Engineering Commons^™

Molecular Survival Strategies Against Kidney Filtration: Implications For Therapeutic Protein Engineering, William Heaps, Anna Elise Packard, Kristina M. Mccammon, Tyler P. Green, Joseph P. Talley, Bradley C. Bundy, Dennis Della Corte

Faculty Publications

The glomerular filtration barrier poses a significant challenge for circulating proteins, with molecules below ~60–70 kDa facing rapid renal clearance. Endogenous proteins have evolved sophisticated evasion mechanisms including oligomerization, carrier binding, electrostatic repulsion, and FcRn-mediated recycling. Understanding these natural strategies provides blueprints for engineering therapeutic proteins with improved pharmacokinetics. This review examines how endogenous proteins resist filtration, evaluates their application in protein engineering, and discusses clinical translation including established technologies (PEGylation, Fc-fusion) and emerging strategies (albumin-binding domains, glycoengineering). We address critical challenges of balancing half-life extension with tissue penetration, biological activity, and immunogenicity—essential considerations for the rational design of next-generation …

Precision Acoustofluidics For High-Throughput Mechanobiology In Suspension Cells, Kaichun Yang, Ruoyu Zhong, Ke Li, John Mai, Pengzhan Liu, Ye He, Joseph Rich, Ying Chen, Janna Wang, Zhiteng Ma, Zhiteng Ma, Xianchen Xu, Qian Wu, Tony Jun Huang

Faculty Publications

Mechanomodulation, the process of altering cellular behavior through applied mechanical forces, plays a critical role in physiological processes and has substantial implications for cancer therapy, immunology, and drug development. However, precise and efficient stimulation of nonadherent cells remains a major challenge, limiting the investigation of mechanotransduction pathways and the development of targeted therapeutics. Here, we developed an acoustofluidic platform named Suspension-cell Targeted Response to Excitation via Acoustofluidic Mechanomodulation (STREAM) to enable precise, high-throughput stimulation of suspension cells. STREAM accomplishes this using 101.14-megahertz high-frequency surface acoustic waves to deliver controlled mechanical stimulation at a throughput of 500,000 cells per minute. STREAM …

Guitar Amplifier Directivity, Rachel C. Edelman, Brian E. Anderson, Samuel D. Bellows, Timothy W. Leishman

Directivity

No abstract provided.

Efficiently Stowed Flashers With Uniform-Thickness Panels Based On Non-Developable Origami, Larry L. Howell, Robert J. Lang, Specer P. Magleby, Davis Wing

Faculty Publications

We present the mathematical construction of a deployable flasher pattern with near-uniform nonzero thickness in the deployed form and efficient face-to-face packing in the stowed form. We demonstrate its fabrication, deployment, and stowage. The results facilitate the design and manufacture of deployable systems with panels whose substantial thickness is dictated by the end application, with particular utility for space systems.

Influence Of Surface Features On Heat Transfer During Dropwise Condensation Over Superhydrophobic Surfaces In Shear Flow, Shaur Humayun, R. Daniel Maynes, Julie Crocket, Brian D. Iverson

Faculty Publications

This study investigates heat transfer during dropwise condensation (DWC) on superhydrophobic (SH) surfaces in humid air shear flow, emphasizing the effect of increased drop mobility and the influence of surface micro/nanostructure on heat transfer rates. Experiments were conducted on smooth hydrophobic, microstructured SH, nanostructured carbon-infiltrated carbon nanotube (CICNT) surfaces, and two-tiered SH surfaces with both micro and nanostructures. Heat transfer rates were measured under humid air flow rates in the range of 2–4 CFM. Experimental results demonstrate that surfaces with nanostructure (including two-tiered structures) exhibit increased drop mobility and coalescence-induced drop jumping, enhancing drop removal rates and overall heat transfer …

The Composition Of Gases From A Diffusion Flame Above Longleaf Pine Needle Fuel Beds, David R. Weise, Thomas H. Fletcher, Timothy J. Johnson, Weimin Hao, Russell G. Tonkyn, Catherine A. Banach, Javier Palarea-Albaladejo, Mahsa Alizadeh, Stephen Baker

Faculty Publications

The gas and tar composition of a wildland fire diffusion flame from longleaf pine needles is currently relatively unmeasured and more data are needed to fill in the gap between pyrolysis data and smoke plume data, thus improving physical and chemical modeling of wildland smoke formation. A pilot experiment to measure light gas and tar composition of such a flame is described for three flame zones: persistent flame (flame base), intermittent flame, and smoke plume. Flame gases from 24 experimental fires were collected in canisters and analyzed for CO2, CO, H2, CH4, and C2 to C7 hydrocarbon gases. Other light …

