Engineering Commons^™

Exposure To Pcb126 During The Nursing Period Reversibly Impacts Early-Life Glucose Tolerance, Brittany B. Rice, Keegan W. Sammons, Sara Y. Ngo Tenlep, Madeline T. Weltzer, Leryn J. Reynolds, Cetewayo S. Rashid, Hollie I. Swanson, Kevin J. Pearson

Human Movement Studies & Special Education Faculty Publications

Polychlorinated biphenyls (PCBs) are persistent environmental organic pollutants known to have detrimental health effects. Using a mouse model, we previously demonstrated that PCB126 exposure before and during pregnancy and throughout the perinatal period adversely affected offspring glucose tolerance and/or body composition profiles. The purpose of this study was to investigate the glucose tolerance and body composition of offspring born to dams exposed to PCB126 during the nursing period only. Female ICR mice were bred, and half of the dams were exposed to either vehicle (safflower oil) or 1 µmole PCB126 per kg of body weight via oral gavage on postnatal …

Extracellular Vesticles In Acute Respiratory Distress Syndrome: Understanding Protective And Harmful Signaling For The Development Of New Therapeutics, Matthew Bavuso, Noel Miller, Joshua M. Sill, Anca Dobrian, Ruben M. L. Colunga Biancatelli

Bioelectrics Publications

Acute respiratory distress syndrome (ARDS) is a severe respiratory condition characterized by increased lung permeability, hyper-inflammatory state, and fluid leak into the alveolar spaces. ARDS is a heterogeneous disease, with multiple direct and indirect causes that result in a mortality of up to 40%. Due to the ongoing Covid-19 pandemic, its incidence has increased up to ten-fold. Extracellular vesicles (EVs) are small liposome-like particles that mediate intercellular communication and play a major role in ARDS pathophysiology. Indeed, they participate in endothelial barrier dysfunction and permeability, neutrophil, and macrophage activation, and also in the development of a hypercoagulable state. A more …

Interactions Of Carboxylated Nanodiamonds With Mouse Macrophages Cell Line And Primary Cells, Maisoun Bani-Hani, Stephen J. Beebe, Michael W. Stacey, Christopher Osgood

Bioelectrics Publications

Nanodiamonds (ND) have attracted significant interest for their use in several biomedical applications. These applications can be very useful if the safety and compatibility of ND are proven. We assessed the effects of ND (100 nm, Carboxylated) on primary macrophages and a macrophage-like cell line and found that these particles are not toxic to these cells at lower concentrations but may interfere with cell functions and differentiation. Internalization of ND by these cells in a time- and dose-dependent manner was mostly via phagocytosis and clathrin-dependent endocytosis and localized to the cytoplasm but not into the nucleus. No significant induction of …

Evaluation Of Cold Atmospheric Plasma For The Decontamination Of Flexible Endoscopes, R. C. Hervé, Michael G. Kong, Sudhir Bhatt, Hai-Lan Chen, E. E. Comoy, J-P. Deslys, T. J. Secker, C. W. Keevil

Bioelectrics Publications

Background: Despite adherence to standard protocols, residues including live microorganisms may remain on the various surfaces of reprocessed flexible endoscopes. Prions are infectious proteins notoriously difficult to eliminate.

Aim: We tested the potential of cold atmospheric plasma (CAP) for the decontamination of flexible endoscope various surfaces, measuring total proteins and prion-residual infectivity as an indicator of efficacy.

Methods: New PTFE endoscope channels and metal test surfaces spiked with test soil or prion-infected tissues were treated using different CAP-generating prototypes. Surfaces were then examined for the presence of residues using very sensitive fluorescence epi-microscopy. Prion residual infectivity was determined using the …

Pulsed Electric Field Ablation Of Esophageal Malignancies And Mitigating Damage To Smooth Muscle: An In Vitro Study, Emily Gudvangen, Uma Mangalanathan, Iurii Semenov, Allen S. Kiester, Mark A. Keppler, Bennett L. Ibey, Joel N. Bixler, Andrei G. Pakhomov

