Engineering Commons^™

Updated Perspectives On The Role Of Biomechanics In Copd: Considerations For The Clinician, Jennifer M. Yentes, Wai-Yan Liu, Kuan Zhang, Eric J. Markvicka, Stephen I. Rennard

Department of Electrical and Computer Engineering: Faculty Publications

Patients with chronic obstructive pulmonary disease (COPD) demonstrate extra-pulmonary functional decline such as an increased prevalence of falls. Biomechanics offers insight into functional decline by examining mechanics of abnormal movement patterns. This review discusses biomechanics of functional outcomes, muscle mechanics, and breathing mechanics in patients with COPD as well as future directions and clinical perspectives. Patients with COPD demonstrate changes in their postural sway during quiet standing compared to controls, and these deficits are exacerbated when sensory information (eg, eyes closed) is manipulated. If standing balance is disrupted with a perturbation, patients with COPD are slower to return to baseline …

Sers Spectroscopy With Machine Learning To Analyze Human Plasma Derived Sevs For Coronary Artery Disease Diagnosis And Prognosis, Xi Huang, Bo Liu, Shenghan Guo, Weihong Guo, Ke Liao, Guoku Hu, Wen Shi, Mitchell Kuss, Michael J. Duryee, Daniel R. Anderson, Yongfeng Lu, Bin Duan

Department of Electrical and Computer Engineering: Faculty Publications

Coronary artery disease (CAD) is one of the major cardiovascular diseases and represents the leading causes of global mortality. Developing new diagnostic and therapeutic approaches for CAD treatment are critically needed, especially for an early accurate CAD detection and further timely intervention. In this study, we successfully isolated human plasma small extracellular vesicles (sEVs) from four stages of CAD patients, that is, healthy control, stable plaque, non-ST-elevation myocardial infarction, and ST-elevation myocardial infarction. Surface-enhanced Raman scattering (SERS) measurement in conjunction with five machine learning approaches, including Quadratic Discriminant Analysis, Support Vector Machine (SVM), K-Nearest Neighbor, Artificial Neural network, were then …

Sers Spectroscopy With Machine Learning To Analyze Human Plasma Derived Sevs For Coronary Artery Disease Diagnosis And Prognosis, Xi Huang, Bo Liu, Shenghan Guo, Weihong Guo, Ke Liao, Guoku Hu, Wen Shi, Mitchell Kuss, Michael J. Duryee, Daniel R. Anderson, Yongfeng Lu, Bin Duan

Department of Electrical and Computer Engineering: Faculty Publications

Coronary artery disease (CAD) is one of the major cardiovascular diseases and represents the leading causes of global mortality. Developing new diagnostic and therapeutic approaches for CAD treatment are critically needed, especially for an early accurate CAD detection and further timely intervention. In this study, we successfully isolated human plasma small extracellular vesicles (sEVs) from four stages of CAD patients, that is, healthy control, stable plaque, non-ST-elevation myocardial infarction, and ST-elevation myocardial infarction. Surface-enhanced Raman scattering (SERS) measurement in conjunction with five machine learning approaches, including Quadratic Discriminant Analysis, Support Vector Machine (SVM), K-Nearest Neighbor, Artificial Neural network, were then …

Nonlinear Strong Coupling By Second-Harmonic Generation Enhancement In Plasmonic Nanopatch Antennas, Bryson Krause, Dhananjay Mishra, Jiyang Chen, Christos Argyropoulos, Thang Hoang

Department of Electrical and Computer Engineering: Faculty Publications

Enhanced electromagnetic fields within plasmonic nanocavity mode volumes enable multiple significant effects that lead to applications in both the linear and nonlinear optical regimes. In this work, we demonstrate enhanced second harmonic generation from individual plasmonic nanopatch antennas which are formed by separating silver nanocubes from a smooth gold film using a sub-10 nm zinc oxide spacer layer. When the nanopatch antennas are excited at their fundamental plasmon frequency, a 10⁴-fold increase in the intensity of the second harmonic generation wave is observed. Moreover, by integrating quantum emitters that have an absorption energy at the fundamental frequency, a …

A New Implementation Of Federated Learning For Privacy And Security Enhancement, Xiang Ma, Haijian Sun, Rose Qingyang Hu, Yi Qian

Department of Electrical and Computer Engineering: Faculty Publications

Motivated by the ever-increasing concerns on personal data privacy and the rapidly growing data volume at local clients, federated learning (FL) has emerged as a new machine learning setting. An FL system is comprised of a central parameter server and multiple local clients. It keeps data at local clients and learns a centralized model by sharing the model parameters learned locally. No local data needs to be shared, and privacy can be well protected. Nevertheless, since it is the model instead of the raw data that is shared, the system can be exposed to the poisoning model attacks launched by …