Mission-Focused Multidisciplinary Design Optimization Of Tilt-Rotor Evtol Propulsion System, Tyler Critchfield, Andrew Ning

Faculty Publications

Tilt-rotor propulsion system design requires a multidisciplinary approach to tackle important challenges and competing tradeoffs between disciplines. In this paper, we model rotor aerodynamics, blade structures, vehicle drag, electric propulsion, and tonal/broadband acoustics for a tilt-rotor, electric vertical takeoff and landing aircraft using low-to-mid fidelity tools. We use gradient-based design optimization with automatic differentiation and parameter sensitivity analyses to explore the design space and complex tradeoffs of tilt-rotor distributed electric propulsion systems, exploring effects of variations in payload/empty weight, battery specific energy, and blade tip speed. This framework models multiple operating points with a mission-focused objective to account for the …

Effect Of Inter Electrode Distance On Electrochemical Mineralization Of Calcium Carbonate In Mildly Acidic Environments, Irene Walker, Ivy Wu, Steven Decaluwe, Robert Bell, Kerry Rippy

Reviews, Analyses, and Instructional Studies in Electrochemistry (RAISE)

The effect of inter electrode distance (IED) on electrochemical mineralization in a parallel plate cell with a stainless-steel working electrode is presented. Three IEDs were tested, 6.5 mm, 15.5 mm, and 22.0 mm, for their water reduction effectiveness to create a region of local alkalinity that stimulates calcium carbonate precipitation in mildly acidic conditions. Chronoamperometry at -1.6 V for 30 minutes with ex-situ optical microscopy and scanning electron microscopy (SEM) were used. At the smallest IEDs, crystal clusters formed in growth-favored regimes as compared to the largest IED, where nucleation dominated, leading to encasement of the SS mesh. Rapid precipitation …

Optimal Sizing Of Battery Energy Storage Systems For Peak Shaving And Demand Response Using A Degradation-Aware Bayesian Optimization-Mixed-Integer Linear Programming Framework, Jiwei Yao, Blake Billings, Tao Gao, John Hedengren, Kody M. Powell

Faculty Publications

The increasing integration of renewable energy and rising electricity demand highlight the importance of battery energy storage systems for peak shaving and demand response. Unlike prior approaches that overlook operational impacts on degradation, this study proposes a Bayesian Optimization–Mixed Integer Linear Programming framework for optimal battery energy storage system sizing. In this framework, Mixed Integer Linear Programming determines short-term scheduling while a calibrated electrochemical model iteratively evaluates degradation. The central hypothesis is that the framework can efficiently identify optimal sizes that yield realistic and economically robust outcomes. The method is tested across three scenarios: peak shaving, peak shaving with energy-reduction …

Cybernest: A Step Forward For Training Cybersecurity Professionals, Justin Mott

Theses and Dissertations

The growing complexity of cyber threats has exposed a critical gap between academic cybersecurity education and the operational demands of the workforce. This thesis presents a pilot study for a use-case of CyberNEST, a simulation-based training platform that integrates adversary emulation and threat-informed learning to create realistic, hands-on experiences for cybersecurity students.(17) The system was designed to replicate Security Operations Center (SOC) environments and incident response workflows, allowing participants to investigate, analyze, and respond to simulated attacks under authentic conditions. This pilot-study performed training simulations using the CyberNEST platform, developed by Brigham Young University, with students, collecting data from pre- …

Evaluating The Performance Of The Primary Heat Exchanger In A Sco2 Brayton Cycle While Firing Solid Fuels, Brian Jeffrey Schooff

Theses and Dissertations

The sCO2 closed-loop Brayton cycle is an alternative to the standard steam-Rankine cycle for generating electrical power from a heat source. The sCO2 Brayton cycle is advantageous because it can be more efficient, use less water, and have smaller turbomachinery than the steam-Rankine cycle. While there are several research groups advancing the technology necessary to utilize the sCO2 Brayton cycle on an industrial scale, none of these groups use solid fuel combustion as the heat source. A Brigham Young University-led project developed and tested a pilot-scale sCO2 Brayton cycle unit (1.6 MWth) using natural gas, pulverized coal, and pulverized biomass …

Programmable Acoustofluidic Engineering For Creating Gradient Biomaterials, Jujing Lu, Ye He, Jianping Xia, Mingyuan Liu, Joseph Rich, Ke Jin, Ruoyu Zhong, Kaichun Yang, Jiao Qian, Ying Chen, Ke Li, Zhiteng Ma, Tony Jun Huang