Bioelectrics Publications

Cancer ablation therapies aim to be efficient while minimizing damage to healthy tissues. Nanosecond pulsed electric field (nsPEF) is a promising ablation modality because of its selectivity against certain cell types and reduced neuromuscular effects. We compared cell killing efficiency by PEF (100 pulses, 200 ns–10 µs duration, 10 Hz) in a panel of human esophageal cells (normal and pre-malignant epithelial and smooth muscle). Normal epithelial cells were less sensitive than the pre-malignant ones to unipolar PEF (15–20% higher LD50, p < 0.05). Smooth muscle cells (SMC) oriented randomly in the electric field were more sensitive, with 30–40% lower LD50 (p < 0.01). Trains of ten, 300-ns pulses at 10 kV/cm caused twofold weaker electroporative uptake of YO-PRO-1 dye in normal epithelial cells than in either pre-malignant cells or in SMC oriented perpendicularly to the field. Aligning SMC with the field reduced the dye uptake fourfold, along with a twofold reduction in Ca²⁺ transients. A 300-ns pulse induced a twofold smaller transmembrane potential in cells aligned with the field, making them …

Développement De Stratégie Visant À Contrôler Le Niveau De Contamination Des Piscines Par Les Sous-Produits De Désinfection, Maximilien Debia, Elham Ahmadpour, Isabelle Valois, Sami Haddad, Robert Tardif, Stéphane Hallé, Hélène Proulx, Manuel Rodriguez, François Proulx, Ianis Delpla, Jean Sérodes, Sabrina Simard

Rapports de recherche scientifique

La présence de sous-produits de désinfection dans l’eau et l’air des piscines intérieures est une problématique de santé publique et de santé au travail. L’exposition aux sous-produits de désinfection et notamment à la trichloramine est associée à différents effets délétères comme l’irritation des voies respiratoires, l’irritation oculaire et l’hyperréactivité bronchique. La présence des sous-produits de désinfection résulte des réactions chimiques qui surviennent entre les agents désinfectants ajoutés et les matières organiques ou azotées présentes naturellement dans l’eau ou qui y sont amenées par les baigneurs.

L’objectif général de recherche visait à améliorer les connaissances sur les pratiques de gestion et …

Utilisation Des Ponts Élévateurs De Véhicules Hors Terre À Deux Colonnes : Identification De Déterminants Techniques De Stabilité Et Des Déterminants Du Travail Des Techniciens Automobiles, Damien Burlet-Vienney, Sylvie Beaugrand, Bertrand Galy, Maud Gonella, François Gauthier, Élise Ledoux, Isabelle Berger, Isvieysys Armas Marrero, Kariane Cusson Bertrand

Rapports de recherche scientifique

Cette recherche porte spécifiquement sur l’utilisation des ponts élévateurs de véhicules (PEV) hors terre à deux colonnes (HT2C). Les PEV HT2C sont utilisés par les techniciens automobiles lors de l’entretien et de la réparation des véhicules et les amènent à travailler sous ou à proximité d’une charge surélevée de plusieurs tonnes. La mort d’un jeune technicien en 2014 est à l’origine d’une concertation du secteur de la réparation automobile et de ces travaux de recherche. La chute d’un véhicule d’un PEV HT2C est le risque ciblé par cette étude.

De nombreux facteurs sont susceptibles de contribuer à la chute d’un …

Unveiling Similarities And Differences Between Cutaneous And Ocular Melanomas, Abdallah Badou, Nour El Imane Issam Salah, Mohamed Elbelhadji

Health Sciences

Melanomas are outstandingly aggressive cancers, still their incidence is increasing. They can occur in the skin as cutaneous melanoma or in the eye as ocular melanoma. Their pathogenesis is generally similar; however, the prognosis of ocular melanoma patients is still poor, due to its special genetic profile and tumor microenvironment. Here we review the similarities and differences between cutaneous and ocular melanoma, with a focus on their prognostic significance, their molecular signature, and their tumor microenvironment, in order to understand the strategies adopted to escape immune response. Gathering and understanding available knowledge of melanomas and their specificities may help to …

Modeling Of The Chest Wall Response To Prolonged Bracing In Pectus Carinatum, Brandon Sargent, Katie Varela, Dennis Eggett, Emily Mckenna, Christina Bates, Rebeccah Brown, Victor Garcia, Larry Howell

Biomedical Engineering Faculty Scholarship

Pectus carinatum is a chest wall deformity that is often treated through the wearing of an external brace. The treatment of the deformity could benefit from a greater understanding of chest wall characteristics under prolonged loading. These characteristics are difficult to model directly but empirical studies can be used to create statistical models. 185 patients from 2018-2020 received bracing treatment. Data on the severity of the deformity, treatment pressures, and time of wear were recorded at the first fitting and all subsequent follow-up visits. This data was analyzed using a statistical mixed effects model to identify significant measures and trends …

Accessibility Of Health Data Representations For Older Adults: Challenges And Opportunities For Design, Peterson Jean, Emma Murphy, Enda Bates

