Engineering Commons^™

Collision Tracking And Brain Mapping, Carl Russell Iii

The Journal of Purdue Undergraduate Research

No abstract provided.

Continuous Liquid-Liquid Extraction Of Lomustine Synthesis, Devna Grover

The Journal of Purdue Undergraduate Research

No abstract provided.

État Des Récentes Avancées En Matière De Développement De Sièges À Suspension, Subhash Rakheja, Pierre Marcotte, Karim Hamouda, Krishna Dewangan, Darshan Dorugade

Rapports de recherche scientifique

Dans divers secteurs d’activité du Québec, les conducteurs de véhicules sont exposés à des niveaux notables de vibrations globales du corps (VGC) et à des chocs intermittents, associés dans les deux cas à un risque accru de douleurs lombaires et de dégénérescence de la colonne vertébrale. Les sièges à suspension sont largement utilisés pour limiter l'exposition des conducteurs aux VGC. L’efficacité d'un siège à suspension à réduire les vibrations est fortement dépendante de la nature des vibrations du véhicule (amplitude, direction et fréquence). Un siège à suspension ne peut donc offrir une efficacité optimale que lorsque la suspension est mise …

State-Of-The-Art In Recent Developments Concerning Suspension Seats, Subhash Rakheja, Pierre Marcotte, Karim Hamouda, Krishna Dewangan, Darshan Dorugade

Rapports de recherche scientifique

Dans divers secteurs d’activité du Québec, les conducteurs de véhicules sont exposés à des niveaux notables de vibrations globales du corps (VGC) et à des chocs intermittents, associés dans les deux cas à un risque accru de douleurs lombaires et de dégénérescence de la colonne vertébrale. Les sièges à suspension sont largement utilisés pour limiter l'exposition des conducteurs aux VGC. L’efficacité d'un siège à suspension à réduire les vibrations est fortement dépendante de la nature des vibrations du véhicule (amplitude, direction et fréquence). Un siège à suspension ne peut donc offrir une efficacité optimale que lorsque la suspension est mise …

Adapting Global Service-Learning Project And Community Partnership Outcomes Using A “Tele-Engineering” Approach In Response To The Covid-19 Pandemic, Christiane Ley, Danielle Angert, Tessa Hudelson, Jordan Harris

Purdue Journal of Service-Learning and International Engagement

The Water Supply in Developing Countries (WSDC) service-learning course at Purdue University has fostered a strong partnership with the La Vega region in the Dominican Republic since 2012. During this time, an interdisciplinary group of engineering and science students has helped design drinking water treatment systems and the group has developed water, sanitation, and health (WASH) education materials. These WASH education and water safety approaches often have been conducted in person in the past. However, with the state of the COVID-19 pandemic and the inability to travel in the fall and spring semesters of the 2020–2021 academic year, the students …

Creating Reel Designs: Reflecting On Arthrogryposis Multiplex Congenita In The Community, Iris Layadi

Purdue Journal of Service-Learning and International Engagement

Because of its extreme rarity, the genetic disease arthrogryposis multiplex congenita (AMC) and the needs of individuals with the diagnosis are often overlooked. AMC refers to the development of nonprogressive contractures in disparate areas of the body and is characterized by decreased flexibility in joints, muscle atrophy, and developmental delays. Colton Darst, a seven-year-old boy from Indianapolis, Indiana, was born with the disorder, and since then, he has undergone numerous surgical interventions and continues to receive orthopedic therapy to reduce his physical limitations. His parents, Michael and Amber Darst, have hopes for him to regain his limbic motion and are …

Synergistic Anticancer Response Of Curcumin And Piperine Loaded Lignin-G-P (Nipam-Co-Dmaema) Gold Nanogels Against Glioblastoma Multiforme, Xinyi Zhao, Bilal Javad, Daxing Cui, James Curtin, Furong Tian

Articles

Glioblastoma multiforme (GBM) is the most aggressive and commonly diag- 11 nosed brain cancer and presents a strong resistance to routine chemotherapeutic drugs. 12 The present study involves the synthesis of Lignin-g- p (NIPAM-co-DMAEMA) gold 13 nanogel, loaded with curcumin and piperine to treat GBM. The application has three 14 functions: (1) overcome the limitations of biodistribution, (2) enhance the toxicity of an- 15 ticancer drugs against GBM, (3) identify the uptake pathway. Atom transfer radical 16 polymerization was used to synthesize the Lignin-g-PNIPAM network, crosslinked with 17 the gold nanoparticles (GNPs) to self-assemble into nanogels. The size distribution and …