Faculty Publications

Gradient biomaterials that exhibit spatially varying physical, chemical, or biological properties can be used in various applications such as tissue engineering, organoid development, mechanobiology, and spatially controlled drug delivery. However, current fabrication methods often suffer from limited gradient precision, restricted material compatibility, and poor reproducibility. Here, we introduced gradient regulation via acoustofluidic dynamic engineering (GRADE), a programmable system to generate high-fidelity gradient biomaterials across different material systems. By incorporating focused interdigital transducers with the pulsed surface acoustic wave actuation, GRADE can achieve tunable and directional acoustic streaming (0 to 22 millimeters per second), which allows accurate regulation of the gradient …

Cavitation On Superhydrophobic Propellers, John Tyson Danby

Theses and Dissertations

This thesis investigates the impact of superhydrophobic (SH) surface treatments on the cavitation behavior of small-scale marine propellers. Cavitation, the formation of vapor cavities in liquid due to local pressure reductions, can lead to efficiency losses, noise, and structural damage in marine propulsion systems. Although SH surfaces have shown promise in reducing drag and altering nucleation behavior in static or low-speed flow contexts, their effect on cavitation onset in rapidly rotating propellers remains underexplored. To address this, eight 1-inch aluminum propellers were tested, including variations in pitch, solidity, and blade number. Each design was produced in two versions: one treated …

Cyclic Testing Of Special Moment Frame Connections With Buckling-Restrained Fuse Plates, Jeremiah John Merrell

Theses and Dissertations

This thesis presents the development and evaluation of a new special steel moment frame connection that employs replaceable buckling-restrained fuse plates that can enhance seismic performance and post-earthquake repairability. A total of eight unique specimens were tested on two series of beam-to-column subassemblies (W36 and W24) to investigate connection behavior under cyclic loading. The experiments examined the influence of fuse plate geometry, bolt configuration, and buckling-restraints on strength, ductility, and deformation capacity. Results indicated that the buckling-restraint washers and bolts were effective at preventing out-of-plane buckling. Specimen M1.5 was successful in meeting the AISC 341-22 qualifications requirements for special moment …

Validation Of A Mesh-Based Computational Fluid Dynamics Model, The Generataion Of Reference Wake Mixing Data, And A Preliminary Comparison To A Lagrangian Vortex Based Model, Justin Don Hawkins

Theses and Dissertations

Three things are accomplished in this work. First, a verified wind turbine model is developed for both turbulent and non-turbulent flows. The verified model is created using AMR-Wind, a mesh-based CFD solver which uses an actuator line model to represent the turbine blades. Second, a database of turbine forces and wake data is compiled using the verified wake model. This data is collected for simulations of two turbines operating in close proximity to one another in various configurations. When the wake of one turbine interacts with another, wake mixing occurs. Wake mixing affects turbine performance and is important for predicting …

Enhancing Fuel Performance Of Molten Salt Reactors Through Improved Thermophysical Property Data, High-Fidelity Simulation, And Advanced Control Strategies, Jackson Seth Ivory

Theses and Dissertations

The deployment of molten salt reactors (MSRs) as next-generation nuclear technology requires accurate thermophysical property data, validated system models, and advanced control strategies to ensure safe and economically competitive operation. This dissertation, Enhancing Fuel Performance of Molten Salt Reactors Through Improved Thermophysical Property Data, High-Fidelity Simulation, and Advanced Control Strategies, integrates experimental measurements, thermal hydraulic simulation, and model predictive control (MPC) to enhance understanding of MSR fuel behavior under steady state and transient conditions. New density and heat capacity measurements of UF4-FLiNaK molten salts were obtained using Archimedean and differential scanning calorimetry methods, respectively, to address critical gaps for fueled …

Utah Lake From Space: Analysis Of Sentinel 2 And Modis Data Shows Spatiotemporal Trends And Patterns In Chlorophyll-A, Turbidity, And Temperature, Kaylee Brook Tanner

Theses and Dissertations

Harmful algal blooms (HABs) are a serious and growing risk to waterbodies around the world. Excessive algal growth, especially when it involves cyanobacteria, impairs the functioning of aquatic ecosystems and threatens the health of humans and animals using the water. There is currently great interest in developing effective prevention and mitigation strategies for these blooms, particularly in ecologically and economically vital freshwater lakes. Such development, however, requires detailed understanding of HAB drivers and dynamics, which can be highly complex and difficult to characterize. High-frequency, high-resolution imagery from earth observation satellites provides spatially and temporally comprehensive data on global lakes--data which …

