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Articles 1 - 30 of 95
Full-Text Articles in Engineering
Using Noninvasive Calibrated Cuff Plethysmography To Observe The Effects Of Cold-Water Immersion On Arterial Compliance, Rita M. Grigorian
Using Noninvasive Calibrated Cuff Plethysmography To Observe The Effects Of Cold-Water Immersion On Arterial Compliance, Rita M. Grigorian
Biomedical Engineering: Graduate Reports and Projects
As the prevalence of cardiovascular diseases continues to exponentially grow in populations across the globe, the necessity of determining underlying factors, effective methods of diagnoses, and universally available preventive measures also grows. Early detection of endothelial dysfunction, a proven precursor of cardiovascular diseases, can be extremely impactful in encouraging preventative measures and early intervention before medical conditions become chronic. In recent years, ice plunging, a form of cryotherapy involving full body immersion in cold water, has gained popularity within circles of fitness and health practitioners, gaining the interest of people of all backgrounds. Certain parallels observed between the human physiological …
Using Noninvasive Calibrated Cuff Plethysmography To Observe The Effects Of Cold-Water Immersion On Arterial Compliance, Rita M. Grigorian
Using Noninvasive Calibrated Cuff Plethysmography To Observe The Effects Of Cold-Water Immersion On Arterial Compliance, Rita M. Grigorian
Master's Theses
As the prevalence of cardiovascular diseases continues to exponentially grow in populations across the globe, the necessity of determining underlying factors, effective methods of diagnoses, and universally available preventive measures also grows. Early detection of endothelial dysfunction, a proven precursor of cardiovascular diseases, can be extremely impactful in encouraging preventative measures and early intervention before medical conditions become chronic. In recent years, ice plunging, a form of cryotherapy involving full body immersion in cold water, has gained popularity within circles of fitness and health practitioners, gaining the interest of people of all backgrounds. Certain parallels observed between the human physiological …
Static Vascular Modeling Of Diabetes Progression, Andrea Skattenborg
Static Vascular Modeling Of Diabetes Progression, Andrea Skattenborg
Master's Theses
Cardiovascular disease is the leading cause of mortality in diabetic patients, and diabetes is one of the main causes of cardiovascular disease. Risk factors for cardiovascular disease result in structural and functional changes in the vascular wall. Arterial stiffness is a prominent structural change observed in the arterial wall that can be measured in clinical settings. The purpose of this thesis was to create a static model of the changes in arterial stiffness seen in diabetes. Elastic tubes with varying wall thicknesses were used to create artificial arteries for this purpose. Compliance (inverse of stiffness) of the arteries was determined …
Functionality Of The Gracilis Collateral Is Impaired Following Arteriogenesis And Cell Transplantation, Ada A. Tadeo
Functionality Of The Gracilis Collateral Is Impaired Following Arteriogenesis And Cell Transplantation, Ada A. Tadeo
Biomedical Engineering
Peripheral Arterial Disease involves narrowed arteries, reducing blood flow to limbs. Increasing blood flow to those extremities is possible by redirecting the blood to flow through natural bypasses (i.e. collateral arteries), which can enlarge via arteriogenesis to maintain blood supply once the prominent arteries have become occluded. This study aims to investigate how arteriogenesis affects collateral function, if myoblast transplantation can stimulate collateral growth, and how that in turn may affect collateral function. Femoral artery ligation was performed to mimic the blockage that occurs in patients with ischemic diseases on lean mice and mice with diet induced obesity (DIO). A …
Self-Balancing Bicycle Device, Charles Cole, Raffy Lorenzo, Neil Boyal
Self-Balancing Bicycle Device, Charles Cole, Raffy Lorenzo, Neil Boyal
Biomedical Engineering
The sponsor, Justin Shaw, is currently developing a bicycle for an athlete who has lost movement in their legs. This athlete can no longer experience the unmatched feeling of naturally banking a bicycle at corners. The Self-Balancing Bike Device Team will create a device that can self-balance an electric recumbent bicycle at low speeds while being almost undetectable while turning. This document will outline the team’s background research into self-balancing vehicles, define the needs that must be solved, and delineate a schedule for future milestones.
