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Pet/Mr Imaging Of Hypoxic Atherosclerotic Plaque Using 64cu-Atsm, Xingyu Nie
Pet/Mr Imaging Of Hypoxic Atherosclerotic Plaque Using 64cu-Atsm, Xingyu Nie
McKelvey School of Engineering Theses & Dissertations
ABSTRACT OF THE DISSERTATION
PET/MR Imaging of Hypoxic Atherosclerotic Plaque Using 64Cu-ATSM
by
Xingyu Nie
Doctor of Philosophy in Biomedical Engineering
Washington University in St. Louis, 2017
Professor Pamela K. Woodard, Chair
Professor Suzanne Lapi, Co-Chair
It is important to accurately identify the factors involved in the progression of atherosclerosis because advanced atherosclerotic lesions are prone to rupture, leading to disability or death. Hypoxic areas have been known to be present in human atherosclerotic lesions, and lesion progression is associated with the formation of lipid-loaded macrophages and increased local inflammation which are potential major factors in the formation of vulnerable …
Molecularly Targeted Nanoparticles For Modulation Of Inflammatory Mediators In Atherosclerosis, Rohun Udatta Palekar
Molecularly Targeted Nanoparticles For Modulation Of Inflammatory Mediators In Atherosclerosis, Rohun Udatta Palekar
McKelvey School of Engineering Theses & Dissertations
The enzyme thrombin has been demonstrated through experimental and clinical studies to play a crucial role in mediating both inflammation and thrombosis in atherosclerosis. The cellular effects of thrombin in promoting atherosclerosis involve the activation of signaling pathways that result in the secretion of a host of various chemokines, cytokines, cell adhesion molecules, etc. that promote vascular inflammation. Due in part to thrombin and other pro-atherogenic molecules, this prolonged inflammatory state in atherosclerosis results in the deterioration of the endothelium, increasing the risk of focal thrombosis. Current treatment strategies to address the role of thrombin in atherosclerosis, despite efficacy of …