental Impact Of The Mechanical Coal Processing Plant, Witold Bialy, Wes Grebski, Greg Galecki, Wojciech Kaniak

Mining Engineering Faculty Research & Creative Works

The enrichment of hard coal is one of the stages of mineral resources management. It is aimed at adapting its quality parameters to different recipients' requirements, considered as a stage of mineral resources management. This process is treated as a stage of clean coal technologies or as a process of improving the economics of mining plants, which takes place in the Mechanical Coal Processing Plant (ZMPW). Adaptation of the quality of commercial coal products to the needs of specific recipients consists of removing useless components of the excavated material. In this publication, factors having a negative impact on the environment …

A Novel Data-Driven Scheme For The Ship Wake Identification On The 2-D Dynamic Sea Surface, Yanming Zhang, Lijun Jiang

Electrical and Computer Engineering Faculty Research & Creative Works

Because the ship wake spreads into an area much larger than that of the ship hull in the sea surface, it has been widely used in the ship detection. However, due to the complex sea wave motion and the high sea state, the ship wake detection is still a challenging task. In this paper, we propose a novel data-driven method based on dynamic mode decomposition (DMD) to detect, reconstruct, and locate the Kelvin wake on the two-dimensional dynamic sea surface. Through the proposed method, the sea's dynamic characteristics including the oscillation frequency and decay/growth rate of ship wakes and the …

Real-Time Assembly Operation Recognition With Fog Computing And Transfer Learning For Human-Centered Intelligent Manufacturing, Wenjin Tao, Md Al-Amin, Haodong Chen, Ming-Chuan Leu, Zhaozheng Yin, Ruwen Qin

Mechanical and Aerospace Engineering Faculty Research & Creative Works

In a human-centered intelligent manufacturing system, every element is to assist the operator in achieving the optimal operational performance. The primary task of developing such a human-centered system is to accurately understand human behavior. In this paper, we propose a fog computing framework for assembly operation recognition, which brings computing power close to the data source in order to achieve real-time recognition. For data collection, the operator's activity is captured using visual cameras from different perspectives. For operation recognition, instead of directly building and training a deep learning model from scratch, which needs a huge amount of data, transfer learning …

Thermodynamic Properties Of Hydroxylammonium Nitrate-Based Electric Solid Propellant Plasma, Matthew S. Glascock, Patrick D. Drew, Joshua L. Rovey, Kurt A. Polzin

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Electric solid propellants are advanced solid chemical rocket propellants controlled by electric current. An electric solid propellant may also be used in an electric propulsion system: specifically, an ablative pulsed plasma thruster. Previous experiments with the electric solid propellant known as high-performance electric propellant, or HIPEP, suggest its ablation processes are similar to the traditional propellant polytetrafluoroethylene (C2 F4). Better understanding of the ablation and the resulting propulsion performance of HIPEP requires a model of its vapor composition, bulk plasma quantities, and thermodynamic properties. Such a model was developed and favorably compared with previous analogous model predictions found in the …

On The Effects Of High-K Dielectric Resurf In High-Voltage Bulk Finfets, Chia Hui Cheng, Jun Wei Lai, Kai Ting Hu, Chih Fang Huang, Feng Zhao

Electrical and Computer Engineering Faculty Research & Creative Works

High-K dielectric reduced surface field (RESURF) effects in high-voltage bulk FinFETs through three-dimensional simulation are discussed in this paper for the first time. Compared to a planar gate LDMOSFET where the length of the drift region is the same, dielectric RESURF significantly increases the optimal implant dose for the drift region to a higher value, although BV2/Ron,sp is similar. By using a high-K dielectric in the shallow trench isolation (STI) to further enhance the dielectric RESURF, the BV is increased and the Ron,sp is reduced, yielding a significantly improved BV2/Ron,sp, together with a better ON/OFF current ratio. However, with the …