Bone And Cartilage Compression Simulator, Karoline M. Wucherer, Benjamin A. Parmentier, Thomasina E. Hinkle
Bone And Cartilage Compression Simulator, Karoline M. Wucherer, Benjamin A. Parmentier, Thomasina E. Hinkle
Biomedical Engineering
A device was developed that delivers mechanical loads to bone and soft tissue samples under physiological conditions to aid in the research of tissue engineering bone and cartilage. To begin the design process, a Network Diagram and Gantt Chart were produced to create a general timeline for the project to follow. This allowed us to measure our progress and determine what effects (if any) delays could have on our project.
Feverdots, Kameryn Laureano, Heidi Silk, Rita Grigorian
Feverdots, Kameryn Laureano, Heidi Silk, Rita Grigorian
Biomedical Engineering
FeverDots are wearable temperature sensitive stickers that change color from black to pink at 99°F when placed on the temple or forehead. The objective of this project was to develop an efficient manufacturing method for FeverDots, and manufacture a device along with it. To create the FeverDots manufacturing device, the full design process was executed. The team went through a thorough ideation phase before ultimately defining and specifying the scope of the project.
The key customer requirements of this device include that it is lightweight, portable, durable, simple to assemble, easy to use, and able to generate uniform ink and …
Classifying Electrocardiogram With Machine Learning Techniques, Hillal Jarrar
Classifying Electrocardiogram With Machine Learning Techniques, Hillal Jarrar
Master's Theses
Classifying the electrocardiogram is of clinical importance because classification can be used to diagnose patients with cardiac arrhythmias. Many industries utilize machine learning techniques that consist of feature extraction methods followed by Naive- Bayesian classification in order to detect faults within machinery. Machine learning techniques that analyze vibrational machine data in a mechanical application may be used to analyze electrical data in a physiological application. Three of the most common feature extraction methods used to prepare machine vibration data for Naive-Bayesian classification are the Fourier transform, the Hilbert transform, and the Wavelet Packet transform. Each machine learning technique consists of …
Noninvasive Measurement Of Arterial Compliance With A Blood Pressure Cuff Using A Surrogate Arm Bench Top Model For Oscillometric Use, Shane Wilsey
Master's Theses
A surrogate arm model was created that is capable of being used for oscillometry. This model is capable of being used as a bench top model for blood pressure cuff devices. The arm consists of endplates and internal supports that are 3D printed with ABS, a silicone rubber outer sleeve, and interchangeable arteries made from two silicone rubber strips glued together at the edges. The interchangeable arteries have varying compliances that can be used as different inputs for oscillometric testing. A process was established to measure the artery compliances with a curve fit correlation of 0.95. However, testing revealed that …
Modeling Action Potential Propagation During Hypertrophic Cardiomyopathy Through A Three-Dimensional Computational Model, Julia Elizabeth Kelley
Modeling Action Potential Propagation During Hypertrophic Cardiomyopathy Through A Three-Dimensional Computational Model, Julia Elizabeth Kelley
Master's Theses
Hypertrophic cardiomyopathy (HCM) is the most common monogenic disorder and the leading cause of sudden arrhythmic death in children and young adults. It is typically asymptomatic and first manifests itself during cardiac arrest, making it a challenge to diagnose in advance. Computational models can explore and reveal underlying molecular mechanisms in cardiac electrophysiology by allowing researchers to alter various parameters such as tissue size or ionic current amplitudes. The goal of this thesis is to develop a computational model in MATLAB and to determine if this model can accurately indicate cases of hypertrophic cardiomyopathy. This goal is achieved by combining …
Hand Strength And Dexterity Enhancer, Julia Ann Denison, Autumn B. Rexford, Melissa A. Kurani, Christina K. Fong
Hand Strength And Dexterity Enhancer, Julia Ann Denison, Autumn B. Rexford, Melissa A. Kurani, Christina K. Fong
Biomedical Engineering
Good Grips created the hand strength and dexterity enhancer project to meet the challenge presented by Bill Phelps. He has Inclusion Body Myositis (IBM), an inflammatory muscle disease characterized by progressive muscle weakness and atrophy. Bill has limited strength in both hands and lost the ability to bend his fingers, making it difficult to grip anything. He needed a device that would help with everyday tasks such as writing, lifting, and holding various objects.
