Conducting Polypyrrole Hydrogel Biomaterials For Drug Delivery And Cartilage Tissue Regeneration, Iryna Liubchak

Electronic Thesis and Dissertation Repository

Articular cartilage tissue has limited capacity for self-regeneration leading to challenges in the treatment of joint injuries and diseases such as osteoarthritis. The tissue engineering approach combines biomaterials, cells and bioactive molecules to provide a long-term and stable cartilage repair. In the following work, electroactive polymer polypyrrole~(PPy) was incorporated into the synthetic hydrogel to enhance the mechanical properties of the material for cartilage applications. PPy was loaded with drug compound and the \emph{on demand} drug release was demonstrated. The composite PPy hydrogel was 3D printed using stereolithography to create a porous tissue engineering scaffold. Biocompatibility and cell adhesion to the …

Anonymization & Generation Of Network Packet Datasets Using Deep Learning, Spencer K. Vecile

Electronic Thesis and Dissertation Repository

Corporate networks are constantly bombarded by malicious actors trying to gain access. The current state of the art in protecting networks is deep learning-based intrusion detection systems (IDS). However, for an IDS to be effective it needs to be trained on a good dataset. The best datasets for training an IDS are real data captured from large corporate networks. Unfortunately, companies cannot release their network data due to privacy concerns creating a lack of public cybersecurity data. In this thesis I take a novel approach to network dataset anonymization using character-level LSTM models to learn the characteristics of a dataset; …

Configuration And Sizing Of Small Modular Reactor With Thermal Energy Storage Within A Microgrid For Off-Grid Communities, Michael W. C. Davis

Electronic Thesis and Dissertation Repository

Many off-grid communities in Canada rely on diesel generators for their electricity needs. This is not only expensive but also produces significant greenhouse gas emissions. Small modular reactors (SMRs) have been proposed to replace diesel generators and can be combined with photovoltaic (PV) sources to form a microgrid. However, fluctuations in loads and PV create challenges for SMRs. Integrating a thermal energy storage (TES) system with the SMR can increase the flexibility of the power system to operate more effectively. This thesis first examines methodologies to determine suitable configurations of such a microgrid. Through analysis of the system components and …

The Design And Evaluation Of A Subacromial Implant In Restoring Normal Glenohumeral Joint Stability In The Presence Of A Massive Irreparable Rotator Cuff Tear, Cole T. Fleet

Electronic Thesis and Dissertation Repository

Massive irreparable rotator cuff tears are a common cause of pain and disability. Several different treatment options are available for this pathology; however, these treatments have been associated with poor clinical outcomes when used to treat younger (<65 years), more active patients. The purpose of this thesis was to design and evaluate a subacromial implant in its ability to restore normal glenohumeral stability and range of motion. The implant was created as a modular device, which captured different implant thicknesses (5mm and 8mm) and constraints (high and low) within its design. In-vitro testing compared the ability of these implants to restore normal shoulder biomechanics. The results indicated the 5mm high constraint implant to be the most effective in restoring normal joint position. Furthermore, range of motion increased when the implant was paired with a tuberoplasty procedure. These results suggest this implant may be advantageous in treating younger patients.

Numerical Analysis Of Internal Hydraulic Jump In Complex Topography, Dylan Macriner

Electronic Thesis and Dissertation Repository

Topographic effects on internal hydraulic jumps in stratified flow over complex geometry are studied. The simulations are motivated by flow conditions present in a channel in Hood Canal, Washington with continuous density profiles and constant inlet velocities.

Results show that mixing in the domain is typically increased by topographic variation, where isolated expansions saw an increase in mixing, but the associated velocity decrease in expansions had contrasting effects on mixing. Likewise, a contraction with an increased velocity caused more mixing, seeing geometry change and velocity acting as compounding factors. 2D results including along channel topographic variation modelled after Hood Canal's …

Optimized And Automated Machine Learning Techniques Towards Iot Data Analytics And Cybersecurity, Li Yang

Electronic Thesis and Dissertation Repository

The Internet-of-Things (IoT) systems have emerged as a prevalent technology in our daily lives. With the wide spread of sensors and smart devices in recent years, the data generation volume and speed of IoT systems have increased dramatically. In most IoT systems, massive volumes of data must be processed, transformed, and analyzed on a frequent basis to enable various IoT services and functionalities. Machine Learning (ML) approaches have shown their capacity for IoT data analytics. However, applying ML models to IoT data analytics tasks still faces many difficulties and challenges. The first challenge is to process large amounts of dynamic …

