Engineering Commons^™

Numerical Prediction Of The Haemodynamic Impact Of Coronary Stent Implantation, Jonathan Murphy

Doctoral

Arterial restenosis limits the effectiveness of coronary stenting. Restenosis is caused by excessive tissue growth which is stimulated by arterial injury and alterations to the arterial WSS. The altered WSS results from stent-induced disturbances to the natural haelnodynamics of the artery. Recent numerical studies have predcted only minor digerences in altered WSS between different stent designs using a commonly employed threshold assessment technique. While it is possible that there are only minor differences, it is more likely that the assessment technique is incapable of fully elucidating the altered WSS created by stent implantation. This thesis proposes a methodology that involves …

Retrospective Geospatial Modeling Of Pm10 Exposures From Open Burning At Joint Base Balad, Iraq, John P. Rinker

Theses and Dissertations

Predicting, determining, and linking theater-related source-specific exposures to health effects has proven difficult. The purpose of this research is to delineate retrospective exposure zones using spatially interpolated particulate air sampling point data from Joint Base Balad, create burn pit exposure isopleths from dispersion model outputs, and merge into a combined exposure model in GIS. Interpolated monitoring results and dispersion modeled results were combined to compare modeled exposures across base. Burn pit contribution to total PM10 was also modeled. The combined dispersion and interpolation map showed elevated concentrations within a 1 kilometer buffer of the burn pit. Buildings within this area …

Characterization Of Graphite Composite Material Particulates From Usaf Aircraft Maintenance Operations, Richard E. Yon

Theses and Dissertations

Due to the benefits of their material properties, advanced composite materials (ACM) are increasingly being used as structural components on aircraft, especially within the United States Air Force. As a result, the potential exists for occupational exposures to structural maintenance employees while repairing and fabricating aircraft components. Two field studies were conducted for this thesis in order to characterize ACM aerosol size distribution, determine the feasibility of utilizing direct reading instruments (DRIs) in the field, and ensure workers are protected with adequate controls. In order to characterize exposure, traditional integrated air sampling and DRIs were positioned together near an ACM …

A Primary Care Workload Production Model For Estimating Relative Value Unit Output, Rachel G. Murphy

Theses and Dissertations

Health care costs have grown to unsustainable levels nationally and within the Department of Defense. Military health care costs have historically been difficult to isolate, causing budget cuts to be the vehicle for cost control. Maximum efficiency, therefore, is the goal in order to show improvement. With the Air Force’s new preventive health plan, they aim to drive a long-term posture for cost reduction through prevention. This research effort aimed to develop a tool to assist in future efforts to understand and improve efficiency in workload output, and whether a relationship exists between patient workload demand and the per-encounter variables …

Topscholar® Creating Opportunities [2011 Brochure], Connie Foster, Jennifer Wilson

TopSCHOLAR® Presentations and Reports

No abstract provided.

Laser Etched Pmma Microfluidic Chip Design And Manufacture With Applications In Capillary Zone Electrophoresis, Evan Allen Barbre

Master's Theses

This thesis encompasses a feasibility study of using low-cost materials to manufacture microfluidic chips that can perform the same functions as chips manufactured using traditional methods within an acceptable range of efficiency of chips created with more exotic methods and materials. The major parts of the project are the selection and characterization of the fabrication methods for creating the channels for fluid flow, the methods for sealing the channels to create a usable chip and the electrophoretic separations of carboxylated microspheres of different potentials. In this work we seek to answer the question if laser-etched PMMA microfluidic chips are comparable …

Intelligibility Of Electrolarynx Speech Using A Novel Hands-Free Actuator, Brian Madden, Mark Nolan, Ted Burke, James Condron, Eugene Coyle

Conference Papers

During voiced speech, the larynx provides quasi-periodic acoustic excitation of the vocal tract. In most electrolarynxes, mechanical vibrations are produced by a linear electromechanical actuator, the armature of which percusses against a metal or plastic plate at a frequency within the range of glottal excitation. In this paper, the intelligibility of speech produced using a novel hands-free actuator is compared to speech produced using a conventional electrolarynx. Two able-bodied speakers (one male, one female) performed a closed response test containing 28 monosyllabic words, once using a conventional electrolarynx and a second time using the novel design. The resulting audio recordings …

Augmented Control Of A Hands-Free Electrolarynx, Brian Madden, James Condron, Eugene Coyle

Conference Papers

During voiced speech, the larynx acts as the sound source, providing a quasi-periodic excitation of the vocal tract. Following a total laryngectomy, some people speak using an electrolarynx which employs an electromechanical actuator to perform the excitatory function of the absent larynx. Drawbacks of conventional electrolarynx designs include the monotonic sound emitted, the need for a free-hand to operate the device, and the difficulty experienced by many laryngectomees in adapting to its use. One improvement to the electrolarynx, which clinicians and users frequently suggest, is the provision of a convenient hands-free control facility. This would allow more natural use of …