Influence Of Aluminum Addition On The Laser Powder Bed Fusion Of Copper-Aluminum Mixtures, Nada Kraiem, Loic Constantin, A. Mao, Fei Wang, Bai Cui, Jean-François Silvain, Yongfeng Lu

Department of Electrical and Computer Engineering: Faculty Publications

The high optical reflectivity of copper (Cu) in the near infrared (NIR) domain and its elevated heat dissipation make Cu a challenging metal for laser powder bed fusion (LPBF), even with high energy densities (EDs). In this study, we demonstrated that adding aluminum (Al) powder by as little as 0.75, 1.5, and 3 wt.% substantially enhances Cu processability, leading to denser (up to 98%) and smoother (Ra = 3.3 𝜇m) Cu-Al parts as compared to 95% and 18 𝜇m, respectively, for the parts printed using pure Cu. In addition, this method reduces the ED required by a factor of two …

Asymmetric Control Of Light At The Nanoscale, Christos Argyropoulos

Department of Electrical and Computer Engineering: Faculty Publications

Breaking reciprocity at the nanoscale can produce directional formation of images due to the asymmetric nonlinear optical response of subwavelength anisotropic resonators. The self-induced passive non-reciprocity has advantages compared to magnet or time modulation approaches and may impact both classical and quantum photonics.

Halide Perovskites Enable Polaritonic Xy Spin Hamiltonian At Room Temperature, Renjie Tao, Kai Peng, Louis Haeberlé, Quanwei Li, Dafei Jin, Graham R. Fleming, Stéphane Kéna-Cohen, Xiang Zhang, Wei Bao

Department of Electrical and Computer Engineering: Faculty Publications

Exciton polaritons, the part-light and part-matter quasiparticles in semiconductor optical cavities, are promising for exploring Bose–Einstein condensation, non-equilibrium many-body physics and analogue simulation at elevated temperatures. However, a room-temperature polaritonic platform on par with the GaAs quantum wells grown by molecular beam epitaxy at low temperatures remains elusive. The operation of such a platform calls for long-lifetime, strongly interacting excitons in a stringent material system with large yet nanoscale-thin geometry and homogeneous properties. Here, we address this challenge by adopting a method based on the solution synthesis of excitonic halide perovskites grown under nanoconfinement. Such nanoconfinement growth facilitates the synthesis …

Rechargeable Multi-Cell Battery, Wei Qiao, Taesic Kim, Liyan Qu

Department of Electrical and Computer Engineering: Faculty Publications

A method for power management of a multi - cell battery includes identifying a desired power value and voltage value , determining a battery voltage value and a battery current value for a battery , determining a number of battery banks from a plurality of battery banks to use for the battery , where each battery bank includes one or more battery cells ( or battery modules ) , checking availability of each of the one or more battery cells ( or battery modules ) , selecting one or more battery banks from the plurality of battery banks , where …

A High-Density Theta Burst Paradigm Enhances The Aftereffects Of Transcranial Magnetic Stimulation: Evidence From Focal Stimulation Of Rat Motor Cortex, Qinglei Meng, Hieu Nguyen, Antonia Vrana, Simone Baldwin, Charlotte Qiong Li, Antonia Giles, Jun Wang, Yihong Yang, Hanbing Lu

Department of Electrical and Computer Engineering: Faculty Publications

Background: Theta burst stimulation (TBS) is an efficient noninvasive neuromodulation paradigm that has been widely adopted, clinically. However, the efficacy of TBS treatment remains similarly modest as conventional 10 Hz repetitive transcranial magnetic stimulation (rTMS).

Objective/hypothesis: To develop a new TBS paradigm that enhances the effects of TMS administration while maintaining high time-efficiency.