The Development Of A Motion Sensing Device For Use In A Home Setting, Jaspreet K. Kalsi

Electronic Thesis and Dissertation Repository

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease, with over 10 million individuals diagnosed with PD world-wide. The most common symptom characterized by PD is tremor. Tremor is an involuntary oscillatory motion that most prominently occurs in upper limb, specifically in the hand and wrist that has a measurable frequency and amplitude. This thesis aims to evaluate the usability and functionality of a tremor sensing device designed to collect quantitative data on individuals with PD. The designed device uses 23 commercially-available inertial measuring units (IMUs) located between 21 joints: distal interphalangeal (DIP) joints, proximal interphalangeal (PIP) joints, Interphalangeal …

Ai-Based Traffic Forecasting In 5g Network, Maryam Mohseni

Electronic Thesis and Dissertation Repository

Forecasting of the telecommunication traffic is the foundation for enabling intelligent management features as cellular technologies evolve toward fifth-generation (5G) technology. Since a significant number of network slices are deployed over a 5G network, it is crucial to evaluate the resource requirements of each network slice and how they evolve over time. Mobile network carriers should investigate strategies for network optimization and resource allocation due to the steadily increasing mobile traffic. Network management and optimization strategies will be improved if mobile operators know the cellular traffic demand at a specific time and location beforehand. The most effective techniques nowadays devote …

Identification And Distribution Analysis Of The Mid-Phase In A Low-Velocity Gas-Solid Fluidized Bed, Zhenan Zhang

Electronic Thesis and Dissertation Repository

The intermediate phase in low-velocity gas-solid fluidized beds generally presents excellent gas-solid contact in the systems. However, no comprehensive understanding of this vital phase is available in the literature. Therefore, this study proposed a statistical method to identify this intermediate phase, named ‘mid-phase’ in this thesis, to interpret the system performance based on the analysis of solids holdup in a low-velocity gas-solid fluidized bed.

The distributions of the mid-phase are investigated along both radial and axial directions in consideration of different flow regimes. The result shows that the turbulent regime contains a higher amount of mid-phase and the spatial mid-phase …

Intracardiac Ultrasound Guided Systems For Transcatheter Cardiac Interventions, Hareem Nisar

Electronic Thesis and Dissertation Repository

Transcatheter cardiac interventions are characterized by their percutaneous nature, increased patient safety, and low hospitalization times. Transcatheter procedures involve two major stages: navigation towards the target site and the positioning of tools to deliver the therapy, during which the interventionalists face the challenge of visualizing the anatomy and the relative position of the tools such as a guidewire. Fluoroscopic and transesophageal ultrasound (TEE) imaging are the most used techniques in cardiac procedures; however, they possess the disadvantage of radiation exposure and suboptimal imaging. This work explores the potential of intracardiac ultrasound (ICE) within an image guidance system (IGS) to facilitate …

Comparison Of Layered Nickel Cobalt Manganese Oxide Cathodes With Different Compositions And Morphologies In Lithium-Ion Batteries, Fanny Poon

Electronic Thesis and Dissertation Repository

The revolutionary rechargeable lithium-ion battery paves the way for environmentally-friendly applications such as electric vehicles. Nevertheless, further improvements are required to match or exceed the performance of conventional internal combustion engine vehicles, such as higher energy density, faster charging speed, longer lifetime, better safety and lower cost. Lithium layered nickel cobalt manganese oxides (NCM) are a popular choice of cathode material, but they still suffer from problems such as cation mixing, volume changes, microcracking, surface side reactions, high temperature performance issues and structural reconstruction. This thesis compares various NCM materials to figure out what guidelines should be followed to improve …

A Two-Layer Continuous-Capillary Oxygen Transport Model: Development And Application To Blood Flow Regulation In Resting Skeletal Muscle., Keith C. Afas

Electronic Thesis and Dissertation Repository

In skeletal muscle (SM), the microcirculation distributes blood flow to capillary networks to meet local oxygen (O₂) demand. Experiments using intra-vital video microscopy (IVVM) have quantified blood flow and O₂ supply in capillary networks, and using an O₂ exchange chamber have measured local changes in blood flow believed due to O₂-dependent regulation. However, IVVM is unable to simultaneously measure capillary O₂ supply and SM O₂ content, implying the need for theoretical models to understand how flow regulation and SM oxygenation interact. In this thesis, a novel blood-tissue O₂ transport model using …