Artificial Synaptic Behavior Of Aloe Polysaccharides-Based Device With Au As Top Electrode, Z. X. Lim, I. A. Tayeb, Z. A.A. Hamid, M. F. Ain, A. M. Hashim, J. M. Abdullah, A. A. Sivkov, F. Zhao, K. Y. Cheong

Electrical and Computer Engineering Faculty Research & Creative Works

Formulated, processed, and dried Aloe polysaccharides thin film sandwiched between ITO as bottom electrode and Au as top electrode has been adopted as an artificial synapse to emulate behavior of neuromorphic computing. The synaptic plasticity or weight has been modulated with this simple metal-insulator-metal structure by applying voltage sweep and voltage pulse, with excitatory postsynaptic current being monitored. Synaptic potentiation and depression have been demonstrated by applying 6 consecutive sweeps of voltage in positive and negative polarity, respectively. By varying number (10 - 50) of voltage pulses, variable synaptic weight has been measured with paired pulse facilitation and post-tetanic potentiation …

A Brief Review On 3d Bioprinted Skin Substitutes, Fateme Fayyazbakhsh, Ming-Chuan Leu

Mechanical and Aerospace Engineering Faculty Research & Creative Works

The global escalating cases of skin donor shortage for patients with severe wounds warn the vital need for alternatives to skin allografts. Over the last three decades, research in the skin regeneration area has addressed the unmet need for artificial skin substitutes. 3D bioprinting is a promising innovative technology to accurately fabricate skin constructs based on natural or synthetic bioinks, whether loaded or not loaded with native skin cells (i.e., keratinocytes and fibroblasts) or stem cells in the prescribed 3D hierarchal structure to create artificial multilayer and single cell-laden construct. In this paper, the recent developments in 3D bioprinting for …

A B-Spline-Based Generative Adversarial Network Model For Fast Interactive Airfoil Aerodynamic Optimization, Xiaosong Du, Ping He, Joaquim R.R.A. Martins

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Airfoil aerodynamic optimization is of great importance in aircraft design; however, it relies on high-fidelity physics-based models that are computationally expensive to evaluate. In this work, we provide a methodology to reduce the computational cost for airfoil aerodynamic optimization. Firstly, we develop a B-spline based generative adversarial networks (BSplineGAN) parameterization method to automatically infer design space with sufficient shape variability. Secondly, we construct multi-layer neural network (MNN) surrogates for fast predictions on aerodynamic drag, lift, and pitching moment coefficients. The BSplineGAN has a relative error lower than 1% when fitting to UIUC database. Verification of MNN surrogates shows the root …

Applications Of Polynomial Chaos-Based Cokriging To Aerodynamic Design Optimization Benchmark Problems, Jethro Nagawkar, Leifur Leifsson, Xiaosong Du

Mechanical and Aerospace Engineering Faculty Research & Creative Works

In this work, the polynomial chaos-based Cokriging (PC-Cokriging) is applied to a benchmark aerodynamic design optimization problem. The aim is to perform fast design optimization using this multifidelity metamodel. Multifidelity metamodels use information at multiple levels of fidelity to make accurate and fast predictions. Higher amount of lower fidelity data can provide important information on the trends to a limited amount of high-fidelity (HF) data. The PC-Cokriging metamodel is a multivariate version of the polynomial chaos-based Kriging (PC-Kriging) metamodel and its construction is similar to Cokriging. It combines the advantages of the interpolation-based Kriging metamodel and the regression-based polynomial chaos …

Mesh Networking And Full-Duplex Communication For Wireless Networks, Arul Mathi Maran Chandran

Doctoral Dissertations

“Connectivity with large coverage area; and an increase in spectral efficiency of communications are highly desired features for any wireless network. The presented research work addresses these two feature improvements. First, the work analyzed mesh networks to enhance connectivity for wireless networks. The work analyzed both homogeneous and heterogeneous mesh networks. The work includes the development of an Android application to enable smartphones with multiple interfaces, such as Wi-Fi, Bluetooth, and cellular services, to become convergence devices. These convergence devices are then used to build a heterogeneous mesh network improving connectivity and coverage area. Second, the work explored full-duplex communications, …