Our team consists of four engineering students attending Cal Poly, San Luis Obispo. We researched, designed, manufactured, and tested a device that would fulfill the problem …
The Impact Of Myoblast Transplantation On Collateral Capillary Arteriogenesis And Macrophage Phenotype, Christine Hue Do
The Impact Of Myoblast Transplantation On Collateral Capillary Arteriogenesis And Macrophage Phenotype, Christine Hue Do
Biomedical Engineering
Gangrene, pain, loss of limb function, amputation, and death are only few of the grievous consequences associated with peripheral arterial disease (PAD), a vascular disease caused by an obstruction that narrows the blood vessels. Since some patients have collateral vessels that can re-route blood to its downstream destination, much focus has been spotlighted upon discovering the mechanism of this process, termed arteriogenesis, as well as cell therapies to increase arterial diameter of collateral vessels. Since some patients do not have native pre-existing collateral vessels, another method to re-route blood is through arterialized collateral capillaries (ACC), which is the conversion of …
A Novel Method To Commercialize Medical Devices Initially Developed At California Polytechnic State University San Luis Obispo, Christina Grigorian
A Novel Method To Commercialize Medical Devices Initially Developed At California Polytechnic State University San Luis Obispo, Christina Grigorian
Master's Theses
California Polytechnic State University, San Luis Obispo is a university that encourages students to approach learning hands-on. As such, there is cutting-edge technology being developed by students in all departments on campus. Being that the university possesses an outstanding biomedical engineering department, there are groundbreaking medical devices that students are creating at Cal Poly SLO. These are devices that can better the lives of individuals suffering from ailments or fulfill needs in the medical industry. Subsequently, it is vital that these devices make it out of campus laboratories and into the hands of consumers. In order to move a product …
Reading Robot, Gillian Watts, Andrew Myers, Sabrinna Tan, Taylor Klein, Omeed Djassemi
Reading Robot, Gillian Watts, Andrew Myers, Sabrinna Tan, Taylor Klein, Omeed Djassemi
General Engineering
Presently, there is an insufficient availability of human experts to assist students in reading competency and comprehension. Our team’s goal was to create an improved socially assistive robot for use by therapists, teachers, and parents to help children and adults develop reading skills while they do not have access to specialists. HAPI is a socially assistive robot that we created with the goal of helping students practice their reading comprehension skills. HAPI enables a student to improve their reading skills without an educator present, while enabling educators to review the student's performance remotely. Design constraints included: physical size, weight, duration …
Septal Closure Device, Olivia N. Welch, Hillal H. Jarrar, Kai Harrison
Septal Closure Device, Olivia N. Welch, Hillal H. Jarrar, Kai Harrison
Biomedical Engineering
The septal closure device was designed to seal defects in the atrial septum. To fully seal an atrial defect, the device was designed to consist of two circular seals to cover the defect in both the right and left atria, attached with a central rod. The materials were chosen for compressibility (for ease of insertion), biocompatibility, and tissue ingrowth. A CAD model was drafted in SolidWorks. Key customer requirements include ease of implantation (specifications: adjustable sizing and clear directions for use), physician controlled (specifications: short implantation time and compatibility with current catheter/scope techniques), and a long lifetime (specifications: materials that …
Investigation Of Experimental Variation Of Bovine Sphingomyelin As A Novel Ingredient For Ultraviolet Protection, Esther Chen
Investigation Of Experimental Variation Of Bovine Sphingomyelin As A Novel Ingredient For Ultraviolet Protection, Esther Chen
Master's Theses
Skin cancer is a prevalent disease that globally affects 2-3 million people per year [1]. This number is expected to grow tenfold as depletion of the ozone layer contributes to harsher rays reaching Earth’s surface [2]. A common way to protect against those ultraviolet waves is to apply sunscreen, however, recent reports call into question the safety of some active ingredients as they can enter through the skin into the bloodstream [3]. This thesis aims to investigate an alternative solution that uses bovine sphingomyelin (BSM) as photoprotective solution against UV irradiation.
In order to evaluate the effectiveness of BSM against …
Ikioo Flying Robot, Nicholas Michael Lapidus, Bosung Josh Kim, Jenny Fong
Ikioo Flying Robot, Nicholas Michael Lapidus, Bosung Josh Kim, Jenny Fong
Biomedical Engineering
No abstract provided.
Solostand, Hau Nhat Doan, Sydney Gray, Celina Dioso
Solostand, Hau Nhat Doan, Sydney Gray, Celina Dioso
Biomedical Engineering
The purpose of this scope of work is to highlight the progress and development of SoloStand sponsored by Derek Herrera, chief technical officer and founder of SpinalSingularity. SoloStand is an attachment to a wheelchair that will benefit paraplegics that use wheelchairs. A portable and customizable attachment to a wheelchair will allow the user to do everyday tasks without transferring into a separate standing wheelchair and travel more easily. This document outlines everything that has been done in fulfillment of our senior project requirements.