Books/Book Chapters

Health data of consumer off-the-shelf wearable devices is often conveyed to users through visual data representations and analyses. However, this is not always accessible to people with disabilities or older people due to low vision, cognitive impairments or literacy issues. Due to trade-offs between aesthetics predominance or information overload, real-time user feedback may not be conveyed easily from sensor devices through visual cues like graphs and texts. These difficulties may hinder critical data understanding. Additional auditory and tactile feedback can also provide immediate and accessible cues from these wearable devices, but it is necessary to understand existing data representation limitations …

Pronostic Of Colo-Rectal Cancer (Crc) Using Machine Learning Models On Organoids Derived Of Patient, Claudia Andrea Leiva Acevedo

ICT

Colorectal Cancer (CRC) is a globally prevalent and deadly carcinoma, necessitating advanced treatment approaches. Despite ongoing advancements, the mortality rate remains high. Various biological models, including animal studies, cell lines, and the emerging organoid model, contribute to understanding molecular mechanisms. Organoids, 3D cultures derived from tumor epithelial cells, offer advantages such as enhanced diversity, genetic modification, and extended culture capabilities. Recent applications of machine learning (ML) in predicting CRC treatment responses using organoids and tissue data indicate a promising avenue for advancing personalized therapies.

Business Meeting Report (Secretary's And Treasurer's Report), Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Efficient Training On Alzheimer’S Disease Diagnosis With Learnable Weighted Pooling For 3d Pet Brain Image Classification, Xin Xing, Muhammad Usman Rafique, Gongbo Liang, Hunter Blanton, Zu Zhang, Chris Wang, Nathan Jacobs, Ai-Ling Lin

Computer Science Faculty Publications (Archived)

Three-dimensional convolutional neural networks (3D CNNs) have been widely applied to analyze Alzheimer’s disease (AD) brain images for a better understanding of the disease progress or predicting the conversion from cognitively impaired (CU) or mild cognitive impairment status. It is well-known that training 3D-CNN is computationally expensive and with the potential of overfitting due to the small sample size available in the medical imaging field. Here we proposed a novel 3D-2D approach by converting a 3D brain image to a 2D fused image using a Learnable Weighted Pooling (LWP) method to improve efficient training and maintain comparable model performance. By …

Climate Change And The Law Of National Security Adaptation, Mark P. Nevitt

Faculty Articles

The Department of Defense (DoD) is the largest employer in the world, owns and operates an enormous global real estate portfolio, and emits more Greenhouse Gases (GHGs) than many nations. Entrusted with the national security, the DoD is now threatened by a new enemy—climate change. Climate change imperils national security infrastructure while undermining the military’s capacity to respond to climate-driven disasters at home and abroad. However, legal scholarship has yet to address what I call “the law of national security adaptation” and related questions. For example, how do environmental and climate change laws apply to the U.S. military? What laws …

Synthesis, Characterization, And Application Of Chitosan Nanoparticles For In Vitro Studies On Hela Cancer Cells, Rejeena Jha

Graduate Theses/Dissertations

Chitosan is a fibrous substance that is derived from chitin, a natural substance in the shells of crustaceans. It possesses all the necessary qualities for being used as carrier for the transport of drugs and genes into tumor, such as biodegradability, biocompatibility, hydrophilicity, and non-toxicity and cationic in nature. Ionic gelation method was used to synthesize chitosan (CS) nanoparticles (NPs). Ionic gelation is a very benign process chemically that requires mixing a CS aqueous solution with a sodium tripolyphosphate (TPP) aqueous solution at room temperature. In addition, a surfactant polyethylene oxide (PEO) alone and a diblock copolymer of PEO and …

Optimizing Biomechanical Models: Estimation Of Muscle Tendon Parameters And Ankle Foot Orthosis Stiffness, Sepehr Ramezani

Electronic Theses and Dissertations, 2020-2023

The complexity of the human musculoskeletal system presents challenges in accurately identifying its characteristics, particularly due to the presence of redundant actuators on a single joint. Non-invasive measures are necessary to overcome these challenges. Optimization algorithms have emerged as a crucial tool to advance subject-specific musculoskeletal modeling allows a more realistic representation of biomechanical behaviors, enhancing our understanding of human movement and enabling better clinical decision-making. Furthermore, optimization algorithms play a vital role in customizing rehabilitation and assistive devices, such as orthoses and prostheses. The current ankle-foot orthosis (AFO) stiffness measurement methods require bulky, complex designs, and often permanent modification …

Modeling Behavior And Vaccine Hesitancy For Predicting Daily Vaccination Inoculations Using Trends, Case, Death, And Twitter Sentiment Data, Talal Daghriri