Methods: We describe here a new TMS paradigm, named High-Density Theta Burst Stimulation (hdTBS). This paradigm delivers up to 6 pulses per burst, as opposed to only 3 in conventional TBS, while maintaining the inter-burst interval of 200 ms (or 5 Hz) - a …

Queueing Theory Model Of Pentose Phosphate Pathway, Sylwester M. Kloska, Krzysztof Pałczyński, Tomasz Marciniak, Tomasz Talaśka, Marissa Miller, Beata J. Wysocki, Paul H. Davis, Tadeusz A. Wysocki

Department of Electrical and Computer Engineering: Faculty Publications

Due to its role in maintaining the proper functioning of the cell, the pentose phosphate pathway (PPP) is one of the most important metabolic pathways. It is responsible for regulating the concentration of simple sugars and provides precursors for the synthesis of amino acids and nucleotides. In addition, it plays a critical role in maintaining an adequate level of NADPH, which is necessary for the cell to fight oxidative stress. These reasons prompted the authors to develop a computational model, based on queueing theory, capable of simulating changes in PPP metabolites’ concentrations. The model has been validated with empirical data …

A Precise Dispenser Design For Canine Cognition Research, Walker Arce, Jeffrey R. Stevens

Department of Electrical and Computer Engineering: Faculty Publications

Some forms of canine cognition research require a dispenser that can accurately dispense precise quantities of treats. When using off-the-shelf or retrofitted dispensers, there is no guarantee that a precise number of treats will be dispensed. Often, they will over-dispense treats, which may not be acceptable for some tasks. Here we describe a 3D-printed precise treat dispenser with a 59-treat capacity driven by a stepper motor drive and controlled by an integrated Raspberry Pi. The dispenser can be built for less than 200 USD and is fully 3D printable. While off-the-shelf dispensers can result in an error rate of 20–30%, …

Infrared Dielectric Functions And Brillouin Zone Center Phonons Of Α-Ga2O3 Compared To Α-Al2O3, Megan Stokey, Rafal Korlacki, Matthew J. Hilfiker, Sean Knight, Steffen Richter, Vanya Darakchieva, Riena Jinno, Yongjin Cho, Huili Grace Xing, Debdeep Jena, Yuichi Oshima, Kamruzzaman Khan, Elaheh Ahmadi, Mathias Schubert

Department of Electrical and Computer Engineering: Faculty Publications

We determine the anisotropic dielectric functions of rhombohedral α-Ga₂O₃ by far-infrared and infrared generalized spectroscopic ellipsometry and derive all transverse optical and longitudinal optical phonon mode frequencies and broadening parameters. We also determine the high-frequency and static dielectric constants. We perform density functional theory computations and determine the phonon dispersion for all branches in the Brillouin zone, and we derive all phonon mode parameters at the Brillouin zone center including Raman-active, infrared-active, and silent modes. Excellent agreement is obtained between our experimental and computation results as well as among all previously reported partial information from experiment …

Nanomechanical Resonators: Toward Atomic Scale, Bo Xu, Pengcheng Zhang, Jiankai Zhu, Zuheng Liu, Alexander Eichler, Xu-Qian Zheng, Jaesung Lee, Aneesh Dash, Swapnil More, Song Wu, Yanan Yanan, Hao Jia, Akshay Naik, Adrian Bachtold, Rui Yang, Philip X.-L. Feng, Zenghui Wang

Department of Electrical and Computer Engineering: Faculty Publications

The quest for realizing and manipulating ever smaller man-made movable structures and dynamical machines has spurred tremendous endeavors, led to important discoveries, and inspired researchers to venture to new grounds. Scientific feats and technological milestones of miniaturization of mechanical structures have been widely accomplished by advances in machining and sculpturing ever shrinking features out of bulk materials such as silicon. With the flourishing multidisciplinary field of low-dimensional nanomaterials, including one-dimensional (1D) nanowires/nanotubes, and two-dimensional (2D) atomic layers such as graphene/phosphorene, growing interests and sustained efforts have been devoted to creating mechanical devices toward the ultimate limit of miniaturization— genuinely down …

Serum Protein Signatures Using Aptamer-Based Proteomics For Minimal Change Disease And Membranous Nephropathy, Daniel A. Muruve, Hanna Debiec, Simon T. Dillon, Xuesong Gu, Emmanuelle Plaisier, Handan Can, Hasan H. Otu, Towia A. Libermann, Pierre Ronco

Department of Electrical and Computer Engineering: Faculty Publications

Introduction: Minimal change disease (MCD) and membranous nephropathy (MN) are glomerular diseases (glomerulonephritis [GN]) that present with the nephrotic syndrome. Although circulating PLA2R antibodies have been validated as a biomarker for MN, the diagnosis of MCD and PLA2R-negative MN still relies on the results of kidney biopsy or empirical corticosteroids in children. We aimed to identify serum protein biomarker signatures associated with MCD and MN pathogenesis using aptamer-based proteomics.

Methods: Quantitative SOMAscan proteomics was applied to the serum of adult patients with MCD (n = 15) and MN(n = 37) and healthy controls (n = …