Left Atrial Appendage Printing Process, Areli Reyes, Brandon James Mukai, Mia Noelle Von Knorring
Left Atrial Appendage Printing Process, Areli Reyes, Brandon James Mukai, Mia Noelle Von Knorring
Biomedical Engineering
The left atrial appendage senior design team aims to assist in closing off the left atrial appendage that is susceptible to coagulation due to non-valvular atrial fibrillation. Coagulation in the left atrial appendage (LAA) can be life threatening as it can lead to a stroke. Dr. Chris Porterfield performs a procedure that uses the Boston Scientific Watchman to close the appendage. He finds that sizing the Watchman properly is difficult with limited visuals from live CT scans. He proposed converting the CT scans into a 3D printed model of the left atrial appendage and left atrium so he can visually …
Insulative (Direct Current) Dielectrophoretic Foul-Less Filtration In Microfuidic Systems, Matthew A A Whitman
Insulative (Direct Current) Dielectrophoretic Foul-Less Filtration In Microfuidic Systems, Matthew A A Whitman
Master's Theses
Filtration is a technology that is used almost ubiquitously in society from uses raging from filtration of macroparticles from water to pharmaceutical grade filtration products to remove anything larger than a protein. However, with such a wide range of uses, most filtration products have the same issue; membrane clogging (fouling) that prevents continuous use and requires frequent maintenance. This thesis hypothesizes that by applying a direct current (DC) to an insulating array of posts, they will create a foul-less insulative dielectrophoretic filter (iDEP) that does not clog since particles will levitate above the insulating array.
This thesis tested an inherited …
Blood Glucose Predictor, Jessica Patterson
Blood Glucose Predictor, Jessica Patterson
Electrical Engineering
For my senior project, I perform data analysis using statistical methods to determine body metrics that correlate with blood glucose levels. Working with Dr. Tina Smilkstein, I take repeat measurements from 6 different volunteers to establish trends in bodily metric data. The data taken includes weight, body fat, pulse rate, VO2, blood glucose, blood pressure, hours slept, and quality of sleep. Using these values, I use the program MiniTab to view results.
A few examples of correlations with blood glucose found in this project are:
- Systolic blood pressure for females had a regression line of 124.0 -0.3366*Blood Pressure. This indicates …
Single-Cell Impedance Spectroscopy, David Paul Lange
Single-Cell Impedance Spectroscopy, David Paul Lange
Master's Theses
Impedance spectroscopy (IS) is an important tool for cell detection and characterization in medical and food safety applications. In this thesis, the Cal Poly Biofluidics Lab’s impedance spectroscopy system was re-evaluated and optimized for single-cell impedance spectroscopy. To evaluate the IS system, an impedance spectroscopy bioMEMS chip was fabricated in the Cal Poly Microfabcrication lab, software was developed to run IS experiments, and studies were run to validate the system. To explore IS optimization, Maxwell’s mixture theorem and the Schwartz-Christoffel transform were used to calculate an analytic impedance solution to the co-planar electrode system,a novel volume fraction to account for …
Cooking Hand Multi-Tool, Amanda D. Meares, Amy H. Wilson, Ethan G. Littlejohn, Duania A. Evans
Cooking Hand Multi-Tool, Amanda D. Meares, Amy H. Wilson, Ethan G. Littlejohn, Duania A. Evans
Biomedical Engineering
The purpose of this project was to devise a solution for Jorge Segura, a US Marine who was wounded in Afghanistan and had to have his non-dominant arm amputated above the elbow. His current prosthetic attachments are not suited to cooking tasks, so he needed a way to cook more effectively with either prosthetic attachments or accessibility devices. The main tasks that he needed help with was holding down food on cutting boards and stabilizing pots, pans, and bowls especially when stirring. After background research, exploring commercially available devices, and talking with our challenger, our solution was to design three …
A 3-Dimensional In Silico Test Bed For Radiofrequency Ablation Catheter Design Evaluation And Optimization, Carolyn Teng
A 3-Dimensional In Silico Test Bed For Radiofrequency Ablation Catheter Design Evaluation And Optimization, Carolyn Teng
Master's Theses