Electronic Theses and Dissertations, 2020-2023

Over the past 100 years, epidemiological models have evolved to incorporate greater facets of the process. With the advent of social networking, massive computational power, population sentiment analysis can now be added to the epidemiological modeling process. Sentiment analysis is greater understanding of the fears, uncertainties, motivation, and trends of the public with respect to vaccination and associated events. Lack of public confidence in the efficacy of models, safety of vaccines, and appropriateness of policies confounds vaccine inoculation prediction. Sentiment analysis of social media is a seminal technique that accesses shared users' contents and tweets on the Twitter platform for …

Marineepi: A Gui-Based Matlab Toolbox To Simulate Marine Pathogen Transmission, Gorka Bidegain, Tal Ben-Horin, Eric N. Powell, John M. Klinck, Eileen E. Hofmann

CCPO Publications

The Graphical User Interface (GUI) MarineEpi is presented as a Matlab toolbox for easily (i) constructing disease transmission models for different marine host-pathogen systems, (ii) running simulations by specifying initial conditions and model parameters, and (iii) interpreting the resulting time series of the host and pathogen population dynamics. MarineEpi users can generate models for systems in which pathogen transmission occurs through contact with infected individuals (SI), contact with dead infected individuals (SID), contact with environmental pathogens released by infected individuals (SIP), and contact with environmental pathogens released by dead infected individuals (SIPD). MarineEpi is a freely available GUI that provides …

Portable Hepa Filtration Successfully Augments Natural-Ventilation-Mediated Airborne Particle Clearance In A Legacy Design Hospital Ward, Mehael Fennelly, S. Hellebust, J. Wenger, D. O'Connor, G.W. Griffith, B.J. Plant, A.P.C. Microbiome Institute

Articles

As the severe acute respiratory syndrome coronavirus-2 pandemic has proceeded, ventilation has been recognized increasingly as an important tool in infection control. Many hospitals in Ireland and the UK do not have mechanical ventilation and depend on natural ventilation. The effectiveness of natural ventilation varies with atmospheric conditions and building design. In a challenge test of a legacy design ward, this study showed that portable air filtration significantly increased the clearance of pollutant aerosols of respirable size compared with natural ventilation, and reduced spatial variation in particle persistence. A combination of natural ventilation and portable air filtration is significantly more …

New Records Of Distribution And Natural History Of Vertebrates In Arkansas: 2020-2023, R. Tumlison, H.W. Robison, M.B. Connior, D.B. Sasse, T.S. Risch, K. Edmonds, J.D. Wilhide, C.R. Allen

Journal of the Arkansas Academy of Science

Small details of natural history often go undocumented to science if those details are not parts of larger studies. However, knowledge of small details can provide insights that lead to interesting questions about ecological relationships or environmental change. We have compiled recent important observations of natural history of vertebrates, including several distributional and size records of fishes, atypical carapace shape in a common snapping turtle, an unusual support structure for a bird nest, healed damage to a broken jaw of a young deer, and numerous distributional records of bats.

Chronic Anemia Revealing An Idiopathic Watermelon Stomach: Case Report, Hanane Delsa, Imane Rahmouni, Yassamin Benhayoun Sadafyine, Fatima Belabbes, Anass Nadi, Fedoua Rouibaa

Health Sciences

Watermelon stomach, also known as gastric antral vascular ectasia (GAVE) syndrome, is a rare entity. Patients often present with profound unexplained anemia with or without bleeding externalization. We made the diagnosis during a digestive endoscopy for an etiological assessment of this anemia. Endoscopically, antral erythematous lesions in stripes with a punctate appearance, sometimes hemorrhagic, may suggest a watermelon stomach. The pathophysiology of the watermelon stomach remains complex and unclear. Although several pathologies remain implicated, sometimes, it can be idiopathic. The effectiveness of numerous treatments has been evaluated with relatively satisfactory results. This is a rare case of an idiopathic watermelon …

The Strength Of Motivation For Dental Students, Manal Elhijazi, Ihsane Benyahya

Health Sciences

Context: Motivation plays a key role in academic success. It is a dynamic process that maintains perseverance and tenacity in the face of difficulty. The purpose of our study was to measure and compare the strength of dental students' motivation at the beginning and the end of their training Material and methods: an anonymous self-administered voluntary questionnaire was distributed to 1st and 6th year students at the Faculty of Dentistry in Casablanca This questionnaire consisted of 30 closed questions divided into 3 sections, the first of which provided information on socio-demographic data, the second is devoted to measuring the strength …