Effective Resource Scheduling For Collaborative Computing In Edge-Assisted Internet Of Things Systems, Qianqian Wang

Electronic Thesis and Dissertation Repository

Along with rapidly evolving communications technologies and data analytics, Internet of Things (IoT) systems interconnect billions of smart devices to gather, exchange, analyze data, and perform tasks autonomously, which poses a huge pressure on IoT devices' computing capabilities. Taking advantage of collaborative computing enabled by cloud computing and edge computing technologies, IoT devices can offload computation tasks to idle computing devices and remote servers, thus alleviating their pressure. However, scheduling resources effectively to realize collaborative computing remains a severe challenge due to diverse application objectives, limited distributed resources, and unpredictable environments. To overcome the above challenges, this thesis aims to …

Flexural Behaviour Of Concrete Beams With High Strength Reinforcement, Sohaib Akbar

Electronic Thesis and Dissertation Repository

Using High Strength Reinforcement (HSR) in concrete construction allows steel volumes to be reduced, and economies to be realized. CSA Standard A23.3:19 “Design of Concrete Structures” limits the maximum yield strength for design to 500 MPa. This thesis investigates the flexural behavior of concrete beams reinforced with HSR to assess whether current code provisions are appropriate. Curvature ductility ratios are calculated for cross-sections with varying concrete compressive strengths, and reinforcement types and quantities. The effects of utilizing HSR on extreme fibre concrete compressive strains at Ultimate Limit State (ULS), moment redistribution at ULS, and deflections at Serviceability Limit States, are …

Simulation Of Non-Homogeneous Wind Processes, Comparison Between Numerical And Experimental Model Of A Bridge, Héctor Hernández Landero

Electronic Thesis and Dissertation Repository

The scaled aerodynamic model of a bridge is often tested in the boundary layer wind tunnel laboratory (BLWTL). In this study a numerical model of the Baluarte Bridge subjected to wind loading is investigated. The scaled full bridge aerodynamic model was previously studied at the University of Western Ontario, Canada. For the numerical model a finite element model (FEM) is implemented, and the characterization of the buffeting forces are considered on the frequency and time domain. In the former case, the so-called pseudo excitation method is used to characterize the wind load, while in the latter the spectral representation method …

Non-Orthogonal Multi-Dimensional Modulation And Nonlinear Distortion Compensation For Beyond 5g, Thakshanth Uthayakumar

Electronic Thesis and Dissertation Repository

The introduction of new advanced technologies such as higher carrier frequencies, ultra-wide bandwidth, and increased transmission rate in 5G to support ever growing quality-of-service (QoS) demands have brought new challenges such as transmitter-receiver pair specific and domain specific non-orthogonality induced among spatial, time-frequency, and delay-doppler domain radio resource blocks and nonlinear distortions induced among multiple-input multiple-output (MIMO) antennas in spatial domain. In such conditions, current communication systems encounter severe performance degradation and incur higher operational cost. Based on this observation, this thesis aims at creating new multi-dimensional modulation techniques and nonlinear predistortion architectures to achieve higher communication performance with less …

Development Of A Cold Model Fuild Coker Pilot Plant, Jessica A. Godin

Electronic Thesis and Dissertation Repository

Fluid Coking^TM is an upgrading process used to produce higher-value products from heavy hydrocarbons through thermal cracking. A Hot Pilot Plant is being designed for potential use to optimize commercial Fluid Cokers.

A Cold Model Fluid Coker was operated in this thesis to identify design limitations restricting operation at the required conditions. Design changes were implemented, and their impact on the system fluid dynamics were characterized. Successful operation of at required conditions was demonstrated.

Pressure measurements provided rapid feedback on potential issues. Models for bed expansion and entrainment flux were developed, which can be used to extrapolate to the …

Motion And Crosslinked Polyethylene Wear In Reverse Total Shoulder Arthroplasty, Christopher Millward

Electronic Thesis and Dissertation Repository

The reverse total shoulder arthroplasty (RTSA) has quickly grown to become the most commonly used shoulder arthroplasty design; however, reports have shown evidence of RTSA failures related to polyethylene wear and damage. Therefore, the present work investigated the wear of crosslinked polyethylene (XLPE) in environments similar to that of an in vivo RTSA. Additionally, a computational model was developed based on a previous study of the shoulder motions obtained from a selection of typical patients with RTSA. This model quantified the amount of glenohumeral motion that an RTSA may be subjected to in vivo and provided an approximate value for …