Atrial fibrillation (AF) is the disordered activation of the atrial myocardium, which is a major cause of stroke. Currently, the most effective, minimally traumatic treatment for AF is percutaneous catheter ablation to isolate arrhythmogenic areas from the rest of the atrium. The standard in vitro evaluation of ablation catheters through lesion studies is a resource intensive effort due to tissue variability and visual measurement methods, necessitating large sample sizes and multiple prototype builds. A computational test bed for ablation catheter evaluation was built in SolidWorks® using the morphology and dimensions of the left atrium adjacent structures. From this geometry, the …
Concussion Indication Device, Taylor O'Donoghue, Isabel Jellen, Eric Shechter
Concussion Indication Device, Taylor O'Donoghue, Isabel Jellen, Eric Shechter
Biomedical Engineering
In this document we summarize our intent to design and manufacture a device that will be used in conjunction with a football helmet, will detect impact forces to the head, and notify the user to seek out further medical attention when subjected to forces large enough to cause concussions. We describe the large market including all levels of football players and the need for improved technology that will not only be effective in elucidating risks but encouraging players to use the device over the alternatives. To design the device, we have researched the problem of concussions in football and have …
Slit Lamp Ophthalmoscope Redesign, Michael Hostetler, Austin Mattmiller, Alexis Brewer
Slit Lamp Ophthalmoscope Redesign, Michael Hostetler, Austin Mattmiller, Alexis Brewer
Biomedical Engineering
The slit lamp ophthalmoscope is used by ophthalmologists for diagnosis of pathologies in the eye. The device is used for identifying ocular diseases or indications of other possible systemic diseases to treat them before the diseases progress. Redesign of the ergonomics and adjustment mechanisms of the slit lamp ophthalmoscope will attempt to improve the compatibility of the device across a greater variety of patients. The wider headrest tower of 12.75 inches, the wider table cutout of 12 inches, and the 12 inches of extension of the headrest tower creates a better ergonomic fit for the patient and doctor. The wider …
Ideomotion Gait Training Thigh Prompt, Kristin Schmidt, Elizabeth Peterson, Dalton Jennings
Ideomotion Gait Training Thigh Prompt, Kristin Schmidt, Elizabeth Peterson, Dalton Jennings
Biomedical Engineering
This document serves as our project report at its completion for developing thigh prompts to be used with the LiftWalker. In this document we outline our project from its beginning to end. We describe our process from understanding the background and our customer requirements, transforming these customer requirements into engineering specifications, performing the stage gate process, developing and evolving the design, testing the design, and finally drawing conclusions and making recommendations for the future.
Foot Support Taping Device For Off-Loading Wounds, Andres Fojaco Gomez, Mikaela Williams, Josh Pelegrin
Foot Support Taping Device For Off-Loading Wounds, Andres Fojaco Gomez, Mikaela Williams, Josh Pelegrin
Biomedical Engineering
No abstract provided.
Accelerated Wear Reactor Testing, Tristan Frisella, Daniel Alanis, Kian Ashoubi
Accelerated Wear Reactor Testing, Tristan Frisella, Daniel Alanis, Kian Ashoubi
Biomedical Engineering
Carbon dioxide accounts for a large amount of global greenhouse gases released into the environment. Because plastic degradation emits carbon dioxide, there has been interest to investigate how much carbon dioxide various plastics generate as they degrade. We have been tasked to create a dehumidifier and carbon dioxide sensor assembly for an accelerated wear testing apparatus that degrades plastic. Several products and literature currently exist that share similarity with our assembly but have not been manufactured to achieve the same combination of measurements we are expecting of our accelerated wear testing device. The following report shall introduce these products and …
Development Of A Myoelectric Detection Circuit Platform For Computer Interface Applications, Nickolas Andrew Butler
Development Of A Myoelectric Detection Circuit Platform For Computer Interface Applications, Nickolas Andrew Butler
Master's Theses
Personal computers and portable electronics continue to rapidly advance and integrate into our lives as tools that facilitate efficient communication and interaction with the outside world. Now with a multitude of different devices available, personal computers are accessible to a wider audience than ever before. To continue to expand and reach new users, novel user interface technologies have been developed, such as touch input and gyroscopic motion, in which enhanced control fidelity can be achieved. For users with limited-to-no use of their hands, or for those who seek additional means to intuitively use and command a computer, novel sensory systems …