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Full-Text Articles in Engineering
Controlled Membrane Remodeling By Nanospheres And Nanorods: Experiments Targeting The Design Principles For Membrane-Based Materials, Sarah Zuraw-Weston
Controlled Membrane Remodeling By Nanospheres And Nanorods: Experiments Targeting The Design Principles For Membrane-Based Materials, Sarah Zuraw-Weston
Doctoral Dissertations
In this thesis we explore two experimental systems probing the interactions of nanoparticles with lipid bilayer membranes. Inspired by the ability of cell membranes to alter their shape in response to bound particles, we report two experimental studies: one of nanospheres the other of long, slender nano-rods binding to lipid bilayer vesicles and altering the membrane shape. Our work illuminates the role of particle geometry, particle concentration, adhesion strength and membrane tension in how membrane morphology is determined. We combine giant unilamellar vesicles with oppositely charged nanoparticles, carefully tuning adhesion strength, membrane tension and particle concentration. In the case of …
Nanoceria Distribution And Effects Are Mouse-Strain Dependent, Robert A. Yokel, Michael T. Tseng, D. Allan Butterfield, Matthew L. Hancock, Eric A. Grulke, Jason M. Unrine, Arnold J. Stromberg, Alan K. Dozier, Uschi M. Graham
Nanoceria Distribution And Effects Are Mouse-Strain Dependent, Robert A. Yokel, Michael T. Tseng, D. Allan Butterfield, Matthew L. Hancock, Eric A. Grulke, Jason M. Unrine, Arnold J. Stromberg, Alan K. Dozier, Uschi M. Graham
Pharmaceutical Sciences Faculty Publications
Prior studies showed nanoparticle clearance was different in C57BL/6 versus BALB/c mice, strains prone to Th1 and Th2 immune responses, respectively. Objective: Assess nanoceria (cerium oxide, CeO2 nanoparticle) uptake time course and organ distribution, cellular and oxidative stress, and bioprocessing as a function of mouse strain. Methods: C57BL/6 and BALB/c female mice were i.p. injected with 10 mg/kg nanoceria or vehicle and terminated 0.5 to 24 h later. Organs were collected for cerium analysis; light and electron microscopy with elemental mapping; and protein carbonyl, IL-1β, and caspase-1 determination. Results: Peripheral organ cerium significantly increased, generally more …
Scanning Electron Microscopy (Sem) Investigation Of Morphology Changes In The Reduction Of Silica Nanoparticles To Elemental Silicon, Allison M. Cairns
Scanning Electron Microscopy (Sem) Investigation Of Morphology Changes In The Reduction Of Silica Nanoparticles To Elemental Silicon, Allison M. Cairns
University Honors Theses
The application of silicon nanoparticles varies from energy storage materials, to drug-delivery, and molecular recognition. Various chemical and physical properties of the Si nanoparticles arise from their morphology. This paper aims to reveal the morphology of Si nanoparticles following magnesiothermic reduction of silica (SiO2) nanoparticles. Two sets of SiO2 nanoparticles were used, commercially available NanoXact nanoparticles and laboratory-synthesized Stöber nanoparticles. A Zeiss Sigma VP FEG SEM was used to examine the morphology. Following the magnesiothermic reduction, the nanoparticles were etched with HF. Ten sets of images were taken of both Stöber and NanoXact nanoparticles: 1,2: the SiO …
Tunable Refractive Index Through Spatially Modified Nanoparticle Films For Long-Range Spr Biosensing Applications, Stephen Joshua Binderup
Tunable Refractive Index Through Spatially Modified Nanoparticle Films For Long-Range Spr Biosensing Applications, Stephen Joshua Binderup
Graduate Research Theses & Dissertations
Despite optics and refraction being among the oldest scientific principles, material limitations have prevented scientists from taking full advantage of the potential this technology holds. Indeed, films with designer optical properties have potential for use in exotic cloaking architectures, advanced waveguides, and precise optical biosensors. This thesis focuses on the fabrication methodology for making thin films with refractive index tuned to a desired value through self-assembly of amorphous nanoparticle films made of organosilicate materials. The inclusion of a slowly evaporating polymer phase along with the organosilicate nanoparticles results in nanopores formed within the film, which effectively reduce the film’s refractive …