A Framework For A Successful Additive Repair System, Todd E. Sparks

Doctoral Dissertations

“The goal of this research is to generate a revolutionary improvement to the usability and usefulness of additive repair technology by integrating a set of tools into a seamless work flow. Insufficient automation in the current repair process is a huge hurdle in achieving cost-effective, reliable repairs. Many opportunities have been missed due to inconsistency, quality issues and lack of robustness and flexibility. The present work addresses deficiencies in preparatory steps such as 2D and 3D geometry processing, parameter estimation, and path planning as well as on-machine execution of the path plan. The bulk of the effort is focused on …

Accurate Modeling Techniques For Power Delivery, Jingdong Sun

Doctoral Dissertations

“Power delivery is essential in electronic systems to provide reliable power from voltage sources to load devices. Driven by the ambitious user demands and technology evolutions, the power delivery design is posed serious challenges. In this work, we focus on modeling two types of power delivery paths: the power distribution network (PDN) and the wireless power transfer (WPT) system.

For the modeling of PDN, a novel pattern-based analytical method is proposed for PCB-level PDN impedance calculations, which constructs an equivalent circuit with one-to-one correspondences to the PCB’s physical structure. A practical modeling methodology is also introduced to optimize the PDN …

Advanced Control Methods On Three-Phase Inverters In Distributed Energy Resources, Sara Yazdani

Doctoral Dissertations

“This research is an endeavor to apply new and well-established control methodologies to improve transient response, stability and reliability of three-phase inverters in grid-connected and isolated mode of operation. In the course of studying the effect of these methodologies, model-based control is introduced and is extensively applied which is relatively a new approach. In addition, the application of this concept has been studied on developing “grid-forming” controls to allow wind and solar inverters to support voltage and frequency levels like traditional generators.

This research encloses the details of three major works of this research and their possible contributions on improving …

Magnetic Control Of Transport Of Particles And Droplets In Low Reynolds Number Shear Flows, Jie Zhang

Doctoral Dissertations

“Magnetic particles and droplets have been used in a wide range applications including biomedicine, biological analysis and chemical reaction. The manipulation of magnetic microparticles or microdroplets in microscale fluid environments is one of the most critical processes in the systems and platforms based on microfluidic technology. The conventional methods are based on magnetic forces to manipulate magnetic particles or droplets in a viscous fluid.

In contrast to conventional magnetic separation method, several recent experimental and theoretical studies have demonstrated a different way to manipulate magnetic non-spherical particles by using a uniform magnetic field in the microchannel. However, the fundamental mechanism …

Integrated Approach To Investigate The Wellbore Integrity Under Downhole Conditions, Weicheng Zhang

Doctoral Dissertations

“The integrity of the cement sheath is the key part to maintain zonal isolation and prevent the inter-zonal communication. Loads arising from multiple stages of wellbore life span may induce various modes of cement failure within the cement (disking and radial cracks) and at the cement-casing and the cement-formation interfaces (debonding fractures). This research utilizes the integrated laboratory and numerical approach to investigate the cement hardening process, to predict the cement failure under various loading conditions. An innovative experimental setup is established to measure the cement pore pressure variation during the hardening process under downhole conditions, and a staged 3D …

Combustion And Emission Characteristics Of Ic Engines Fueled By Hydrogen And Hydrogen/Diesel Mixtures And Multi-Objective Optimization Of Operating Parameters, Abdulhakim Issa Jabbr

Doctoral Dissertations

“The present study considers combustion of hydrogen in IC engines. In general, the work focuses on simulating the engine performance and emissions at different operation parameters, and using optimization techniques. Task I work deals with the engine performance and emissions of a single cylinder spark-ignition (SI) engine fueled by hydrogen. The engine was simulated at different equivalence ratios, exhaust gas recirculation (EGR) and ignition timing. The results indicate that NOx emissions, engine power, and efficiency are reduced by increasing EGR level, and increased with increasing equivalence ratio and advanced ignition timing. The best operating conditions for hydrogen engines were obtained …