Characterizing Temperature-Dependent Properties Of Fat For Improving High Intensity Focused Ultrasound Simulations, Brian Easthope

Theses and Dissertations

High-intensity focused ultrasound (HIFU) is a non-invasive therapeutic technique that relies on the precise delivery of acoustic energy to ablate diseased tissue. The presence of subcutaneous fat can significantly alter focal accuracy and treatment efficiency due to its distinct thermal and acoustic behavior. This study characterized the temperature-dependent thermal conductivity, thermal diffusivity, specific heat capacity, acoustic attenuation, and acoustic velocity of human subcutaneous fat to improve pretreatment modeling for HIFU therapies. Measurements were performed using a dual needle probe for thermal conductivity and diffusivity, differential scanning calorimetry for specific heat capacity, radiation force balance for attenuation, and through-transmission methods for …

Measuring And Modeling Nonlinear Vibrations In Structures With Mechanical Joints, Suzanna Gilbert

Theses and Dissertations

Many assembled structures have bolted or riveted joints. Aside from providing a convenient method of assembly, mechanical joints have an important effect on the structure's dynamic response to its environment. Friction and microslip within the joints help to damp out unwanted vibration. However, the joints also introduce nonlinearity into the response. Most notably, the natural vibrational modes of the structure no longer have constant natural frequencies and damping ratios. Rather, they shift as a function of vibration amplitude. Several methods exist to characterize the dynamics of nonlinear systems, yet they are generally validated on simple benchmark structures, and many still …

Inelastic Behavior Of Three-Story Buildings With Concrete-Filled Composite Plate Shear Walls Subjected To Wind Loads, Joshua John Blom

Theses and Dissertations

Although elastic design of the main wind force resisting system in a building is the conventional approach it is not always desirable. In this study, nonlinear static and dynamic analyses are used to predict the inelastic behavior of a three-story building with concrete-filled composite plate shear walls subjected to wind loads. To explore the potential for inelastic design, two types of planar composite shear wall buildings are examined: individual shear walls designed using an elastic approach, and coupled shear wall pairs designed using an inelastic approach adopted from seismic design provisions. Nonlinear static "pushover" analyses are run using an assumed …

Experimental Testing Of Axially Loaded Fuse Plates Without Continuous Buckling Restraint, Rebekah Elizabeth Higgins

Theses and Dissertations

Current seismic design practice is to design structures to avoid collapse and protect life. Buildings are designed to resist seismic loading through strength and ductility. In moment frames, this ductility traditionally comes from inelastic deformation of beams. Moment frame connections move inelastic deformation away from the column and allow a plastic hinge to form in the beam. This plastic hinge prevents collapse but leaves the building difficult to repair. Some proprietary moment frame connections address this issue with replaceable fuse plate connections. These fuse plate connections move the plastic hinge out of the beam and into the replaceable fuse, allowing …

A New Model For Predicting Two-Zone Parameters Based On Geometric Modifications In Computational Fluid Dynamics Simulations, Jason B. Metten

Theses and Dissertations

This study uses Computational Fluid Dynamics (CFD) to create a new and improved model for key Two-Zone modeling parameters, 𝜒 and 𝛿2𝑝. It explores how geometric changes to centrifugal compressors impact these modeling parameters. While centrifugal impellers are an important part of many systems, the flow through such impellers is inherently complex, making performance often difficult to predict. There are many approaches for modeling this complex flow environment, one method being the Two-Zone model developed by Dave Japikse. Values for 𝜒 and 𝛿2𝑝 are often determined from data obtained from test rigs or correlations. In this study high-fidelity CFD simulations …

Power Resilience In Utah's Water Sector: A Survey Of Stakeholder Practices, Preferences And Potential, Tyler Christopher Peterson

Theses and Dissertations

Drinking water and wastewater services are vulnerable to disruptions because they rely heavily on the electric grid. As a result, power outages can lead to water outages, creating cascading failures that compromise sanitation, firefighting, healthcare, and daily routines. Although an important topic, there are little to no studies of water and wastewater power resilience at a geographic or state level. In this study we investigate the extent of existing backup power and renewable energy integration as well as the motivations and barriers around their power resilience. We collect our data through semi-structured interviews with staff at 19 urban and rural …

Experimental And Theoretical Characterization Of Molten Salt Thermal Conductivity, Jacob C. Numbers