New Host Records Of Apicomplexan Blood Parasites (Haemogregarinidae And Hepatozoidae) Infecting Two Reptiles (Testudines; Ophidia) From Arkansas, C.T. Mcallister, H.W. Robison

Journal of the Arkansas Academy of Science

Relatively few records of apicomplexan blood parasites from reptiles in Arkansas have been published although the effects of these parasites on reptilian health may be of concern. Using photomicrographs we describe the morphotypes of parasite gamonts found in blood samples from the Midland smooth softshell turtle, Apalone mutica mutica, and a western Milksnake Lampropeltis gentilis from Arkansas. The turtle possessed four distinct morphological gamont forms of a Haemogregarina sp. The snake possessed two morphological forms of gamonts of a Hepatozoon sp. Both infections are new host records and the western milksnake has not been described as a host elsewhere for …

Hemoparasites (Apicomplexa: Hepatozoon; Kinetoplastida: Trypanosoma) Of Two Anurans (Hylidae; Ranidae), From Polk County, Arkansas, C.T. Mcallister, H.W. Robison

Journal of the Arkansas Academy of Science

Arkansas supports 26 species/subspecies of anurans and only one (4%), the green frog, Rana clamitans, has been previously reported with hemoparasites. Here, we collected blood samples from three species of anurans, five American green treefrogs, Dryophytes cinereus, five American bullfrogs, Rana catesbeianus, two southern leopard frogs, Rana sphenocephalus utricularius, and two Fowler’s toads, Anaxyrus fowleri from Polk County and examined each for hemoparasites. American green treefrogs and American bullfrogs harbored hemoparasites, including two (40%) D. cinereus and four (80%) R. catesbeianus with trypanosomes, and one (20%) R. catesbeiana with a Hepatozoon sp. This is the first time these two anurans …

Novel Reproductive Data On Blue Sucker, Cycleptus Elongatus (Cypriniformes: Catostomidae), From Northeastern Arkansas, C.T. Mcallister, D.G. Cloutman, E.M. Leis, H.W. Robison

Journal of the Arkansas Academy of Science

Nothing has been published in the scientific literature concerning the reproductive biology of the Blue Sucker, Cycleptus elongatus in Arkansas. We examined seven female C. elongatus collected in late February 2021 and 2022 and again in early March 2023 from the Black River, Lawrence County. Egg mass (g) averaged 15.8% of the total weight of these gravid females. It appears that this sucker can spawn as early as February in this population. This is the first time information on female reproduction in this species has been published from any population of C. elongatus in the state.

Rare Birds In Arkansas: Historical Observations And New Records, R. Tumlison, R. Kannan

Journal of the Arkansas Academy of Science

Diligent members of birding communities are quick to report rare sightings of birds, which often lead to multiple observations and photographic documentation. Verified reports and images of birds in Arkansas are curated by the Arkansas Audubon Society (AAS), which has led to an appreciation of which species are common versus rare. We gathered historic (literature) and more recent unpublished records of rare birds (those with fewer than 10 reports, per AAS) to document the historic and current state of knowledge of those species. Currently, there are a total of 425 species of birds reported in Arkansas, of which 54 are …

Journal Acknowledgements And Editorial Board, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Table Of Contents, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Sodium Hyaluronate Based Drug Delivery To The Outer And Inner Ear, Emma Barrett-Catton

Graduate Student Theses, Dissertations, & Professional Papers

We have developed two projects using sodium hyaluronate (HA)-based systems for drug delivery to the ear. First, we investigated an HA-based hydrogel for use as a single use antibiotic treatment for otitis externa. Otitis externa, also known as outer ear infection, is a frequent affliction in both humans and animals. The most prevalent treatment for otitis externa is ear drops, but it is difficult to adhere properly to this treatment, causing poor patient compliance and the potential for complications. As a result, we have developed an HA-based hydrogel for use as a single application treatment for otitis externa to increase …

Gated Deep Reinforcement Learning With Red Deer Optimization For Medical Image Classification, Narayanan Ganesh, Sambandan Jayalakshmi, Rama Chandran Narayanan, Miroslav Mahdal, Hossam Zawbaa, Ali Wagdy Mohamed

Articles

The brain is one of the most important and complex organs in the body, consisting of billions of individual cells. Uncontrolled growth and expansion of aberrant cell populations within or around the brain are the main causes of brain tumors. These cells have the potential to harm healthy cells and impair brain function [1]. Tumors can be detected using medical imaging techniques, which are considered the most popular and accurate way to classify different types of cancer, and this procedure is even more crucial as it is noninvasive [2]. Magnetic resonance imaging (MRI) is one such medical imaging technique that …