Compound Flooding Analysis Over The Canadian Coastal Regions, Farshad Jalili Pirani

Electronic Thesis and Dissertation Repository

The communities settling in the Canadian coastal regions are threatened by multiple flood-generating mechanisms including riverine, pluvial, and sea level forces. Reliable design flood estimation and risk assessment in these regions demand characterization of the interrelationships between different drivers as well as the corresponding compounding effects. In this study, as our first step, we assess the compound flood risks across Canada’s coasts considering eight bivariate flooding scenarios acquired from four flooding drivers including total water level, streamflow, precipitation and the skew surge at 41 sites located at three main regions of the Pacific, the Great Lakes (GL) and the Atlantic. …

Damage In Non-Crimp Fabric Carbon Fiber Reinforced Epoxy Composites Under Various Mechanical Loading Conditions, Aaditya Pradeep Suratkar

Electronic Thesis and Dissertation Repository

Composite materials have emerged in the recent years as a frontrunning lightweight replacement for metals for structural applications in lightweight automobiles. However, the key adoption criteria for composites in lightweight vehicles is their crashworthiness, i.e., the amount of energy a structure made with composites would absorb in a crash event. The energy is absorbed in composites through various damage modes such as matrix cracks, delamination, fiber breakage, etc. Therefore, adoption of a certain composite material system requires thorough understanding of the initiation and propagation of damage until failure in that system under various mechanical loading conditions, which is also the …

To Develop A Clinically Friendly Multi-Segment Kinematic And Kinetic Foot Model And Test It On Pre-/Post-Hto Patients With Medial Knee Osteoarthritis And Knee Varus, Songlin Zhu

Electronic Thesis and Dissertation Repository

This study aims to develop a clinically useful multi-segment foot model that will enable the analysis of foot kinematics and kinetics in an optical motion capture laboratory setting. This study will also test the new multi-segment foot model on patients with knee osteoarthritis and varus knee alignment that is corrected by high tibial osteotomy (HTO). The multi-segment foot model divides the foot into four functional segments: the hindfoot, midfoot, forefoot and hallux. An X-Z-Y-Cardan angle rotation convention was used to determine intersegmental dorsi/plantar flexion, inversion/eversion, and internal/external rotation. Joint moments, joint powers and medio-longitudinal arch (MLA) height/length ratio were also …

Large-Scale Analysis And Automated Detection Of Trunnion Corrosion On Hip Arthroplasty Devices, Anastasia M. Codirenzi

Electronic Thesis and Dissertation Repository

Corrosion at the modular head-neck taper interface of total and hemiarthroplasty hip implants (trunnionosis) is a cause of implant failure and thus a clinical concern. Patient and device factors contributing to the occurrence of trunnionosis have been investigated in prior implant retrieval studies. The Goldberg corrosion scoring method is considered the gold standard for observing trunnionosis, but it is labour-intensive. As a result, previous studies have generally looked at under 250 implants for analysis. The purpose of this thesis was to do a large-scale analysis of trunnionosis and explore its relationship to device and patient factors and compare to previously …

Machine Learning With Big Data For Electrical Load Forecasting, Alexandra L'Heureux

Electronic Thesis and Dissertation Repository

Today, the amount of data collected is exploding at an unprecedented rate due to developments in Web technologies, social media, mobile and sensing devices and the internet of things (IoT). Data is gathered in every aspect of our lives: from financial information to smart home devices and everything in between. The driving force behind these extensive data collections is the promise of increased knowledge. Therefore, the potential of Big Data relies on our ability to extract value from these massive data sets. Machine learning is central to this quest because of its ability to learn from data and provide data-driven …

Biomechanical Investigation Of Complete And Partial Medial Collateral Ligament Injuries, Callahan Doughty

Electronic Thesis and Dissertation Repository

The medial collateral ligament (MCL) is composed of two major components: the deep MCL (dMCL) and superficial MCL (sMCL). Recent indications have raised questions as to the validity of previous descriptions of the MCL’s role in knee stability. Despite the relative likelihood of partial injuries to the sMCL, as opposed to complete tears, the impact of these injuries remains largely misunderstood. This thesis set out to (1) interpret the roles of the sMCL and dMCL; and (2) investigate the effect of partial sMCL injuries on knee stability.