Development Of A System Architecture For The Prediction Of Student Success Using Machine Learning Techniques, Tatiana A. Cardona

Doctoral Dissertations

“ The goals of higher education have evolved through time based on the impact that technology development and industry have on productivity. Nowadays, jobs demand increased technical skills, and the supply of prepared personnel to assume those jobs is insufficient. The system of higher education needs to evaluate their practices to realize the potential of cultivating an educated and technically skilled workforce. Currently, completion rates at universities are too low to accomplish the aim of closing the workforce gap. Recent reports indicate that 40 percent of freshman at four-year public colleges will not graduate, and rates of completion are even …

Applications Of Information Theory In Filtering And Sensor Management, Matthew James Gualdoni

Doctoral Dissertations

“A classical sensor tasking methodology is analyzed in the context of generating sensor schedules for monitoring resident space objects (RSOs). This approach, namely maximizing the expected Kullback-Leibler divergence in a measurement update, is evaluated from a probabilistic perspective to determine the accuracy of the conventional approach. In this investigation, a newdivergence-based approach is proposed to circumvent themyopic nature of the measure, forecasting the potential information contribution to a time of interest and leveraging the system dynamics and measurement model to do so. The forecasted objective exploits properties of a batch measurement update to frequently exhibit faster optimization times when compared …

Geo-Engineered Induced Seismicity And The Effects On Federal Infrastructure, Merissa L. Zuzulock

Doctoral Dissertations

“The study of human-induced seismicity and the effects on civil engineering systems are not completely understood or often studied. Moreover, existing studies are focused on the cause of the seismicity and not on the potential damage to infrastructure from these seismic events. There are recent studies that are beginning to focus on shallow induced seismic activity and the effects on infrastructure by establishing innovative ways to quantify that damage. These studies that focus on the potential damage neglect to included considerations for small magnitude cluster events. As geo-induced seismic events increase, soil fatigue becomes of greater concern to structures within …

An Approach To System Of Systems Resiliency Using Architecture And Agent-Based Behavioral Modeling, Paulette Bootz Acheson

Doctoral Dissertations

”In today’s world it is no longer a question of whether a system will be compromised but when the system will be compromised. Consider the recent compromise of the Democratic National Committee (DNC) and Hillary Clinton emails as well as the multiple Yahoo breaches and the break into the Target customer database. The list of exploited vulnerabilities and successful cyber-attacks goes on and on. Because of the amount and frequency of the cyber-attacks, resiliency has taken on a whole new meaning. There is a new perspective within defense to consider resiliency in terms of Mission Success.

This research develops a …

Development Of A Modeling Algorithm To Predict Lean Implementation Success, Richard Charles Barclay

Doctoral Dissertations

”Lean has become a common term and goal in organizations throughout the world. The approach of eliminating waste and continuous improvement may seem simple on the surface but can be more complex when it comes to implementation. Some firms implement lean with great success, getting complete organizational buy-in and realizing the efficiencies foundational to lean. Other organizations struggle to implement lean. Never able to get the buy-in or traction needed to really institute the sort of cultural change that is often needed to implement change. It would be beneficial to have a tool that organizations could use to assess their …

Enabling Flexibility Through Strategic Management Of Complex Engineering Systems, Walter Louis Barnes Ii

Doctoral Dissertations

”Flexibility is a highly desired attribute of many systems operating in changing or uncertain conditions. It is a common theme in complex systems to identify where flexibility is generated within a system and how to model the processes needed to maintain and sustain flexibility. The key research question that is addressed is: how do we create a new definition of workforce flexibility within a human-technology-artificial intelligence environment?

Workforce flexibility is the management of organizational labor capacities and capabilities in operational environments using a broad and diffuse set of tools and approaches to mitigate system imbalances caused by uncertainties or changes. …