High-Frequency Ultrasound For Intraoperative Margin Assessments In Breast Conservation Surgery: A Feasibility Study, Timothy E. Doyle, Rachel E. Factor, Christina L. Ellefson, Kristina M. Sorensen, Brady J. Ambrose, Jeffrey B. Goodrich, Vern P. Hart, Scott C. Jensen, Hemang Patel, Leigh A. Neumayer

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

In addition to breast imaging, ultrasound offers the potential for characterizing and distinguishing between benign and malignant breast tissues due to their different microstructures and material properties. The aim of this study was to determine if high-frequency ultrasound (20-80 MHz) can provide pathology sensitive measurements for the ex vivo detection of cancer in margins during breast conservation surgery.

Methods

Ultrasonic tests were performed on resected margins and other tissues obtained from 17 patients, resulting in 34 specimens that were classified into 15 pathology categories. Pulse-echo and through-transmission measurements were acquired from a total of 57 sites on the …

Santa Clara Magazine, Volume 52, Number 3, Winter 2010, Santa Clara University

Santa Clara Magazine

14 - GOOD LIT By Alicia K. Gonzales '09 and Steven Boyd Saum. It's time to light 10 candles on the birthday cake for SCU's California Legacy Series. To date: 43 books, 500 radio broadcasts, and a handful of movies. What's next? Something big.

16 - SHAPING THE FUTURE by Adolfo Nicolas, S.J. What can Jesuit universities do-together-to make the world a more humane, just, and sustainable place? It starts with imagination, an unequaled global network, and a conference in Mexico City- where Jesuit Superior General Adolfo Nicolas takes stock of challenges to Jesuit higher education today.

24 - A …

The Influence Of Interleukin-4 On Ligament Healing, Connie S. Chamberlain, Ellen M. Leiferman, Kayt E. Frisch, Sijian Wang, Xipei Yang, Stacey L. Brickson, Ray Vanderby

Faculty Publications - Biomedical, Mechanical, and Civil Engineering

Despite a complex cascade of cellular events to reconstruct the damaged extracellular matrix, ligament healing results in a mechanically inferior scarred ligament. During normal healing, granulation tissue expands into any residual normal ligamentous tissue (creeping substitution), resulting in a larger region of healing, greater mechanical compromise and an inefficient repair process. To control creeping substitution and possibly enhance the repair process, the antiinflammatory cytokine, interleukin-4 (IL-4), was administered to rats before and after rupture of their medial collateral ligaments. In vitro experiments showed a time-dependent effect on fibroblast proliferation after IL-4 treatment. In vivo treatments with IL-4 (100 ng/mL IV) …

Ultrasound Echo Is Related To Stress And Strain In Tendon, Sarah Duenwald, Hirohito Kobayashi, Kayt E. Frisch, Roderic Lakes, Ray Vanderby Jr.

Faculty Publications - Biomedical, Mechanical, and Civil Engineering

The mechanical behavior of tendons has been well studied in vitro. A noninvasive method to acquire mechanical data would be highly beneficial. Elastography has been a promising method of gathering in vivo tissue mechanical behavior, but it has inherent limitations. This study presents acoustoelasticity as an alternative ultrasound-based method of measuring tendon stress and strain by reporting a relationship between ultrasonic echo intensity (B-mode ultrasound image brightness) and mechanical behavior of tendon in vitro. Porcine digital flexor tendons were cyclically loaded in a mechanical testing system while an ultrasonic echo response was recorded. We report that echo intensity …

The Influence Of Macrophage Depletion On Ligament Healing, Connie S. Chamberlain, Ellen M. Leiferman, Kayt E. Frisch, Sijian Wang, Xipei Yang, Nico Van Rooijen, Geoff S. Baer, Stacey L. Brickson, Ray Vanderby

Faculty Publications - Biomedical, Mechanical, and Civil Engineering

Despite a complex cascade of cellular events to reconstruct damaged extracellular matrix (ECM), ligament healing results in a mechanically inferior, scar-like tissue. During normal healing, the number of macrophages significantly increases within the wound site. Then, granulation tissue expands into any residual, normal ligamentous tissue (creeping substitution), resulting in a larger region of healing, greater mechanical compromise, and an inefficient repair process. To study the effects of macrophages on the repair process, bilateral, surgical rupture of their medial collateral ligaments (MCLs) was done on rats. Treatment animals received liposome-encapsulated clodronate, 2 days before rupture to ablate phagocytosing macrophages. Ligaments were …

Custom-Molded Foot-Orthosis Intervention And Multisegment Medial Foot Kinematics During Walking, Mark Geil

Faculty Articles

No abstract provided.