Pairwise Correlation Analysis Of The Alzheimer’S Disease Neuroimaging Initiative (Adni) Dataset Reveals Significant Feature Correlation, Erik D. Huckvale, Matthew W. Hodgman, Brianna B. Greenwood, Devorah O. Stucki, Katrisa M. Ward, Mark T. W. Ebbert, John S. K. Kauwe, The Alzheimer’S Disease Neuroimaging Initiative, The Alzheimer’S Disease Metabolomics Consortium, Justin B. Miller

Sanders-Brown Center on Aging Faculty Publications

The Alzheimer’s Disease Neuroimaging Initiative (ADNI) contains extensive patient measurements (e.g., magnetic resonance imaging [MRI], biometrics, RNA expression, etc.) from Alzheimer’s disease (AD) cases and controls that have recently been used by machine learning algorithms to evaluate AD onset and progression. While using a variety of biomarkers is essential to AD research, highly correlated input features can significantly decrease machine learning model generalizability and performance. Additionally, redundant features unnecessarily increase computational time and resources necessary to train predictive models. Therefore, we used 49,288 biomarkers and 793,600 extracted MRI features to assess feature correlation within the ADNI dataset to determine the …

Open Source Software Toolchain For Automated Non‐Targeted Screening For Toxins In Alternative Foods, S. W. Breuer, L. Toppen, S. K. Schum, J. M. Pearce

Michigan Tech Publications, Part 1

Previous published methods for non-targeted screening of toxins in alternative foods such as leaf concentrate, agricultural residues or plastic fed to biological consortia are time consuming and expensive and thus present accessibility, as well as, time-constraint issues for scientists from under resourced settings to identify safe alternative foods. The novel methodology presented here, utilizes a completely free and open source software toolchain for automatically screening unknown alternative foods for toxicity using experimental data from ultra-high-pressure liquid chromatography and mass spectrometry. The process uses three distinct tools (mass spectrometry analysis with MZmine 2, formula assignment with MFAssignR, and data filtering with …

Artificial Image Objects For Classification Of Breast Cancer Biomarkers With Transcriptome Sequencing Data And Convolutional Neural Network Algorithms, Xiangning Chen, Daniel G. Chen, Zhongming Zhao, Justin M. Balko, Jingchun Chen

School of Medicine Faculty Research

Background: Transcriptome sequencing has been broadly available in clinical studies. However, it remains a challenge to utilize these data effectively for clinical applications due to the high dimension of the data and the highly correlated expression between individual genes. Methods: We proposed a method to transform RNA sequencing data into artificial image objects (AIOs) and applied convolutional neural network (CNN) algorithms to classify these AIOs. With the AIO technique, we considered each gene as a pixel in an image and its expression level as pixel intensity. Using the GSE96058 (n = 2976), GSE81538 (n = 405), and GSE163882 (n = …

Characterization Of Indoor Arenas Through An Anonymous Survey, Staci Mcgill, Morgan D. Hayes, Kimberly I. Tumlin, Robert Coleman

Biosystems and Agricultural Engineering Faculty Publications

Equine farms are building both stables for the horses to live in and additional facilities to train and work horses (Kidd et al., 1997). For many of these farms, an outdoor arena that has an all-weather footing is the first working facility built. During inclement weather the ability to train in the outdoor arenas is inhibited, which in turn means the trainers, riders, and farms lose income as money is only made when horses are working, training, and competing. Indoor arenas allow for horses to continue to be worked no matter the weather conditions. The equine industry contributes a total …

Santa Clara Magazine, Volume 62 Number 2, Fall 2021, Santa Clara University

Santa Clara Magazine

18 - WE ARE THE CHAMPIONS The pandemic stole an entire year of games from them. But this team still won it all. Written by Harold Gutmann. Illustrated by Liam Eisenberg.

26 - INFORMED BY STRUGGLE. How hardship forged a sense of gratitude in SCU finance professor Meir Statman and his wife, Navah. Written by Deborah Lohse.

30 - TWEETING GOOD There’s a Bronco who finds hope, God, and cat pictures online. We talk with @padreSJ. Interviewed by Leslie Griffy. Illustrated by Kyle Hilton.