Theses and Dissertations

Molten salts form an ideal heat transfer fluid for advanced energy generation systems, including molten salt reactors (MSR). Accurate characterization of molten salt thermal conductivity is needed to confidently predict transient thermal behavior and optimize salt properties. Measurements are hindered by salts' challenging material properties, which---in the case of the needle probe device---induced unaccounted physical changes that limited its accuracy and repeatability. Sparse thermal conductivity data in general is exacerbated by a limited fundamental understanding of molecular energy transfer in liquids. This work extends the experimental capacity for compositional studies using the needle probe and proposes a theoretical model for …

Fabrication And Evaluation Of Large Alumina Crucibles By Vat Photopolymerization Additive Manufacturing For High-Temperature Actinide Chemistry, R. Joey Griffiths, Christy Santoyo, Jean-Baptise Forien, Bradley Childs, Andrew J. Swift, Andrew Cho, Alexander Wilson-Heid, George Ankrah, Devin Rappleye, Aiden A. Martin, Jason Jeffries, Kiel Holliday

Faculty Publications

Additive manufacturing (AM) offers opportunities to advance the design and function of ceramic tooling in high temperature actinide pyrochemistry. In technical ceramics such as alumina, conventional forming techniques often restrict design flexibility and can limit experimental progress. In this study, we investigate the use of vat photopolymerization (VP) with commercial resins to fabricate large-scale alumina crucibles, reaching dimensions up to 125 mm, which is significantly larger than typically reported for dense VP ceramics. Notably, these additively manufactured components are produced using consumer-grade hardware, which limits process control, but offers significant upside in scalability and accessibility. Using microscopy and X-ray computed …

Polydopamine-Coated Magnetic Nanoparticles Data, William G. Pitt

ScholarsArchive Data

This data archive contains raw data and processed data related to research and development of magnetic nanoparticles that adhere to bacteria. This data is the foundation of data in the MS thesis of Bowen Houser, and publications and presentations related to that research effort. Polydopamine-coated magnetic nanoparticles are found to be very adhesive to gram-positive bacteria, and less adhesive to gram-negative bacteria. These data files contain information for S. aureus, S. epidermidis, S. mutans, E. coli, P. aeruginosa, and N. perflava. Some data include the kinetics of capture.

Data Release Of 5-Fluorouracil From Polylactic Acid Microparticles Containing Magnetic Nanoparticles, William G. Pitt

ScholarsArchive Data

This data archive contains raw data and processed data related to research and development of the release of the chemotherapy drug 5-fluororacil from microparticles of poly(lactic acid) which also contain superparamagnetic magnetite nanoparticles. This data is the foundation of data in the MS thesis of Tyler Green, and publications and presentations related to that research effort.

Modeling Xilinx 7-Series Fpgas Within The Verilog To Routing Project, Joshua Peter Fife

Theses and Dissertations

Verilog to Routing (VTR) is the most widely used open-source tool for experimenting with FPGA placement and routing algorithms, as well as assessing how architectural changes impact routability, timing, and power consumption.

Historically, VTR has been tailored specifically for Intel’s Altera-like FPGAs, lacking support for key features that would enable greater flexibility in describing other architectures. In this work, we introduce a fully functional 7-Series architecture capture from the Xilinx family, utilizing VTR’s scalable architecture description language. We detail the necessary upgrades to achieve this description, including the ability to describe L and T-shaped wires and target hard multipliers with …

On The Derivation Of The Ungerboeck Observation Model For Offset Qpsk, Michael Rice

Faculty Publications

This report derives maximum likelihood sequence estimator for Offset QPSK (OQPSK) operating over frequency selective channel. The maximum likelihood sequence estimator takes the form of the Viterbi Algorithm operating on a trellis defined intersymbol interference caused by the frequency selective channel. Because the distorted pulse shape does not satisfy the Nyquist no-ISI criterion, the matched filter output samples contain correleted noise. The derivation uses Ungerboeck’s method to create a recursive causal metric suitable for use with the Viterbi Algorithm.

Pyrolysis Of Foliage From 24 U.S. Plant Species With Recommendations For Physics-Basedwildland Fire Models, Mahsa Alizadeh, Thomas H. Fletcher

Faculty Publications

Pyrolysis of 24 samples of foliage from three U.S. regions with frequent wildland fires (Southeastern U.S., northern Utah and Southern California) was studied in a fuel-rich flat-flame burner system at 765 ◦C (for Southeastern U.S. samples) and 725 ◦C (for northern Utah and Southern California species), with a heating rate of approximately 180 ◦C/s. These conditions were selected to mimic the conditions of wildland fires. Individual plant samples were introduced to the high temperature zone in a flat-flame burner and pyrolysis products were collected. Tar was extracted and later analyzed by GC/MS. Light gases were collected and analyzed by GC/TCD. …