Santa Clara Magazine, Volume 53 Number 1, Summer 2011, Santa Clara University

Santa Clara Magazine

18 - WHAT DO INVESTORS REALLY WANT? By Meir Statman. A renowned behavioral finance expert reveals how our desires shape our actions when it comes to investing. (Hint: It's not just money that we're after.)

20 - LAW AT 100. A century of legal education at SCU. See snapshots from across the years-and look at the big picture of how the legal landscape has changed

22 - THE BIG IDEA!: Michael S. Malone '75, MBA '77 on Silicon Valley high tech gold and a brief history of intellectual property law.

24 - WOMEN'S WORK: Stephanie M. Wildman on jobs, the …

Santa Clara Magazine, Volume 53 Number 2, Fall 2011, Santa Clara University

Santa Clara Magazine

18 - CHANGE THE WORLD. OR AT LEAST HOW YOU SEE IT. Edited by John Deever and Steven Boyd Saum. The U.S. Peace Corps turned 50 this year, with more than 340 Santa Clara grads (and faculty and staff) having served as volunteers over the years. A few of them recount their time in-country-and where it's taken them.

26 - HOW CAN YOU DEFEND THOSE PEOPLE? by Steven Boyd Saum. Public defenders on the Homicide Task Force in Chicago have heard that question time and again. Between them, Robert Strunck '76 and Crystal Marchigiani '78 have some 40 years on …

Identification And Analysis Of Common Bean (Phaseolus Vulgaris L.) Transcriptomes By Massively Parallel Pyrosequencing, Venu Kalavacharla, Zhanji Liu, Blake C. Meyers, Jyothi Thimmapuram, Kalpalatha Melmaiee

Cyber Center Publications

Common bean (Phaseolus vulgaris) is the most important food legume in the world. Although this crop is very important to both the developed and developing world as a means of dietary protein supply, resources available in common bean are limited. Global transcriptome analysis is important to better understand gene expression, genetic variation, and gene structure annotation in addition to other important features. However, the number and description of common bean sequences are very limited, which greatly inhibits genome and transcriptome research. Here we used 454 pyrosequencing to obtain a substantial transcriptome dataset for common bean.

Privacy-Preserving Assessment Of Location Data Trustworthiness, Chenyun Dai, Fang-Yu Rao, Gabriel Ghinita, Elisa Bertino

Cyber Center Publications

Assessing the trustworthiness of location data corresponding to individuals is essential in several applications, such as forensic science and epidemic control. To obtain accurate and trustworthy location data, analysts must often gather and correlate information from several independent sources, e.g., physical observation, witness testimony, surveillance footage, etc. However, such information may be fraudulent, its accuracy may be low, and its vol-
ume may be insufficient to ensure highly trustworthy data. On the other hand, recent advancements in mobile computing and positioning systems, e.g., GPS-enabled cell phones, highway sensors, etc., bring new and effective technological means to track the location of …

Eastern Michigan University Undergraduate Catalog, 2011-2012, Office Of The Registrar

Undergraduate Catalogs

No abstract provided.

Eastern Michigan University Undergraduate Catalog, 2011-2012, Office Of The Registrar

Undergraduate Catalogs

No abstract provided.

Prox-Rbac: A Proximity-Based Spatially Aware Rbac, Michael Kirkpatrick, Maria Luisa Damiani, Elisa Bertino

Cyber Center Publications

As mobile computing devices are becoming increasingly dominant in enterprise and government organizations, the need for fine-grained access control in these environments continues to grow. Specifically, advanced forms of access control can be deployed to ensure authorized users can access sensitive resources only when in trusted locations. One technique that has been proposed is to augment role-based access control (RBAC) with spatial constraints. In such a system, an authorized user must be in a designated location in order to exercise the privileges associated with a role. In this work, we extend spatially aware RBAC systems by defining the notion of …

Modeling And Surveillance Of Pandemic Influenza Outbreaks, Diana Prieto

USF Tampa Graduate Theses and Dissertations

Pandemic outbreaks are unpredictable as to their virus strain, transmissibility, and impact on our quality of life. Hence, the decision support models for mitigation of pandemic outbreaks must be user-friendly and operational, and also incorporate valid estimates of disease transmissibility and severity. This dissertation research is aimed at 1) reviewing the existing pandemic simulation models to identify their implementation gaps with regard to usability and operability, and suggesting research remedies, 2) increasing operability of simulation models by calibrating them via an epidemiological model that estimates infection probabilities using viral shedding profiles of concurrent pandemic and seasonal influenza, and 3) developing …

Eastern Ichigan University Graduate Catalog, 2011-2012, Office Of The Registrar

Graduate Catalogs

No abstract provided.