34 - SIGNALS FROM A CHANGING PLANET. The imprints of humans on the environment spell a …

Numerical Study Of Fully Coupled Fluid-Structure Interaction Of Stented Ureter By Varying The Stent Side-Holes, Erick Martinez, Ben Xu, Jianzhi Li, Yingchen Yang

Mechanical Engineering Faculty Publications

Ureteral stents are a measure used for many medical issues involving urology, such as kidney stones or kidney transplants. The purpose of applying stents is to help relieve the urine flow while the ureter is either blocked or trying to close itself, which creates blockages. These ureteral stents, while necessary, cause pain and discomfort to patients due to them being a solid that moves around inside the patients’ body. The ureter normally moves urine to the bladder through peristaltic forces. Due to the ureter being a hyperelastic material, these peristaltic forces cause the ureter to deform easily, making it necessary …

Viability And Application Of Mounting Personal Pid Voc Sensors To Small Unmanned Aircraft Systems, Cheri Marcham

Publications

Small Unmanned Aerial Systems in Emergency Response

Current sUAS Uses

• Search and rescue
• Thermal imaging
• Evaluating structural stability
• Spread of wildfires
• Storm damage

Human-Machine Communication: Complete Volume. Volume 3. Diffusion Of Human-Machine Communication During And After The Covid-19 Pandemic

Human-Machine Communication

This is the complete volume of HMC Volume 3. Diffusion of Human-Machine Communication During and After the COVID-19 Pandemic

The Role Of Vidura Chatbot In The Diffusion Of Knowcovid-19 Gateway, Kerk F. Kee, Prasad P. Calyam, Hariharan Regunath

Human-Machine Communication

The COVID-19 pandemic is an unprecedented global emergency. Clinicians and medical researchers are suddenly thrown into a situation where they need to keep up with the latest and best evidence for decision-making at work in order to save lives and develop solutions for COVID-19 treatments and preventions. However, a challenge is the overwhelming numbers of online publications with a wide range of quality. We explain a science gateway platform designed to help users to filter the overwhelming amount of literature efficiently (with speed) and effectively (with quality), to find answers to their scientific questions. It is equipped with a chatbot …

Covid-19 Et Gestion Des Troubles Gastro-Intestinaux : Expérience D’Un Centre Hospitalier Marocaincovid-19, Gastrointestinal Disorders, Pandemic., Hanane Delsa, Mohamed Cherkaoui Jaouad Reda, Amine Benfaida, Anass Nadi, Fedoua Rouibaa

Health Sciences

Pandemic Covid-19 is a real challenge for the medical profession. SARS-CoV-2 virus attacks several human organs, including the digestive tract. Digestive disorders have been described as revealing symptoms or accompanying signs of infection. The treatment of these symptoms must be early and codified. At Cheikh Khalifa International University Hospital in Casablanca, a codified treatment protocol has been proposed to facilitate the management of these disorders.

Fabrication And Comparative Study Of Horizontal And Vertical Electrospun Protein-Polysaccharide Nanofiber Biomaterials, Ashley Rivera-Galleti

Theses and Dissertations

The use of biocompatible and biodegradable composite materials for biomedical applications has attracted the attention of many researchers in the past few years. In this study, we fabricated nanofibers of silk fibroin and cellulose and its derivatives to amalgamate their unique properties into a single material. The production of these nanofibers via electrospinning is of particular interest, and whereas several studies have been done on normal nanofibers, the formation of branched nanofibers is an exciting area not currently explored. Blend solutions are formed by dissolving silk and cellulose/cellulose acetate in formic acid separately and mixing to achieve the desired ratios. …

Bone Quality And Fractures In Women With Osteoporosis Treated With Bisphosphonates For 1 To 14 Years, Hartmut H. Malluche, Jin Chen, Florence Lima, Lucas J. Liu, Marie-Claude Monier-Faugere, David A. Pienkowski

Internal Medicine Faculty Publications

Oral bisphosphonates are the primary medication for osteoporosis, but concerns exist regarding potential bone-quality changes or low-energy fractures. This cross-sectional study used artificial intelligence methods to analyze relationships among bisphosphonate treatment duration, a wide variety of bone-quality parameters, and low-energy fractures. Fourier transform infrared spectroscopy and histomorphometry quantified bone-quality parameters in 67 osteoporotic women treated with oral bisphosphonates for 1 to 14 years. Artificial intelligence methods established two models relating bisphosphonate treatment duration to bone-quality changes and to low-energy clinical fractures. The model relating bisphosphonate treatment duration to bone quality demonstrated optimal performance when treatment durations of 1 to 8 …