A joint motion simulator was used to determine the role of the dMCL …

Performance And Ultimate Limit State Of Large-Span Soil-Steel Structures, Kareem Embaby

Electronic Thesis and Dissertation Repository

This thesis investigates the structural behavior and soil-structure interaction mechanism of large-span soil-steel structures utilizing steel plates with the deepest corrugation profile, 500 mm X 237 mm. The world’s largest-span soil-steel bridge, with a span of 32.40 m, was constructed using 12 mm thick steel plates with the deepest corrugation profile and was instrumented extensively to monitor the displacements and straining actions of the steel structure. Lateral reinforcement steel mesh was attached to the steel structure and the ends of the structure were strengthened by circumferential reinforced concrete collars. Three-dimensional (3D) nonlinear finite element (FE) model was conducted and validated …

Hydration Kinetics, Microstructure, And Mechanical Strength Development Of Cement-Based Composites Incorporating Phase Change Materials, Afshin Marani

Electronic Thesis and Dissertation Repository

The research conducted in this thesis investigates the effects of phase change materials (PCMs) on the hydration kinetics and strength development of cement-based composites using extensive experimental and numerical analyses. Purposefully, the effect of microencapsulated PCMs (MPCMs) on the strength development of cement-based mortars and concretes was evaluated using powerful machine learning models trained with the largest available experimental data. Furthermore, a novel ternary machine learning approach was proposed to optimize the mixture design of mortars and concretes based on the thermos-physical properties of the MPCMs. The results obtained from machine learning simulations suggest the assessment of the effects of …

Carbon Nanotube-Based Microscale Capacitive Flow Sensors, Nathaniel Holmes

Electronic Thesis and Dissertation Repository

Micro-scale flow sensors present several advantages over traditional flow sensing
methods, including minimal flow disruption, high spatial resolution, and low unit
cost. Many existing micro-scale thermal and piezo flow sensors struggle with temperature drift and require complicated fabrication processes. This thesis details
the development of a 60 μm by 60 μm by 50 μm drag-based capacitive flow sensor
constructed from vertically aligned carbon nanotube forests. The construction
of a thermal chemical vapour deposition system for sensor synthesis is also de-
tailed. Manual manipulation of the sensor with an atomic force microscope probe
was found to produce a full scale signal …

Assessment Of Geo-Mechanical Properties Of Lunar Simulants, Devansh Joshi

Electronic Thesis and Dissertation Repository

Abstract

Sophisticated manned and unmanned lunar missions are being developed by international collaborations of the USA, Canada, EU, India, China, Japan etc. for a long-term human presence on the moon. These lunar missions require prototype testing of rovers and other hardware on the earth to successfully interact with the lunar surface. This laboratory testing requires various simulant (terrestrial soil mimicking one or more lunar regolith characteristics) testbeds. Actual lunar soil is too pristine and scarce to be used for destructive testing. Hence, simulants have been developed by research institutions, space research organizations, or commercial manufacturers to cater to a wide …

Development Of Brain-Derived Bioscaffolds For Neural Progenitor Cell Culture And Delivery, Julia Terek

Electronic Thesis and Dissertation Repository

The use of brain extracellular matrix (ECM) as a biomaterial has the potential to promote neural tissue regeneration by providing cell-instructive cues that direct survival, proliferation, and differentiation. This study developed a novel detergent-free decellularization protocol that effectively reduced cellular content while preserving key ECM components in porcine and rat brains. The resulting decellularized brain tissue (DBT) was incorporated into microcarriers to assess its effects on the growth, phenotype and neurotrophic factor gene expression of rat brain-derived progenitor cells cultured within spinner flask bioreactors, using purified collagen microcarriers as a control. Both types of microcarriers supported cell expansion and survival, …

Performance Of Fouled Railroad Superstructure Subjected To Traversing Heavy Haul Trains, Majid Kh Touqan

Electronic Thesis and Dissertation Repository

Railway transportation offers capacity, efficiency, and safety to serve the needs of modern societies for moving freight and people. Therefore, the sustainability and safety of railroad infrastructure are of paramount importance for securing transportation needs. Freight train passby loads increase the surface deformation of railroad substructure due to cumulative plastic strains, which lead to surface deviation of the railroad tracks. Correspondingly, railroad maintenance is necessary to sustain track geometry alignment and to prevent deterioration of the sub-structure over time, which can increase operating costs significantly. Therefore, this thesis evaluates the performance of fouled railroad superstructure through laboratory testing of fouled …