Low-Cost Prosthetic Leg For The Vida Nueva Prosthesis Clinic, Sarah M. Baker, Justin G. Lekos, Jen Van Donk, Kevin Yamauchi

Mechanical Engineering

The Piernas de Vida team partnered with the Vida Nueva Clinic of Prostheses and Orthoses in Choluteca, Honduras to design, plan, and implement a prosthetic foot that could be manufactured entirely by the technicians at the clinic in order to reduce their costs and ultimately allow them to serve more patients each year. Currently, the clinic uses a prefabricated prosthetic lower limb provided by the International Committee of the Red Cross (ICRC) which can be adapted to both transDfemoral and transDtibial patients. The team has successfully developed a foot, currently called the Layer Foot, which can be used by the …

Nanosecond Pulse Electrical Fields Used In Conjunction With Multi-Wall Carbon Nanotubes As A Potential Tumor Treatment, Michael W. Stacey, Christopher Osgood, Bhargava Subhash Kalluri, Wei Cao, Hani Elsayed-Ali, Tarek Abdel-Fattah

Bioelectrics Publications

The objectives of this communication were to fabricate pure samples of multi-walled carbon nanotubes (MWCNTs) and to determine their toxicity in tumor cell lines. MWCNTs were dispersed in a concentration of the surfactant T80 that was minimally toxic. Cell-type variation in toxicity to MWCNTs was observed but was not significantly different to unexposed controls. Additionally, we investigated the increased cell killing of the pancreatic cancer cell line PANC1 when exposed to ultrashort (nanosecond) pulsed electrical fields (nsPEF) in the presence of MWCNTs as a potential form of cancer therapy. We hypothesized that the unique electronic properties of MWCNTs disrupt cell …

Nanosecond Pulsed Electric Field Induced Cytoskeleton, Nuclear Membrane And Telomere Damage Adversely Impact Cell Survival, Michael W. Stacey, P. Fox, S. Buescher, Juergen F. Kolb

Bioelectrics Publications

We investigated the effects of nanosecond pulsed electric fields (nsPEF) on three human cell lines and demonstrated cell shrinkage, breakdown of the cytoskeleton, nuclear membrane and chromosomal telomere damage. There was a differential response between cell types coinciding with cell survival. Jurkat cells showed cytoskeleton, nuclear membrane and telomere damage that severely impacted cell survival compared to two adherent cell lines. Interestingly, disruption of the actin cytoskeleton in adherent cells prior to nsPEF exposure significantly reduced cell survival. We conclude that nsPEF applications are able to induce damage to the cytoskeleton and nuclear membrane. Telomere sequences, regions that tether and …

Program And Proceedings: Nebraska Academy Of Sciences 1880–2011, 131st Anniversary Year, One Hundred-Twenty-First Annual Meeting

Nebraska Academy of Sciences: Programs and Proceedings

Program

Aeronautics and Space Science

Collegiate Academy: Biology

Collegiate Academy: Chemistry and Physics

Chemistry and Physics

Biological and Medical Sciences

Junior Academy, Senior High Competition

Nebraska Wesleyan University Health and Sciences Graduate School Fair, Olin and Smith Curtiss Halls

Teaching of Science and Math

Aeronautics and Space Science, Poster Session

Applied Science and Technology

Maiben Memorial Lecture: Erin Flynn, Omaha Henry Doorly Zoo

Aeronautics

Anthropology

Earth Science

Junior Academy, Junior High Competition

Building Spaces To Grow New Ideas: Research 2011, University Office Of Research, South Dakota State University

State of Discovery South Dakota State University's Research Magazine

CONTENTS:

Feeding the World [Page] 2
A Light on New Possibilities [Page] 4
Designing New Tools [Page] 6
Wellness Science [Page] 8
Renovating a Science Resource [Page] 10
Connect World Possibilities [Page] 12
Transfer Research [Page] 14

The Journal Of Undergraduate Research: Volume 09

The Journal of Undergraduate Research

This is the complete issue of the South Dakota State University Journal of Undergraduate Research, Volume 13.

Assessment Of Intra-Urban Traffic-Related Air Pollution On Asthmatic Children's Exposure At Schools In The Paso Del Norte Region, Amit Ugamraj Raysoni

Open Access Theses & Dissertations

Traffic-related air pollution can be a major public health concern in any urban area. This problem is compounded in the Paso del Norte region that has experienced rapid economic growth, and a substantial number of people living in close vicinity of major roadways. The desert surroundings, arid weather, frequent temperature inversions, heavy border traffic at the international ports of entry between El Paso and Ciudad Juárez, and poorly maintained vehicle fleet further exacerbates this problem. A growing body of air quality and epidemiologic research has discerned the linkage between traffic emissions and respiratory disorders.

Initial health investigations in the Paso …