In Situ Imaging Of Bacterial Outer Membrane Projections And Associated Protein Complexes Using Electron Cryo-Tomography, Mohammed Kaplan, Georges Chreifi, Lauren Ann Metskas, Janine Liedtke, Cecily R. Wood, Catherine M. Oikonomou, William J. Nicolas, Poorna Subramanian, Lori A. Zacharoff, Yuhang Wang, Yi-Wei Chang, Morgan Beeby, Megan J. Dobro, Yongtao Zhu, Mark J. Mcbride, Ariane Briegel, Carrie L. Shaffer, Grant J. Jensen

Veterinary Science Faculty Publications

The ability to produce outer membrane projections in the form of tubular membrane extensions (MEs) and membrane vesicles (MVs) is a widespread phenomenon among diderm bacteria. Despite this, our knowledge of the ultrastructure of these extensions and their associated protein complexes remains limited. Here, we surveyed the ultrastructure and formation of MEs and MVs, and their associated protein complexes, in tens of thousands of electron cryo-tomograms of ~90 bacterial species that we have collected for various projects over the past 15 years (Jensen lab database), in addition to data generated in the Briegel lab. We identified outer MEs and MVs …

High Shear Stress Enhances Endothelial Permeability In The Presence Of The Risk Haplotype At 9p21.3, Evan L. Tang, Evan M. Masutami, Benjamin Yeoman, Jessica Fung, Rachel Lian, Brenda Ngo, Aditya Kumar, Jesse K. Placone, Valentina Lo Sardo, Adam J. Engler

Physics & Engineering Faculty Publications

Single nucleotide polymorphisms (SNPs) are exceedingly common in non-coding loci, and while they are significantly associated with a myriad of diseases, their specific impact on cellular dysfunction remains unclear. Here, we show that when exposed to external stressors, the presence of risk SNPs in the 9p21.3 coronary artery disease (CAD) risk locus increases endothelial monolayer and microvessel dysfunction. Endothelial cells (ECs) derived from induced pluripotent stem cells of patients carrying the risk haplotype (R/R WT) differentiated similarly to their non-risk and isogenic knockout (R/R KO) counterparts. Monolayers exhibited greater permeability and reactive oxygen species signaling when the risk haplotype was …

Molecular Dynamics Simulations Of Self-Assemblies In Nature And Nanotechnology, Phu Khanh Tang

Dissertations, Theses, and Capstone Projects

Nature usually divides complex systems into smaller building blocks specializing in a few tasks since one entity cannot achieve everything. Therefore, self-assembly is a robust tool exploited by Nature to build hierarchical systems that accomplish unique functions. The cell membrane distinguishes itself as an example of Nature’s self-assembly, defining and protecting the cell. By mimicking Nature’s designs using synthetically designed self-assemblies, researchers with advanced nanotechnological comprehension can manipulate these synthetic self-assemblies to improve many aspects of modern medicine and materials science. Understanding the competing underlying molecular interactions in self-assembly is always of interest to the academic scientific community and industry. …

Pulmon-C: A Real-Time Monitoring Framework Of Pulmonary Function, Md Saiful Islam, Maria Valero, Shahriar Hossain

Symposium of Student Scholars

This project will develop PulMon-C, a real-time monitoring framework of pulmonary function to diagnose COVID-19 patients who are being self-quarantined at home. The tool will identify anomalies in breathe rate and predict pulmonary deterioration to raise alert for immediate actions. The uniqueness of the tool is using non-invasive sensors placed under-mattress that are able to communicate data about the respiratory signal. The customer segment of PulMon-C will be the diagnosed COVID-19 patients and healthcare providers. PulMon-C will assist with the remote monitoring of COVID-19 patients as an urgent need in the USA and will bring larger impact in delivering …

Oral Minimal Model For Gestational Diabetes, Sarah Peters

Symposium of Student Scholars

Gestational diabetes is one of the most common issues that a pregnant woman encounters that could result in harm to both the woman and child. Due to this issue, the woman’s glucose and insulin levels should be carefully monitored throughout her pregnancy to assess the need for prescribed diabetic medication to help regulate those levels. In this research, the objectives is to develop a MATLAB computer program of the Oral Minimal Model, which is a model that can be used to estimate a person’s insulin sensitivity from an oral glucose tolerance test (OGTT) where plasma glucose and insulin levels are …

Multi-Stage Stochastic Optimization And Reinforcement Learning For Forestry Epidemic And Covid-19 Control Planning, Sabah Bushaj

Dissertations

This dissertation focuses on developing new modeling and solution approaches based on multi-stage stochastic programming and reinforcement learning for tackling biological invasions in forests and human populations. Emerald Ash Borer (EAB) is the nemesis of ash trees. This research introduces a multi-stage stochastic mixed-integer programming model to assist forest agencies in managing emerald ash borer insects throughout the U.S. and maximize the public benets of preserving healthy ash trees. This work is then extended to present the first risk-averse multi-stage stochastic mixed-integer program in the invasive species management literature to account for extreme events. Significant computational achievements are obtained using …

Stochastic Programming And Agent-Based Simulation Approaches For Epidemics Control And Logistics Planning, Xuecheng Yin

Dissertations

This dissertation addresses the resource allocation challenges of fighting against infectious disease outbreaks. The goal of this dissertation is to formulate multi-stage stochastic programming and agent-based models to address the limitations of former literature in optimizing resource allocation for preventing and controlling epidemics and pandemics. In the first study, a multi-stage stochastic programming compartmental model is presented to integrate the uncertain disease progression and the logistics of resource allocation to control a highly contagious infectious disease. The proposed multi-stage stochastic program, which involves various disease growth scenarios, optimizes the distribution of treatment centers and resources while minimizing the total expected …

Towards Quality By Design (Qbd) Of Pharmaceutical Oral Films Loaded With Poorly Watersoluble Drugs, Eylul Cetindag

Dissertations

Oral films are an emerging drug delivery dosage form with numerous advantages such as ease of handling, the possibility to circumvent the first-pass metabolism, better patient compliance, capability for continuous manufacturing, and as a platform for personalized medicine. As films are different from other final dosages by their dimensions and their matrix form, further research is required to better understand the impact of excipient and drug on product performance to assure a consistent and good quality product. Therefore, this dissertation aims to contribute towards the processability and manufacturability of films by examining the impact of the materials and processes. First, …

Exploring Fused Deposition Modeling (Fdm) Three-Dimensional Printing Tablet Design Options For Pharmaceutical Dosage Forms, Guluzar Gorkem Buyukgoz

Dissertations

This dissertation examines the use of Fused Deposition Modeling (FDM) based three-dimensional (3D) printing approach for developing patient-specific dosage forms and addressing related technical challenges in such drug delivery systems. The first main objective is to explore pharmaceutical tablet design options using novel FDM 3D printing technology as the drug delivery platform such that drug form and tablet properties are tailored by considering patient age-specific formulations and dissolution control. Of the five different design options, two proposed options meet the main objective of providing similar drug release, whereas the popular option of fixed drug concentration but differing tablet size could …

Unintended Consequences Of Air Cleaning Chemistry, Douglas B. Collins, Delphine K. Farmer

Faculty Journal Articles

Amplified interest in maintaining clean indoor air associated with the airborne transmission risks of SARS-CoV-2 have led to an expansion in the market for commercially available air cleaning systems. While the optimal way to mitigate indoor air pollutants or contaminants is to control (remove) the source, air cleaners are a tool for use when absolute source control is not possible. Interventions for indoor air quality management include physical removal of pollutants through ventilation or collection on filters and sorbent materials, along with chemically reactive processes that transform pollutants or seek to deactivate biological entities. This perspective intends to highlight the …

Patient Transport In The Time Of Covid-19: Using Health Care Failure Mode And Effect Analysis With Simulation To Test And Modify A Protocol, John Kwock, Jeffrey Holmes, Shelly Chipman, Erin Siebers, Angela Berry, Sonja Orff, Victoria Boutin, Leah Mallory

Journal of Maine Medical Center

Introduction: In March 2020, in response to the COVID-19 pandemic, an interprofessional, interdisciplinary team at Maine Medical Center used Healthcare Failure Mode and Effect Analysis (HFMEA) and in situ simulation to rapidly identify and mitigate latent safety threats (LST) in patient transport protocols.

Methods: Following HFMEA steps, stakeholders representing a variety of disciplines assembled to address transport of patients with COVID-19. A process map was created to describe the process. With hazard analysis using table-top simulation followed by in situ simulation, we identified, categorized, and scored LSTs. Mitigation strategies were identified during structured debriefing.

Results: Fourteen LSTs were identified in …